IL125305A - Anticalculus dentifrice containing highly soluble pyrophosphate - Google Patents
Anticalculus dentifrice containing highly soluble pyrophosphateInfo
- Publication number
- IL125305A IL125305A IL12530597A IL12530597A IL125305A IL 125305 A IL125305 A IL 125305A IL 12530597 A IL12530597 A IL 12530597A IL 12530597 A IL12530597 A IL 12530597A IL 125305 A IL125305 A IL 125305A
- Authority
- IL
- Israel
- Prior art keywords
- composition
- weight
- amount
- anticalculus
- fluoride
- Prior art date
Links
- 239000000551 dentifrice Substances 0.000 title claims abstract description 78
- 230000002272 anti-calculus Effects 0.000 title claims abstract description 41
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 title claims abstract description 28
- 235000011180 diphosphates Nutrition 0.000 title description 23
- 239000000203 mixture Substances 0.000 claims abstract description 137
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims abstract description 62
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims abstract description 54
- 239000005844 Thymol Substances 0.000 claims abstract description 30
- 229960000790 thymol Drugs 0.000 claims abstract description 30
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 29
- 229940041616 menthol Drugs 0.000 claims abstract description 29
- 229960001047 methyl salicylate Drugs 0.000 claims abstract description 26
- 229960005233 cineole Drugs 0.000 claims abstract description 23
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims abstract description 22
- -1 alkali metal pyrophosphate salt Chemical class 0.000 claims abstract description 22
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 claims abstract description 21
- 229910052783 alkali metal Inorganic materials 0.000 claims abstract description 21
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims abstract description 18
- 150000001875 compounds Chemical class 0.000 claims abstract description 18
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 11
- 239000004599 antimicrobial Substances 0.000 claims abstract description 10
- 230000002708 enhancing effect Effects 0.000 claims abstract description 10
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract 7
- 239000000341 volatile oil Substances 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 16
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical group [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 claims description 15
- 230000015572 biosynthetic process Effects 0.000 claims description 11
- 210000000214 mouth Anatomy 0.000 claims description 8
- 230000002401 inhibitory effect Effects 0.000 claims description 5
- 230000007062 hydrolysis Effects 0.000 claims description 4
- 238000006460 hydrolysis reaction Methods 0.000 claims description 4
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 claims description 4
- 229960002799 stannous fluoride Drugs 0.000 claims description 4
- 229910001515 alkali metal fluoride Inorganic materials 0.000 claims 3
- SFUAZWIOGQKJQL-UHFFFAOYSA-K aluminum difluorophosphinate Chemical compound [Al+3].[O-]P(F)(F)=O.[O-]P(F)(F)=O.[O-]P(F)(F)=O SFUAZWIOGQKJQL-UHFFFAOYSA-K 0.000 claims 3
- 229940074371 monofluorophosphate Drugs 0.000 claims 3
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 25
- 235000003599 food sweetener Nutrition 0.000 description 19
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 14
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- 150000002500 ions Chemical class 0.000 description 7
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- 208000006558 Dental Calculus Diseases 0.000 description 5
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 5
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- 238000009472 formulation Methods 0.000 description 5
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- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 5
- 239000011775 sodium fluoride Substances 0.000 description 5
- 235000013024 sodium fluoride Nutrition 0.000 description 5
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- 125000000129 anionic group Chemical group 0.000 description 4
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- 229920000388 Polyphosphate Polymers 0.000 description 3
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- 238000005498 polishing Methods 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
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- 235000010378 sodium ascorbate Nutrition 0.000 description 1
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- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- HSFQBFMEWSTNOW-UHFFFAOYSA-N sodium;carbanide Chemical group [CH3-].[Na+] HSFQBFMEWSTNOW-UHFFFAOYSA-N 0.000 description 1
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- 229910001631 strontium chloride Inorganic materials 0.000 description 1
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- BJIOGJUNALELMI-UHFFFAOYSA-N trans-isoeugenol Natural products COC1=CC(C=CC)=CC=C1O BJIOGJUNALELMI-UHFFFAOYSA-N 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- 235000012141 vanillin Nutrition 0.000 description 1
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- 229960002675 xylitol Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1134596P | 1996-02-08 | 1996-02-08 | |
| PCT/US1997/000254 WO1997028782A1 (en) | 1996-02-08 | 1997-01-02 | Anticalculus dentifrice containing highly soluble pyrophosphate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL125305A0 IL125305A0 (en) | 1999-03-12 |
| IL125305A true IL125305A (en) | 2001-12-23 |
Family
ID=21749987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12530597A IL125305A (en) | 1996-02-08 | 1997-01-02 | Anticalculus dentifrice containing highly soluble pyrophosphate |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5811079A (pt) |
| EP (1) | EP0901366B1 (pt) |
| JP (1) | JP2001518064A (pt) |
| AT (1) | ATE216217T1 (pt) |
| AU (1) | AU730963B2 (pt) |
| BR (1) | BR9707365A (pt) |
| CA (1) | CA2246348C (pt) |
| DE (1) | DE69712054T2 (pt) |
| DK (1) | DK0901366T3 (pt) |
| EA (1) | EA001791B1 (pt) |
| ES (1) | ES2175332T3 (pt) |
| HU (1) | HUP9903442A3 (pt) |
| IL (1) | IL125305A (pt) |
| IS (1) | IS1972B (pt) |
| NO (1) | NO315731B1 (pt) |
| NZ (1) | NZ326668A (pt) |
| PL (1) | PL187382B1 (pt) |
| PT (1) | PT901366E (pt) |
| SK (1) | SK284210B6 (pt) |
| TR (1) | TR199801528T2 (pt) |
| WO (1) | WO1997028782A1 (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5945088A (en) * | 1997-03-31 | 1999-08-31 | Pfizer Inc | Taste masking of phenolics using citrus flavors |
| DE19730651A1 (de) * | 1997-07-17 | 1999-01-21 | Henkel Kgaa | Mund- und Zahnpflegemittel für empfindliche Zähne |
| US6221340B1 (en) * | 1999-04-08 | 2001-04-24 | Warner-Lambert Company | Zinc containing dentifrice compositions |
| US6861048B2 (en) * | 1999-04-08 | 2005-03-01 | Warner-Lambert Company | Dentifrice compositions having reduced abrasivity |
| JP2002187808A (ja) * | 2000-12-20 | 2002-07-05 | Gc Corp | 根管充填材除去剤 |
| JP2004535370A (ja) * | 2001-03-05 | 2004-11-25 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 味をマスクした液体製薬学的組成物 |
| US6361762B1 (en) * | 2001-05-21 | 2002-03-26 | Vi-Jon Laboratories, Inc. | Prebrushing liquid oral composition |
| KR20030089047A (ko) * | 2002-05-16 | 2003-11-21 | 주식회사 엘지생활건강 | 구강위생 증진용 조성물 |
| JP2004018470A (ja) * | 2002-06-18 | 2004-01-22 | Takasago Internatl Corp | 抗菌香料組成物および口臭抑制香料組成物ならびにそれらを含有する口腔用組成物 |
| BRPI0407009A (pt) * | 2003-01-28 | 2006-01-10 | Ecosmart Technologies Inc | Composições herbicidas e métodos para matar ervas daninhas e gramas |
| JP4838139B2 (ja) * | 2003-10-28 | 2011-12-14 | エモリー ユニバーシティー | 透析液並びに透析液に関連した方法及びシステム |
| US20060045851A1 (en) * | 2004-09-02 | 2006-03-02 | The Procter & Gamble Company | Oral care composition comprising essential oils |
| US20060134025A1 (en) * | 2004-12-17 | 2006-06-22 | Colgate-Palmolive Company | Oral compositions containing extracts of Rosmarinus and related methods |
| US20080253976A1 (en) * | 2007-04-16 | 2008-10-16 | Douglas Craig Scott | Personal Care Compositions Comprising An Antimicrobial Blend of Essential Oils or Constituents Thereof |
| MD3801G2 (ro) * | 2007-10-11 | 2009-08-31 | Валериу ФАЛА | Pastă de dinţi pentru îndepărtarea tartrului dentar (variante) |
| MD3591G2 (ro) * | 2007-10-11 | 2008-12-31 | Валериу ФАЛА | Pastă gel pentru dinţi sensibili (variante) |
| MD3590G2 (ro) * | 2007-10-11 | 2008-12-31 | Валериу ФАЛА | Pastă de dinţi curativoprofilactică pentru copii (variante) |
| AU2014414014B2 (en) | 2014-12-18 | 2018-05-10 | Colgate-Palmolive Company | Oral care compositions having high water content and micro robustness |
| WO2019121660A1 (en) * | 2017-12-20 | 2019-06-27 | Firmenich Sa | Oral care compositions |
| US11033485B1 (en) | 2019-05-16 | 2021-06-15 | Shear Kershman Laboratories, Inc. | Dental care system containing anti-tartar and anti-plaque actives |
| CA3143233A1 (en) | 2019-07-01 | 2021-01-07 | Colgate-Palmolive Company | Oral care compositions and methods |
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-
1997
- 1997-01-02 IL IL12530597A patent/IL125305A/en not_active IP Right Cessation
- 1997-01-02 BR BR9707365A patent/BR9707365A/pt not_active Application Discontinuation
- 1997-01-02 AU AU15294/97A patent/AU730963B2/en not_active Ceased
- 1997-01-02 DK DK97901384T patent/DK0901366T3/da active
- 1997-01-02 AT AT97901384T patent/ATE216217T1/de not_active IP Right Cessation
- 1997-01-02 PT PT97901384T patent/PT901366E/pt unknown
- 1997-01-02 DE DE69712054T patent/DE69712054T2/de not_active Expired - Fee Related
- 1997-01-02 EP EP97901384A patent/EP0901366B1/en not_active Expired - Lifetime
- 1997-01-02 PL PL97328413A patent/PL187382B1/pl not_active IP Right Cessation
- 1997-01-02 CA CA002246348A patent/CA2246348C/en not_active Expired - Fee Related
- 1997-01-02 JP JP52850497A patent/JP2001518064A/ja active Pending
- 1997-01-02 WO PCT/US1997/000254 patent/WO1997028782A1/en active IP Right Grant
- 1997-01-02 ES ES97901384T patent/ES2175332T3/es not_active Expired - Lifetime
- 1997-01-02 SK SK1069-98A patent/SK284210B6/sk unknown
- 1997-01-02 HU HU9903442A patent/HUP9903442A3/hu not_active Application Discontinuation
- 1997-01-02 EA EA199800681A patent/EA001791B1/ru not_active IP Right Cessation
- 1997-01-02 TR TR1998/01528T patent/TR199801528T2/xx unknown
- 1997-01-02 NZ NZ326668A patent/NZ326668A/xx unknown
- 1997-02-05 US US08/795,921 patent/US5811079A/en not_active Expired - Fee Related
-
1998
- 1998-07-24 IS IS4807A patent/IS1972B/is unknown
- 1998-08-06 NO NO19983608A patent/NO315731B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK106998A3 (en) | 1999-06-11 |
| IL125305A0 (en) | 1999-03-12 |
| EP0901366B1 (en) | 2002-04-17 |
| AU1529497A (en) | 1997-08-28 |
| IS1972B (is) | 2004-12-15 |
| AU730963B2 (en) | 2001-03-22 |
| DK0901366T3 (da) | 2002-07-29 |
| NO315731B1 (no) | 2003-10-20 |
| PT901366E (pt) | 2002-09-30 |
| JP2001518064A (ja) | 2001-10-09 |
| EA199800681A1 (ru) | 1999-02-25 |
| NO983608D0 (no) | 1998-08-06 |
| EP0901366A1 (en) | 1999-03-17 |
| PL187382B1 (pl) | 2004-06-30 |
| TR199801528T2 (xx) | 1998-11-23 |
| DE69712054D1 (de) | 2002-05-23 |
| CA2246348C (en) | 2003-03-18 |
| PL328413A1 (en) | 1999-01-18 |
| NZ326668A (en) | 2000-03-27 |
| EA001791B1 (ru) | 2001-08-27 |
| HUP9903442A3 (en) | 2001-11-28 |
| CA2246348A1 (en) | 1997-08-14 |
| IS4807A (is) | 1998-07-24 |
| ES2175332T3 (es) | 2002-11-16 |
| HUP9903442A2 (en) | 2000-07-28 |
| US5811079A (en) | 1998-09-22 |
| BR9707365A (pt) | 1999-07-20 |
| ATE216217T1 (de) | 2002-05-15 |
| NO983608L (no) | 1998-08-06 |
| SK284210B6 (en) | 2004-11-03 |
| DE69712054T2 (de) | 2002-10-24 |
| WO1997028782A1 (en) | 1997-08-14 |
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Legal Events
| Date | Code | Title | Description |
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| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |