DE69527506D1 - Delta 12,16-isotaxol analoge mit antineoplastischer wirkung und pharmazeutische zusammensetzungen sie enthaltend - Google Patents

Delta 12,16-isotaxol analoge mit antineoplastischer wirkung und pharmazeutische zusammensetzungen sie enthaltend

Info

Publication number
DE69527506D1
DE69527506D1 DE69527506T DE69527506T DE69527506D1 DE 69527506 D1 DE69527506 D1 DE 69527506D1 DE 69527506 T DE69527506 T DE 69527506T DE 69527506 T DE69527506 T DE 69527506T DE 69527506 D1 DE69527506 D1 DE 69527506D1
Authority
DE
Germany
Prior art keywords
delta
isotaxol
analog
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69527506T
Other languages
English (en)
Other versions
DE69527506T2 (de
Inventor
C Kelly
G Wuts
Anne Wicnienski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Application granted granted Critical
Publication of DE69527506D1 publication Critical patent/DE69527506D1/de
Publication of DE69527506T2 publication Critical patent/DE69527506T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Lining Or Joining Of Plastics Or The Like (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69527506T 1994-01-28 1995-01-26 Delta 12,16-isotaxol analoge mit antineoplastischer wirkung und pharmazeutische zusammensetzungen sie enthaltend Expired - Fee Related DE69527506T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18923594A 1994-01-28 1994-01-28
PCT/US1995/000551 WO1995020582A1 (en) 1994-01-28 1995-01-26 Δ12,13-iso-taxol analogs, antineoplastic use and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
DE69527506D1 true DE69527506D1 (de) 2002-08-29
DE69527506T2 DE69527506T2 (de) 2003-03-20

Family

ID=22696514

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69527506T Expired - Fee Related DE69527506T2 (de) 1994-01-28 1995-01-26 Delta 12,16-isotaxol analoge mit antineoplastischer wirkung und pharmazeutische zusammensetzungen sie enthaltend

Country Status (28)

Country Link
US (1) US5821363A (de)
EP (1) EP0741716B1 (de)
JP (1) JPH09508385A (de)
KR (1) KR100378972B1 (de)
CN (1) CN1163492C (de)
AT (1) ATE221059T1 (de)
AU (1) AU691575B2 (de)
CA (1) CA2179176A1 (de)
CZ (1) CZ208996A3 (de)
DE (1) DE69527506T2 (de)
DK (1) DK0741716T3 (de)
ES (1) ES2181766T3 (de)
FI (1) FI962952A (de)
HU (1) HUT74508A (de)
IL (7) IL127599A (de)
LV (1) LV13120B (de)
MX (1) MX9603052A (de)
MY (1) MY130544A (de)
NO (1) NO317832B1 (de)
NZ (2) NZ279625A (de)
PL (1) PL187409B1 (de)
PT (1) PT741716E (de)
RU (1) RU2142950C1 (de)
SI (1) SI0741716T1 (de)
SK (1) SK283780B6 (de)
TW (1) TW464645B (de)
WO (1) WO1995020582A1 (de)
ZA (1) ZA95668B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
FR2742754B1 (fr) * 1995-12-22 1998-01-16 Rhone Poulenc Rorer Sa Procede de preparation de taxoides
DE69504843T2 (de) * 1994-06-28 1999-02-11 Pharmacia & Upjohn Co., Kalamazoo, Mich. 7-äther-taxol ähnliche verbindungen antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
EP0738266A1 (de) * 1994-11-04 1996-10-23 PHARMACIA S.p.A. Taxanderivate
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
CA2170661A1 (en) 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
FR2743074B1 (fr) * 1995-12-27 1998-03-27 Seripharm Procede de protection selective des derives de la baccatine et son utilisation dans la synthese des taxanes
US5696152A (en) * 1996-05-07 1997-12-09 Wisconsin Alumni Research Foundation Taxol composition for use as organ preservation and cardioplegic agents
CZ293508B6 (cs) 1996-05-08 2004-05-12 Pharmaciaá@Áupjohnácompany Fenylisoserinestery silylového baccatinu III
US5902822A (en) * 1997-02-28 1999-05-11 Bristol-Myers Squibb Company 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
JP2001521503A (ja) 1997-03-31 2001-11-06 ネオルックス コーポレイション 血管平滑筋細胞の治療的阻害物質
US8791081B2 (en) * 1999-08-13 2014-07-29 Case Western Reserve University MGMT inhibitor combination for the treatment of neoplastic disorders
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
DE60131537T2 (de) 2000-06-22 2008-10-23 Nitromed, Inc., Lexington Nitrosierte und nitrosylierte taxane, zubereitungen und methoden der verwendung
RU2345719C2 (ru) * 2001-01-16 2009-02-10 Васкулар Терапиез, Ллс. Способ предотвращения или лечения уменьшения доступа для гемодиализа сосудов и устройство для его осуществления и другие сосудистые графты
ITMI20021921A1 (it) 2002-09-10 2004-03-11 Indena Spa Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
EP1562927B1 (de) * 2002-10-09 2009-05-13 Chatham Biotec Ltd. Thio-analoga von paclitaxel und deren vorprodukte
FR2853651B1 (fr) * 2003-04-14 2005-05-20 Aventis Pharma Sa Procede de preparation du 4,10 beta-diacetoxy-2 alpha- benzoyloxy-5 beta, 20-epoxy-1, 13 alpha-dihydroxy-9-oxo-19- norcyclopropa[g]tax-11-ene
US6956124B2 (en) 2003-04-14 2005-10-18 Aventis Pharma S.A. Process for the preparation of 4,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-1,13α-dihydroxy-9-oxo-19-norcyclopropa[g]tax-11-ene
US20070111328A1 (en) * 2005-08-19 2007-05-17 Bristol-Myers Squibb Company Scintillation proximity assay for the identification of P-glycoprotein modulators
EP2557087A1 (de) * 2006-10-19 2013-02-13 Monell Chemical Senses Center Menschlicher Salzgeschmackrezeptor und Verfahren zur Modulation der Salzgeschmackwahrnehmung
CN101468974B (zh) * 2007-12-28 2011-02-09 上海百灵医药科技有限公司 多烯紫杉醇的半合成方法
CN104650012A (zh) * 2013-11-22 2015-05-27 天士力控股集团有限公司 一种紫杉烷类化合物
CN104109142A (zh) * 2014-06-22 2014-10-22 南京工业大学 一种以巴卡丁iii为原料制备卡巴他赛的方法
CN108976217B (zh) * 2018-09-11 2021-03-26 济南爱思医药科技有限公司 一种多西他赛-1,2,3,-三氮唑化合物及其合成工艺和应用
CN115260130A (zh) * 2022-07-07 2022-11-01 上海卓鼎生物技术有限公司 一种10-脱乙酰基紫杉醇的制备方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
US4876399A (en) * 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
US5157049A (en) * 1988-03-07 1992-10-20 The United States Of America As Represented By The Department Of Health & Human Services Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
EP0366841A1 (de) * 1988-11-03 1990-05-09 Dresser-Rand Company Kreuzkopf und Kreuzkopfzapfenbefestigung
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
IL95436A (en) * 1989-08-23 1996-07-23 Centre Nat Rech Scient Process for preparing the history of phenylisosarine
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
FR2658510B1 (fr) * 1990-02-21 1992-04-30 Rhone Poulenc Sante Nouveau derive de la beta-phenylisoserine, sa preparation et son emploi.
FR2658513B1 (fr) * 1990-02-21 1994-02-04 Rhone Poulenc Sante Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r).
FR2662440B1 (fr) * 1990-05-22 1992-07-31 Rhone Poulenc Sante Procede de preparation stereoselective de derives de la phenylisoserine.
FR2662441B1 (fr) * 1990-05-22 1992-10-23 Rhone Poulenc Sante Procede de preparation enantioselective de derives de la phenylisoserine.
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
FR2679230B1 (fr) * 1991-07-16 1993-11-19 Rhone Poulenc Rorer Sa Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent.
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
FR2687151B1 (fr) * 1992-02-07 1994-03-25 Rhone Poulenc Rorer Sa Nouveaux derives de la baccatine iii et de la desacetyl-10 baccatine iii, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5248796A (en) * 1992-06-18 1993-09-28 Bristol-Myers Squibb Company Taxol derivatives
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
AU656475B2 (en) * 1992-07-01 1995-02-02 Bristol-Myers Squibb Company Fluoro taxols
US5294637A (en) * 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
FR2696458B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696459B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696464B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2697522B1 (fr) * 1992-10-30 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
CA2109861C (en) * 1992-12-04 1999-03-16 Shu-Hui Chen 6,7-modified paclitaxels
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
ZA95668B (en) 1996-07-29
MY130544A (en) 2007-06-29
SK90296A3 (en) 1998-03-04
IL127598A (en) 2003-04-10
SK283780B6 (en) 2004-01-08
IL127592A0 (en) 1999-10-28
KR100378972B1 (ko) 2003-06-19
NZ331211A (en) 2000-03-27
IL112412A0 (en) 1995-03-30
IL127598A0 (en) 1999-10-28
LV13120B (en) 2004-03-20
PL187409B1 (pl) 2004-07-30
TW464645B (en) 2001-11-21
SI0741716T1 (en) 2002-12-31
DE69527506T2 (de) 2003-03-20
EP0741716B1 (de) 2002-07-24
CN1163492C (zh) 2004-08-25
CZ208996A3 (en) 1996-11-13
EP0741716A1 (de) 1996-11-13
FI962952A0 (fi) 1996-07-24
NZ279625A (en) 1998-10-28
IL127597A (en) 2003-07-31
IL112412A (en) 2000-02-29
NO963133L (no) 1996-09-13
ATE221059T1 (de) 2002-08-15
ES2181766T3 (es) 2003-03-01
HUT74508A (en) 1997-01-28
PT741716E (pt) 2002-12-31
PL315576A1 (en) 1996-11-12
US5821363A (en) 1998-10-13
WO1995020582A1 (en) 1995-08-03
CN1139925A (zh) 1997-01-08
FI962952A (fi) 1996-07-24
HU9602051D0 (en) 1996-09-30
IL127599A (en) 2004-06-01
NO963133D0 (no) 1996-07-26
CA2179176A1 (en) 1995-08-03
IL127597A0 (en) 1999-10-28
AU1680695A (en) 1995-08-15
RU2142950C1 (ru) 1999-12-20
MX9603052A (es) 1997-06-28
JPH09508385A (ja) 1997-08-26
DK0741716T3 (da) 2002-11-18
AU691575B2 (en) 1998-05-21
NO317832B1 (no) 2004-12-20

Similar Documents

Publication Publication Date Title
DE69527506D1 (de) Delta 12,16-isotaxol analoge mit antineoplastischer wirkung und pharmazeutische zusammensetzungen sie enthaltend
MY118151A (en) Pharmaceutical formulations containing voriconazole.
HUT67742A (en) Phosphono-oxymethyl-ethers of taxane derivatives
FI962154A (fi) Koostumus terapeuttisten tuotteiden in vivo valmistusta varten
IL124674A0 (en) Piperazine derivatives pharmaceutical compositions containing the same and use thereof
ATE177114T1 (de) Polypeptide und daraus hergestellte, gegen hiv wirksame substanzen
DE69326776D1 (de) Verwendung von n-arylmethylen ethylendiamintriacetate, n-arylmethylen iminodiacetat oder n,n'-diarylmethylen ethylendiamindiacetat gegen oxidativen stress
MX9704030A (es) 1,1-dioxidos de 2-heterocicliloxi y tiometil-1,2,5-tiadiazolidin-3-ona y composiciones y metodo de uso de los mismos.
DE69528710D1 (de) 2-substituierte 1,2,5-thiadiazolidin-3-on-1,1-dioxiden, zusammensetzung und deren verwendung
ZA984463B (en) Fused dihydropyrans
BR0207699A (pt) Produto para aplicação axilar
SE9802937D0 (sv) Novel compounds
MX9704034A (es) Derivados y composiciones de 1,1-dioxido de 2-arilcarboniloximetil-1,2,5-tiadiazolidin-3-ona substituido y metodo de uso.
MY114282A (en) Anthracycline derivatives
RU94041028A (ru) Применение производных мелатонина для лечения десинхронизационных нарушений, фармацевтическая композиция
IL105475A (en) PHARMACEUTICAL COMPOSITIONS CONTAINING 1a, 24(R) - DIHYDROXY-22(E)-DEHYDRO- VITAMIN D3 FOR TREATING OSTEOPOROSIS
AU7188494A (en) Use of rosmanol derivatives for producing antiradical and/or antilipoperoxidative and/or hepatotropic drugs
EP1011329A4 (de) 7-methylthiooxomethyl- und 7-methylthiodioxomethyl-paclitaxele
MX9704036A (es) 1,1-dioxidos y composiciones de 2-(2,3,5,6-tetrafluoro-4-piridil)-1,2,5-thiadizaolidin-3-ona y metodo de uso.
ATE150026T1 (de) Benzo(f>chinoxalindionderivative, deren herstellung und verwendung in arzneimitteln
MX9800697A (es) Uso de glicosidos de calendula para el tratamiento de psoriasis.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee