IL111590A0 - Heterocyclic compounds, their production and use - Google Patents
Heterocyclic compounds, their production and useInfo
- Publication number
- IL111590A0 IL111590A0 IL11159094A IL11159094A IL111590A0 IL 111590 A0 IL111590 A0 IL 111590A0 IL 11159094 A IL11159094 A IL 11159094A IL 11159094 A IL11159094 A IL 11159094A IL 111590 A0 IL111590 A0 IL 111590A0
- Authority
- IL
- Israel
- Prior art keywords
- stands
- optionally substituted
- ring
- hydrogen atom
- hydrocarbon residue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28117893 | 1993-11-10 | ||
| JP33748893 | 1993-12-28 | ||
| JP3363794 | 1994-03-03 | ||
| JP13855194 | 1994-06-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL111590A0 true IL111590A0 (en) | 1995-01-24 |
Family
ID=27459814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11159094A IL111590A0 (en) | 1993-11-10 | 1994-11-10 | Heterocyclic compounds, their production and use |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5585385A (cs) |
| EP (1) | EP0652218B1 (cs) |
| KR (1) | KR950014108A (cs) |
| CN (1) | CN1052004C (cs) |
| AT (1) | ATE203024T1 (cs) |
| AU (1) | AU678295B2 (cs) |
| BR (1) | BR9404403A (cs) |
| CA (1) | CA2135440A1 (cs) |
| DE (1) | DE69427675T2 (cs) |
| FI (1) | FI945281L (cs) |
| HU (1) | HUT68810A (cs) |
| IL (1) | IL111590A0 (cs) |
| NO (1) | NO301764B1 (cs) |
| NZ (1) | NZ264887A (cs) |
| RU (1) | RU2135471C1 (cs) |
| TW (1) | TW263498B (cs) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770590A (en) * | 1995-03-24 | 1998-06-23 | Takeda Chemical Industries, Ltd. | Cyclic compounds, their prudiction and use |
| ATE242243T1 (de) * | 1995-03-24 | 2003-06-15 | Takeda Chemical Industries Ltd | Zyklische verbindungen, ihre herstellung und ihre verwendung als tachykininrezeptorantagonisten |
| FR2732221B1 (fr) * | 1995-03-28 | 1997-04-25 | Oreal | Utilisation d'un antagoniste de cgrp pour traiter les rougeurs cutanees d'origine neurogene et composition obtenue |
| GB9524104D0 (en) * | 1995-11-24 | 1996-01-24 | Smithkline Beecham Spa | Novel compounds |
| CA2301614A1 (en) * | 1997-09-23 | 1999-04-01 | Merck & Co., Inc. | Thrombin inhibitors |
| US6087373A (en) * | 1997-09-23 | 2000-07-11 | Merck & Co., Inc. | Thrombin inhibitors |
| US6323214B1 (en) | 1997-10-29 | 2001-11-27 | Medco Research, Inc | Allosteric adenosine receptor modulators |
| US6727258B2 (en) * | 1997-10-29 | 2004-04-27 | King Pharmaceutical Research & Development, Inc. | Allosteric adenosine receptor modulators |
| US5939432A (en) * | 1997-10-29 | 1999-08-17 | Medco Research, Inc. | Thiophenes useful for modulating the adenosine receptor |
| AU5305299A (en) * | 1998-08-26 | 2000-03-21 | Tanabe Seiyaku Co., Ltd. | Naphthyridine derivatives and process for the preparation thereof |
| WO2000023443A1 (fr) * | 1998-10-22 | 2000-04-27 | Akzo Nobel N.V. | Derives de tetrahydropyridopyridine, et produits intermediaires permettant de produire lesdits derives |
| US6239132B1 (en) | 1999-04-23 | 2001-05-29 | Merck & Co., Inc. | Thrombin inhibitors |
| AU5451400A (en) | 1999-06-04 | 2000-12-28 | Merck & Co., Inc. | Thrombin inhibitors |
| US20040152727A1 (en) * | 2001-05-18 | 2004-08-05 | Hay Douglas William Pierre | Novel use |
| WO2003050123A1 (fr) * | 2001-12-10 | 2003-06-19 | Kyorin Pharmaceutical Co., Ltd. | Derives bicycliques fusionnes de pyridine en tant qu'antagonistes du recepteur de la tachykinine |
| BR0307156A (pt) * | 2002-01-18 | 2004-12-07 | Kyorin Seiyaku Kk | Derivado de pirimidina bicìclica fundida, composto, antagonistas de receptores e agentes profiláticos e terapêuticos |
| EP1484320A1 (en) * | 2002-02-13 | 2004-12-08 | Takeda Chemical Industries, Ltd. | Jnk inhibitor |
| EP1496836B1 (en) | 2002-03-15 | 2008-09-24 | Merck & Co., Inc. | N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors |
| WO2003080626A1 (fr) * | 2002-03-26 | 2003-10-02 | Kyorin Pharmaceutical Co., Ltd. | Derive de pyrimidine bicyclique et fusionne comme antagoniste des recepteurs de tachykinine |
| AU2003300898A1 (en) * | 2002-12-13 | 2004-07-09 | Neurogen Corporation | Carboxylic acid, phosphate or phosphonate substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators |
| RU2229475C1 (ru) * | 2003-03-06 | 2004-05-27 | ООО "Исследовательский институт химического разнообразия | 6-сульфамоилхинолин-4-карбоновые кислоты, их производные и комбинаторная библиотека |
| EP1667977A4 (en) * | 2003-09-23 | 2009-09-09 | Merck & Co Inc | Isoquinolinone POTASSIUM CHANNEL INHIBITORS |
| EP1667973B1 (en) | 2003-09-23 | 2013-12-04 | Merck Sharp & Dohme Corp. | Quinoline potassium channel inhibitors |
| US20090186874A1 (en) * | 2004-01-14 | 2009-07-23 | Yoshinori Ikeura | Carboxamide derivative and use thereof |
| KR100781704B1 (ko) * | 2005-04-20 | 2007-12-03 | 에스케이케미칼주식회사 | 피리딘 유도체와 이의 제조방법, 및 이를 포함하는약제조성물 |
| AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
| TW200740782A (en) * | 2005-09-01 | 2007-11-01 | Tanabe Seiyaku Co | Thiomorpholine compound and process for preparing the same |
| RU2359962C1 (ru) * | 2007-12-13 | 2009-06-27 | Общество с ограниченной ответственностью "Консорциум-ПИК" (ООО "Консорциум-ПИК") | Нейротропное средство и способ его получения |
| RU2429230C1 (ru) * | 2010-05-27 | 2011-09-20 | Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) | Способ получения n-метил-4-бензилкарбамидопиридиния йодида |
| ES2786298T3 (es) * | 2011-03-03 | 2020-10-09 | Zalicus Pharmaceuticals Ltd | Inhibidores de benzimidazol del canal de sodio |
| CN102358730A (zh) * | 2011-08-24 | 2012-02-22 | 济南赛文医药技术有限公司 | 一种小分子mek蛋白激酶抑制剂 |
| WO2013097052A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
| ES2625945T3 (es) | 2012-11-14 | 2017-07-21 | Glaxosmithkline Llc | Tieno[3,2-c]piridin-4(5H)-onas como inhibidores de bet |
| AU2014303193A1 (en) | 2013-06-28 | 2016-01-28 | Abbvie Inc. | Bromodomain inhibitors |
| CN107427502B (zh) | 2015-03-04 | 2021-06-04 | 万达制药公司 | 使用川地匹坦的治疗方法 |
| EP3133065A1 (en) | 2015-08-21 | 2017-02-22 | Merck Patent GmbH | Compounds for optically active devices |
| UA124764C2 (uk) | 2016-04-15 | 2021-11-17 | Еббві Інк. | Інгібітори бромодомену |
| EP3363786A1 (en) | 2017-02-15 | 2018-08-22 | Merck Patent GmbH | Compounds for optically active devices |
| EP3363793A1 (en) | 2017-02-15 | 2018-08-22 | Merck Patent GmbH | Hydrophobic compounds for optically active devices |
| KR20200054232A (ko) | 2017-09-13 | 2020-05-19 | 반다 파마슈티칼즈, 인코퍼레이티드. | 트라디피탄트를 이용한 아토피 피부염의 개선된 치료 |
| JP2023526087A (ja) | 2020-05-20 | 2023-06-20 | エイエムオー・アイルランド | 光学活性装置で使用するためのアザクマリン及びアザチオクマリン誘導体 |
| US11691971B2 (en) | 2020-06-19 | 2023-07-04 | Incyte Corporation | Naphthyridinone compounds as JAK2 V617F inhibitors |
| WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
| TW202216713A (zh) | 2020-07-02 | 2022-05-01 | 美商英塞特公司 | 作為ｊａｋ２ ｖ６１７ｆ抑制劑之三環脲化合物 |
| US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
| WO2022046989A1 (en) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| WO2022140231A1 (en) | 2020-12-21 | 2022-06-30 | Incyte Corporation | Deazaguaine compounds as jak2 v617f inhibitors |
| EP4298099A1 (en) | 2021-02-25 | 2024-01-03 | Incyte Corporation | Spirocyclic lactams as jak2 v617f inhibitors |
| PE20251706A1 (es) | 2022-03-17 | 2025-07-02 | Incyte Corp | Compuestos de urea triciclica como inhibidores de v617f de jak2 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU173438B (hu) * | 1975-11-27 | 1979-05-28 | Chinoin Gyogyszer Es Vegyeszet | Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom |
| IL75987A (en) * | 1984-08-25 | 1991-07-18 | Goedecke Ag | Tri-and tetrasubstituted-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them |
| IE892088L (en) * | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
| TW205037B (cs) * | 1989-10-06 | 1993-05-01 | Takeda Pharm Industry Co Ltd | |
| FR2654725B1 (fr) * | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| UA41251C2 (uk) * | 1990-01-04 | 2001-09-17 | Пфайзер, Інк. | Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі |
| CA2075632C (en) * | 1990-02-10 | 2001-10-16 | Kanji Meguro | Chromene derivatives, their production and use |
| US5143919A (en) * | 1990-08-17 | 1992-09-01 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives and their pharmaceutical use |
| DE69110828T2 (de) * | 1990-10-16 | 1995-11-30 | Takeda Chemical Industries Ltd | Heterozyklische Aminderivate, deren Herstellung und deren Verwendung. |
| TW241258B (cs) * | 1992-04-15 | 1995-02-21 | Takeda Pharm Industry Co Ltd | |
| DE4215588A1 (de) * | 1992-05-12 | 1993-11-18 | Bayer Ag | Biphenylmethyl-substituierte Pyridone |
| DE4215587A1 (de) * | 1992-05-12 | 1993-11-18 | Bayer Ag | Sulfonylbenzyl-substituierte Benzo- und Pyridopyridone |
| NO179904C (no) * | 1992-09-04 | 1997-01-08 | Takeda Chemical Industries Ltd | Kondenserte heterocykliske forbindelser og deres anvendelse |
| JPH06298757A (ja) * | 1993-04-15 | 1994-10-25 | Kissei Pharmaceut Co Ltd | ピペリジノ−３，４−ジヒドロカルボスチリル誘導体 |
-
1994
- 1994-11-05 TW TW083110229A patent/TW263498B/zh active
- 1994-11-08 DE DE69427675T patent/DE69427675T2/de not_active Expired - Fee Related
- 1994-11-08 EP EP94117576A patent/EP0652218B1/en not_active Expired - Lifetime
- 1994-11-08 AT AT94117576T patent/ATE203024T1/de not_active IP Right Cessation
- 1994-11-08 NO NO944252A patent/NO301764B1/no not_active IP Right Cessation
- 1994-11-09 BR BR9404403A patent/BR9404403A/pt not_active Application Discontinuation
- 1994-11-09 FI FI945281A patent/FI945281L/fi unknown
- 1994-11-09 CA CA002135440A patent/CA2135440A1/en not_active Abandoned
- 1994-11-09 NZ NZ264887A patent/NZ264887A/en unknown
- 1994-11-09 AU AU77738/94A patent/AU678295B2/en not_active Ceased
- 1994-11-09 RU RU94040174A patent/RU2135471C1/ru active
- 1994-11-10 CN CN94113866A patent/CN1052004C/zh not_active Expired - Fee Related
- 1994-11-10 US US08/338,762 patent/US5585385A/en not_active Expired - Fee Related
- 1994-11-10 KR KR1019940029451A patent/KR950014108A/ko not_active Abandoned
- 1994-11-10 HU HU9403230A patent/HUT68810A/hu unknown
- 1994-11-10 IL IL11159094A patent/IL111590A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO944252D0 (no) | 1994-11-08 |
| US5585385A (en) | 1996-12-17 |
| CA2135440A1 (en) | 1995-05-11 |
| NZ264887A (en) | 1996-12-20 |
| BR9404403A (pt) | 1995-07-18 |
| CN1052004C (zh) | 2000-05-03 |
| RU2135471C1 (ru) | 1999-08-27 |
| NO301764B1 (no) | 1997-12-08 |
| EP0652218A1 (en) | 1995-05-10 |
| FI945281A7 (fi) | 1995-05-11 |
| EP0652218B1 (en) | 2001-07-11 |
| ATE203024T1 (de) | 2001-07-15 |
| CN1107476A (zh) | 1995-08-30 |
| AU7773894A (en) | 1995-05-18 |
| AU678295B2 (en) | 1997-05-22 |
| TW263498B (cs) | 1995-11-21 |
| HU9403230D0 (en) | 1995-01-30 |
| DE69427675T2 (de) | 2002-05-16 |
| KR950014108A (ko) | 1995-06-15 |
| NO944252L (no) | 1995-05-11 |
| DE69427675D1 (de) | 2001-08-16 |
| FI945281L (fi) | 1995-05-11 |
| HUT68810A (en) | 1995-05-19 |
| RU94040174A (ru) | 1996-10-10 |
| FI945281A0 (fi) | 1994-11-09 |
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