IL122705A - 2-(4-Susbstituted)-benzylamino-2-methyl-propanamide derivatives their preparation and pharmaceutical compositions containing them - Google Patents

2-(4-Susbstituted)-benzylamino-2-methyl-propanamide derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number
IL122705A
IL122705A IL12270596A IL12270596A IL122705A IL 122705 A IL122705 A IL 122705A IL 12270596 A IL12270596 A IL 12270596A IL 12270596 A IL12270596 A IL 12270596A IL 122705 A IL122705 A IL 122705A
Authority
IL
Israel
Prior art keywords
susbstituted
benzylamino
methyl
preparation
pharmaceutical compositions
Prior art date
Application number
IL12270596A
Other languages
English (en)
Other versions
IL122705A0 (en
Original Assignee
Newron Pharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10778352&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL122705(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Newron Pharm Spa filed Critical Newron Pharm Spa
Publication of IL122705A0 publication Critical patent/IL122705A0/xx
Publication of IL122705A publication Critical patent/IL122705A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/28—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/30—Sulfides having the sulfur atom of at least one thio group bound to two carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/33—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
    • C07C323/35—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group
    • C07C323/36—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group the sulfur atom of the sulfide group being further bound to an acyclic carbon atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL12270596A 1995-07-27 1996-07-05 2-(4-Susbstituted)-benzylamino-2-methyl-propanamide derivatives their preparation and pharmaceutical compositions containing them IL122705A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9515412.6A GB9515412D0 (en) 1995-07-27 1995-07-27 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives
PCT/EP1996/002961 WO1997005102A1 (en) 1995-07-27 1996-07-05 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives

Publications (2)

Publication Number Publication Date
IL122705A0 IL122705A0 (en) 1998-08-16
IL122705A true IL122705A (en) 2001-01-28

Family

ID=10778352

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12270596A IL122705A (en) 1995-07-27 1996-07-05 2-(4-Susbstituted)-benzylamino-2-methyl-propanamide derivatives their preparation and pharmaceutical compositions containing them

Country Status (27)

Country Link
US (1) US5945454A (de)
EP (1) EP0842143B3 (de)
JP (1) JP4040089B2 (de)
KR (1) KR100412747B1 (de)
CN (1) CN1085659C (de)
AR (1) AR003469A1 (de)
AT (1) ATE202078T1 (de)
AU (1) AU711309B2 (de)
BR (1) BR9609849B1 (de)
CA (1) CA2226894C (de)
DE (2) DE69613377D1 (de)
DK (1) DK0842143T5 (de)
EA (1) EA001322B1 (de)
ES (1) ES2159749T7 (de)
GB (1) GB9515412D0 (de)
GR (1) GR3036559T3 (de)
HU (1) HU227806B1 (de)
IL (1) IL122705A (de)
MX (1) MX9800718A (de)
NO (1) NO324273B1 (de)
NZ (1) NZ313185A (de)
PL (1) PL184302B1 (de)
PT (1) PT842143E (de)
SI (1) SI0842143T1 (de)
UA (1) UA44331C2 (de)
WO (1) WO1997005102A1 (de)
ZA (1) ZA965998B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
ES2402104T3 (es) 1997-11-21 2013-04-29 Purdue Neuroscience Company Uso de 2-aminoacetamidas sustituidas para el tratamiento o alivio de la ansiedad
GB9727523D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
CA2370030C (en) 1999-04-09 2007-08-14 Euro-Celtique S.A. Sodium channel blocker compositions and the use thereof
AU4961001A (en) * 2000-03-31 2001-10-15 Cocensys Inc Aminopyridines and their use as anticonvulsants and sodium channel blockers
DK1423168T3 (da) 2001-09-03 2006-05-15 Newron Pharm Spa Farmaceutisk præparat omfattende gabapentin eller en analog deraf og et alfa-aminoamid og dets analgetiske anvendelse
US6667327B2 (en) 2002-02-04 2003-12-23 Hoffmann-La Roche Inc. Pyridine amido derivatives
EP1438956A1 (de) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-Aminoamidderivate die als Antimigränemittel nützlich sind
AR044007A1 (es) 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
EP1524267A1 (de) * 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Substituierte Benzylaminoalkylen-Heterozyklen
ATE411027T1 (de) 2003-10-23 2008-10-15 Hoffmann La Roche Benzazepin-derivate als mao-b-hemmer
EP1557166A1 (de) * 2004-01-21 2005-07-27 Newron Pharmaceuticals S.p.A. Alpha-aminoamidderivate für die Behandlung von Funktionsstörungen der niedrigen Harnwege
EP1588704A1 (de) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamidderivate zur Behandlung des Restless-Leg-Syndroms und der Suchterkrankungen
US20080096965A1 (en) * 2004-09-10 2008-04-24 Newron Pharmaceuticals S.P.A. (Halobenzyloxy) Benzylamino-Propanamides as Sodium and/or Calcium Channel Selective Modulators
AU2006307953A1 (en) * 2005-10-26 2007-05-03 Boehringer Ingelheim International Gmbh (Hetero)aryl compounds with MCH antagonistic activity and medicaments comprising these compounds
BRPI0620239B8 (pt) 2005-12-22 2021-05-25 Newron Pharm Spa derivados de 2-feniletilamino.
EP1870097A1 (de) 2006-06-15 2007-12-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamidederivate zur Behandlung von kognitiven Störungen
EP2046451A1 (de) * 2006-07-28 2009-04-15 Alcon Research, Ltd. Monoaminoxidasehemmer zur behandlung von erkrankungen der äusseren netzhaut
JP5440496B2 (ja) 2007-06-15 2014-03-12 ニユーロン・フアーマシユーテイカルズ・エツセ・ピー・アー 置換２−［２−（フェニル）エチルアミノ］アルカンアミド誘導体ならびにナトリウムおよび／またはカルシウムチャネル調節剤としてのこれらの使用
EP2563355B1 (de) * 2010-04-27 2016-06-08 Newron Pharmaceuticals S.p.A. Verfahren zur Herstellung von Ralfinamid-Methansulfonat-Salzen oder deren R-Enantiomere
WO2016198691A1 (en) 2015-06-11 2016-12-15 Basilea Pharmaceutica Ag Efflux-pump inhibitors and therapeutic uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94466A (en) * 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
GB9306899D0 (en) * 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation
GB9306886D0 (en) * 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation

Also Published As

Publication number Publication date
IL122705A0 (en) 1998-08-16
CA2226894A1 (en) 1997-02-13
GR3036559T3 (en) 2001-12-31
SI0842143T1 (de) 2001-08-31
EP0842143B3 (de) 2009-02-18
AU711309C (en) 1997-02-26
CA2226894C (en) 2009-03-31
NO980290L (no) 1998-01-22
ATE202078T1 (de) 2001-06-15
DK0842143T3 (da) 2001-07-23
US5945454A (en) 1999-08-31
CN1192199A (zh) 1998-09-02
DE69613377T2 (de) 2001-09-20
JP2000500732A (ja) 2000-01-25
NO980290D0 (no) 1998-01-22
ES2159749T3 (es) 2001-10-16
EP0842143B1 (de) 2001-06-13
KR19990035843A (ko) 1999-05-25
EA001322B1 (ru) 2001-02-26
CN1085659C (zh) 2002-05-29
EA199800170A1 (ru) 1998-08-27
GB9515412D0 (en) 1995-09-27
DK0842143T5 (da) 2009-06-02
ES2159749T7 (es) 2009-06-18
AU6418796A (en) 1997-02-26
ZA965998B (en) 1997-01-31
PT842143E (pt) 2001-10-30
EP0842143A1 (de) 1998-05-20
AU711309B2 (en) 1999-10-07
JP4040089B2 (ja) 2008-01-30
HUP9900351A3 (en) 1999-11-29
NO324273B1 (no) 2007-09-17
UA44331C2 (uk) 2002-02-15
WO1997005102A1 (en) 1997-02-13
MX9800718A (es) 1998-04-30
PL184302B1 (pl) 2002-09-30
HU227806B1 (en) 2012-03-28
BR9609849A (pt) 1999-03-16
KR100412747B1 (ko) 2004-04-28
DE69613377T4 (de) 2009-08-13
PL324639A1 (en) 1998-06-08
DE69613377D1 (de) 2001-07-19
HUP9900351A2 (hu) 1999-06-28
BR9609849B1 (pt) 2010-05-18
NZ313185A (en) 2000-05-26
AR003469A1 (es) 1998-08-05

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Legal Events

Date Code Title Description
HC Change of name of proprietor(s)
FF Patent granted
KB Patent renewed
KB Patent renewed
HE Change of address of proprietor(s)
NP Permission for amending the patent specification granted (section 66, patents law 1967)
KB Patent renewed
KB Patent renewed
EXP Patent expired