IL129173A - מיקרו-בועיות המכילות גז ותהליך להכנת גורם הדמית irm המכיל אותן - Google Patents

מיקרו-בועיות המכילות גז ותהליך להכנת גורם הדמית irm המכיל אותן

Info

Publication number
IL129173A
IL129173A IL12917398A IL12917398A IL129173A IL 129173 A IL129173 A IL 129173A IL 12917398 A IL12917398 A IL 12917398A IL 12917398 A IL12917398 A IL 12917398A IL 129173 A IL129173 A IL 129173A
Authority
IL
Israel
Prior art keywords
gas
microvesicles
hyperpolarized
gases
mri
Prior art date
Application number
IL12917398A
Other languages
English (en)
Other versions
IL129173A0 (en
Original Assignee
Bracco Research Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Research Sa filed Critical Bracco Research Sa
Publication of IL129173A0 publication Critical patent/IL129173A0/xx
Publication of IL129173A publication Critical patent/IL129173A/he

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Acoustics & Sound (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicinal Preparation (AREA)
  • Soft Magnetic Materials (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
IL12917398A 1997-08-12 1998-08-11 מיקרו-בועיות המכילות גז ותהליך להכנת גורם הדמית irm המכיל אותן IL129173A (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97810563 1997-08-12
PCT/IB1998/001227 WO1999007415A1 (en) 1997-08-12 1998-08-11 Administrable compositions and methods for magnetic resonance imaging

Publications (2)

Publication Number Publication Date
IL129173A0 IL129173A0 (en) 2000-02-17
IL129173A true IL129173A (he) 2002-03-10

Family

ID=8230338

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12917398A IL129173A (he) 1997-08-12 1998-08-11 מיקרו-בועיות המכילות גז ותהליך להכנת גורם הדמית irm המכיל אותן

Country Status (12)

Country Link
US (1) US6042809A (he)
EP (1) EP0968000B1 (he)
JP (1) JP4317270B2 (he)
CN (1) CN1103605C (he)
AT (1) ATE252916T1 (he)
AU (1) AU726115C (he)
CA (1) CA2268324C (he)
DE (1) DE69819309T2 (he)
ES (1) ES2209167T3 (he)
IL (1) IL129173A (he)
NO (1) NO313865B1 (he)
WO (1) WO1999007415A1 (he)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922304A (en) * 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
EP0890114A1 (en) 1996-03-29 1999-01-13 Lawrence Berkeley National Laboratory Enhancement of nmr and mri in the presence of hyperpolarized noble gases
CA2324269C (en) 1998-03-18 2007-06-12 Magnetic Imaging Technologies, Inc. Mr methods for imaging pulmonary and cardiac vasculature and evaluating blood flow using dissolved polarized 129xe
US6423387B1 (en) 1998-06-17 2002-07-23 Medi-Physics, Inc. Resilient containers for hyperpolarized gases and associated methods
BR9911346A (pt) 1998-06-17 2001-03-13 Medi Physics Inc Dispositivo de transporte de gás hiperpolarizado e método de transporte associado
US6128918A (en) * 1998-07-30 2000-10-10 Medi-Physics, Inc. Containers for hyperpolarized gases and associated methods
US6159444A (en) * 1998-09-11 2000-12-12 The Regents Of The University Of California NMR/MRI with hyperpolarized gas and high Tc SQUID
EP1118009A1 (en) * 1998-09-28 2001-07-25 Nycomed Imaging As Method of magnetic resonance imaging
US6237363B1 (en) 1998-09-30 2001-05-29 Medi-Physics, Inc. Hyperpolarized noble gas extraction methods masking methods and associated transport containers
US6523356B2 (en) 1998-09-30 2003-02-25 Medi-Physics, Inc. Meted hyperpolarized noble gas dispensing methods and associated devices
US6286319B1 (en) 1998-09-30 2001-09-11 Medi-Physics, Inc. Meted hyperpolarized noble gas dispensing methods and associated devices
US6284222B1 (en) * 1998-11-03 2001-09-04 Medi--Physics, Inc. Hyperpolarized helium-3 microbubble gas entrapment methods
WO2000050914A1 (en) 1999-02-23 2000-08-31 Medi-Physics, Inc. Portable system for monitoring the polarization level of a hyperpolarized gas during transport
US6295834B1 (en) 1999-06-30 2001-10-02 Medi-Physics, Inc. NMR polarization monitoring coils, hyperpolarizers with same, and methods for determining the polarization level of accumulated hyperpolarized noble gases during production
US6308705B1 (en) * 1999-12-21 2001-10-30 Siemens Aktiengesellschaft Integrated lung therapy method
CN1429086A (zh) 2000-03-13 2003-07-09 医疗物理有限公司 使用气态超极化129Xe的直接注射的诊断步骤以及相关系统和产品
US7061237B2 (en) * 2000-07-13 2006-06-13 The Regents Of The University Of California Remote NMR/MRI detection of laser polarized gases
AU2001284648A1 (en) 2000-07-13 2002-01-30 Medi-Physics, Inc. Diagnostic procedures using 129XE spectroscopy characteristic chemical shift to detect pathology in vivo
US20030165431A1 (en) * 2000-07-13 2003-09-04 The Regents Of The University Of California Method for detecting macromolecular conformational change and binding information
US6652833B2 (en) * 2000-07-13 2003-11-25 The Regents Of The University Of California Functionalized active-nucleus complex sensor
US7179450B2 (en) 2001-09-20 2007-02-20 Medi-Physics, Inc. Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe
CA2418229A1 (en) * 2002-05-16 2003-11-16 Rohan Dharmakumar Microbubble construct for sensitivity enhanced mr manometry
NO20022960D0 (no) 2002-06-19 2002-06-19 Medinnova Sf Apparat og metode for intubasjonsovervåkning
GB0218868D0 (en) 2002-08-14 2002-09-25 Nasir Muhammed A Improved airway management device
US20040167400A1 (en) * 2002-11-27 2004-08-26 Accuimage Diagnostics Corp. Method and apparatus for improving a virtual colonoscopy and A CT angiography
US20050025710A1 (en) * 2003-07-29 2005-02-03 Michel Schneider Reconstitutable formulation and aqueous suspension of gas-filled microvesicles for diagnostic imaging
DE102005026604A1 (de) * 2005-06-09 2006-12-14 Membrana Gmbh Verfahren zum Lösen von Gasen mit kurzlebigen physikalischen Eigenschaften in einer Flüssigkeit
US8377419B2 (en) * 2005-09-28 2013-02-19 The President And Fellows Of Harvard College Hyperpolarized solid materials with long spin relaxation times for use as imaging agents in magnetic resonance imaging
EP1968442A4 (en) * 2005-12-10 2009-11-04 Harvard College In situ hyperpolarization of imaging agents
JP2009523172A (ja) * 2006-01-11 2009-06-18 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ 造影剤のエクスビボ過分極
WO2007136439A2 (en) 2006-02-21 2007-11-29 Avrum Belzer Hyperpolarization methods, systems and compositions
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
US20100092390A1 (en) * 2008-10-09 2010-04-15 President And Fellows Of Harvard College Methods for Making Particles Having Long Spin-Lattice Relaxation Times
JP2013180956A (ja) * 2012-02-29 2013-09-12 Sunstar Engineering Inc 殺菌剤組成物
US20140288411A1 (en) * 2013-03-12 2014-09-25 The Regents Of The University Of California Gas vesicle magnetic resonance imaging contrast agents and methods of using the same
CN103815907B (zh) * 2014-03-04 2016-04-06 合肥工业大学 用于人体呼吸系统检测成像的成像气体及其储气装置
CN103807598B (zh) * 2014-03-04 2016-06-01 合肥工业大学 一种储存成像气体的储气装置
US11350909B2 (en) 2018-04-17 2022-06-07 California Institute Of Technology Cross amplitude modulation ultrasound pulse sequence
JP7313856B2 (ja) * 2019-03-27 2023-07-25 日本液炭株式会社 キセノンウルトラファインバブル発生剤
CN111110657A (zh) * 2020-02-14 2020-05-08 徐州医科大学 可双模成像及靶向治疗乳腺癌的纳米微球及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5922304A (en) * 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
IN172208B (he) * 1990-04-02 1993-05-01 Sint Sa
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5785983A (en) * 1991-05-23 1998-07-28 Euroresearch Srl Non-porous collagen sheet for therapeutic use, and the method and apparatus for preparing it
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5617860A (en) * 1995-06-07 1997-04-08 Smithsonian Astrophysical Observatory Method and system for producing polarized 129 Xe gas
ES2197986T3 (es) * 1996-02-19 2004-01-16 Amersham Health As Mejoras introducidas en o relacionadas con agentes de contraste.
EP0890114A1 (en) * 1996-03-29 1999-01-13 Lawrence Berkeley National Laboratory Enhancement of nmr and mri in the presence of hyperpolarized noble gases
US5694934A (en) * 1996-04-17 1997-12-09 Beth Israel Hospital MR studies in which a paramagnetic gas is administered to a living patient

Also Published As

Publication number Publication date
US6042809A (en) 2000-03-28
EP0968000B1 (en) 2003-10-29
AU8458798A (en) 1999-03-01
DE69819309T2 (de) 2004-07-15
AU726115C (en) 2001-12-20
CN1236323A (zh) 1999-11-24
NO313865B1 (no) 2002-12-16
CN1103605C (zh) 2003-03-26
EP0968000A1 (en) 2000-01-05
CA2268324C (en) 2007-06-12
JP4317270B2 (ja) 2009-08-19
NO991688D0 (no) 1999-04-09
ES2209167T3 (es) 2004-06-16
AU726115B2 (en) 2000-11-02
JP2001501977A (ja) 2001-02-13
CA2268324A1 (en) 1999-02-18
DE69819309D1 (de) 2003-12-04
WO1999007415A1 (en) 1999-02-18
ATE252916T1 (de) 2003-11-15
NO991688L (no) 1999-06-09
IL129173A0 (en) 2000-02-17

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Legal Events

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FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees