IL118141A - 2 Amino - 5phenyl tetralins, their preparation and pharmaceutical preparations containing them - Google Patents

2 Amino - 5phenyl tetralins, their preparation and pharmaceutical preparations containing them

Info

Publication number
IL118141A
IL118141A IL11814196A IL11814196A IL118141A IL 118141 A IL118141 A IL 118141A IL 11814196 A IL11814196 A IL 11814196A IL 11814196 A IL11814196 A IL 11814196A IL 118141 A IL118141 A IL 118141A
Authority
IL
Israel
Prior art keywords
compound
alkyl
free base
addition salt
acid addition
Prior art date
Application number
IL11814196A
Other languages
English (en)
Hebrew (he)
Other versions
IL118141A0 (en
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10774032&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL118141(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL118141A0 publication Critical patent/IL118141A0/xx
Publication of IL118141A publication Critical patent/IL118141A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
IL11814196A 1995-05-05 1996-05-03 2 Amino - 5phenyl tetralins, their preparation and pharmaceutical preparations containing them IL118141A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9509156.7A GB9509156D0 (en) 1995-05-05 1995-05-05 Organic compounds

Publications (2)

Publication Number Publication Date
IL118141A0 IL118141A0 (en) 1996-09-12
IL118141A true IL118141A (en) 2002-11-10

Family

ID=10774032

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11814196A IL118141A (en) 1995-05-05 1996-05-03 2 Amino - 5phenyl tetralins, their preparation and pharmaceutical preparations containing them

Country Status (33)

Country Link
US (1) US6169116B1 (fi)
EP (1) EP0823892B1 (fi)
JP (1) JP3194965B2 (fi)
KR (1) KR100435009B1 (fi)
CN (1) CN1122019C (fi)
AR (1) AR004484A1 (fi)
AT (1) ATE193884T1 (fi)
AU (1) AU706392B2 (fi)
BR (1) BR9608169A (fi)
CA (1) CA2217855C (fi)
CO (1) CO4440486A1 (fi)
CZ (1) CZ292022B6 (fi)
DE (1) DE69608891T2 (fi)
DK (1) DK0823892T3 (fi)
ES (1) ES2148772T3 (fi)
FI (1) FI973530A (fi)
GB (1) GB9509156D0 (fi)
GR (1) GR3033715T3 (fi)
HK (1) HK1014929A1 (fi)
HU (1) HUP9801068A3 (fi)
IL (1) IL118141A (fi)
MX (1) MX9708510A (fi)
NO (1) NO308948B1 (fi)
NZ (1) NZ308471A (fi)
PE (1) PE54797A1 (fi)
PL (1) PL182857B1 (fi)
PT (1) PT823892E (fi)
RU (1) RU2169727C2 (fi)
SK (1) SK282022B6 (fi)
TR (1) TR199701298T1 (fi)
TW (1) TW359667B (fi)
WO (1) WO1996034849A1 (fi)
ZA (1) ZA963540B (fi)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1458386B1 (en) * 2001-12-27 2007-04-18 Ortho-McNeil Pharmaceutical, Inc. Aroyl pyrrole heteroeryl and methanols useful for treating a central nervous system disorder
AU2003241453A1 (en) 2002-05-17 2003-12-02 Janssen Pharmaceutica N.V. Aminotetralin-derived urea modulators of vanilloid vr1 receptor
WO2005037286A1 (en) 2003-03-25 2005-04-28 Vasopharm Biotech Gmbh Use of pteridine derivatives for the treatment of increased intracranial pressure and secondary ischemia
EP1956006A1 (en) 2007-02-06 2008-08-13 Laboratorios del Dr. Esteve S.A. Heterocyclyl-substituted-tetrahydro-naphthalen derivatives as 5-HT7 receptor ligands
EP1975161A1 (en) * 2007-03-28 2008-10-01 Laboratorios del Dr. Esteve S.A. Heterocyclyl-substituted- tetrahydro-napthalen-amine derivatives, their preparation and use as medicaments
WO2008154044A1 (en) * 2007-06-15 2008-12-18 University Of Florida Research Foundation Therapeutic compounds and methods of use
EP2011786A1 (en) * 2007-07-05 2009-01-07 Laboratorios del Dr. Esteve S.A. Indane-amine derivatives, their preparation and use as medicaments
CN106573872B (zh) * 2014-05-19 2021-07-20 东北大学 5-羟色胺受体靶向化合物和方法
AU2021329920A1 (en) * 2020-08-19 2023-04-27 Northeastern University Serotonin receptor modulators

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6045179B2 (ja) * 1977-06-08 1985-10-08 フナイ薬品工業株式会社 新規環状アミノアルコ−ル類およびその製造法
EP0257285A3 (en) 1986-07-28 1989-12-27 Whitby Research Incorporated Method and compositions for reducing the intraocular pressure of mammals
DE3718317A1 (de) 1986-12-10 1988-06-16 Bayer Ag Substituierte basische 2-aminotetraline
EP0381902A1 (en) 1989-01-09 1990-08-16 Merrell Dow Pharmaceuticals Inc. Tetralin derivatives
JP2931986B2 (ja) 1989-02-17 1999-08-09 武田薬品工業株式会社 アラルキルアミン誘導体
SE8901889D0 (sv) 1989-05-26 1989-05-26 Astra Ab Novel 8-substituted-2-aminotetralines
ES2138639T3 (es) 1993-08-27 2000-01-16 Hoffmann La Roche Derivados peptidicos de tetrahidronaftaleno.
FR2711139B1 (fr) 1993-10-15 1995-12-01 Adir Nouveaux dérivés de 1,2,3,4-tétrahydronaphtalène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
ZA963540B (en) 1997-11-03
NO975087D0 (no) 1997-11-04
PT823892E (pt) 2000-11-30
HUP9801068A3 (en) 2000-02-28
JP3194965B2 (ja) 2001-08-06
EP0823892A1 (en) 1998-02-18
AU5812996A (en) 1996-11-21
FI973530A (fi) 1997-11-04
TW359667B (en) 1999-06-01
RU2169727C2 (ru) 2001-06-27
NZ308471A (en) 1999-01-28
DE69608891D1 (de) 2000-07-20
SK282022B6 (sk) 2001-10-08
DE69608891T2 (de) 2000-11-16
PL323037A1 (en) 1998-03-02
IL118141A0 (en) 1996-09-12
KR100435009B1 (ko) 2004-08-16
TR199701298T1 (xx) 1998-02-21
WO1996034849A1 (en) 1996-11-07
FI973530A0 (fi) 1997-08-27
CN1183763A (zh) 1998-06-03
AR004484A1 (es) 1998-12-16
HK1014929A1 (en) 1999-10-08
CA2217855A1 (en) 1996-11-07
NO308948B1 (no) 2000-11-20
SK148597A3 (en) 1998-10-07
US6169116B1 (en) 2001-01-02
CN1122019C (zh) 2003-09-24
CZ348697A3 (cs) 1998-02-18
MX9708510A (es) 1998-03-31
PL182857B1 (pl) 2002-03-29
PE54797A1 (es) 1998-01-21
BR9608169A (pt) 1999-02-09
KR19990008301A (ko) 1999-01-25
CZ292022B6 (cs) 2003-07-16
ES2148772T3 (es) 2000-10-16
EP0823892B1 (en) 2000-06-14
GB9509156D0 (en) 1995-06-28
DK0823892T3 (da) 2000-10-02
ATE193884T1 (de) 2000-06-15
GR3033715T3 (en) 2000-10-31
HUP9801068A2 (hu) 1999-05-28
JPH10513479A (ja) 1998-12-22
CA2217855C (en) 2008-12-09
AU706392B2 (en) 1999-06-17
CO4440486A1 (es) 1997-05-07
NO975087L (no) 1997-11-04

Similar Documents

Publication Publication Date Title
RU2544856C2 (ru) НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
US8278338B2 (en) Saturated and unsaturated 3-pyridyl-benzocycloalkylmethyl-amines for use in treating pain, depression and/or anxiety
KR101922949B1 (ko) 중추신경계 질환 및 질병 치료에 유효한 신규 화합물
NZ212856A (en) Glutarimide derivatives and pharmaceutical compositions
CA2217855C (en) Tetralines
US20100120746A1 (en) Use of r-10-hydroxy-10,11-dihydro-carbamazepine in neuropathic pain
PL90695B1 (fi)
KR920010574B1 (ko) 아민유도체 및 그 제조방법
CA2196370A1 (en) Isoprene derivatives
IE45696B1 (en) Derivatives of 2-(3-phenyl-2-aminopropionyloxy)-acetic acid
US4612312A (en) Glutarimide antianxiety and antihypertensive agents
AU740448B2 (en) Biphenyl derivatives as pharmaceuticals
AU2006221788A1 (en) Benzoxazocines and their therapeutic use
WO1998047889A1 (en) Chroman derivatives
FR2500823A1 (fr) 1-aminoalkyl-1, 2, 3, 4-tetrahydroanphtalenes mono- ou disubstitues utiles notamment comme adrenergiques et medicaments les contenant
EP0462468A2 (de) 9-Amino-2-phenylbicyclo[3.3.1]nonane und 9-Amino-2-phenylbicyclo[3.3.1]-non-2-ene und diese enthaltende therapeutische Mittel
NZ241635A (en) 10,11-dihydro-10,5-(iminomethano)-5h-dibenzo(a,d)cycloheptene derivatives and pharmaceutical compositions
HU205751B (en) Process for producing new 1,3-oxazines and pharmaceutical compositions comprising same

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees