IL116433A - INTRAVAGINAL DRUG DELIVERY DEVICES FOR THE ADMINISTRATION OF 17β-OESTRADIOL PRECURSORS - Google Patents
INTRAVAGINAL DRUG DELIVERY DEVICES FOR THE ADMINISTRATION OF 17β-OESTRADIOL PRECURSORSInfo
- Publication number
- IL116433A IL116433A IL11643395A IL11643395A IL116433A IL 116433 A IL116433 A IL 116433A IL 11643395 A IL11643395 A IL 11643395A IL 11643395 A IL11643395 A IL 11643395A IL 116433 A IL116433 A IL 116433A
- Authority
- IL
- Israel
- Prior art keywords
- oestradiol
- precursor
- moiety
- group
- drug delivery
- Prior art date
Links
- 239000002243 precursor Substances 0.000 title claims abstract description 100
- 238000012377 drug delivery Methods 0.000 title claims abstract description 51
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 title claims abstract description 23
- 229960005309 estradiol Drugs 0.000 title claims 3
- 229920000642 polymer Polymers 0.000 claims abstract description 56
- 239000011159 matrix material Substances 0.000 claims abstract description 38
- -1 isobutyryl Chemical group 0.000 claims abstract description 27
- 230000000903 blocking effect Effects 0.000 claims abstract description 24
- 125000002252 acyl group Chemical group 0.000 claims abstract description 23
- 238000001727 in vivo Methods 0.000 claims abstract description 18
- 241000124008 Mammalia Species 0.000 claims abstract description 14
- 239000000126 substance Substances 0.000 claims abstract description 14
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 11
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims abstract description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 10
- 239000012153 distilled water Substances 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims abstract description 7
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims abstract description 5
- 125000001931 aliphatic group Chemical group 0.000 claims abstract description 5
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 4
- 125000004080 3-carboxypropanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C(O[H])=O 0.000 claims abstract description 3
- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 claims abstract description 3
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 3
- 125000001721 carboxyacetyl group Chemical group 0.000 claims abstract description 3
- 125000003897 citraconoyl group Chemical group C(\C(\C)=C/C(=O)*)(=O)* 0.000 claims abstract description 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims abstract description 3
- 125000004031 fumaroyl group Chemical group C(\C=C\C(=O)*)(=O)* 0.000 claims abstract description 3
- 125000003099 maleoyl group Chemical group C(\C=C/C(=O)*)(=O)* 0.000 claims abstract description 3
- 125000003431 oxalo group Chemical group 0.000 claims abstract description 3
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 3
- 231100000252 nontoxic Toxicity 0.000 claims abstract 5
- 230000003000 nontoxic effect Effects 0.000 claims abstract 5
- 150000002762 monocarboxylic acid derivatives Chemical class 0.000 claims abstract 3
- 238000002657 hormone replacement therapy Methods 0.000 claims description 25
- 238000004519 manufacturing process Methods 0.000 claims description 20
- 208000024891 symptom Diseases 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 18
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 claims description 10
- 229960004400 levonorgestrel Drugs 0.000 claims description 10
- 239000003054 catalyst Substances 0.000 claims description 8
- 239000003431 cross linking reagent Substances 0.000 claims description 6
- 239000000583 progesterone congener Substances 0.000 claims description 6
- 206010033264 Ovarian hyperfunction Diseases 0.000 claims description 5
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 claims description 4
- 230000035558 fertility Effects 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 3
- 230000001939 inductive effect Effects 0.000 claims description 2
- 150000002009 diols Chemical class 0.000 claims 1
- 229940079593 drug Drugs 0.000 description 29
- 239000003814 drug Substances 0.000 description 29
- 238000013461 design Methods 0.000 description 27
- 238000000338 in vitro Methods 0.000 description 25
- 239000000262 estrogen Substances 0.000 description 23
- 239000000203 mixture Substances 0.000 description 17
- 229960000686 benzalkonium chloride Drugs 0.000 description 15
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 15
- 238000007429 general method Methods 0.000 description 15
- 239000012738 dissolution medium Substances 0.000 description 12
- 230000002209 hydrophobic effect Effects 0.000 description 11
- 229920001971 elastomer Polymers 0.000 description 10
- 239000000806 elastomer Substances 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 8
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 8
- 239000004205 dimethyl polysiloxane Substances 0.000 description 8
- 238000003780 insertion Methods 0.000 description 8
- 230000037431 insertion Effects 0.000 description 8
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 8
- 150000003431 steroids Chemical class 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 229930182833 estradiol Natural products 0.000 description 7
- 239000011780 sodium chloride Substances 0.000 description 7
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 6
- 238000011068 loading method Methods 0.000 description 6
- 230000036470 plasma concentration Effects 0.000 description 6
- 230000000757 progestagenic effect Effects 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- 238000009792 diffusion process Methods 0.000 description 5
- 230000007062 hydrolysis Effects 0.000 description 5
- 238000006460 hydrolysis reaction Methods 0.000 description 5
- 230000002459 sustained effect Effects 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000007774 longterm Effects 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 230000016087 ovulation Effects 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 210000000981 epithelium Anatomy 0.000 description 3
- 229960003399 estrone Drugs 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 150000002763 monocarboxylic acids Chemical class 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 239000012086 standard solution Substances 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- KSBAEPSJVUENNK-UHFFFAOYSA-L tin(ii) 2-ethylhexanoate Chemical compound [Sn+2].CCCCC(CC)C([O-])=O.CCCCC(CC)C([O-])=O KSBAEPSJVUENNK-UHFFFAOYSA-L 0.000 description 3
- 229940070710 valerate Drugs 0.000 description 3
- 206010003694 Atrophy Diseases 0.000 description 2
- 206010027304 Menopausal symptoms Diseases 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000037444 atrophy Effects 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 150000001991 dicarboxylic acids Chemical class 0.000 description 2
- 230000001076 estrogenic effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000009245 menopause Effects 0.000 description 2
- 230000000955 neuroendocrine Effects 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 229940095055 progestogen systemic hormonal contraceptives Drugs 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000001839 systemic circulation Effects 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 108010051152 Carboxylesterase Proteins 0.000 description 1
- 102000013392 Carboxylesterase Human genes 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 208000004483 Dyspareunia Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010060800 Hot flush Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 206010024870 Loss of libido Diseases 0.000 description 1
- 206010027940 Mood altered Diseases 0.000 description 1
- 206010048886 Onychoclasis Diseases 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 206010046477 Urethral syndrome Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960003996 chlormadinone Drugs 0.000 description 1
- VUHJZBBCZGVNDZ-TTYLFXKOSA-N chlormadinone Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 VUHJZBBCZGVNDZ-TTYLFXKOSA-N 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 230000002254 contraceptive effect Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229960005352 gestodene Drugs 0.000 description 1
- SIGSPDASOTUPFS-XUDSTZEESA-N gestodene Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](C=C4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 SIGSPDASOTUPFS-XUDSTZEESA-N 0.000 description 1
- 230000010224 hepatic metabolism Effects 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 231100000863 loss of memory Toxicity 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 229960004616 medroxyprogesterone Drugs 0.000 description 1
- 229960002985 medroxyprogesterone acetate Drugs 0.000 description 1
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 1
- 229960001786 megestrol Drugs 0.000 description 1
- RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 230000037211 monthly cycles Effects 0.000 description 1
- 230000007510 mood change Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 229960000417 norgestimate Drugs 0.000 description 1
- KIQQMECNKUGGKA-NMYWJIRASA-N norgestimate Chemical compound O/N=C/1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(OC(C)=O)C#C)[C@@H]4[C@@H]3CCC2=C\1 KIQQMECNKUGGKA-NMYWJIRASA-N 0.000 description 1
- 238000009806 oophorectomy Methods 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 230000011599 ovarian follicle development Effects 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 208000035824 paresthesia Diseases 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 231100000683 possible toxicity Toxicity 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000009256 replacement therapy Methods 0.000 description 1
- 210000005000 reproductive tract Anatomy 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229920000260 silastic Polymers 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000013269 sustained drug release Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- ZQZCOBSUOFHDEE-UHFFFAOYSA-N tetrapropyl silicate Chemical compound CCCO[Si](OCCC)(OCCC)OCCC ZQZCOBSUOFHDEE-UHFFFAOYSA-N 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 239000000003 vaginal tablet Substances 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IES940976 | 1994-12-19 | ||
| IES950247 | 1995-04-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL116433A0 IL116433A0 (en) | 1996-03-31 |
| IL116433A true IL116433A (en) | 2002-02-10 |
Family
ID=26319777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11643395A IL116433A (en) | 1994-12-19 | 1995-12-18 | INTRAVAGINAL DRUG DELIVERY DEVICES FOR THE ADMINISTRATION OF 17β-OESTRADIOL PRECURSORS |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5855906A (de) |
| EP (1) | EP0799025B1 (de) |
| JP (1) | JPH10510825A (de) |
| CN (1) | CN1138526C (de) |
| AR (1) | AR002010A1 (de) |
| AT (1) | ATE178204T1 (de) |
| AU (1) | AU692659B2 (de) |
| CA (1) | CA2207622C (de) |
| DE (1) | DE69508791T2 (de) |
| DK (1) | DK0799025T3 (de) |
| ES (1) | ES2133841T3 (de) |
| FI (1) | FI119414B (de) |
| GR (1) | GR3030614T3 (de) |
| IL (1) | IL116433A (de) |
| NO (1) | NO316707B1 (de) |
| NZ (1) | NZ298490A (de) |
| PE (1) | PE62796A1 (de) |
| TR (1) | TR199501599A2 (de) |
| WO (1) | WO1996019196A1 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6407082B1 (en) * | 1996-09-13 | 2002-06-18 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a vitamin D compound |
| US6511970B1 (en) | 1996-09-13 | 2003-01-28 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium |
| US6765002B2 (en) | 2000-03-21 | 2004-07-20 | Gustavo Rodriguez | Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium |
| US6034074A (en) | 1996-09-13 | 2000-03-07 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a Vitamin D compound |
| US6028064A (en) | 1996-09-13 | 2000-02-22 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of progestin products |
| CN1184957C (zh) | 1997-05-07 | 2005-01-19 | 盖伦(化学制品)有限公司 | 用于给药睾酮和睾酮前体的阴道内给药装置 |
| US6039968A (en) * | 1997-06-24 | 2000-03-21 | Hoechst Marion Roussel | Intravaginal drug delivery device |
| US20010044431A1 (en) * | 2000-03-21 | 2001-11-22 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
| US20040176336A1 (en) * | 2000-03-21 | 2004-09-09 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
| US20050113351A1 (en) * | 2000-03-21 | 2005-05-26 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
| US6811549B2 (en) | 2001-02-16 | 2004-11-02 | William H. Fleming | Administration of therapeutic or diagnostic agents using interlabial pad |
| US6962908B2 (en) * | 2001-12-21 | 2005-11-08 | Warner Chilcott Company Inc. | Oral pharmaceutical products containing 17 β-estradiol-3-lower alkanoate, method of administering the same and process of preparation |
| AU2003226746A1 (en) * | 2002-03-27 | 2003-10-08 | Galen (Chemicals) Limited | Intravaginal matrix drug delivery devices |
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-
1995
- 1995-12-18 IL IL11643395A patent/IL116433A/en not_active IP Right Cessation
- 1995-12-19 TR TR95/01599A patent/TR199501599A2/xx unknown
- 1995-12-19 NZ NZ298490A patent/NZ298490A/xx unknown
- 1995-12-19 AU AU43991/96A patent/AU692659B2/en not_active Ceased
- 1995-12-19 WO PCT/IE1995/000063 patent/WO1996019196A1/en not_active Ceased
- 1995-12-19 JP JP8519650A patent/JPH10510825A/ja not_active Ceased
- 1995-12-19 CA CA002207622A patent/CA2207622C/en not_active Expired - Lifetime
- 1995-12-19 PE PE1995287516A patent/PE62796A1/es not_active Application Discontinuation
- 1995-12-19 ES ES95942772T patent/ES2133841T3/es not_active Expired - Lifetime
- 1995-12-19 DE DE69508791T patent/DE69508791T2/de not_active Expired - Lifetime
- 1995-12-19 EP EP95942772A patent/EP0799025B1/de not_active Expired - Lifetime
- 1995-12-19 US US08/849,329 patent/US5855906A/en not_active Expired - Lifetime
- 1995-12-19 AR ARP950100619A patent/AR002010A1/es unknown
- 1995-12-19 CN CNB951968947A patent/CN1138526C/zh not_active Expired - Lifetime
- 1995-12-19 AT AT95942772T patent/ATE178204T1/de not_active IP Right Cessation
- 1995-12-19 DK DK95942772T patent/DK0799025T3/da active
-
1997
- 1997-06-17 FI FI972579A patent/FI119414B/fi not_active IP Right Cessation
- 1997-06-17 NO NO19972798A patent/NO316707B1/no unknown
-
1999
- 1999-06-29 GR GR990401699T patent/GR3030614T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO316707B1 (no) | 2004-04-13 |
| DE69508791T2 (de) | 1999-12-02 |
| FI972579L (fi) | 1997-06-17 |
| CA2207622A1 (en) | 1996-06-27 |
| NO972798L (no) | 1997-08-19 |
| PE62796A1 (es) | 1996-12-28 |
| US5855906A (en) | 1999-01-05 |
| ES2133841T3 (es) | 1999-09-16 |
| EP0799025A1 (de) | 1997-10-08 |
| TR199501599A2 (tr) | 1996-07-21 |
| IL116433A0 (en) | 1996-03-31 |
| DK0799025T3 (da) | 1999-10-18 |
| JPH10510825A (ja) | 1998-10-20 |
| FI119414B (fi) | 2008-11-14 |
| NZ298490A (en) | 1999-11-29 |
| ATE178204T1 (de) | 1999-04-15 |
| NO972798D0 (no) | 1997-06-17 |
| AU4399196A (en) | 1996-07-10 |
| FI972579A0 (fi) | 1997-06-17 |
| DE69508791D1 (de) | 1999-05-06 |
| CA2207622C (en) | 2006-10-17 |
| CN1170353A (zh) | 1998-01-14 |
| EP0799025B1 (de) | 1999-03-31 |
| GR3030614T3 (en) | 1999-10-29 |
| WO1996019196A1 (en) | 1996-06-27 |
| AR002010A1 (es) | 1998-01-07 |
| AU692659B2 (en) | 1998-06-11 |
| CN1138526C (zh) | 2004-02-18 |
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