IL118483A - Compounds for use in the preparation of medicaments for inhibiting vascular smooth muscle cell migration and pharmaceutical formulations containing them - Google Patents

Compounds for use in the preparation of medicaments for inhibiting vascular smooth muscle cell migration and pharmaceutical formulations containing them

Info

Publication number
IL118483A
IL118483A IL11848396A IL11848396A IL118483A IL 118483 A IL118483 A IL 118483A IL 11848396 A IL11848396 A IL 11848396A IL 11848396 A IL11848396 A IL 11848396A IL 118483 A IL118483 A IL 118483A
Authority
IL
Israel
Prior art keywords
medicaments
compounds
preparation
smooth muscle
pharmaceutical formulations
Prior art date
Application number
IL11848396A
Other languages
English (en)
Other versions
IL118483A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL118483A0 publication Critical patent/IL118483A0/xx
Publication of IL118483A publication Critical patent/IL118483A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL11848396A 1995-06-01 1996-05-30 Compounds for use in the preparation of medicaments for inhibiting vascular smooth muscle cell migration and pharmaceutical formulations containing them IL118483A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/457,700 US5622975A (en) 1995-06-01 1995-06-01 Methods for inhibiting vascular smooth muscle cell migration

Publications (2)

Publication Number Publication Date
IL118483A0 IL118483A0 (en) 1996-09-12
IL118483A true IL118483A (en) 2000-06-29

Family

ID=23817780

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11848396A IL118483A (en) 1995-06-01 1996-05-30 Compounds for use in the preparation of medicaments for inhibiting vascular smooth muscle cell migration and pharmaceutical formulations containing them

Country Status (20)

Country Link
US (1) US5622975A (fr)
EP (1) EP0745384A3 (fr)
JP (1) JPH11509836A (fr)
KR (1) KR19990022053A (fr)
CN (1) CN1089237C (fr)
AU (1) AU707756B2 (fr)
CA (1) CA2222292A1 (fr)
CZ (1) CZ287958B6 (fr)
EA (1) EA000190B1 (fr)
HU (1) HUP9900851A3 (fr)
IL (1) IL118483A (fr)
MY (1) MY112973A (fr)
NO (1) NO975369D0 (fr)
NZ (1) NZ309390A (fr)
PL (1) PL323786A1 (fr)
RO (1) RO117996B1 (fr)
UA (1) UA42835C2 (fr)
WO (1) WO1996038145A1 (fr)
YU (1) YU32196A (fr)
ZA (1) ZA964439B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5770609A (en) 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6197789B1 (en) 1995-06-07 2001-03-06 Neorx Corporation Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
US5843974A (en) * 1995-06-06 1998-12-01 Eli Lilly And Company Methods of inhibiting melanoma using Benzothiophenes as cytotoxic agents per se
US5811437A (en) * 1996-05-21 1998-09-22 Eli Lilly And Company Methods of increasing nitric oxide synthesis
US5747509A (en) * 1996-06-03 1998-05-05 Schering Aktiengesellschaft Method for lowering plasma levels of lipoprotein(a)
US6124260A (en) * 1998-09-30 2000-09-26 Cedars-Sinai Medical Center Inhibition of smooth muscle cell migration by Tenascin-C peptides
ATE301129T1 (de) 1999-05-04 2005-08-15 Strakan Int Ltd Androgen glykoside und die androgenische aktivität davon
US8236048B2 (en) * 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
US6776796B2 (en) 2000-05-12 2004-08-17 Cordis Corportation Antiinflammatory drug and delivery device
US20040243097A1 (en) * 2000-05-12 2004-12-02 Robert Falotico Antiproliferative drug and delivery device
ATE343969T1 (de) 2000-09-29 2006-11-15 Cordis Corp Beschichtete medizinische geräte
US20020051730A1 (en) * 2000-09-29 2002-05-02 Stanko Bodnar Coated medical devices and sterilization thereof
US20020111590A1 (en) * 2000-09-29 2002-08-15 Davila Luis A. Medical devices, drug coatings and methods for maintaining the drug coatings thereon
US7195640B2 (en) * 2001-09-25 2007-03-27 Cordis Corporation Coated medical devices for the treatment of vulnerable plaque
US7108701B2 (en) * 2001-09-28 2006-09-19 Ethicon, Inc. Drug releasing anastomosis devices and methods for treating anastomotic sites
US20030065377A1 (en) * 2001-09-28 2003-04-03 Davila Luis A. Coated medical devices
JP3887588B2 (ja) * 2002-08-30 2007-02-28 株式会社リガク Ｘ線回折による応力測定法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4656187A (en) * 1981-08-03 1987-04-07 Eli Lilly And Company Treatment of mammary cancer
US5075321A (en) * 1987-03-24 1991-12-24 University Of Pennsylvania Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
US5457113A (en) * 1993-10-15 1995-10-10 Eli Lilly And Company Methods for inhibiting vascular smooth muscle cell proliferation and restinosis
ES2215270T3 (es) * 1993-12-21 2004-10-01 Eli Lilly And Company Inhibicion de productos terminales de glicosilacion avanzada.

Also Published As

Publication number Publication date
CZ374497A3 (cs) 1998-06-17
CZ287958B6 (cs) 2001-03-14
AU5954196A (en) 1996-12-18
AU707756B2 (en) 1999-07-22
IL118483A0 (en) 1996-09-12
NO975369L (no) 1997-11-21
HUP9900851A3 (en) 1999-11-29
ZA964439B (en) 1997-12-01
EA000190B1 (ru) 1998-12-24
US5622975A (en) 1997-04-22
MX9709189A (es) 1998-03-31
NO975369D0 (no) 1997-11-21
JPH11509836A (ja) 1999-08-31
CA2222292A1 (fr) 1996-12-05
KR19990022053A (ko) 1999-03-25
EA199700450A1 (ru) 1998-06-25
CN1089237C (zh) 2002-08-21
MY112973A (en) 2001-10-31
WO1996038145A1 (fr) 1996-12-05
NZ309390A (en) 2000-07-28
UA42835C2 (uk) 2001-11-15
RO117996B1 (ro) 2002-12-30
CN1191487A (zh) 1998-08-26
HUP9900851A2 (hu) 1999-09-28
PL323786A1 (en) 1998-04-27
EP0745384A3 (fr) 1997-02-26
YU32196A (sh) 1999-06-15
EP0745384A2 (fr) 1996-12-04

Similar Documents

Publication Publication Date Title
IL118483A (en) Compounds for use in the preparation of medicaments for inhibiting vascular smooth muscle cell migration and pharmaceutical formulations containing them
GB2364304B (en) Novel tricyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them
ZA989790B (en) Novel heterocyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them
IL117265A0 (en) Benzazepine- benzoxazepine- and benzothiazepine-n-acetic acid derivatives their preparation and pharmaceutical compositions containing them
IL117193A0 (en) Poly-pyrrolecarbox-amidenaphthalenic acid derivatives their preparation and pharmaceutical compositions containing them
IL130784A0 (en) Use of an anti-cd40l compound in the manufacture of a medicament for treating a patient with immune complex disease and pharmaceutical compositions containing the same
IL119559A0 (en) Purin -6- one derivatives their preparation and pharmaceutical compositions containing them
IL115905A0 (en) Sordarin derivatives their preparation and pharmaceutical compositions containing them
IL117554A0 (en) Imidazoquinazolines their preparation and pharmaceutical compositions containing them
HUP9900751A3 (en) Stable pharmaceutical forms of administration containing parathormone
IL115072A0 (en) Substituted 4-phenyl-6-amino-nicotinic acid derivatives their preparation pharmaceutical compositions containing them and their use
IL117815A0 (en) Ascomycins their preparation and pharmaceutical compositions containing them
HUP9900186A3 (en) Use of lamellarin alkaloids in therapy and pharmaceutical compositions containing them
IL103502A0 (en) Benzodiazepine derivatives,their preparation and pharmaceutical compositions containing them
IL90315A0 (en) Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them
IL118672A0 (en) Benzisothiazolyl-substituted aminomethylchromans their preparation and pharmaceutical compositions containing them
IL119371A0 (en) Sulfonylaminopyrimidines their preparation and pharmaceutical compositions containing them
AP9300581A0 (en) Benzofuran derivatives processes for their preparation and pharmaceutical compositions containing them and their medical use
ZA948689B (en) New taxicin derivatives their preparation and pharmaceutical compositions containing them
IL91356A0 (en) Therapeutic nucleosides,their preparation and pharmaceutical compositions containing them
IL164513A0 (en) Pyrazolopyrimidines, pharmaceutical compositions containing them, and their use in the preparation of medicaments
HUP9800631A3 (en) 4-aminotetrahydrobenzisoxazole or -isothiazole derivatives, pharmaceutical compositions containing them and their use for the preparation of pharmaceutical compositions
HUP9801751A3 (en) Benzopyrans their preparation and use and pharmaceutical compositions containing them
ZA964517B (en) Oral pharmaceutical composition of piperidinoalkanol compounds in solution form
IL117395A0 (en) Bicyclic compounds preparation thereof and use in pharmaceutical compositions

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees