AR012567A1 - Derivados de imidazol y procedimiento para su preparacion - Google Patents

Derivados de imidazol y procedimiento para su preparacion

Info

Publication number
AR012567A1
AR012567A1 ARP980101441A ARP980101441A AR012567A1 AR 012567 A1 AR012567 A1 AR 012567A1 AR P980101441 A ARP980101441 A AR P980101441A AR P980101441 A ARP980101441 A AR P980101441A AR 012567 A1 AR012567 A1 AR 012567A1
Authority
AR
Argentina
Prior art keywords
cr10r20
heteroaryl
aryl
nnr10c
10alkyl
Prior art date
Application number
ARP980101441A
Other languages
English (en)
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AR012567A1 publication Critical patent/AR012567A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Resins (AREA)

Abstract

Derivados de imidazol que comprende la formula (I) en la que R es alquilo de C1-10 opcionalmente sustituido, arilo opcionalmente sustituido, halogeno,hidroxilo, tiol, alcoxi C1-10, alquiltio de C1-10, alquilsulfinilo de C1-10, CH2-OR12, amino, amino mono - o di-sustituido con alquilo de C1-10, NHR21,N(R10)C(O)Ra, o un anillo N-heterocíclico cuyo anillo tiene de 5 a 7 miembros y que contiene opcionalmente un heteroátomo adicional seleccionado entre oxígeno,azufre o NR15; Ra es hidrogeno, alquilo de C1-6, cicloalquilo de C3-7, arilo, aril-alquilo de C1-4, heteroarilo, heteroarilalquilo de C1-4, heterociclilo, oheterociclil-alquilo de C1-4: R4 es un anillo fenilo, naft-1-ilo o naft-2-ilo, o heteroarilo, opcionalmente sustituido; R2 es-(CR10R20)n, ORg, heterociclilo,heterociclil-alquilo de C1-10, alquilo de C1-10-halo-sustituido,alquenilo de C2-10, alquinilo de C2-10, cicloalquilo de C3-7, cicloalquilo de C3-7-alquilode C1-10, cicloalquenilo de C5-7, cicloalquenilo de C5-7-alquilo de C1-10, arilo, aril-alquilo de C1-10, heteroarilo, heteroaril-alquilo de C1-10,(CR10R20)nOR11, (CR10R20)nS(O)m-R18, (CR10R20)nNHS(O)2R18, (CR10R20)nNR13R14, (CR10R20)rNO2, (CR10R20=nCN, (CR10R20)n,SO2R18, (CR10R20)nS(O)m,NR13R14,(CR10R20)nC(Z)R11, (CR10R20)mOC(Z)R11, (CR10R20)nC(Z)OR11, (CR10R20)nC(Z)- R13R14, (R10R20)nC(Z)NR11OR9, (CR10R20)nNR10C(Z)R11, (CR10R20)nNR10C(Z)NR13R14,(CR10R20)nN(OR6)C(Z)R11, (CR10R20)nC(=NOR6)R11, (CR10R20)nNR10C(=NR19)NR13R14, (CR10R20)nOC(Z)NR13R14, (CR10R20)nNR10C(Z)NR13R14, (CR10R20)nNR10C(Z)OR10,5-(R18)-1,2,4, oxadiazol-3-ilo, o 4-(R12)-5-(R18R19)-4,5-dihidro-1,2,4- oxadiazol-3-ilo; en los que los grupos arilo, arilaquilo, heteroarilo,heteroarilalquilo, heterocíclico y heterocíclicoalquilo pueden estar opcionalmente sustituidos; n es un numero entero que tiene un valor de 1 a 10;
ARP980101441A 1995-12-22 1998-03-30 Derivados de imidazol y procedimiento para su preparacion AR012567A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US909895P 1995-12-22 1995-12-22

Publications (1)

Publication Number Publication Date
AR012567A1 true AR012567A1 (es) 2000-11-08

Family

ID=21735553

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP960105842A AR004405A1 (es) 1995-12-22 1996-12-20 Procedimiento para preparar 5-(2,5-disustituido-pirimidin)-4-il-imidazoles
ARP980101441A AR012567A1 (es) 1995-12-22 1998-03-30 Derivados de imidazol y procedimiento para su preparacion
ARP980101440A AR015579A1 (es) 1995-12-22 1998-03-30 Derivados de propenona-imidazol y procedimiento para su preparacion

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP960105842A AR004405A1 (es) 1995-12-22 1996-12-20 Procedimiento para preparar 5-(2,5-disustituido-pirimidin)-4-il-imidazoles

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP980101440A AR015579A1 (es) 1995-12-22 1998-03-30 Derivados de propenona-imidazol y procedimiento para su preparacion

Country Status (18)

Country Link
US (3) US5917043A (es)
EP (1) EP1019393A4 (es)
JP (1) JP3245175B2 (es)
KR (1) KR19990076625A (es)
CN (1) CN1209128A (es)
AR (3) AR004405A1 (es)
AU (1) AU704500B2 (es)
BR (1) BR9612187A (es)
CZ (1) CZ198598A3 (es)
HU (1) HUP9902466A3 (es)
IL (2) IL143517A (es)
NO (1) NO982850D0 (es)
NZ (1) NZ326574A (es)
PL (1) PL327311A1 (es)
TR (1) TR199801121T2 (es)
TW (1) TW434236B (es)
WO (1) WO1997023479A1 (es)
ZA (1) ZA9610687B (es)

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Also Published As

Publication number Publication date
BR9612187A (pt) 1999-07-13
IL124908A0 (en) 1999-01-26
TW434236B (en) 2001-05-16
IL143517A (en) 2003-09-17
AU1468197A (en) 1997-07-17
AR004405A1 (es) 1998-11-04
TR199801121T2 (xx) 1998-08-21
EP1019393A1 (en) 2000-07-19
NO982850L (no) 1998-06-19
US5917043A (en) 1999-06-29
HUP9902466A2 (hu) 2000-05-28
NZ326574A (en) 2000-01-28
IL143517A0 (en) 2002-04-21
CN1209128A (zh) 1999-02-24
HUP9902466A3 (en) 2002-11-28
US6255491B1 (en) 2001-07-03
NO982850D0 (no) 1998-06-19
AR015579A1 (es) 2001-05-16
IL124908A (en) 2003-05-29
WO1997023479A1 (en) 1997-07-03
US6100399A (en) 2000-08-08
JP3245175B2 (ja) 2002-01-07
AU704500B2 (en) 1999-04-22
PL327311A1 (en) 1998-12-07
CZ198598A3 (cs) 1998-10-14
KR19990076625A (ko) 1999-10-15
JP2000502683A (ja) 2000-03-07
ZA9610687B (en) 1997-09-29
EP1019393A4 (en) 2000-07-19

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