IL122217A - Gaseous emulsions to amplify the contrasts in ultrasound stabilized by fluorinated sites - Google Patents
Gaseous emulsions to amplify the contrasts in ultrasound stabilized by fluorinated sitesInfo
- Publication number
- IL122217A IL122217A IL12221796A IL12221796A IL122217A IL 122217 A IL122217 A IL 122217A IL 12221796 A IL12221796 A IL 12221796A IL 12221796 A IL12221796 A IL 12221796A IL 122217 A IL122217 A IL 122217A
- Authority
- IL
- Israel
- Prior art keywords
- gas
- surfactant
- emulsion
- bubbles
- group
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Colloid Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL13534296A IL135342A0 (en) | 1995-06-07 | 1996-06-05 | A microbubble precursor |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/479,621 US5804162A (en) | 1995-06-07 | 1995-06-07 | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
| PCT/US1996/009068 WO1996040281A2 (fr) | 1995-06-07 | 1996-06-05 | Emulsions gazeuses stabilisees avec des ethers fluores ayant des coefficients d'ostwald faibles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL122217A0 IL122217A0 (en) | 1998-04-05 |
| IL122217A true IL122217A (en) | 2002-03-10 |
Family
ID=23904745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12221796A IL122217A (en) | 1995-06-07 | 1996-06-05 | Gaseous emulsions to amplify the contrasts in ultrasound stabilized by fluorinated sites |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US5804162A (fr) |
| EP (2) | EP1174153B1 (fr) |
| JP (1) | JP4067116B2 (fr) |
| KR (1) | KR100401429B1 (fr) |
| CN (1) | CN1087954C (fr) |
| AT (2) | ATE337018T1 (fr) |
| AU (1) | AU712946B2 (fr) |
| CA (1) | CA2222186A1 (fr) |
| CZ (1) | CZ391397A3 (fr) |
| DE (2) | DE69636486T2 (fr) |
| DK (1) | DK0833669T3 (fr) |
| ES (2) | ES2176462T3 (fr) |
| HU (1) | HUP9900848A3 (fr) |
| IL (1) | IL122217A (fr) |
| NO (1) | NO975317L (fr) |
| PL (1) | PL185883B1 (fr) |
| PT (1) | PT833669E (fr) |
| WO (1) | WO1996040281A2 (fr) |
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| US6146657A (en) | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
| US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
| US5922304A (en) | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
| US6001335A (en) | 1989-12-22 | 1999-12-14 | Imarx Pharmaceutical Corp. | Contrasting agents for ultrasonic imaging and methods for preparing the same |
| US5776429A (en) | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
| US6551576B1 (en) | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
| US5469854A (en) | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
| US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
| US5874062A (en) | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
| US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
| DE69434119T3 (de) * | 1993-07-30 | 2011-05-05 | Imcor Pharmaceutical Co., San Diego | Stabilisierte mikrogasbläschen-zusammensetzungen für echographie |
| US6743779B1 (en) | 1994-11-29 | 2004-06-01 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
| US5997898A (en) | 1995-06-06 | 1999-12-07 | Imarx Pharmaceutical Corp. | Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery |
| US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
| US6139819A (en) | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
| US6033645A (en) | 1996-06-19 | 2000-03-07 | Unger; Evan C. | Methods for diagnostic imaging by regulating the administration rate of a contrast agent |
| US6231834B1 (en) | 1995-06-07 | 2001-05-15 | Imarx Pharmaceutical Corp. | Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same |
| US5804162A (en) * | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
| US7888466B2 (en) | 1996-01-11 | 2011-02-15 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor HSATU68 |
| DE69736981D1 (de) | 1996-05-01 | 2007-01-04 | Imarx Pharmaceutical Corp | In vitro verfahren zum einbringen von nukleinsäuren in eine zelle |
| NZ333962A (en) * | 1996-08-05 | 2000-07-28 | Schering Ag | Process and device for the production of contrast media for magnetic resonance tomography |
| US6414139B1 (en) | 1996-09-03 | 2002-07-02 | Imarx Therapeutics, Inc. | Silicon amphiphilic compounds and the use thereof |
| PT977597E (pt) | 1996-09-11 | 2003-06-30 | Imarx Pharmaceutical Corp | Metodos melhorados para imagiologia de diagnosticoutilizando um agente de contraste e um vasodil atador |
| PL332820A1 (en) * | 1996-10-21 | 1999-10-11 | Nycomed Imaging As | Improved contrast media |
| WO1998023298A1 (fr) * | 1996-11-25 | 1998-06-04 | Imarx Pharmaceutical Corp. | Compositions d'ether perfluore utilisees comme agents de contraste diagnostiques |
| US6090800A (en) | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
| US6537246B1 (en) | 1997-06-18 | 2003-03-25 | Imarx Therapeutics, Inc. | Oxygen delivery agents and uses for the same |
| US6143276A (en) | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
| US20020039594A1 (en) * | 1997-05-13 | 2002-04-04 | Evan C. Unger | Solid porous matrices and methods of making and using the same |
| US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
| US6548047B1 (en) | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
| US6123923A (en) | 1997-12-18 | 2000-09-26 | Imarx Pharmaceutical Corp. | Optoacoustic contrast agents and methods for their use |
| US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
| AU3072799A (en) | 1998-03-19 | 1999-10-11 | Human Genome Sciences, Inc. | Cytokine receptor common gamma chain like |
| AU3501700A (en) | 1999-02-26 | 2000-09-14 | Human Genome Sciences, Inc. | Human endokine alpha and methods of use |
| US6270460B1 (en) * | 1999-06-24 | 2001-08-07 | Acuson Corporation | Apparatus and method to limit the life span of a diagnostic medical ultrasound probe |
| EP1278544A4 (fr) | 2000-04-12 | 2004-08-18 | Human Genome Sciences Inc | Proteines hybrides d'albumine |
| US7700359B2 (en) | 2000-06-02 | 2010-04-20 | Novartis Vaccines And Diagnostics, Inc. | Gene products differentially expressed in cancerous cells |
| WO2001096528A2 (fr) | 2000-06-15 | 2001-12-20 | Human Genome Sciences, Inc. | Facteur de necrose tumorale humain delta et epsilon |
| US6849194B2 (en) | 2000-11-17 | 2005-02-01 | Pcbu Services, Inc. | Methods for preparing ethers, ether compositions, fluoroether fire extinguishing systems, mixtures and methods |
| EP1683865A3 (fr) | 2001-02-02 | 2006-10-25 | Eli Lilly & Company | Protéines de mammifères en particulier CD200 |
| AU2002250032B2 (en) | 2001-02-09 | 2008-06-05 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor (CCR5) HDGNR10 |
| JP2004536579A (ja) | 2001-04-13 | 2004-12-09 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | 血管内皮増殖因子２ |
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1996
- 1996-06-05 EP EP01119824A patent/EP1174153B1/fr not_active Expired - Lifetime
- 1996-06-05 ES ES96918164T patent/ES2176462T3/es not_active Expired - Lifetime
- 1996-06-05 EP EP96918164A patent/EP0833669B1/fr not_active Expired - Lifetime
- 1996-06-05 AU AU60487/96A patent/AU712946B2/en not_active Ceased
- 1996-06-05 ES ES01119824T patent/ES2269262T3/es not_active Expired - Lifetime
- 1996-06-05 DE DE69636486T patent/DE69636486T2/de not_active Expired - Fee Related
- 1996-06-05 PL PL96323868A patent/PL185883B1/pl unknown
- 1996-06-05 DK DK96918164T patent/DK0833669T3/da active
- 1996-06-05 CA CA002222186A patent/CA2222186A1/fr not_active Abandoned
- 1996-06-05 HU HU9900848A patent/HUP9900848A3/hu unknown
- 1996-06-05 AT AT01119824T patent/ATE337018T1/de not_active IP Right Cessation
- 1996-06-05 JP JP50147797A patent/JP4067116B2/ja not_active Expired - Fee Related
- 1996-06-05 CZ CZ973913A patent/CZ391397A3/cs unknown
- 1996-06-05 US US08/973,281 patent/US6193952B1/en not_active Expired - Fee Related
- 1996-06-05 WO PCT/US1996/009068 patent/WO1996040281A2/fr not_active Application Discontinuation
- 1996-06-05 CN CN96195879A patent/CN1087954C/zh not_active Expired - Fee Related
- 1996-06-05 AT AT96918164T patent/ATE216894T1/de not_active IP Right Cessation
- 1996-06-05 PT PT96918164T patent/PT833669E/pt unknown
- 1996-06-05 IL IL12221796A patent/IL122217A/en not_active IP Right Cessation
- 1996-06-05 DE DE69621015T patent/DE69621015T2/de not_active Expired - Fee Related
- 1996-06-05 KR KR1019970709075A patent/KR100401429B1/ko not_active IP Right Cessation
-
1997
- 1997-11-19 NO NO975317A patent/NO975317L/no not_active Application Discontinuation
Also Published As
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