IL119029A0 - Long-acting drugs and pharamaceutical compositions comprising them - Google Patents

Long-acting drugs and pharamaceutical compositions comprising them

Info

Publication number
IL119029A0
IL119029A0 IL11902996A IL11902996A IL119029A0 IL 119029 A0 IL119029 A0 IL 119029A0 IL 11902996 A IL11902996 A IL 11902996A IL 11902996 A IL11902996 A IL 11902996A IL 119029 A0 IL119029 A0 IL 119029A0
Authority
IL
Israel
Prior art keywords
peptide
hirudin
conjugates
long
acting drugs
Prior art date
Application number
IL11902996A
Other languages
English (en)
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Priority to IL11902996A priority Critical patent/IL119029A0/xx
Publication of IL119029A0 publication Critical patent/IL119029A0/xx
Priority to US09/242,026 priority patent/US6504005B1/en
Priority to NZ333845A priority patent/NZ333845A/xx
Priority to AT97933828T priority patent/ATE308998T1/de
Priority to EP97933828A priority patent/EP1019089B1/en
Priority to CZ99369A priority patent/CZ36999A3/cs
Priority to JP50777098A priority patent/JP4416184B2/ja
Priority to KR1019997000941A priority patent/KR20000029806A/ko
Priority to IL12827497A priority patent/IL128274A0/xx
Priority to BR9711045A priority patent/BR9711045A/pt
Priority to CA002261835A priority patent/CA2261835C/en
Priority to AU37060/97A priority patent/AU725468B2/en
Priority to CN97197122A priority patent/CN1227501A/zh
Priority to HU0000809A priority patent/HUP0000809A2/hu
Priority to DE69734607T priority patent/DE69734607T2/de
Priority to PCT/IL1997/000265 priority patent/WO1998005361A2/en
Priority to DK97933828T priority patent/DK1019089T3/da
Priority to ES97933828T priority patent/ES2252787T3/es
Priority to IL128274A priority patent/IL128274A/en
Priority to NO990518A priority patent/NO990518L/no
Priority to US10/408,262 priority patent/US20040092443A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL11902996A 1996-08-06 1996-08-07 Long-acting drugs and pharamaceutical compositions comprising them IL119029A0 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
IL11902996A IL119029A0 (en) 1996-08-07 1996-08-07 Long-acting drugs and pharamaceutical compositions comprising them
ES97933828T ES2252787T3 (es) 1996-08-07 1997-08-05 Principios activos de efecto prolongado y composciones farmaceuticas que los incluyen.
IL12827497A IL128274A0 (en) 1996-08-07 1997-08-05 Long-acting drugs and pharmaceutical compositions comprising them
CA002261835A CA2261835C (en) 1996-08-07 1997-08-05 Long-acting drugs and pharmaceutical compositions comprising them
AT97933828T ATE308998T1 (de) 1996-08-07 1997-08-05 Langwirkende arzneistoffe und diese enthaltende arzneimittel
EP97933828A EP1019089B1 (en) 1996-08-07 1997-08-05 Long-acting drugs and pharmaceutical compositions comprising them
CZ99369A CZ36999A3 (cs) 1996-08-07 1997-08-05 Dlouho působící farmaceutika a farmaceutické sloučeniny, které obsahují tyto látky
JP50777098A JP4416184B2 (ja) 1996-08-07 1997-08-05 長期作用型薬物およびこれらを含む薬剤組成物
KR1019997000941A KR20000029806A (ko) 1996-08-07 1997-08-05 장기간-작용의약및이를포함한약제학적조성물
US09/242,026 US6504005B1 (en) 1996-08-07 1997-08-05 Long-acting drugs and pharmaceutical compositions comprising them
BR9711045A BR9711045A (pt) 1996-08-07 1997-08-05 Drogas de atua-Æo prolongada e composi-{es farmac-uticas compreendendo as mesmas
NZ333845A NZ333845A (en) 1996-08-07 1997-08-05 Long-acting Fmoc-substituted and Fm-substituted pro-drugs
AU37060/97A AU725468B2 (en) 1996-08-07 1997-08-05 Long-acting drugs and pharmaceutical compositions comprising them
CN97197122A CN1227501A (zh) 1996-08-07 1997-08-05 长效药物及含有该长效药物的药物组合物
HU0000809A HUP0000809A2 (hu) 1996-08-07 1997-08-05 Hosszan ható hatóanyagok és azokat tartalmazó gyógyszerkészítmények
DE69734607T DE69734607T2 (de) 1996-08-07 1997-08-05 Langwirkende arzneistoffe und diese enthaltende arzneimittel
PCT/IL1997/000265 WO1998005361A2 (en) 1996-08-07 1997-08-05 Long-acting drugs and pharmaceutical compositions comprising them
DK97933828T DK1019089T3 (da) 1996-08-07 1997-08-05 Langtidsvirkende lægemidler og farmaceutiske præparater der omfatter disse
IL128274A IL128274A (en) 1996-08-07 1999-01-28 Long-acting drugs and pharmaceutical compositions comprising them
NO990518A NO990518L (no) 1996-08-07 1999-02-04 Langtidsvirkende medikamenter og farmas°ytiske sammensetninger som omfatter disse
US10/408,262 US20040092443A1 (en) 1996-08-06 2003-04-08 Long-acting exendins and exendin agonists

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL11902996A IL119029A0 (en) 1996-08-07 1996-08-07 Long-acting drugs and pharamaceutical compositions comprising them

Publications (1)

Publication Number Publication Date
IL119029A0 true IL119029A0 (en) 1996-11-14

Family

ID=11069166

Family Applications (3)

Application Number Title Priority Date Filing Date
IL11902996A IL119029A0 (en) 1996-08-06 1996-08-07 Long-acting drugs and pharamaceutical compositions comprising them
IL12827497A IL128274A0 (en) 1996-08-07 1997-08-05 Long-acting drugs and pharmaceutical compositions comprising them
IL128274A IL128274A (en) 1996-08-07 1999-01-28 Long-acting drugs and pharmaceutical compositions comprising them

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL12827497A IL128274A0 (en) 1996-08-07 1997-08-05 Long-acting drugs and pharmaceutical compositions comprising them
IL128274A IL128274A (en) 1996-08-07 1999-01-28 Long-acting drugs and pharmaceutical compositions comprising them

Country Status (18)

Country Link
US (1) US6504005B1 (https=)
EP (1) EP1019089B1 (https=)
JP (1) JP4416184B2 (https=)
KR (1) KR20000029806A (https=)
CN (1) CN1227501A (https=)
AT (1) ATE308998T1 (https=)
AU (1) AU725468B2 (https=)
BR (1) BR9711045A (https=)
CA (1) CA2261835C (https=)
CZ (1) CZ36999A3 (https=)
DE (1) DE69734607T2 (https=)
DK (1) DK1019089T3 (https=)
ES (1) ES2252787T3 (https=)
HU (1) HUP0000809A2 (https=)
IL (3) IL119029A0 (https=)
NO (1) NO990518L (https=)
NZ (1) NZ333845A (https=)
WO (1) WO1998005361A2 (https=)

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IL139400A0 (en) * 2000-11-01 2001-11-25 Yeda Res & Dev Long-acting cytokine derivatives and pharmaceutical compositions comprising them
US7259233B2 (en) * 2000-12-13 2007-08-21 Eli Lilly And Company Chronic treatment regimen using glucagon-like insulinotropic peptides
US6946137B2 (en) * 2001-10-19 2005-09-20 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
ES2561108T3 (es) * 2001-10-19 2016-02-24 Idexx Laboratories, Inc. Composiciones inyectables para la liberación controlada de compuesto farmacológicamente activo
US20030171285A1 (en) * 2001-11-20 2003-09-11 Finn Rory F. Chemically-modified human growth hormone conjugates
BE1015608A6 (fr) * 2003-07-15 2005-06-07 Messadek Jallal Traitement des arterites.
JP4033382B2 (ja) * 2002-04-08 2008-01-16 久光製薬株式会社 インスリン投与装置
EP2259068B1 (en) * 2003-01-16 2013-08-14 caprotec bioanalytics GmbH Capture compounds and methods for analyzing the proteome
CA2521784C (en) 2003-04-08 2012-03-27 Yeda Research And Development Co. Ltd. Reversible pegylated drugs
DE602004003577T2 (de) * 2003-04-17 2007-09-20 Jallal Messadek Flottierende orale Formulierungen mit kontrollierter Freisetzung von Betain
MXPA06001283A (es) * 2003-08-05 2006-04-11 Novo Nordisk As Derivados de insulina novedosos.
BE1016128A6 (fr) * 2004-07-22 2006-03-07 Messadek Jallal Combinaisons therapeutiques
US7282487B2 (en) * 2004-10-28 2007-10-16 Idexx Laboratories Method for treating bacterial infections in horses or pigs with tilmicosin
WO2006050581A2 (en) * 2004-11-10 2006-05-18 Jallal Messadek Betaine as agent against arthropod - or mosquito -borne diseases
BRPI0610249A2 (pt) * 2005-04-27 2010-06-08 Jallal Messadek associação ou combinação farmacêutica, composição farmacêutica, processo de co-cristalização e o uso de insulina ou análogo de insulina
JP4808785B2 (ja) 2005-12-28 2011-11-02 ノボ・ノルデイスク・エー／エス インスリン組成物および組成物の製造方法
US9034818B2 (en) * 2007-06-13 2015-05-19 Novo Nordisk A/S Pharmaceutical formulations comprising an insulin derivative
WO2009065193A1 (en) * 2007-11-21 2009-05-28 Jallal Messadek Treatment of aspirin resistance with betaine and/or betaine enriched molasses
CN102037008B (zh) 2008-03-18 2016-08-31 诺沃-诺迪斯克有限公司 蛋白酶稳定化的、酰化胰岛素类似物
WO2009158668A1 (en) 2008-06-26 2009-12-30 Prolynx Llc Prodrugs and drug-macromolecule conjugates having controlled drug release rates
WO2010033220A2 (en) * 2008-09-19 2010-03-25 Nektar Therapeutics Modified therapeutics peptides, methods of their preparation and use
EP2341942A1 (en) 2008-09-19 2011-07-13 Nektar Therapeutics Polymer conjugates of therapeutic peptides
CA2740904C (en) * 2008-10-21 2019-01-15 Baxter International Inc. Methods for determining active ingredients in pro-drug peg protein conjugates with releasable peg reagents (in vitro de-pegylation)
AU2009309623B9 (en) * 2008-10-30 2014-10-02 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
EP2403537A1 (en) 2009-03-05 2012-01-11 Ascendis Pharma A/S Interferon alpha carrier prodrugs
WO2011013128A2 (en) 2009-07-31 2011-02-03 Yeda Research And Development Co. Ltd. Vectors for delivery of neurotherapeutics to the central nervous system
EP2566335B1 (en) * 2010-05-05 2016-06-29 Prolynx Llc Controlled release of active compounds from macromolecular conjugates
DK2632478T3 (da) 2010-10-27 2019-10-07 Novo Nordisk As Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
EP2490378B1 (en) 2011-02-18 2014-07-09 NTT DoCoMo, Inc. Apparatus and method for determining a control unit using feasibility requests and feasibility responses
CN104023739A (zh) 2011-06-02 2014-09-03 Opko生物科学有限公司 长效glp-1/胰高血糖素受体激动剂
US10166295B2 (en) 2011-06-02 2019-01-01 Opko Biologics Ltd. Pegylated OXM variants
US9481721B2 (en) 2012-04-11 2016-11-01 Novo Nordisk A/S Insulin formulations
MX362432B (es) 2012-06-04 2019-01-17 Opko Biologics Ltd Variantes de oxm pegilada.
US20150111820A1 (en) 2012-07-09 2015-04-23 Novo Nordisk A/S Novel use of insulin derivatives
JP2016519127A (ja) 2013-04-30 2016-06-30 ノヴォ ノルディスク アー／エス 新規投与レジメン
TWI700091B (zh) 2016-12-16 2020-08-01 丹麥商諾佛 儂迪克股份有限公司 含胰島素醫藥組成物
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
US12441776B2 (en) 2018-11-30 2025-10-14 Eirgen Pharma Ltd. Oxyntomodulin peptide analog formulations
EP3924369A1 (en) 2019-02-11 2021-12-22 OPKO Biologics Ltd. Long-acting glp-2 analogs
US12343383B2 (en) 2019-07-12 2025-07-01 Novo Nordisk A/S High concentration insulin formulation
CA3153644A1 (en) 2019-09-30 2021-04-08 Beijing Xuanyi Pharmasciences Co., Ltd. Protein-macromolecule conjugates and methods of use thereof
CN113773398B (zh) * 2020-06-10 2023-05-23 宁波鲲鹏生物科技有限公司 一种德谷胰岛素衍生物及其应用
CN117551008B (zh) * 2023-11-10 2025-10-17 沈阳药科大学 一种去铁胺偶联物及其制备方法和应用

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GB8717446D0 (en) 1987-07-23 1987-08-26 Merck Sharp & Dohme Chemical compounds
US6313094B1 (en) * 1990-12-11 2001-11-06 Japan Energy Corporation β-amino-α-hydroxycarboxylic acid derivatives and HIV protease inhibitors
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DE4437604A1 (de) * 1994-10-21 1996-04-25 Basf Ag Konjugate aus einem Poly- oder Oligopeptid und einer niedermolekularen lipophilen Verbindung
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US6057297A (en) * 1996-08-06 2000-05-02 Polifarma S.P.A. Inhibitor compounds of zinc-dependent metalloproteinases associated with pathological conditions, and therapeutic use thereof

Also Published As

Publication number Publication date
EP1019089B1 (en) 2005-11-09
CN1227501A (zh) 1999-09-01
CA2261835C (en) 2008-07-29
KR20000029806A (ko) 2000-05-25
ES2252787T3 (es) 2006-05-16
CA2261835A1 (en) 1998-02-12
NZ333845A (en) 2000-09-29
NO990518D0 (no) 1999-02-04
NO990518L (no) 1999-04-06
AU3706097A (en) 1998-02-25
DK1019089T3 (da) 2006-03-13
CZ36999A3 (cs) 1999-07-14
EP1019089A2 (en) 2000-07-19
JP4416184B2 (ja) 2010-02-17
IL128274A (en) 2006-08-01
WO1998005361A2 (en) 1998-02-12
HUP0000809A2 (hu) 2000-11-28
BR9711045A (pt) 1999-08-17
IL128274A0 (en) 1999-11-30
DE69734607T2 (de) 2006-08-03
DE69734607D1 (de) 2005-12-15
US6504005B1 (en) 2003-01-07
WO1998005361A3 (en) 1998-06-18
ATE308998T1 (de) 2005-11-15
JP2000515542A (ja) 2000-11-21
AU725468B2 (en) 2000-10-12

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