IL123502A0 - Biphenyl hydroxamate inhibitors of matrix metalloproteinases - Google Patents
Biphenyl hydroxamate inhibitors of matrix metalloproteinasesInfo
- Publication number
- IL123502A0 IL123502A0 IL12350296A IL12350296A IL123502A0 IL 123502 A0 IL123502 A0 IL 123502A0 IL 12350296 A IL12350296 A IL 12350296A IL 12350296 A IL12350296 A IL 12350296A IL 123502 A0 IL123502 A0 IL 123502A0
- Authority
- IL
- Israel
- Prior art keywords
- matrix metalloproteinases
- biphenyl
- tnf alpha
- hydroxamate inhibitors
- alpha secretion
- Prior art date
Links
- 102000002274 Matrix Metalloproteinases Human genes 0.000 title abstract 4
- 108010000684 Matrix Metalloproteinases Proteins 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title 1
- ZHSDLNXUORTYIN-UHFFFAOYSA-N n-hydroxy-2-phenylbenzamide Chemical compound ONC(=O)C1=CC=CC=C1C1=CC=CC=C1 ZHSDLNXUORTYIN-UHFFFAOYSA-N 0.000 title 1
- 230000028327 secretion Effects 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/555,690 US5665777A (en) | 1995-11-14 | 1995-11-14 | Biphenyl hydroxamate inhibitors of matrix metalloproteinases |
PCT/US1996/018172 WO1997018188A1 (en) | 1995-11-14 | 1996-11-13 | Biphenyl hydroxamate inhibitors of matrix metalloproteinases |
Publications (1)
Publication Number | Publication Date |
---|---|
IL123502A0 true IL123502A0 (en) | 1998-09-24 |
Family
ID=24218248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12350296A IL123502A0 (en) | 1995-11-14 | 1996-11-13 | Biphenyl hydroxamate inhibitors of matrix metalloproteinases |
Country Status (13)
Country | Link |
---|---|
US (1) | US5665777A (ko) |
EP (1) | EP0874808B1 (ko) |
JP (1) | JP2002504073A (ko) |
KR (1) | KR19990067573A (ko) |
AT (1) | ATE236873T1 (ko) |
AU (1) | AU710666B2 (ko) |
DE (1) | DE69627380T2 (ko) |
DK (1) | DK0874808T3 (ko) |
ES (1) | ES2196190T3 (ko) |
IL (1) | IL123502A0 (ko) |
MX (1) | MX9803809A (ko) |
PT (1) | PT874808E (ko) |
WO (1) | WO1997018188A1 (ko) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL126347A (en) * | 1996-03-29 | 2003-11-23 | Lawrence Berkeley National Lab | Enhancement of nmr and mri in the presence of hyperpolarized noble gases |
CA2263154A1 (en) * | 1996-08-07 | 1998-02-12 | Darwin Discovery Limited | Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity |
US6566384B1 (en) | 1996-08-07 | 2003-05-20 | Darwin Discovery Ltd. | Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity |
US6172057B1 (en) * | 1997-02-27 | 2001-01-09 | American Cyanamid Company | N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
JP2001513771A (ja) * | 1997-02-27 | 2001-09-04 | アメリカン・サイアナミド・カンパニー | マトリクス金属プロテイナーゼ阻害薬としてのn−ヒドロキシ−2−(アルキル、アリール、またはヘテロアリールスルファニル、スルフィニルまたはスルホニル)−3−置換アルキル、アリールまたはヘテロアリールアミド |
US6300514B1 (en) | 1997-06-25 | 2001-10-09 | Ono Pharmaceutical Co., Ltd. | Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient |
ATE228998T1 (de) * | 1997-07-31 | 2002-12-15 | Abbott Lab | N-hydroxyformamid-derivate als inhibitoren von metalloproteinasen |
US6235786B1 (en) | 1997-08-06 | 2001-05-22 | Abbott Laboratories | Reverse hydroxamate inhibitors of matrix metalloproteinases |
US6294573B1 (en) | 1997-08-06 | 2001-09-25 | Abbott Laboratories | Reverse hydroxamate inhibitors of matrix metalloproteinases |
CN1282319A (zh) | 1997-10-09 | 2001-01-31 | 小野药品工业株式会社 | 氨基丁酸衍生物 |
US6288063B1 (en) * | 1998-05-27 | 2001-09-11 | Bayer Corporation | Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors |
FR2780402B1 (fr) | 1998-06-30 | 2001-04-27 | Adir | Nouveaux composes acides carboxyliques et hydroxamiques inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US6288261B1 (en) | 1998-12-18 | 2001-09-11 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
WO2000044712A1 (en) * | 1999-01-27 | 2000-08-03 | Abbott Laboratories | N-hydroxyformamide derivatives as inhibitors of matrix metalloproteinases |
NZ520711A (en) * | 2000-02-10 | 2004-03-26 | Ono Pharmaceutical Co | N-hydroxy-5-ethoxymethyloxy-2(S)-methyl-4(S)-(4- phenoxybenzoyl)aminopentanamide useful for treating osteoarthritis |
US20030165431A1 (en) * | 2000-07-13 | 2003-09-04 | The Regents Of The University Of California | Method for detecting macromolecular conformational change and binding information |
US6652833B2 (en) | 2000-07-13 | 2003-11-25 | The Regents Of The University Of California | Functionalized active-nucleus complex sensor |
US7061237B2 (en) * | 2000-07-13 | 2006-06-13 | The Regents Of The University Of California | Remote NMR/MRI detection of laser polarized gases |
JP2004359546A (ja) * | 2001-03-15 | 2004-12-24 | Ono Pharmaceut Co Ltd | ヒドロキサム酸誘導体、それらの非毒性塩およびそれらのプロドラッグ体を有効成分として含有する、固形癌の予防および/または治療剤 |
JPWO2002074298A1 (ja) * | 2001-03-21 | 2004-07-08 | 小野薬品工業株式会社 | Il−6産生阻害剤 |
PE20030701A1 (es) * | 2001-12-20 | 2003-08-21 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
AU2003300076C1 (en) | 2002-12-30 | 2010-03-04 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
WO2007141029A1 (en) * | 2006-06-08 | 2007-12-13 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Specific protease inhibitors and their use in cancer therapy |
US7879911B2 (en) | 2007-02-01 | 2011-02-01 | Johnson Alan T | Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning |
CN102267923B (zh) * | 2010-06-04 | 2015-07-15 | 台北医学大学 | 组蛋白去乙酰化酶抑制剂 |
WO2014151988A1 (en) * | 2013-03-15 | 2014-09-25 | Mallinckrodt Llc | Matrix metalloprotease (mmp) targeted agents for imaging and therapy |
AU2014299457B2 (en) * | 2013-06-27 | 2017-06-08 | Lg Chem, Ltd. | Biaryl derivatives as GPR120 agonists |
KR101829290B1 (ko) * | 2014-12-24 | 2018-02-19 | 주식회사 엘지화학 | Gpr120 효능제로서의 바이아릴 유도체 |
US20210393632A1 (en) | 2018-10-04 | 2021-12-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Egfr inhibitors for treating keratodermas |
CN109820861B (zh) * | 2019-03-13 | 2021-02-26 | 湖北科技学院 | 一种具有抗肿瘤活性的吩噻嗪类衍生物的应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1548641A (ko) * | 1967-10-26 | 1968-12-06 | ||
US3755603A (en) * | 1970-07-01 | 1973-08-28 | Syntex Corp | Biphenylyloxyacetic acids in pharmaceutical compositions |
JPS525730A (en) * | 1975-07-03 | 1977-01-17 | Nippon Shinyaku Co Ltd | Process for preparation of 1,3,5-tri-substituted derivatives |
JPS5762239A (en) * | 1980-08-26 | 1982-04-15 | Hisamitsu Pharmaceut Co Inc | Novel phenylacetic acid derivative |
US4599361A (en) * | 1985-09-10 | 1986-07-08 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
US5036157A (en) * | 1986-03-11 | 1991-07-30 | Burroughs Wellcome Co. | Aryl derivatives |
JPH05503720A (ja) * | 1990-12-03 | 1993-06-17 | セルテック リミテッド | ペプチジル誘導体 |
GB9102635D0 (en) * | 1991-02-07 | 1991-03-27 | British Bio Technology | Compounds |
JPH05205730A (ja) * | 1992-01-29 | 1993-08-13 | Shin Kobe Electric Mach Co Ltd | 薄形鉛蓄電池 |
DE69309047T2 (de) * | 1992-04-07 | 1997-09-11 | British Biotech Pharm | Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren |
US5318964A (en) * | 1992-06-11 | 1994-06-07 | Hoffmann-La Roche Inc. | Hydroxamic derivatives and pharmaceutical compositions |
WO1994002246A1 (en) * | 1992-07-16 | 1994-02-03 | Chevron Chemical Company | Low temperature regeneration of coke deactivated reforming catalysts |
US5310121A (en) * | 1992-07-24 | 1994-05-10 | Consilium Bulk Babcock Atlanta, Inc. | Cold weather bulk stacker/reclaimer apparatus and method |
GB9223904D0 (en) * | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
DE69412469T2 (de) * | 1993-03-16 | 1999-02-04 | British Biotech Pharm | Hydroxamsaeurederivate als metalloproteinase inhibitoren |
WO1995006031A1 (en) * | 1993-08-23 | 1995-03-02 | Immunex Corporation | Inhibitors of tnf-alpha secretion |
GB9320660D0 (en) * | 1993-10-07 | 1993-11-24 | British Bio Technology | Inhibition of cytokine production |
-
1995
- 1995-11-14 US US08/555,690 patent/US5665777A/en not_active Expired - Fee Related
-
1996
- 1996-11-13 DK DK96940406T patent/DK0874808T3/da active
- 1996-11-13 ES ES96940406T patent/ES2196190T3/es not_active Expired - Lifetime
- 1996-11-13 EP EP96940406A patent/EP0874808B1/en not_active Expired - Lifetime
- 1996-11-13 PT PT96940406T patent/PT874808E/pt unknown
- 1996-11-13 WO PCT/US1996/018172 patent/WO1997018188A1/en not_active Application Discontinuation
- 1996-11-13 AU AU77296/96A patent/AU710666B2/en not_active Ceased
- 1996-11-13 AT AT96940406T patent/ATE236873T1/de not_active IP Right Cessation
- 1996-11-13 KR KR1019980703596A patent/KR19990067573A/ko not_active Application Discontinuation
- 1996-11-13 DE DE69627380T patent/DE69627380T2/de not_active Expired - Fee Related
- 1996-11-13 IL IL12350296A patent/IL123502A0/xx unknown
- 1996-11-13 JP JP51903097A patent/JP2002504073A/ja not_active Ceased
-
1998
- 1998-05-13 MX MX9803809A patent/MX9803809A/es unknown
Also Published As
Publication number | Publication date |
---|---|
DE69627380D1 (en) | 2003-05-15 |
US5665777A (en) | 1997-09-09 |
JP2002504073A (ja) | 2002-02-05 |
ATE236873T1 (de) | 2003-04-15 |
AU7729696A (en) | 1997-06-05 |
ES2196190T3 (es) | 2003-12-16 |
EP0874808B1 (en) | 2003-04-09 |
MX9803809A (es) | 1998-09-30 |
EP0874808A1 (en) | 1998-11-04 |
KR19990067573A (ko) | 1999-08-25 |
PT874808E (pt) | 2003-08-29 |
WO1997018188A1 (en) | 1997-05-22 |
DE69627380T2 (de) | 2004-03-25 |
DK0874808T3 (da) | 2003-08-04 |
AU710666B2 (en) | 1999-09-23 |
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