IL129501A0 - Method for producing transgenic animal models with modulated phenotype and animals produced therefrom - Google Patents

Method for producing transgenic animal models with modulated phenotype and animals produced therefrom

Info

Publication number
IL129501A0
IL129501A0 IL12950197A IL12950197A IL129501A0 IL 129501 A0 IL129501 A0 IL 129501A0 IL 12950197 A IL12950197 A IL 12950197A IL 12950197 A IL12950197 A IL 12950197A IL 129501 A0 IL129501 A0 IL 129501A0
Authority
IL
Israel
Prior art keywords
transgene
transgenic animal
pathology
mutant
mutation
Prior art date
Application number
IL12950197A
Other languages
English (en)
Original Assignee
Univ South Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27363376&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL129501(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ South Florida filed Critical Univ South Florida
Publication of IL129501A0 publication Critical patent/IL129501A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Plant Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL12950197A 1996-10-21 1997-10-15 Method for producing transgenic animal models with modulated phenotype and animals produced therefrom IL129501A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2893796P 1996-10-21 1996-10-21
US2971196P 1996-11-12 1996-11-12
US08/903,518 US5898094A (en) 1996-10-21 1997-07-30 Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes
PCT/US1997/018524 WO1998017782A1 (en) 1996-10-21 1997-10-15 Method for producing transgenic animal models with modulated phenotype and animals produced therefrom

Publications (1)

Publication Number Publication Date
IL129501A0 true IL129501A0 (en) 2000-02-29

Family

ID=27363376

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12950197A IL129501A0 (en) 1996-10-21 1997-10-15 Method for producing transgenic animal models with modulated phenotype and animals produced therefrom

Country Status (9)

Country Link
US (1) US5898094A (xx)
EP (1) EP0946712B1 (xx)
JP (1) JP4260892B2 (xx)
AT (1) ATE401389T1 (xx)
AU (1) AU719507B2 (xx)
CA (1) CA2268812C (xx)
DE (1) DE69738840D1 (xx)
IL (1) IL129501A0 (xx)
WO (1) WO1998017782A1 (xx)

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US20030131364A1 (en) * 1999-04-27 2003-07-10 Karen Duff Method for producing transgenic animal models with modulated phenotype and animals produced therefrom
EP1063298A3 (en) * 1999-06-04 2001-03-28 Glaxo Group Limited Transgenic Animal Model for Alzheimer Disease
FR2798556B1 (fr) * 1999-09-17 2004-02-27 Aventis Pharma Sa Nouveau modele animal de la maladie d'alzheimer presentant a la fois des plaques amyloides et des dysfonctionnements mitochondriaux
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FR2798821B1 (fr) 1999-09-27 2001-10-26 Aventis Pharma Sa Animal transgenique exprimant une forme multi-mutee de la preseniline 1
DK1255437T3 (da) * 1999-09-27 2010-08-09 Aventis Pharma Sa Transgent dyr, der eksprimerer en form af presenilin 1, der er muteret flere gange
AR027878A1 (es) * 1999-11-05 2003-04-16 Wyeth Corp Metodos para identificar y utilizar compuestos inhibidores de amiloides
DE60141028D1 (de) * 2000-01-24 2010-02-25 Neurosciences Res Found Verfahren zur funktionellen Kartierung des Gesamtnetzwerkes der Alzheimerischen Krankheit
AU2001249717B2 (en) 2000-04-03 2006-03-30 Bristol-Myers Squibb Company Fluorescence assay for gamma-secretase activity and inhibitors
US7371365B2 (en) * 2000-04-04 2008-05-13 Mayo Foundation For Medical Education And Research Methods for detecting parenchymal plaques in vivo
US20060004086A1 (en) * 2000-04-13 2006-01-05 Mayo Foundation For Medical Education And Research Method of reducing Abeta42 and treating diseases
EP1284729A4 (en) * 2000-04-13 2007-12-19 Mayo Foundation REDUCTION AGENTS OF A (BETA) 42
US7371920B2 (en) * 2000-06-20 2008-05-13 The Governing Council Of The University Of Toronto Transgenic mouse model of neurodegenerative disorders
ATE323408T1 (de) * 2000-06-20 2006-05-15 Univ Toronto Transgenes tiermodell für neurodegenerative erkrankungen
AU2001276995C1 (en) * 2000-07-20 2006-10-26 Cephalon, Inc. Gene-targeted non-human mammal with human fad presenilin mutation and generational offspring
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US20040092013A1 (en) * 2001-08-14 2004-05-13 Snyder Evan Y. Method of treating alzheimer's disease with cell therapy
KR100462180B1 (ko) * 2001-11-20 2004-12-16 (주) 디지탈바이오텍 알츠하이머병 병인 유전자로 형질전환된 동물 및 그 제조방법
US7479579B2 (en) * 2001-12-20 2009-01-20 The Regents Of The University Of California Triple transgenic mouse model of Alzheimer's disease
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KR100584914B1 (ko) * 2004-03-30 2006-05-30 주식회사 뉴로테크 돌연변이 ａｐｐ를 발현하는 알츠하이머병 유발 형질전환마우스
US20070293538A1 (en) * 2004-04-13 2007-12-20 Myriad Genetics, Incorporated Pharmaceutical Composition And Methods For Treating Neurodegenerative Disorders
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JP2008519282A (ja) * 2004-11-05 2008-06-05 ワイス アルツハイマー病治療薬をスクリーニングするための画像診断モダリティー
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CA2607852A1 (en) * 2005-05-27 2006-11-30 Memory Pharmaceuticals Corp. Transgenic alzheimer's mouse model vectors and uses thereof
EA200800360A1 (ru) * 2005-07-22 2008-06-30 Мириад Дженетикс, Инк. Формуляции с высоким содержанием лекарства и дозированные формы
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Also Published As

Publication number Publication date
US5898094A (en) 1999-04-27
WO1998017782A8 (en) 2000-08-03
EP0946712B1 (en) 2008-07-16
DE69738840D1 (de) 2008-08-28
ATE401389T1 (de) 2008-08-15
WO1998017782A1 (en) 1998-04-30
AU719507B2 (en) 2000-05-11
CA2268812A1 (en) 1998-04-30
CA2268812C (en) 2012-04-24
JP4260892B2 (ja) 2009-04-30
EP0946712A4 (en) 2002-05-08
JP2002515750A (ja) 2002-05-28
EP0946712A1 (en) 1999-10-06
AU4820297A (en) 1998-05-15

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