ZA95668B - Delta 12,13-iso-taxol analogs antineoplastic use and pharmaceutical compositions containing them - Google Patents

Delta 12,13-iso-taxol analogs antineoplastic use and pharmaceutical compositions containing them

Info

Publication number
ZA95668B
ZA95668B ZA95668A ZA95668A ZA95668B ZA 95668 B ZA95668 B ZA 95668B ZA 95668 A ZA95668 A ZA 95668A ZA 95668 A ZA95668 A ZA 95668A ZA 95668 B ZA95668 B ZA 95668B
Authority
ZA
South Africa
Prior art keywords
delta
iso
pharmaceutical compositions
compositions containing
pct
Prior art date
Application number
ZA95668A
Other languages
English (en)
Inventor
Peter G M Wuts
Robert C Kelly
Nancy A Wicnienski
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ZA95668B publication Critical patent/ZA95668B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Lining Or Joining Of Plastics Or The Like (AREA)
ZA95668A 1994-01-28 1995-01-27 Delta 12,13-iso-taxol analogs antineoplastic use and pharmaceutical compositions containing them ZA95668B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18923594A 1994-01-28 1994-01-28

Publications (1)

Publication Number Publication Date
ZA95668B true ZA95668B (en) 1996-07-29

Family

ID=22696514

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA95668A ZA95668B (en) 1994-01-28 1995-01-27 Delta 12,13-iso-taxol analogs antineoplastic use and pharmaceutical compositions containing them

Country Status (28)

Country Link
US (1) US5821363A (pt)
EP (1) EP0741716B1 (pt)
JP (1) JPH09508385A (pt)
KR (1) KR100378972B1 (pt)
CN (1) CN1163492C (pt)
AT (1) ATE221059T1 (pt)
AU (1) AU691575B2 (pt)
CA (1) CA2179176A1 (pt)
CZ (1) CZ208996A3 (pt)
DE (1) DE69527506T2 (pt)
DK (1) DK0741716T3 (pt)
ES (1) ES2181766T3 (pt)
FI (1) FI962952A0 (pt)
HU (1) HUT74508A (pt)
IL (7) IL127599A (pt)
LV (1) LV13120B (pt)
MX (1) MX9603052A (pt)
MY (1) MY130544A (pt)
NO (1) NO317832B1 (pt)
NZ (2) NZ331211A (pt)
PL (1) PL187409B1 (pt)
PT (1) PT741716E (pt)
RU (1) RU2142950C1 (pt)
SI (1) SI0741716T1 (pt)
SK (1) SK283780B6 (pt)
TW (1) TW464645B (pt)
WO (1) WO1995020582A1 (pt)
ZA (1) ZA95668B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
FR2742754B1 (fr) * 1995-12-22 1998-01-16 Rhone Poulenc Rorer Sa Procede de preparation de taxoides
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
ES2123996T3 (es) * 1994-06-28 1999-01-16 Upjohn Co Analogos de 7-etertaxol, uso antineoplasico y composiciones farmaceuticas que los contienen.
EP0738266A1 (en) * 1994-11-04 1996-10-23 PHARMACIA S.p.A. Taxane derivatives
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
CA2170661A1 (en) 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
FR2743074B1 (fr) 1995-12-27 1998-03-27 Seripharm Procede de protection selective des derives de la baccatine et son utilisation dans la synthese des taxanes
US5696152A (en) * 1996-05-07 1997-12-09 Wisconsin Alumni Research Foundation Taxol composition for use as organ preservation and cardioplegic agents
PL329637A1 (en) 1996-05-08 1999-04-12 Upjohn Co Taxol obtained method
US5902822A (en) * 1997-02-28 1999-05-11 Bristol-Myers Squibb Company 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
EP2292225B9 (en) 1997-03-31 2012-06-27 Boston Scientific Scimed Limited Dosage form comprising taxol in crystalline form
US8791081B2 (en) * 1999-08-13 2014-07-29 Case Western Reserve University MGMT inhibitor combination for the treatment of neoplastic disorders
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
EP1301500B1 (en) 2000-06-22 2007-11-21 Nitromed, Inc. Nitrosated and nitrosylated taxanes, compositions and methods of use
CN1492759A (zh) 2001-01-16 2004-04-28 Ѫ�������������ι�˾ 预防或治疗血液透析中血管通路和其它血管移植物故障的装置及方法
ITMI20021921A1 (it) 2002-09-10 2004-03-11 Indena Spa Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
ATE431343T1 (de) * 2002-10-09 2009-05-15 Chatham Biotec Ltd Thio-analoga von paclitaxel und deren vorprodukte
US6956124B2 (en) 2003-04-14 2005-10-18 Aventis Pharma S.A. Process for the preparation of 4,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-1,13α-dihydroxy-9-oxo-19-norcyclopropa[g]tax-11-ene
FR2853651B1 (fr) * 2003-04-14 2005-05-20 Aventis Pharma Sa Procede de preparation du 4,10 beta-diacetoxy-2 alpha- benzoyloxy-5 beta, 20-epoxy-1, 13 alpha-dihydroxy-9-oxo-19- norcyclopropa[g]tax-11-ene
US20070111328A1 (en) * 2005-08-19 2007-05-17 Bristol-Myers Squibb Company Scintillation proximity assay for the identification of P-glycoprotein modulators
AU2007309516B2 (en) * 2006-10-19 2013-10-24 Monell Chemical Senses Center Human salty taste receptor and methods of modulating salty taste perception
CN101468974B (zh) * 2007-12-28 2011-02-09 上海百灵医药科技有限公司 多烯紫杉醇的半合成方法
CN104650012A (zh) * 2013-11-22 2015-05-27 天士力控股集团有限公司 一种紫杉烷类化合物
CN104109142A (zh) * 2014-06-22 2014-10-22 南京工业大学 一种以巴卡丁iii为原料制备卡巴他赛的方法
CN108976217B (zh) * 2018-09-11 2021-03-26 济南爱思医药科技有限公司 一种多西他赛-1,2,3,-三氮唑化合物及其合成工艺和应用
CN115260130A (zh) * 2022-07-07 2022-11-01 上海卓鼎生物技术有限公司 一种10-脱乙酰基紫杉醇的制备方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
US4876399A (en) * 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
US5157049A (en) * 1988-03-07 1992-10-20 The United States Of America As Represented By The Department Of Health & Human Services Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
EP0366841A1 (en) * 1988-11-03 1990-05-09 Dresser-Rand Company A crosshead and crosshead pin coupling arrangement
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
IL95436A (en) * 1989-08-23 1996-07-23 Centre Nat Rech Scient Process for preparing the history of phenylisosarine
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
FR2658510B1 (fr) * 1990-02-21 1992-04-30 Rhone Poulenc Sante Nouveau derive de la beta-phenylisoserine, sa preparation et son emploi.
FR2658513B1 (fr) * 1990-02-21 1994-02-04 Rhone Poulenc Sante Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r).
FR2662441B1 (fr) * 1990-05-22 1992-10-23 Rhone Poulenc Sante Procede de preparation enantioselective de derives de la phenylisoserine.
FR2662440B1 (fr) * 1990-05-22 1992-07-31 Rhone Poulenc Sante Procede de preparation stereoselective de derives de la phenylisoserine.
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
FR2679230B1 (fr) * 1991-07-16 1993-11-19 Rhone Poulenc Rorer Sa Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent.
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
FR2687151B1 (fr) * 1992-02-07 1994-03-25 Rhone Poulenc Rorer Sa Nouveaux derives de la baccatine iii et de la desacetyl-10 baccatine iii, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5248796A (en) * 1992-06-18 1993-09-28 Bristol-Myers Squibb Company Taxol derivatives
US5294637A (en) * 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
EP0577082B1 (en) * 1992-07-01 1996-04-10 Bristol-Myers Squibb Company Fluoro taxols with antitumor activity
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696464B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
FR2696458B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696459B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2697522B1 (fr) * 1992-10-30 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
CA2109861C (en) * 1992-12-04 1999-03-16 Shu-Hui Chen 6,7-modified paclitaxels
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
PT741716E (pt) 2002-12-31
PL187409B1 (pl) 2004-07-30
KR100378972B1 (ko) 2003-06-19
IL127598A0 (en) 1999-10-28
CZ208996A3 (en) 1996-11-13
NZ331211A (en) 2000-03-27
ATE221059T1 (de) 2002-08-15
IL127597A0 (en) 1999-10-28
SI0741716T1 (en) 2002-12-31
CN1139925A (zh) 1997-01-08
HUT74508A (en) 1997-01-28
NO963133L (no) 1996-09-13
IL127597A (en) 2003-07-31
NO963133D0 (no) 1996-07-26
HU9602051D0 (en) 1996-09-30
TW464645B (en) 2001-11-21
IL127598A (en) 2003-04-10
RU2142950C1 (ru) 1999-12-20
EP0741716A1 (en) 1996-11-13
FI962952A (fi) 1996-07-24
US5821363A (en) 1998-10-13
WO1995020582A1 (en) 1995-08-03
FI962952A0 (fi) 1996-07-24
IL112412A (en) 2000-02-29
ES2181766T3 (es) 2003-03-01
CN1163492C (zh) 2004-08-25
EP0741716B1 (en) 2002-07-24
SK90296A3 (en) 1998-03-04
IL112412A0 (en) 1995-03-30
CA2179176A1 (en) 1995-08-03
DE69527506D1 (de) 2002-08-29
LV13120B (en) 2004-03-20
SK283780B6 (en) 2004-01-08
DE69527506T2 (de) 2003-03-20
IL127592A0 (en) 1999-10-28
AU691575B2 (en) 1998-05-21
IL127599A (en) 2004-06-01
PL315576A1 (en) 1996-11-12
MY130544A (en) 2007-06-29
AU1680695A (en) 1995-08-15
NO317832B1 (no) 2004-12-20
JPH09508385A (ja) 1997-08-26
DK0741716T3 (da) 2002-11-18
MX9603052A (es) 1997-06-28
NZ279625A (en) 1998-10-28

Similar Documents

Publication Publication Date Title
ZA95668B (en) Delta 12,13-iso-taxol analogs antineoplastic use and pharmaceutical compositions containing them
MY118151A (en) Pharmaceutical formulations containing voriconazole.
IL108520A0 (en) Imidazopyridine derivatives, processes for the preparation thereof, and pharmaceutical compositions containing them
ZA926276B (en) 2,4-thiazolidinedione compounds, process for preparing them and pharmaceutical compositions containing them.
DE60116761D1 (en) Adamantanderivate
HK1048990A1 (en) Novel compounds.
PL366198A1 (en) Novel compounds
ZA965235B (en) Pharmaceutical and diet formulations for the prophylaxis and treatment of gastrointestinal disorders
IL114241A0 (en) Thiazolidine derivatives their preparation and compositions containing them
IL131407A0 (en) Tetrahydropyrido compounds medicaments containing the same and the use thereof
IL113365A0 (en) 5-heterocyclo-1,5-benzodiazepine derivatives, their preparation and use and pharmaceutical compositions containing them
MY114282A (en) Anthracycline derivatives
IL112999A0 (en) Crystalline salts of 2,3,4,5- tetrahydro -1h-3-benzazepine compounds, their preparation and pharmaceutical compositions containing them
IL105475A (en) PHARMACEUTICAL COMPOSITIONS CONTAINING 1a, 24(R) - DIHYDROXY-22(E)-DEHYDRO- VITAMIN D3 FOR TREATING OSTEOPOROSIS
HUT73231A (en) Pharmaceutical compositions with 17-beta-monosubstituted-carbamoyl-4-aza-5-alpha-androst-1-en-3-ones for treatment of chronic prostatitis
GR3025050T3 (en) Etoposide derivatives, process for their preparation, their use as a drug and in the preparation of a drug for treating cancer.
TW261605B (pt)
ES2091039T3 (es) Nuevos bis-fenil-hexenos.
MY138319A (en) 1,5-benzodiazepine derivatives