IL120742A - Phenyl substituted 4-azasteroid fluoro derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents

Phenyl substituted 4-azasteroid fluoro derivatives, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL120742A
IL120742A IL12074296A IL12074296A IL120742A IL 120742 A IL120742 A IL 120742A IL 12074296 A IL12074296 A IL 12074296A IL 12074296 A IL12074296 A IL 12074296A IL 120742 A IL120742 A IL 120742A
Authority
IL
Israel
Prior art keywords
formula
compound
aza
oxo
group
Prior art date
Application number
IL12074296A
Other languages
English (en)
Other versions
IL120742A0 (en
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of IL120742A0 publication Critical patent/IL120742A0/xx
Publication of IL120742A publication Critical patent/IL120742A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL12074296A 1995-09-14 1996-08-09 Phenyl substituted 4-azasteroid fluoro derivatives, process for their preparation and pharmaceutical compositions containing them IL120742A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9518858.7A GB9518858D0 (en) 1995-09-14 1995-09-14 Phenylsubstituted 4-azasteroid fluoroderivatives
PCT/EP1996/003518 WO1997010257A1 (en) 1995-09-14 1996-08-09 Phenylsubstituted 4-azasteroid fluoroderivatives

Publications (2)

Publication Number Publication Date
IL120742A0 IL120742A0 (en) 1997-08-14
IL120742A true IL120742A (en) 2002-04-21

Family

ID=10780746

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12074296A IL120742A (en) 1995-09-14 1996-08-09 Phenyl substituted 4-azasteroid fluoro derivatives, process for their preparation and pharmaceutical compositions containing them

Country Status (28)

Country Link
US (2) US5922728A (cs)
EP (1) EP0793671B1 (cs)
JP (1) JPH10509188A (cs)
KR (1) KR100448745B1 (cs)
CN (1) CN1104439C (cs)
AR (1) AR004511A1 (cs)
AT (1) ATE189681T1 (cs)
AU (1) AU715858B2 (cs)
BR (1) BR9606638A (cs)
CA (1) CA2204002A1 (cs)
CZ (1) CZ291450B6 (cs)
DE (1) DE69606623T2 (cs)
DK (1) DK0793671T3 (cs)
EA (1) EA000362B1 (cs)
ES (1) ES2144765T3 (cs)
GB (1) GB9518858D0 (cs)
GR (1) GR3033315T3 (cs)
HU (1) HUP9702038A3 (cs)
IL (1) IL120742A (cs)
MY (1) MY116271A (cs)
NO (1) NO309527B1 (cs)
NZ (1) NZ316060A (cs)
PL (1) PL185196B1 (cs)
PT (1) PT793671E (cs)
TW (1) TW357149B (cs)
UA (1) UA66748C2 (cs)
WO (1) WO1997010257A1 (cs)
ZA (1) ZA967631B (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6054446A (en) * 1997-12-24 2000-04-25 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6548491B2 (en) * 1997-12-24 2003-04-15 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
AU2001241779A1 (en) 2000-02-25 2001-09-03 Hollis-Eden Pharmaceuticals, Inc. Method of treatment of prostate cancer
US7402577B2 (en) * 2001-10-03 2008-07-22 Merck & Co., Inc. Androstane 17-beta-carboxamides as androgen receptor modulators
EP1641535A4 (en) * 2003-06-30 2008-05-14 Merck & Co Inc 17-ACETAMIDO-4-AZASTEROID DERIVATIVES AS ANDROGEN RECEPTOR MODULATORS
AU2004255749B2 (en) 2003-06-30 2008-12-18 Merck Sharp & Dohme Corp. 17-acetamido-4-azasteroid derivatives as androgen receptor modulators
JP2007522087A (ja) * 2003-06-30 2007-08-09 メルク　エンド　カムパニー　インコーポレーテッド アンドロゲン受容体モジュレータとしての１７−アセトアミド−４−アザステロイド誘導体
AU2004255200A1 (en) * 2003-06-30 2005-01-20 Merck & Co., Inc. 17-acetamido-4-azasteroid derivatives as androgen receptor modulators
CN103787894B (zh) * 2014-02-08 2015-09-16 济南大学 从甲苯二异氰酸酯制备过程中形成的残渣废料中回收甲苯二胺的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9002922D0 (en) * 1990-02-09 1990-04-04 Erba Carlo Spa 17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
GB9216284D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives
GB9216329D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa 17beta-substituted 4-aza-5alpha-androstan-3-one derivatives
GB9608045D0 (en) * 1996-04-18 1996-06-19 Pharmacia Spa Process for preparing steroids having a carboxamide side-chain
US5686501A (en) * 1996-04-19 1997-11-11 Foamex L.P. Breathable open cell urethane polymers

Also Published As

Publication number Publication date
CZ291450B6 (cs) 2003-03-12
PL185196B1 (pl) 2003-03-31
TW357149B (en) 1999-05-01
CA2204002A1 (en) 1997-03-20
NO972186D0 (no) 1997-05-13
MY116271A (en) 2003-12-31
CN1104439C (zh) 2003-04-02
US5922728A (en) 1999-07-13
EA199700063A1 (ru) 1997-12-30
WO1997010257A1 (en) 1997-03-20
PL320114A1 (en) 1997-09-15
NO972186L (no) 1997-07-02
KR100448745B1 (ko) 2004-12-14
ATE189681T1 (de) 2000-02-15
EA000362B1 (ru) 1999-06-24
AU6820596A (en) 1997-04-01
HUP9702038A2 (hu) 1998-03-30
EP0793671A1 (en) 1997-09-10
NO309527B1 (no) 2001-02-12
JPH10509188A (ja) 1998-09-08
UA66748C2 (en) 2004-06-15
DE69606623D1 (de) 2000-03-16
ZA967631B (en) 1997-04-16
AU715858B2 (en) 2000-02-10
CN1165520A (zh) 1997-11-19
ES2144765T3 (es) 2000-06-16
EP0793671B1 (en) 2000-02-09
DK0793671T3 (da) 2000-07-17
NZ316060A (en) 1999-08-30
GR3033315T3 (en) 2000-09-29
US6114345A (en) 2000-09-05
HUP9702038A3 (en) 1998-11-30
PT793671E (pt) 2000-07-31
CZ146097A3 (en) 1997-10-15
IL120742A0 (en) 1997-08-14
BR9606638A (pt) 1997-11-11
MX9703464A (es) 1997-07-31
GB9518858D0 (en) 1995-11-15
AR004511A1 (es) 1998-12-16
DE69606623T2 (de) 2000-08-31

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees