IL114212A - Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same - Google Patents

Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same

Info

Publication number
IL114212A
IL114212A IL11421295A IL11421295A IL114212A IL 114212 A IL114212 A IL 114212A IL 11421295 A IL11421295 A IL 11421295A IL 11421295 A IL11421295 A IL 11421295A IL 114212 A IL114212 A IL 114212A
Authority
IL
Israel
Prior art keywords
taxine
oil
taxol
stable oil
water emulsions
Prior art date
Application number
IL11421295A
Other languages
English (en)
Other versions
IL114212A0 (en
Original Assignee
Hemagen Pfc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemagen Pfc filed Critical Hemagen Pfc
Publication of IL114212A0 publication Critical patent/IL114212A0/xx
Publication of IL114212A publication Critical patent/IL114212A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Colloid Chemistry (AREA)
IL11421295A 1994-07-19 1995-06-19 Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same IL114212A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/276,899 US5616330A (en) 1994-07-19 1994-07-19 Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same

Publications (2)

Publication Number Publication Date
IL114212A0 IL114212A0 (en) 1995-10-31
IL114212A true IL114212A (en) 1999-07-14

Family

ID=23058551

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11421295A IL114212A (en) 1994-07-19 1995-06-19 Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same

Country Status (10)

Country Link
US (1) US5616330A (xx)
EP (1) EP0768876B1 (xx)
JP (1) JPH10502921A (xx)
CN (1) CN1097458C (xx)
AT (1) ATE204165T1 (xx)
AU (1) AU690299B2 (xx)
CA (1) CA2194226C (xx)
DE (1) DE69522227T2 (xx)
IL (1) IL114212A (xx)
WO (1) WO1996002247A1 (xx)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5439686A (en) * 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US20030133955A1 (en) * 1993-02-22 2003-07-17 American Bioscience, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US6964946B1 (en) * 1995-10-26 2005-11-15 Baker Norton Pharmaceuticals, Inc. Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same
US6245805B1 (en) * 1995-10-26 2001-06-12 Baker Norton Pharmaceuticals, Inc. Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
US20070092563A1 (en) * 1996-10-01 2007-04-26 Abraxis Bioscience, Inc. Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US8853260B2 (en) * 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
HU230338B1 (hu) * 1997-06-27 2016-02-29 Abraxis Bioscience Llc Gyógyászati hatóanyagokat tartalmazó új készítmények, eljárás ilyen készítmények előállítására és alkalmazására
KR101180181B1 (ko) * 1997-06-27 2012-09-05 아브락시스 바이오사이언스, 엘엘씨 나노 입자 및 그의 제조 방법
SI1052974T1 (sl) * 1998-02-05 2009-10-31 Novartis Ag Farmacevtska formulacija, ki vsebuje epotilon
CA2326485C (en) * 1998-04-01 2008-12-09 Rtp Pharma Inc. Anticancer compositions
US6979456B1 (en) * 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
US7030155B2 (en) * 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
DE19843968A1 (de) * 1998-09-24 2000-04-13 Hans Dietl Taxane enthaltende pharmazeutische Zubereitung zur intravenösen Applikation und Verfahren zu ihrer Herstellung
CN1236813C (zh) * 1998-12-11 2006-01-18 药品处理公司 水难溶性药物的自乳化组合物
US6682758B1 (en) 1998-12-22 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services Water-insoluble drug delivery system
DE19900054A1 (de) * 1999-01-04 2000-07-06 Hans Dietl Taxane enthaltende stabile und sterile Emulsion und Verfahren zu ihrer Herstellung
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6267985B1 (en) 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6761903B2 (en) 1999-06-30 2004-07-13 Lipocine, Inc. Clear oil-containing pharmaceutical compositions containing a therapeutic agent
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US6383471B1 (en) 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
NZ515644A (en) * 1999-06-04 2004-12-24 Skyepharma Inc Oil-core compositions for the sustained release of hydrophobic drugs
US6309663B1 (en) 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US6458383B2 (en) 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US6982281B1 (en) * 2000-11-17 2006-01-03 Lipocine Inc Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
TW422706B (en) 1999-07-01 2001-02-21 Wang Iz Rung An oil-in-water emulsion type of paclitaxel
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6720001B2 (en) 1999-10-18 2004-04-13 Lipocine, Inc. Emulsion compositions for polyfunctional active ingredients
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US6638973B2 (en) * 2000-02-02 2003-10-28 Fsu Research Foundation, Inc. Taxane formulations
US6452024B1 (en) 2000-02-22 2002-09-17 Chaichem Pharmaceuticals International Process for extraction and purification of paclitaxel from natural sources
DE10036871A1 (de) * 2000-07-28 2002-02-14 Pharmasol Gmbh Dispersionen zur Formulierung wenig oder schwer löslicher Wirkstoffe
WO2002009695A1 (en) * 2000-08-02 2002-02-07 Atossa Healthcare, Inc. Bimodal emulsions of taxanes and butyrate polyalcohol esters
WO2002102311A2 (en) 2001-06-15 2002-12-27 Cornerstone Pharmaceuticals Nanoparticles for treating targeted tissues and cells
EP1435908A4 (en) * 2001-09-13 2006-03-15 Korea Inst Sci & Tech OILY PACLITAXEL COMPOSITION AND FORMULATION FOR CHEMOEMOLISATION AND METHOD OF MANUFACTURING THEREOF
KR100533458B1 (ko) * 2002-07-20 2005-12-07 대화제약 주식회사 파클리탁셀의 가용화용 조성물 및 그의 제조 방법
KR100573289B1 (ko) * 2002-07-20 2006-04-24 대화제약 주식회사 방광내 투여를 통한 방광암치료용 파클리탁셀 조성물 및그의 제조 방법
US20040213837A1 (en) * 2002-08-05 2004-10-28 Sankaram Mantripragada Oil-core compositions for the sustained release of hydrophobic drugs
AU2003299590B8 (en) 2002-12-09 2010-04-08 Abraxis Bioscience, Llc Compositions and methods of delivery of pharmacological agents
US6759539B1 (en) 2003-02-27 2004-07-06 Chaichem Pharmaceuticals International Process for isolation and purification of paclitaxel from natural sources
US20070196914A1 (en) * 2003-10-02 2007-08-23 Sembiosys Genetics Inc. Methods for preparing oil bodies comprising active ingredients
US20060003002A1 (en) * 2003-11-03 2006-01-05 Lipocine, Inc. Pharmaceutical compositions with synchronized solubilizer release
US20050129719A1 (en) * 2003-12-15 2005-06-16 Yu-Fang Hu Concentrated emulsion formulation for silatecan
WO2005065677A1 (ja) * 2004-01-09 2005-07-21 Otsuka Pharmaceutical Factory, Inc. パクリタキセルまたはドセタキセルを溶解または分散させるための脂肪乳剤
WO2005065676A1 (ja) * 2004-01-09 2005-07-21 Otsuka Pharmaceutical Factory, Inc. パクリタキセルまたはドセタキセルを含む脂肪乳剤
US8557861B2 (en) * 2004-09-28 2013-10-15 Mast Therapeutics, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
CN100462076C (zh) * 2005-01-20 2009-02-18 江苏正大天晴药业股份有限公司 供静脉用长春花生物碱的稳定水包油乳剂及其制备方法
CN100333722C (zh) * 2005-03-11 2007-08-29 江苏正大天晴药业股份有限公司 静脉用棓丙酯的稳定水包油乳剂及其制备方法
WO2006098241A1 (ja) * 2005-03-14 2006-09-21 Otsuka Pharmaceutical Factory, Inc. 難水溶性薬物を含有する医薬組成物
US20070032438A1 (en) * 2005-08-02 2007-02-08 Tty Biopharm Company Limited Pharmaceutical compositions containing taxanes and methods for preparing the pharmaceutical compositions
TWI376239B (en) * 2006-02-01 2012-11-11 Andrew Xian Chen Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
WO2008058366A1 (en) * 2006-09-28 2008-05-22 Université de Montréal Oil-in-water emulsions, methods of use thereof, methods of preparation thereof and kits thereof
EP2025333A1 (en) * 2007-08-14 2009-02-18 Pharmatex Italia Srl Injectable pharmaceutical formulation of taxoids
US20090087460A1 (en) * 2007-10-02 2009-04-02 Hamamatsu Photonics K.K. Solid composition, microparticles, microparticle dispersion liquid, and manufacturing methods for these
US20090098168A1 (en) * 2007-10-08 2009-04-16 The Regents Of The University Of California Multiple-layer microbubble liposphere drug delivery vehicle and system
FR2922107B1 (fr) * 2007-10-10 2010-02-26 Aventis Pharma Sa Nouvelles compositions a base de taxoides
US8861813B2 (en) * 2008-03-13 2014-10-14 Mallinckrodt Llc Multi-function, foot-activated controller for imaging system
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
CN102048688B (zh) * 2009-10-29 2014-03-05 中国医学科学院药物研究所 以胆固醇复合物为中间载体的紫杉醇亚微乳
CN102048725B (zh) * 2009-10-29 2014-07-16 中国医学科学院药物研究所 紫杉醇胆固醇复合物
TWI438009B (zh) * 2010-02-19 2014-05-21 Teikoku Pharma Usa Inc 紫杉烷前－乳劑調配物及其製造與使用之方法
BR112012028037A2 (pt) * 2010-05-03 2016-08-02 Teikoku Pharma Usa Inc formulação de pró-emulsão líquida de taxano não aquosa, métodos para administrar um taxano a um paciente e para fabricar uma formulação de pró-emulsão de taxano, composição de emulsão de taxano, e, kit
JP2012051823A (ja) * 2010-08-31 2012-03-15 Fujifilm Corp 難容性薬物含有水中油型乳化組成物及びその製造方法
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
WO2014208901A1 (ko) * 2013-06-24 2014-12-31 한국콜마주식회사 난용성 의약품의 수중유적형 에멀젼 조성물 및 이의 제조방법
WO2016033556A1 (en) 2014-08-28 2016-03-03 Lipocine Inc. BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
KR102424837B1 (ko) 2014-09-19 2022-07-25 헤론 테라퓨틱스 인코포레이티드 아프레피탄트의 에멀젼 제형
US9974742B2 (en) 2016-02-01 2018-05-22 Heron Therapeutics, Inc. Emulsion formulations of an NK-1 receptor antagonist and uses thereof
US20180147215A1 (en) 2016-11-28 2018-05-31 Lipocine Inc. Oral testosterone undecanoate therapy
CN111920782A (zh) * 2019-05-13 2020-11-13 中国医学科学院药物研究所 复合脂质纳米囊组合物及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993581A (en) * 1973-10-05 1976-11-23 The Green Cross Corporation Process for preparing stable oxygen transferable emulsion
US4073943A (en) * 1974-09-11 1978-02-14 Apoteksvarucentralen Vitrum Ab Method of enhancing the administration of pharmalogically active agents
US4168308A (en) * 1976-03-12 1979-09-18 Apoteksvarucentralen Vitrum Ab Composition for enhancing the administration of pharmacologically active agents
US4784845A (en) * 1985-09-16 1988-11-15 American Cyanamid Company Emulsion compostions for the parenteral administration of sparingly water soluble ionizable hydrophobic drugs
SE8600632D0 (sv) * 1986-02-13 1986-02-13 Kabivitrum Ab Novel pharmaceutical composition
JP2847783B2 (ja) * 1988-08-11 1999-01-20 日清製粉株式会社 抗癌活性増強剤
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5407683A (en) * 1990-06-01 1995-04-18 Research Corporation Technologies, Inc. Pharmaceutical solutions and emulsions containing taxol
JPH05221852A (ja) * 1992-02-18 1993-08-31 L T T Kenkyusho:Kk 制ガン剤の新規製剤調製方法
CA2151491A1 (en) * 1992-12-24 1994-07-07 Robert J. Kaufman Fluorocarbon emulsions

Also Published As

Publication number Publication date
CA2194226A1 (en) 1996-02-01
AU690299B2 (en) 1998-04-23
EP0768876B1 (en) 2001-08-16
DE69522227D1 (de) 2001-09-20
WO1996002247A1 (en) 1996-02-01
CN1153474A (zh) 1997-07-02
ATE204165T1 (de) 2001-09-15
US5616330A (en) 1997-04-01
JPH10502921A (ja) 1998-03-17
CA2194226C (en) 2000-10-24
IL114212A0 (en) 1995-10-31
DE69522227T2 (de) 2002-06-13
CN1097458C (zh) 2003-01-01
AU2872095A (en) 1996-02-16
EP0768876A1 (en) 1997-04-23

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