IL123294A0 - Monoclonal antibody BR110 and uses thereof - Google Patents

Monoclonal antibody BR110 and uses thereof

Info

Publication number
IL123294A0
IL123294A0 IL12329496A IL12329496A IL123294A0 IL 123294 A0 IL123294 A0 IL 123294A0 IL 12329496 A IL12329496 A IL 12329496A IL 12329496 A IL12329496 A IL 12329496A IL 123294 A0 IL123294 A0 IL 123294A0
Authority
IL
Israel
Prior art keywords
antigen
monoclonal antibody
complex
ligands
ligand
Prior art date
Application number
IL12329496A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL123294A0 publication Critical patent/IL123294A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL12329496A 1995-10-19 1996-10-07 Monoclonal antibody BR110 and uses thereof IL123294A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US564195P 1995-10-19 1995-10-19
PCT/US1996/016070 WO1997014796A1 (fr) 1995-10-19 1996-10-07 Anticorps monoclonal br110 et ses utilisations

Publications (1)

Publication Number Publication Date
IL123294A0 true IL123294A0 (en) 1998-09-24

Family

ID=21716930

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12329496A IL123294A0 (en) 1995-10-19 1996-10-07 Monoclonal antibody BR110 and uses thereof

Country Status (11)

Country Link
US (1) US5840854A (fr)
EP (1) EP0856054B1 (fr)
JP (1) JP2001501801A (fr)
AT (1) ATE265532T1 (fr)
AU (1) AU7394296A (fr)
CA (1) CA2235269C (fr)
DE (1) DE69632333T2 (fr)
ES (1) ES2219699T3 (fr)
IL (1) IL123294A0 (fr)
NO (1) NO321548B1 (fr)
WO (1) WO1997014796A1 (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7354587B1 (en) * 1994-07-06 2008-04-08 Immunomedics, Inc. Use of immunoconjugates to enhance the efficacy of multi-stage cascade boosting vaccines
US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US6366762B1 (en) * 1999-03-31 2002-04-02 Qualcomm, Inc. System and method for measuring round trip delay on the paging and access channels
US6617432B1 (en) * 1999-10-15 2003-09-09 University Of Pittsburgh Nuclear matrix proteins polynucleotide sequences encoding them and their use
US20030009781A1 (en) * 2001-03-29 2003-01-09 Allen Keith D. Transgenic mice containing Kir3.3 potassium channel gene disruptions
US20020155109A1 (en) * 2001-04-20 2002-10-24 Lynch David H. Bispecific antibodies that bind TRAIL-R1 and TRAIL-R2
US8435529B2 (en) 2002-06-14 2013-05-07 Immunomedics, Inc. Combining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy
PT3483183T (pt) 2002-03-01 2021-06-02 Immunomedics Inc Imunoconjugado compreendendo anticorpos rs7 humanizados
US9745380B2 (en) 2002-03-01 2017-08-29 Immunomedics, Inc. RS7 antibodies
US9770517B2 (en) * 2002-03-01 2017-09-26 Immunomedics, Inc. Anti-Trop-2 antibody-drug conjugates and uses thereof
US9701754B1 (en) 2002-10-23 2017-07-11 City Of Hope Covalent disulfide-linked diabodies and uses thereof
US20080305104A1 (en) * 2006-02-24 2008-12-11 Young David S F Cytotoxicity mediation of cells evidencing surface expression of TROP-2
US20080213267A1 (en) * 2006-02-24 2008-09-04 Arius Research, Inc. Cytotoxicity mediation of cells evidencing surface expression of TROP-2
US7420040B2 (en) * 2006-02-24 2008-09-02 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of TROP-2
US20080131428A1 (en) * 2006-02-24 2008-06-05 Arius Research, Inc. Cytotoxicity mediation of cells evidencing surface expression of TROP-2
CA2646329C (fr) 2006-03-20 2018-07-03 The Regents Of The University Of California Anticorps modifies diriges contre l'antigene de cellules souches prostatiques servant a cibler le cancer
JP4689521B2 (ja) * 2006-04-07 2011-05-25 財団法人電力中央研究所 抗鉛モノクローナル抗体
WO2009032949A2 (fr) 2007-09-04 2009-03-12 The Regents Of The University Of California Anticorps d'antigène de cellule souche anti-prostate (psca) à haute affinité pour un ciblage et une détection de cancer
CA2752510C (fr) 2009-02-17 2024-01-23 Neil Bander Procedes et kits pour le diagnostic d'un cancer et la prediction d'une valeur therapeutique
CN102753194B (zh) 2009-12-02 2015-07-08 伊麦吉纳博公司 靶向人前列腺特异性膜抗原的j591微抗体和双抗体
EA201500220A1 (ru) * 2010-05-17 2015-10-30 Ливтех, Инк. Антитело против trop-2 человека, обладающее противоопухолевой активностью in vivo
EP2594589A1 (fr) * 2010-06-10 2013-05-22 Sapporo Medical University ANTICORPS ANTI-Trop-2
RU2014116406A (ru) 2011-11-11 2015-12-20 Ринат Ньюросайенс Корп. Антитела, специфичные к trop-2, и их применения
US9427464B2 (en) 2011-11-22 2016-08-30 Chiome Bioscience Inc. Anti-human TROP-2 antibody having an antitumor activity in vivo
CN106132436B (zh) 2014-02-21 2021-06-15 Ibc药品公司 通过诱导对trop-2表达细胞的免疫应答的疾病疗法
AU2016252771B2 (en) 2015-04-22 2021-12-16 Immunomedics, Inc. Isolation, detection, diagnosis and/or characterization of circulating Trop-2-positive cancer cells
EP4137158A1 (fr) 2015-08-07 2023-02-22 Imaginab, Inc. Constructions de liaison d'antigène se liant à des molécules cibles
WO2018147960A1 (fr) 2017-02-08 2018-08-16 Imaginab, Inc. Séquences d'extension pour dianticorps
EP3876998A1 (fr) 2018-11-05 2021-09-15 Synaffix B.V. Anticorps-conjugués pour le ciblage de tumeurs exprimant trop -2
CN115398010A (zh) 2020-03-20 2022-11-25 免疫医疗公司 用于戈沙妥珠单抗疗法的生物标志物
AU2021362977A1 (en) 2020-10-14 2023-05-04 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. Anti-trop-2 antibody, antigen-binding fragment thereof or mutant thereof, and medical use thereof
CN115429893A (zh) 2021-06-02 2022-12-06 百奥泰生物制药股份有限公司 药物偶联物及其用途
AU2022350725A1 (en) 2021-09-23 2024-03-28 Changzhou Hansoh Pharmaceutical Co., Ltd. Antibody-drug conjugate, preparation method therefor, and pharmaceutical use thereof
WO2023180485A1 (fr) 2022-03-23 2023-09-28 Synaffix B.V. Anticorps-conjugués pour le ciblage de tumeurs exprimant trop-2

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185254A (en) * 1988-12-29 1993-02-09 The Wistar Institute Gene family of tumor-associated antigens
ATE138688T1 (de) * 1989-04-21 1996-06-15 Us Health Rekombinantes antikörper-toxin-fusion-protein
CA2120507A1 (fr) * 1991-10-18 1993-04-29 Alban J. Linnenbach Variants solubles de proteines membranaires de type 1 et methodes d'utilisation

Also Published As

Publication number Publication date
JP2001501801A (ja) 2001-02-13
NO981745L (no) 1998-04-17
ATE265532T1 (de) 2004-05-15
CA2235269C (fr) 2006-09-19
WO1997014796A1 (fr) 1997-04-24
DE69632333T2 (de) 2004-12-30
ES2219699T3 (es) 2004-12-01
EP0856054A1 (fr) 1998-08-05
MX9802129A (es) 1998-05-31
EP0856054B1 (fr) 2004-04-28
DE69632333D1 (de) 2004-06-03
NO981745D0 (no) 1998-04-17
CA2235269A1 (fr) 1997-04-24
NO321548B1 (no) 2006-05-29
AU7394296A (en) 1997-05-07
US5840854A (en) 1998-11-24

Similar Documents

Publication Publication Date Title
IL123294A0 (en) Monoclonal antibody BR110 and uses thereof
ES2106195T3 (es) Anticuerpo igg aglicosilado anti cd3.
AU6954398A (en) Antagonistic anti-avb3 integrin antibodies
AU2001257012A1 (en) Methods for selective targeting
GEP20105118B (en) Anti-vegf antibodies
PT724456E (pt) Anticorpos contra cd4
AU8432498A (en) Human-cd28 specific monoclonal antibodies for antigen non-specific activation oft-lymphocytes
GB2383331A (en) Monoclonal antibody DS6 Tumor-associated antigen CA6 and methods of use thereof
EP1071460A4 (fr) Anticorps erbb2 d'internalisation
CA2442182A1 (fr) Module d'interactions entre le recepteur pd-1 et ses ligands
EP1378525A3 (fr) Anticorps humanisés qui se lient à l'antigène relié par l'anticorp NR-LU-13 et leur utilisation dans des méthodes de ciblage
WO2004025248A3 (fr) Methodes relatives a un dosage d'une paire d'anticorps
IL162117A0 (en) Humanized collagen antibodies and methods utilizing the same
AU1406195A (en) Metal ion-ligand coordination complexes, antibodies directed thereto, and assays using such antibodies
AU4441799A (en) Monoclonal antibodies that recognize antigens associated with tumor metastasis
IL108607A0 (en) Preparation of photoprotein conjugates and methods of use thereof
WO2003072727A3 (fr) Anticorps monoclonaux specifiques d'egfrviii, ribozymes d'egfrviii et utilisations en detection, traitement ou prevention de cancer associe a l'egfrviii
GB2307041B (en) Sheets,kits and methods for detecting antigens or antibodies
AU5924699A (en) Methods for identifying hot-spot residues of binding proteins and small compounds that bind to the same
DE59608073D1 (de) Antikörper gegen ein, einen histidin-anteil aufweisendes fusionspolypeptid
AU2169797A (en) Improved production of antibodies through the use of antigen antibody complexes
NO20001051D0 (no) Monoklonale antistoffer som binder testosteron
AU6068000A (en) Peptide ligands that bind igm antibodies and block interaction with antigen
AU9161991A (en) Carcinoma orosomucoid-related antigen, a monoclonal antibody thereto, and their uses
ZA986064B (en) Ancrod-specific monoclonal antibodies, antibody fragments, mixtures or derivatives thereof and their use.