IL124908A - Processes for the preparation of 5-pyrimidinyl substituted imidazoles and aminoalkyl carbonyl imidazole intermediates thereor - Google Patents

Processes for the preparation of 5-pyrimidinyl substituted imidazoles and aminoalkyl carbonyl imidazole intermediates thereor

Info

Publication number
IL124908A
IL124908A IL12490896A IL12490896A IL124908A IL 124908 A IL124908 A IL 124908A IL 12490896 A IL12490896 A IL 12490896A IL 12490896 A IL12490896 A IL 12490896A IL 124908 A IL124908 A IL 124908A
Authority
IL
Israel
Prior art keywords
thereor
processes
preparation
substituted imidazoles
pyrimidinyl substituted
Prior art date
Application number
IL12490896A
Other languages
English (en)
Other versions
IL124908A0 (en
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Priority to IL14351796A priority Critical patent/IL143517A/xx
Publication of IL124908A0 publication Critical patent/IL124908A0/xx
Publication of IL124908A publication Critical patent/IL124908A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Resins (AREA)
IL12490896A 1995-12-22 1996-12-20 Processes for the preparation of 5-pyrimidinyl substituted imidazoles and aminoalkyl carbonyl imidazole intermediates thereor IL124908A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL14351796A IL143517A (en) 1995-12-22 1996-12-20 Imidazole compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US909895P 1995-12-22 1995-12-22
PCT/US1996/020599 WO1997023479A1 (en) 1995-12-22 1996-12-20 Novel synthesis

Publications (2)

Publication Number Publication Date
IL124908A0 IL124908A0 (en) 1999-01-26
IL124908A true IL124908A (en) 2003-05-29

Family

ID=21735553

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14351796A IL143517A (en) 1995-12-22 1996-12-20 Imidazole compounds
IL12490896A IL124908A (en) 1995-12-22 1996-12-20 Processes for the preparation of 5-pyrimidinyl substituted imidazoles and aminoalkyl carbonyl imidazole intermediates thereor

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL14351796A IL143517A (en) 1995-12-22 1996-12-20 Imidazole compounds

Country Status (18)

Country Link
US (3) US6100399A (xx)
EP (1) EP1019393A1 (xx)
JP (1) JP3245175B2 (xx)
KR (1) KR19990076625A (xx)
CN (1) CN1209128A (xx)
AR (3) AR004405A1 (xx)
AU (1) AU704500B2 (xx)
BR (1) BR9612187A (xx)
CZ (1) CZ198598A3 (xx)
HU (1) HUP9902466A3 (xx)
IL (2) IL143517A (xx)
NO (1) NO982850D0 (xx)
NZ (1) NZ326574A (xx)
PL (1) PL327311A1 (xx)
TR (1) TR199801121T2 (xx)
TW (1) TW434236B (xx)
WO (1) WO1997023479A1 (xx)
ZA (1) ZA9610687B (xx)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
ZA9610687B (en) * 1995-12-22 1997-09-29 Smithkline Beecham Corp Novel synthesis.
WO1997025045A1 (en) * 1996-01-11 1997-07-17 Smithkline Beecham Corporation Novel substituted imidazole compounds
ZA9711092B (en) * 1996-12-11 1999-07-22 Smithkline Beecham Corp Novel compounds.
US6514977B1 (en) 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
US6979686B1 (en) 2001-12-07 2005-12-27 Pharmacia Corporation Substituted pyrazoles as p38 kinase inhibitors
WO1998052941A1 (en) 1997-05-22 1998-11-26 G.D. Searle And Co. PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS
EP1023066A4 (en) 1997-06-13 2001-05-23 Smithkline Beecham Corp NEW PYRAZOLE AND PYRAZOLINE SUBSTITUTED COMPOUND
CA2294137A1 (en) 1997-06-19 1998-12-23 Smithkline Beecham Corporation Novel aryloxy substituted pyrimidine imidazole compounds
US6562832B1 (en) 1997-07-02 2003-05-13 Smithkline Beecham Corporation Substituted imidazole compounds
US7301021B2 (en) 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
US6489325B1 (en) 1998-07-01 2002-12-03 Smithkline Beecham Corporation Substituted imidazole compounds
JP2001518507A (ja) 1997-10-08 2001-10-16 スミスクライン・ビーチャム・コーポレイション 新規シクロアルケニル置換化合物
AU1924699A (en) 1997-12-19 1999-07-12 Smithkline Beecham Corporation Compounds of heteroaryl substituted imidazole, their pharmaceutical compositionsand uses
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
ATE266399T1 (de) 1998-08-20 2004-05-15 Smithkline Beecham Corp Neue substituierte triazolverbindungen
ATE258055T1 (de) * 1998-11-04 2004-02-15 Smithkline Beecham Corp Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine
US6239279B1 (en) * 1998-12-16 2001-05-29 Smithkline Beecham Corporation Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
US20050274801A1 (en) * 1999-01-29 2005-12-15 Intermec Ip Corp. Method, apparatus and article for validating ADC devices, such as barcode, RFID and magnetic stripe readers
US6857013B2 (en) * 1999-01-29 2005-02-15 Intermec Ip.Corp. Remote anomaly diagnosis and reconfiguration of an automatic data collection device platform over a telecommunications network
US7122666B2 (en) 1999-07-21 2006-10-17 Sankyo Company, Limited Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
US6976062B1 (en) * 1999-09-22 2005-12-13 Intermec Ip Corp. Automated software upgrade utility
DE60020595T2 (de) 1999-11-23 2006-03-16 Smithkline Beecham Corp. 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p38-kinase-inhibitoren
ATE281439T1 (de) 1999-11-23 2004-11-15 Smithkline Beecham Corp 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p38-kinase-inhibitoren
DE60023025T2 (de) 1999-11-23 2006-07-13 Smithkline Beecham Corp. 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren
US6759410B1 (en) * 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
US7235551B2 (en) * 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
CN100525768C (zh) * 2000-10-23 2009-08-12 史密丝克莱恩比彻姆公司 新化合物
DE60223339T2 (de) 2001-01-22 2008-08-28 Sankyo Co., Ltd. Durch bicyclische aminogruppen substituierte verbindungen
WO2002094267A1 (fr) * 2001-05-24 2002-11-28 Sankyo Company, Limited Preparation pharmaceutique pour prevenir ou traiter l'arthrite
AR039241A1 (es) * 2002-04-04 2005-02-16 Biogen Inc Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
UA80295C2 (en) 2002-09-06 2007-09-10 Biogen Inc Pyrazolopyridines and using the same
CL2004000234A1 (es) * 2003-02-12 2005-04-15 Biogen Idec Inc Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid
KR20080002865A (ko) * 2005-03-25 2008-01-04 글락소 그룹 리미티드 피리도[２,３-ｄ]피리미딘-７-온 및３,４-디히드로피리미도[４,５-ｄ]피리미딘-２(１ｈ)-온유도체의 제조 방법
PE20100737A1 (es) * 2005-03-25 2010-11-27 Glaxo Group Ltd Nuevos compuestos
US8944332B2 (en) 2006-08-04 2015-02-03 Intermec Ip Corp. Testing automatic data collection devices, such as barcode, RFID and/or magnetic stripe readers
US11760701B2 (en) 2018-02-27 2023-09-19 The Research Foundation For The State University Of New Yrok Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2748119A (en) * 1954-06-23 1956-05-29 Searle & Co 6-furyl and 6-thienyl derivatives of 4-trifluoromethyl-2-pyrimidinamines
US3557114A (en) * 1968-12-23 1971-01-19 Merck & Co Inc 1-substituted-3-(2-pyrimidinyl) imidazolium salts
US3707475A (en) * 1970-11-16 1972-12-26 Pfizer Antiinflammatory imidazoles
US3940486A (en) * 1971-05-10 1976-02-24 Ciba-Geigy Corporation Imidazole derivatives in the treatment of pain
US3929807A (en) * 1971-05-10 1975-12-30 Ciba Geigy Corp 2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles
US4058614A (en) * 1973-12-04 1977-11-15 Merck & Co., Inc. Substituted imidazole compounds and therapeutic compositions therewith
US4199592A (en) * 1978-08-29 1980-04-22 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-nitroimidazoles
CA1175431A (en) * 1980-07-25 1984-10-02 Alfred Sallmann Tri-substituted imidazole derivatives, processes for their manufacture, pharmaceutical preparations containing them, and their use
US4503065A (en) * 1982-08-03 1985-03-05 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl 1-2-halo imidazoles
US4565875A (en) * 1984-06-27 1986-01-21 Fmc Corporation Imidazole plant growth regulators
US4686231A (en) * 1985-12-12 1987-08-11 Smithkline Beckman Corporation Inhibition of 5-lipoxygenase products
ES2087056T3 (es) * 1986-01-13 1996-07-16 American Cyanamid Co 2-pirimidinaminas sustituidas en las posiciones 4, 5 y 6.
IL83467A0 (en) * 1986-08-15 1988-01-31 Fujisawa Pharmaceutical Co Imidazole derivatives,processes for their preparation and pharmaceutical compositions containing the same
GB8906965D0 (en) * 1989-03-28 1989-05-10 Schering Agrochemicals Ltd Fungicides
US5312828A (en) * 1989-06-14 1994-05-17 Finkelstein Joseph A Substituted imidazoles having angiotensin II receptor blocking activity
US5234917A (en) * 1989-12-29 1993-08-10 Finkelstein Joseph A Substituted 5-(alkyl)carboxamide imidazoles
AU9137591A (en) * 1990-12-13 1992-07-08 Smithkline Beecham Corporation Novel csaids
AU9169991A (en) * 1990-12-13 1992-07-08 Smithkline Beecham Corporation Novel csaids
MX9300141A (es) * 1992-01-13 1994-07-29 Smithkline Beecham Corp Compuestos de imidazol novedosos, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
US5656644A (en) * 1994-07-20 1997-08-12 Smithkline Beecham Corporation Pyridyl imidazoles
US5670527A (en) * 1993-07-16 1997-09-23 Smithkline Beecham Corporation Pyridyl imidazole compounds and compositions
US5593992A (en) * 1993-07-16 1997-01-14 Smithkline Beecham Corporation Compounds
US5593991A (en) * 1993-07-16 1997-01-14 Adams; Jerry L. Imidazole compounds, use and process of making
IL110296A (en) * 1993-07-16 1999-12-31 Smithkline Beecham Corp Imidazole compounds process for their preparation and pharmaceutical compositions containing them
US5612340A (en) * 1993-10-01 1997-03-18 Ciba-Geigy Corporation Pyrimidineamine derivatives and processes for the preparation thereof
WO1995009853A1 (en) * 1993-10-01 1995-04-13 Ciba-Geigy Ag Pharmacologically active pyridine derivatives and processes for the preparation thereof
US5543520A (en) * 1993-10-01 1996-08-06 Ciba-Geigy Corporation Pyrimidine derivatives
ATE325113T1 (de) * 1993-10-01 2006-06-15 Novartis Pharma Gmbh Pharmacologisch wirksame pyrimidinderivate und verfahren zu deren herstellung
DE4337611A1 (de) * 1993-11-04 1995-05-11 Boehringer Ingelheim Kg Neue Benzoylguanidine, ihre Herstellung und ihre Verwendung in Arzneimitteln
MX9705296A (es) * 1995-01-12 1997-10-31 Smithkline Beecham Corp Compuestos novedosos de imidazol 1,4,5-susbtituidos y el uso de los mismos para preparar composiciones para uso en terapia.
US5658903A (en) * 1995-06-07 1997-08-19 Smithkline Beecham Corporation Imidazole compounds, compositions and use
US5739143A (en) * 1995-06-07 1998-04-14 Smithkline Beecham Corporation Imidazole compounds and compositions
ZA9610687B (en) * 1995-12-22 1997-09-29 Smithkline Beecham Corp Novel synthesis.
WO1997025045A1 (en) * 1996-01-11 1997-07-17 Smithkline Beecham Corporation Novel substituted imidazole compounds
AP9700912A0 (en) * 1996-01-11 1997-01-31 Smithkline Beecham Corp Novel cycloalkyl substituted imidazoles
EP0883402A4 (en) * 1996-01-11 1999-08-11 Smithkline Beecham Corp NEW CYCLOALKYL-SUBSTITUTED IMIDAZOLES
ZA97175B (en) * 1996-01-11 1997-11-04 Smithkline Beecham Corp Novel substituted imidazole compounds.
US6096739A (en) * 1996-03-25 2000-08-01 Smithkline Beecham Corporation Treatment for CNS injuries
JP2000507545A (ja) * 1996-03-25 2000-06-20 スミスクライン・ビーチャム・コーポレイション Ｃｎｓ損傷についての新規な治療

Also Published As

Publication number Publication date
AR015579A1 (es) 2001-05-16
ZA9610687B (en) 1997-09-29
JP3245175B2 (ja) 2002-01-07
AR004405A1 (es) 1998-11-04
PL327311A1 (en) 1998-12-07
AU1468197A (en) 1997-07-17
IL143517A0 (en) 2002-04-21
NZ326574A (en) 2000-01-28
US6255491B1 (en) 2001-07-03
KR19990076625A (ko) 1999-10-15
TR199801121T2 (xx) 1998-08-21
AR012567A1 (es) 2000-11-08
BR9612187A (pt) 1999-07-13
JP2000502683A (ja) 2000-03-07
US6100399A (en) 2000-08-08
TW434236B (en) 2001-05-16
US5917043A (en) 1999-06-29
HUP9902466A2 (hu) 2000-05-28
EP1019393A4 (en) 2000-07-19
AU704500B2 (en) 1999-04-22
CN1209128A (zh) 1999-02-24
IL124908A0 (en) 1999-01-26
NO982850L (no) 1998-06-19
NO982850D0 (no) 1998-06-19
CZ198598A3 (cs) 1998-10-14
EP1019393A1 (en) 2000-07-19
HUP9902466A3 (en) 2002-11-28
WO1997023479A1 (en) 1997-07-03
IL143517A (en) 2003-09-17

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
NP Permission for amending the patent specification granted (section 66, patents law 1967)
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees