IL127597A - Iso-taxol analogs - Google Patents

Iso-taxol analogs

Info

Publication number
IL127597A
IL127597A IL12759795A IL12759795A IL127597A IL 127597 A IL127597 A IL 127597A IL 12759795 A IL12759795 A IL 12759795A IL 12759795 A IL12759795 A IL 12759795A IL 127597 A IL127597 A IL 127597A
Authority
IL
Israel
Prior art keywords
pct
iso
taxol
taxol analogs
sec
Prior art date
Application number
IL12759795A
Other languages
English (en)
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of IL127597A publication Critical patent/IL127597A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Lining Or Joining Of Plastics Or The Like (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL12759795A 1994-01-28 1995-01-23 Iso-taxol analogs IL127597A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18923594A 1994-01-28 1994-01-28
IL11241295A IL112412A (en) 1994-01-28 1995-01-23 Delta 12,13-iso-taxol analogs and antineoplastic pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
IL127597A true IL127597A (en) 2003-07-31

Family

ID=22696514

Family Applications (7)

Application Number Title Priority Date Filing Date
IL12759795A IL127597A (en) 1994-01-28 1995-01-23 Iso-taxol analogs
IL12759995A IL127599A (en) 1994-01-28 1995-01-23 Process for preparing isotaxol analogs
IL11241295A IL112412A (en) 1994-01-28 1995-01-23 Delta 12,13-iso-taxol analogs and antineoplastic pharmaceutical compositions containing them
IL12759895A IL127598A (en) 1994-01-28 1995-01-23 Process for preparing isotaxol analogs
IL12759898A IL127598A0 (en) 1994-01-28 1998-12-16 A process for preparing iso-taxol analogs
IL12759298A IL127592A0 (en) 1994-01-28 1998-12-16 Method and apparatus for producing plastic sleeves
IL12759798A IL127597A0 (en) 1994-01-28 1998-12-16 Iso-taxol analogs

Family Applications After (6)

Application Number Title Priority Date Filing Date
IL12759995A IL127599A (en) 1994-01-28 1995-01-23 Process for preparing isotaxol analogs
IL11241295A IL112412A (en) 1994-01-28 1995-01-23 Delta 12,13-iso-taxol analogs and antineoplastic pharmaceutical compositions containing them
IL12759895A IL127598A (en) 1994-01-28 1995-01-23 Process for preparing isotaxol analogs
IL12759898A IL127598A0 (en) 1994-01-28 1998-12-16 A process for preparing iso-taxol analogs
IL12759298A IL127592A0 (en) 1994-01-28 1998-12-16 Method and apparatus for producing plastic sleeves
IL12759798A IL127597A0 (en) 1994-01-28 1998-12-16 Iso-taxol analogs

Country Status (28)

Country Link
US (1) US5821363A (pt)
EP (1) EP0741716B1 (pt)
JP (1) JPH09508385A (pt)
KR (1) KR100378972B1 (pt)
CN (1) CN1163492C (pt)
AT (1) ATE221059T1 (pt)
AU (1) AU691575B2 (pt)
CA (1) CA2179176A1 (pt)
CZ (1) CZ208996A3 (pt)
DE (1) DE69527506T2 (pt)
DK (1) DK0741716T3 (pt)
ES (1) ES2181766T3 (pt)
FI (1) FI962952A (pt)
HU (1) HUT74508A (pt)
IL (7) IL127597A (pt)
LV (1) LV13120B (pt)
MX (1) MX9603052A (pt)
MY (1) MY130544A (pt)
NO (1) NO317832B1 (pt)
NZ (2) NZ331211A (pt)
PL (1) PL187409B1 (pt)
PT (1) PT741716E (pt)
RU (1) RU2142950C1 (pt)
SI (1) SI0741716T1 (pt)
SK (1) SK283780B6 (pt)
TW (1) TW464645B (pt)
WO (1) WO1995020582A1 (pt)
ZA (1) ZA95668B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
FR2742754B1 (fr) * 1995-12-22 1998-01-16 Rhone Poulenc Rorer Sa Procede de preparation de taxoides
NZ288802A (en) * 1994-06-28 1998-05-27 Upjohn Co Ether taxol derivatives, preparation and pharmaceutical compositions thereof
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
WO1996014309A1 (en) * 1994-11-04 1996-05-17 Pharmacia & Upjohn S.P.A Taxane derivatives
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
CA2170661A1 (en) 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
FR2743074B1 (fr) * 1995-12-27 1998-03-27 Seripharm Procede de protection selective des derives de la baccatine et son utilisation dans la synthese des taxanes
US5696152A (en) * 1996-05-07 1997-12-09 Wisconsin Alumni Research Foundation Taxol composition for use as organ preservation and cardioplegic agents
PL329637A1 (en) 1996-05-08 1999-04-12 Upjohn Co Taxol obtained method
US5902822A (en) * 1997-02-28 1999-05-11 Bristol-Myers Squibb Company 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
ES2388248T3 (es) 1997-03-31 2012-10-11 Boston Scientific Scimed Limited Forma de dosificación que comprende taxol en forma cristalina
US8791081B2 (en) * 1999-08-13 2014-07-29 Case Western Reserve University MGMT inhibitor combination for the treatment of neoplastic disorders
EP2289549A3 (en) 1999-10-01 2011-06-15 Immunogen, Inc. Immunoconjugates for treating cancer
CA2410632A1 (en) 2000-06-22 2001-12-27 David S. Garvey Nitrosated and nitrosylated taxanes, compositions and methods of use
US6726923B2 (en) 2001-01-16 2004-04-27 Vascular Therapies, Llc Apparatus and methods for preventing or treating failure of hemodialysis vascular access and other vascular grafts
ITMI20021921A1 (it) * 2002-09-10 2004-03-11 Indena Spa Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
ATE431343T1 (de) * 2002-10-09 2009-05-15 Chatham Biotec Ltd Thio-analoga von paclitaxel und deren vorprodukte
US6956124B2 (en) 2003-04-14 2005-10-18 Aventis Pharma S.A. Process for the preparation of 4,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-1,13α-dihydroxy-9-oxo-19-norcyclopropa[g]tax-11-ene
FR2853651B1 (fr) * 2003-04-14 2005-05-20 Aventis Pharma Sa Procede de preparation du 4,10 beta-diacetoxy-2 alpha- benzoyloxy-5 beta, 20-epoxy-1, 13 alpha-dihydroxy-9-oxo-19- norcyclopropa[g]tax-11-ene
US20070111328A1 (en) * 2005-08-19 2007-05-17 Bristol-Myers Squibb Company Scintillation proximity assay for the identification of P-glycoprotein modulators
JP5657890B2 (ja) * 2006-10-19 2015-01-21 モネル ケミカル センシズ センターＭｏｎｅｌｌ Ｃｈｅｍｉｃａｌ Ｓｅｎｓｅｓ Ｃｅｎｔｅｒ ヒト塩味受容体および塩味知覚を調節する方法
CN101468974B (zh) * 2007-12-28 2011-02-09 上海百灵医药科技有限公司 多烯紫杉醇的半合成方法
CN104650012A (zh) * 2013-11-22 2015-05-27 天士力控股集团有限公司 一种紫杉烷类化合物
CN104109142A (zh) * 2014-06-22 2014-10-22 南京工业大学 一种以巴卡丁iii为原料制备卡巴他赛的方法
CN108976217B (zh) * 2018-09-11 2021-03-26 济南爱思医药科技有限公司 一种多西他赛-1,2,3,-三氮唑化合物及其合成工艺和应用
CN115260130A (zh) * 2022-07-07 2022-11-01 上海卓鼎生物技术有限公司 一种10-脱乙酰基紫杉醇的制备方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
US4876399A (en) * 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
US5157049A (en) * 1988-03-07 1992-10-20 The United States Of America As Represented By The Department Of Health & Human Services Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
EP0366841A1 (en) * 1988-11-03 1990-05-09 Dresser-Rand Company A crosshead and crosshead pin coupling arrangement
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
CA2023645C (fr) * 1989-08-23 2002-03-26 Jean-Noel Denis Procede pour la preparation enantioselective de derives de la phenylisoserine
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
FR2658513B1 (fr) * 1990-02-21 1994-02-04 Rhone Poulenc Sante Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r).
FR2658510B1 (fr) * 1990-02-21 1992-04-30 Rhone Poulenc Sante Nouveau derive de la beta-phenylisoserine, sa preparation et son emploi.
FR2662440B1 (fr) * 1990-05-22 1992-07-31 Rhone Poulenc Sante Procede de preparation stereoselective de derives de la phenylisoserine.
FR2662441B1 (fr) * 1990-05-22 1992-10-23 Rhone Poulenc Sante Procede de preparation enantioselective de derives de la phenylisoserine.
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
FR2679230B1 (fr) * 1991-07-16 1993-11-19 Rhone Poulenc Rorer Sa Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent.
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
FR2687151B1 (fr) * 1992-02-07 1994-03-25 Rhone Poulenc Rorer Sa Nouveaux derives de la baccatine iii et de la desacetyl-10 baccatine iii, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5248796A (en) * 1992-06-18 1993-09-28 Bristol-Myers Squibb Company Taxol derivatives
US5294637A (en) * 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
ATE136460T1 (de) * 1992-07-01 1996-04-15 Bristol Myers Squibb Co Fluor-taxole mit antitumor-wirkung
FR2696458B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696459B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696464B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2697522B1 (fr) * 1992-10-30 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
CA2109861C (en) * 1992-12-04 1999-03-16 Shu-Hui Chen 6,7-modified paclitaxels
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
AU1680695A (en) 1995-08-15
IL127599A (en) 2004-06-01
IL127598A0 (en) 1999-10-28
KR100378972B1 (ko) 2003-06-19
LV13120B (en) 2004-03-20
JPH09508385A (ja) 1997-08-26
MY130544A (en) 2007-06-29
MX9603052A (es) 1997-06-28
EP0741716A1 (en) 1996-11-13
CN1139925A (zh) 1997-01-08
NO963133L (no) 1996-09-13
CZ208996A3 (en) 1996-11-13
CN1163492C (zh) 2004-08-25
DE69527506T2 (de) 2003-03-20
FI962952A0 (fi) 1996-07-24
AU691575B2 (en) 1998-05-21
RU2142950C1 (ru) 1999-12-20
PL315576A1 (en) 1996-11-12
DK0741716T3 (da) 2002-11-18
PT741716E (pt) 2002-12-31
NO963133D0 (no) 1996-07-26
TW464645B (en) 2001-11-21
NZ331211A (en) 2000-03-27
NO317832B1 (no) 2004-12-20
PL187409B1 (pl) 2004-07-30
HU9602051D0 (en) 1996-09-30
CA2179176A1 (en) 1995-08-03
IL127597A0 (en) 1999-10-28
ZA95668B (en) 1996-07-29
IL112412A0 (en) 1995-03-30
IL127592A0 (en) 1999-10-28
US5821363A (en) 1998-10-13
WO1995020582A1 (en) 1995-08-03
ES2181766T3 (es) 2003-03-01
SK90296A3 (en) 1998-03-04
IL112412A (en) 2000-02-29
ATE221059T1 (de) 2002-08-15
IL127598A (en) 2003-04-10
DE69527506D1 (de) 2002-08-29
SI0741716T1 (en) 2002-12-31
EP0741716B1 (en) 2002-07-24
SK283780B6 (en) 2004-01-08
HUT74508A (en) 1997-01-28
NZ279625A (en) 1998-10-28
FI962952A (fi) 1996-07-24

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