IL124006A - Therapeutic compositions for the treatment of bronchial asthma containing 2-phenyl-1, 2-benzoisoselenazole-3 (2h)-one - Google Patents
Therapeutic compositions for the treatment of bronchial asthma containing 2-phenyl-1, 2-benzoisoselenazole-3 (2h)-oneInfo
- Publication number
- IL124006A IL124006A IL12400697A IL12400697A IL124006A IL 124006 A IL124006 A IL 124006A IL 12400697 A IL12400697 A IL 12400697A IL 12400697 A IL12400697 A IL 12400697A IL 124006 A IL124006 A IL 124006A
- Authority
- IL
- Israel
- Prior art keywords
- group
- phenyl
- benzoisoselenazole
- bronchial asthma
- treatment
- Prior art date
Links
- 208000006673 asthma Diseases 0.000 title claims abstract description 57
- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 208000030603 inherited susceptibility to asthma Diseases 0.000 title claims abstract description 18
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 12
- DYEFUKCXAQOFHX-UHFFFAOYSA-N Ebselen Chemical compound [se]1C2=CC=CC=C2C(=O)N1C1=CC=CC=C1 DYEFUKCXAQOFHX-UHFFFAOYSA-N 0.000 title abstract description 15
- 150000003839 salts Chemical class 0.000 claims abstract description 13
- 239000004480 active ingredient Substances 0.000 claims abstract description 8
- 230000004044 response Effects 0.000 claims description 25
- 150000001875 compounds Chemical class 0.000 description 14
- 229950010033 ebselen Drugs 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 241000700198 Cavia Species 0.000 description 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 9
- 239000000427 antigen Substances 0.000 description 9
- 102000036639 antigens Human genes 0.000 description 9
- 108091007433 antigens Proteins 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 8
- 229960003957 dexamethasone Drugs 0.000 description 6
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 208000037883 airway inflammation Diseases 0.000 description 5
- 239000003246 corticosteroid Substances 0.000 description 5
- -1 methoxyl group Chemical group 0.000 description 5
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 229960005205 prednisolone Drugs 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 229940125388 beta agonist Drugs 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 229910052711 selenium Inorganic materials 0.000 description 3
- 239000011669 selenium Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 150000003573 thiols Chemical group 0.000 description 3
- 206010006482 Bronchospasm Diseases 0.000 description 2
- 241000700199 Cavia porcellus Species 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 2
- 230000007885 bronchoconstriction Effects 0.000 description 2
- 229960001334 corticosteroids Drugs 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000006199 nebulizer Substances 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 230000009325 pulmonary function Effects 0.000 description 2
- 229940044551 receptor antagonist Drugs 0.000 description 2
- 239000002464 receptor antagonist Substances 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 description 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 206010008469 Chest discomfort Diseases 0.000 description 1
- 206010011416 Croup infectious Diseases 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 229940122236 Histamine receptor antagonist Drugs 0.000 description 1
- 208000019025 Hypokalemia Diseases 0.000 description 1
- 206010074052 Hypothalamic pituitary adrenal axis suppression Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 239000000867 Lipoxygenase Inhibitor Substances 0.000 description 1
- 102000003820 Lipoxygenases Human genes 0.000 description 1
- 108090000128 Lipoxygenases Proteins 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000010428 Muscle Weakness Diseases 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010050346 Oropharyngeal candidiasis Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 108010058846 Ovalbumin Proteins 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- 206010040925 Skin striae Diseases 0.000 description 1
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 description 1
- 108010069102 Thromboxane-A synthase Proteins 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 206010047924 Wheezing Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
- 230000036428 airway hyperreactivity Effects 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 208000037849 arterial hypertension Diseases 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 201000010549 croup Diseases 0.000 description 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 230000002497 edematous effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000003979 eosinophil Anatomy 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 238000011597 hartley guinea pig Methods 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000000842 isoxazolyl group Chemical group 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 229940092253 ovalbumin Drugs 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 208000024896 potassium deficiency disease Diseases 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000036412 respiratory physiology Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 229940065287 selenium compound Drugs 0.000 description 1
- 150000003343 selenium compounds Chemical class 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 230000016160 smooth muscle contraction Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1184896 | 1996-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL124006A true IL124006A (en) | 2004-07-25 |
Family
ID=11789151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12400697A IL124006A (en) | 1996-01-26 | 1997-01-27 | Therapeutic compositions for the treatment of bronchial asthma containing 2-phenyl-1, 2-benzoisoselenazole-3 (2h)-one |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0876144B1 (cs) |
| CN (1) | CN1116876C (cs) |
| AT (1) | ATE207746T1 (cs) |
| AU (1) | AU728713B2 (cs) |
| BR (1) | BR9707303A (cs) |
| CA (1) | CA2244085C (cs) |
| CZ (1) | CZ292670B6 (cs) |
| DE (2) | DE59705183D1 (cs) |
| DK (1) | DK0876144T3 (cs) |
| EA (1) | EA001066B1 (cs) |
| ES (1) | ES2165034T3 (cs) |
| HU (1) | HUP9901639A3 (cs) |
| IL (1) | IL124006A (cs) |
| NO (1) | NO983217L (cs) |
| NZ (1) | NZ330198A (cs) |
| PL (1) | PL187620B1 (cs) |
| PT (1) | PT876144E (cs) |
| TR (1) | TR199801398T2 (cs) |
| WO (1) | WO1997026968A2 (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000016935A (ja) * | 1998-07-01 | 2000-01-18 | Dai Ichi Seiyaku Co Ltd | シクロオキシゲナーゼ阻害剤 |
| WO2000058281A1 (en) | 1999-03-31 | 2000-10-05 | Daiichi Pharmaceutical Co., Ltd. | Substrates for thioredoxin reductase |
| RU2011141794A (ru) | 2009-03-17 | 2013-04-27 | Дайити Санкио Компани, Лимитед | Амидное производное |
| US10058542B1 (en) | 2014-09-12 | 2018-08-28 | Thioredoxin Systems Ab | Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith |
| CN105622478B (zh) * | 2014-10-27 | 2017-08-25 | 中国科学院大连化学物理研究所 | 3,3‑二烷硫基‑2‑苯硒基‑2‑丙烯‑1‑酮衍生物及合成 |
| CN109627198B (zh) * | 2019-02-01 | 2020-11-10 | 河南科技大学 | 一种2-丙酮基硒基苯甲酰胺类化合物及其制备方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4778814A (en) * | 1987-03-18 | 1988-10-18 | Ciba-Geigy Corporation | Method of treating ocular allergy by topical application of a 2-substituted-1,2-benzisoselenazol-3(2H)-one |
| DZ1460A1 (fr) * | 1989-11-22 | 2004-09-13 | Sod Conseils Rech Applic | Nouveaux dérivés du sélénophèn ainsi que leur procédé de préparation. |
| IT1250751B (it) * | 1991-08-02 | 1995-04-21 | Boehringer Mannheim Italia | (3h,7h)selenazolo(3,4-a|piridine con attivita' antiasmatica ed antiinfiammatoria delle vie aereea |
| JP2553434B2 (ja) * | 1992-04-28 | 1996-11-13 | 第一製薬株式会社 | 粒状製剤 |
| JPH07233056A (ja) * | 1993-09-03 | 1995-09-05 | Dai Ichi Seiyaku Co Ltd | リポキシゲナーゼ阻害剤 |
| DE19506669A1 (de) * | 1995-02-25 | 1996-08-29 | Nattermann A & Cie | Lipoxygenasehemmer |
-
1997
- 1997-01-27 AT AT97914084T patent/ATE207746T1/de not_active IP Right Cessation
- 1997-01-27 IL IL12400697A patent/IL124006A/en not_active IP Right Cessation
- 1997-01-27 CN CN97191886A patent/CN1116876C/zh not_active Expired - Fee Related
- 1997-01-27 DE DE59705183T patent/DE59705183D1/de not_active Expired - Lifetime
- 1997-01-27 HU HU9901639A patent/HUP9901639A3/hu unknown
- 1997-01-27 DE DE19780042T patent/DE19780042D2/de not_active Ceased
- 1997-01-27 EA EA199800658A patent/EA001066B1/ru not_active IP Right Cessation
- 1997-01-27 DK DK97914084T patent/DK0876144T3/da active
- 1997-01-27 CZ CZ19982356A patent/CZ292670B6/cs not_active IP Right Cessation
- 1997-01-27 CA CA002244085A patent/CA2244085C/en not_active Expired - Fee Related
- 1997-01-27 TR TR1998/01398T patent/TR199801398T2/xx unknown
- 1997-01-27 PT PT97914084T patent/PT876144E/pt unknown
- 1997-01-27 EP EP97914084A patent/EP0876144B1/de not_active Expired - Lifetime
- 1997-01-27 WO PCT/DE1997/000135 patent/WO1997026968A2/de not_active Ceased
- 1997-01-27 ES ES97914084T patent/ES2165034T3/es not_active Expired - Lifetime
- 1997-01-27 BR BR9707303-2A patent/BR9707303A/pt not_active Application Discontinuation
- 1997-01-27 PL PL97328198A patent/PL187620B1/pl not_active IP Right Cessation
- 1997-01-27 NZ NZ330198A patent/NZ330198A/en unknown
- 1997-01-27 AU AU21497/97A patent/AU728713B2/en not_active Ceased
-
1998
- 1998-07-13 NO NO983217A patent/NO983217L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL187620B1 (pl) | 2004-08-31 |
| HUP9901639A1 (hu) | 1999-09-28 |
| BR9707303A (pt) | 2000-05-02 |
| AU728713B2 (en) | 2001-01-18 |
| HUP9901639A3 (en) | 2000-10-30 |
| CN1219127A (zh) | 1999-06-09 |
| ATE207746T1 (de) | 2001-11-15 |
| CA2244085A1 (en) | 1997-07-31 |
| WO1997026968A2 (de) | 1997-07-31 |
| NO983217L (no) | 1998-09-25 |
| ES2165034T3 (es) | 2002-03-01 |
| NZ330198A (en) | 2000-06-23 |
| EA001066B1 (ru) | 2000-10-30 |
| PL328198A1 (en) | 1999-01-18 |
| TR199801398T2 (xx) | 1998-10-21 |
| CZ235698A3 (cs) | 1999-04-14 |
| NO983217D0 (no) | 1998-07-13 |
| DE59705183D1 (de) | 2001-12-06 |
| WO1997026968A3 (de) | 1997-09-25 |
| EA199800658A1 (ru) | 1999-02-25 |
| DE19780042D2 (de) | 1999-01-28 |
| PT876144E (pt) | 2002-04-29 |
| CN1116876C (zh) | 2003-08-06 |
| HK1019862A1 (en) | 2000-03-03 |
| EP0876144B1 (de) | 2001-10-31 |
| AU2149797A (en) | 1997-08-20 |
| DK0876144T3 (da) | 2002-02-25 |
| EP0876144A2 (de) | 1998-11-11 |
| CZ292670B6 (cs) | 2003-11-12 |
| CA2244085C (en) | 2008-10-14 |
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