IL129519A - אנלוגים הפטאפפטידיים בעלי פעילות אנטגוניסטית לאוקסיטוצין, שיטות הכנתם, הרכבים רוקחיים המכילים אותם, ושימושם ביצור תרופות - Google Patents

אנלוגים הפטאפפטידיים בעלי פעילות אנטגוניסטית לאוקסיטוצין, שיטות הכנתם, הרכבים רוקחיים המכילים אותם, ושימושם ביצור תרופות

Info

Publication number
IL129519A
IL129519A IL12951997A IL12951997A IL129519A IL 129519 A IL129519 A IL 129519A IL 12951997 A IL12951997 A IL 12951997A IL 12951997 A IL12951997 A IL 12951997A IL 129519 A IL129519 A IL 129519A
Authority
IL
Israel
Prior art keywords
residue
abu
asn
mpa
ile
Prior art date
Application number
IL12951997A
Other languages
English (en)
Other versions
IL129519A0 (en
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of IL129519A0 publication Critical patent/IL129519A0/xx
Publication of IL129519A publication Critical patent/IL129519A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
IL12951997A 1996-11-26 1997-11-21 אנלוגים הפטאפפטידיים בעלי פעילות אנטגוניסטית לאוקסיטוצין, שיטות הכנתם, הרכבים רוקחיים המכילים אותם, ושימושם ביצור תרופות IL129519A (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9604341A SE9604341D0 (sv) 1996-11-26 1996-11-26 Hepta-peptide oxytocin analogue
PCT/SE1997/001968 WO1998023636A1 (en) 1996-11-26 1997-11-21 Heptapeptide oxytocin analogues

Publications (2)

Publication Number Publication Date
IL129519A0 IL129519A0 (en) 2000-02-29
IL129519A true IL129519A (he) 2004-09-27

Family

ID=20404757

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12951997A IL129519A (he) 1996-11-26 1997-11-21 אנלוגים הפטאפפטידיים בעלי פעילות אנטגוניסטית לאוקסיטוצין, שיטות הכנתם, הרכבים רוקחיים המכילים אותם, ושימושם ביצור תרופות

Country Status (35)

Country Link
US (1) US6143722A (he)
EP (1) EP0938496B1 (he)
JP (1) JP3405460B2 (he)
KR (1) KR100463132B1 (he)
CN (1) CN1129606C (he)
AR (1) AR008531A1 (he)
AT (1) ATE242264T1 (he)
AU (1) AU713424B2 (he)
BR (1) BR9713366B1 (he)
CA (1) CA2272990C (he)
CZ (1) CZ299532B6 (he)
DE (1) DE69722651T2 (he)
DK (1) DK0938496T3 (he)
EE (1) EE03832B1 (he)
ES (1) ES2203823T3 (he)
HK (1) HK1022481A1 (he)
HR (1) HRP970630B1 (he)
HU (1) HU228568B1 (he)
IL (1) IL129519A (he)
LT (1) LT4650B (he)
LV (1) LV12350B (he)
MY (1) MY125555A (he)
NO (1) NO321380B1 (he)
NZ (1) NZ336445A (he)
PL (1) PL189292B1 (he)
PT (1) PT938496E (he)
RO (1) RO120772B1 (he)
RU (1) RU2180668C2 (he)
SE (1) SE9604341D0 (he)
SI (1) SI20026B (he)
SK (1) SK283800B6 (he)
TR (1) TR199901028T2 (he)
UA (1) UA54459C2 (he)
WO (1) WO1998023636A1 (he)
ZA (1) ZA9710518B (he)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2181297C2 (ru) 2000-06-20 2002-04-20 Эпштейн Олег Ильич Способ лечения патологического синдрома и лекарственное средство
US6476072B1 (en) * 2000-11-21 2002-11-05 Arthur Vanmoor Method of treating menstrual pain by enhancing the effectiveness of the human immune system
ES2277640T3 (es) * 2002-02-27 2007-07-16 Ferring Bv Productos intermedios y metodos para preparar analogos de heptapeptido de oxitocina.
US20060014147A1 (en) * 2002-05-02 2006-01-19 Stefan Golz Diagnostics and therapeutics for diseases associated with oxytocin receptor (oxtr)
GB0210397D0 (en) * 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
UA76639C2 (uk) * 2002-08-02 2006-08-15 Олєг Ільіч Епштєйн Гомеопатичний лікарський засіб та спосіб лікування еректильних дисфункцій
EP1530967B1 (en) * 2003-11-13 2006-05-03 Ferring B.V. Blister pack and solid dosage form comprising desmopressin
EP1555029A1 (en) 2004-01-19 2005-07-20 Ferring B.V. Use of substances having oxytocin antagonistic properties for the preparation of a medicament for treating hypertension
US20060171909A1 (en) * 2005-02-03 2006-08-03 The Procter & Gamble Company Cosmetic compositions comprising colorants with low free dye
SE528446C2 (sv) * 2006-03-02 2006-11-14 Ferring Int Ct Sa Farmaceutisk sammansättning innefattande desmopressin, kiseldioxid och stärkelse
KR20140143461A (ko) 2007-08-06 2014-12-16 알레간 인코포레이티드 데스모프레신 약물 전달을 위한 방법 및 장치
BRPI0910345B1 (pt) * 2008-03-31 2021-08-17 Ferring B.V. Compostos análogos de oxitocina, composição farmacêutica compreendendo os mesmos e uso dos ditos análogos
TR201819189T4 (tr) 2008-05-21 2019-01-21 Ferring Bv Noktüri İle Bozulmayan İlk Uyku Periyodunun Arttırılması İçin Ağızda Dağılan Desmopressin
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
TWI463990B (zh) * 2009-09-21 2014-12-11 Ferring Bv 催產素受體促進劑
US9308275B2 (en) 2010-07-15 2016-04-12 Oleg Iliich Epshtein Method of increasing the effect of an activated-potentiated form of an antibody
JO3400B1 (ar) * 2010-09-30 2019-10-20 Ferring Bv مركب صيدلاني من كاربيتوسين
EP2684888B1 (en) 2011-03-09 2019-05-15 Jitsubo Co., Ltd. Novel cross-linked peptides containing non-peptide cross-linked structure, method for synthesizing cross-linked peptides, and novel organic compound used in method
CN102875650B (zh) * 2012-09-26 2014-06-11 深圳翰宇药业股份有限公司 巴卢西班的制备方法
US9365615B2 (en) 2013-09-09 2016-06-14 Jitsubo Co., Ltd. Cross-linked peptides containing non-peptide cross-linked structure, method for synthesizing cross-linked peptides, and novel organic compound used in method
PL3037101T3 (pl) * 2014-12-22 2019-06-28 Ferring B.V. Terapia antagonistą receptora oksytocyny w fazie lutealnej w celu implantacji i uzyskania ciąży u kobiet poddawanych technikom wspomaganego rozrodu
US9744239B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
CN108290929A (zh) 2015-10-06 2018-07-17 辉凌公司 制造巴芦西班及其中间体的新型方法
HUE058872T2 (hu) 2016-01-04 2022-09-28 ObsEva SA Hidroxipropil-tiazolidin-karboxamid származék alfa-amino-észtere és tokolitikus szer együttes alkalmazása
EP3487493B1 (en) 2016-07-21 2021-09-01 ObsEva S.A. Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage
JP2022546716A (ja) 2019-09-03 2022-11-07 オブセヴァ エス．エー． 胚着床を促進し、流産を防止するためのオキシトシンアンタゴニスト投与レジメン
CA3167121A1 (en) 2020-02-10 2021-08-19 ObsEva S.A. Biomarkers for oxytocin receptor antagonist therapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2036973A1 (en) * 1990-02-27 1991-08-28 Mark G. Bock Cyclic hexapeptide oxytocin antagonists
SE9002384D0 (sv) * 1990-07-09 1990-07-09 Ferring Ab Derivat av baklobshormoner
SE501678C2 (sv) * 1993-07-13 1995-04-10 Ferring Bv Peptid med oxytocinantagonistaktivitet samt farmaceutisk komposition innehållande nämnda peptid
SE523819C2 (sv) 1994-01-27 2004-05-18 Per-Ingvar Nilsson Accelerationsmunstycke samt metod för dess användning
SE9400918L (sv) 1994-03-18 1995-09-19 Anne Fjellstad Paulsen Stabiliserad komposition för oral administrering av peptider
SE503085C2 (sv) 1995-01-25 1996-03-25 Valeo Engine Cooling Ab Värmeväxlartank med ändstycken, förfarande för framställning av en sådan tank, samt värmeväxlare försedd med en sådan

Also Published As

Publication number Publication date
AU5142998A (en) 1998-06-22
LV12350B (en) 1999-11-20
ZA9710518B (en) 1998-06-10
SI20026A (sl) 2000-02-29
ATE242264T1 (de) 2003-06-15
HRP970630A2 (en) 1998-10-31
IL129519A0 (en) 2000-02-29
KR100463132B1 (ko) 2004-12-23
DK0938496T3 (da) 2003-10-06
HU228568B1 (en) 2013-04-29
JP3405460B2 (ja) 2003-05-12
AU713424B2 (en) 1999-12-02
HUP0000577A3 (en) 2001-02-28
UA54459C2 (uk) 2003-03-17
WO1998023636A1 (en) 1998-06-04
CZ183299A3 (cs) 2000-05-17
CZ299532B6 (cs) 2008-08-27
LV12350A (lv) 1999-09-20
PL189292B1 (pl) 2005-07-29
NO992532D0 (no) 1999-05-26
KR20000069045A (ko) 2000-11-25
LT99052A (en) 2000-01-25
HRP970630B1 (en) 2002-04-30
PT938496E (pt) 2003-10-31
JP2000507617A (ja) 2000-06-20
CN1238781A (zh) 1999-12-15
DE69722651T2 (de) 2004-04-08
EP0938496A1 (en) 1999-09-01
SK70499A3 (en) 2000-10-09
CA2272990C (en) 2002-11-19
SK283800B6 (sk) 2004-02-03
ES2203823T3 (es) 2004-04-16
CA2272990A1 (en) 1998-06-04
AR008531A1 (es) 2000-01-19
MY125555A (en) 2006-08-30
EP0938496B1 (en) 2003-06-04
RU2180668C2 (ru) 2002-03-20
RO120772B1 (ro) 2006-07-28
CN1129606C (zh) 2003-12-03
NO992532L (no) 1999-05-26
TR199901028T2 (xx) 1999-07-21
HUP0000577A2 (hu) 2000-11-28
BR9713366B1 (pt) 2010-05-18
HK1022481A1 (en) 2000-08-11
US6143722A (en) 2000-11-07
SE9604341D0 (sv) 1996-11-26
NO321380B1 (no) 2006-05-02
EE9900210A (et) 1999-12-15
BR9713366A (pt) 2000-01-25
LT4650B (lt) 2000-04-25
NZ336445A (en) 2000-06-23
EE03832B1 (et) 2002-08-15
SI20026B (sl) 2000-06-30
DE69722651D1 (en) 2003-07-10

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