IL111431A0 - Endothelin receptor antagonists - Google Patents
Endothelin receptor antagonistsInfo
- Publication number
- IL111431A0 IL111431A0 IL11143194A IL11143194A IL111431A0 IL 111431 A0 IL111431 A0 IL 111431A0 IL 11143194 A IL11143194 A IL 11143194A IL 11143194 A IL11143194 A IL 11143194A IL 111431 A0 IL111431 A0 IL 111431A0
- Authority
- IL
- Israel
- Prior art keywords
- receptor antagonists
- endothelin receptor
- endothelin
- antagonists
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93810760 | 1993-11-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL111431A0 true IL111431A0 (en) | 1994-12-29 |
Family
ID=8215056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11143194A IL111431A0 (en) | 1993-11-01 | 1994-10-27 | Endothelin receptor antagonists |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5780498A (ru) |
| EP (1) | EP0728145A1 (ru) |
| JP (1) | JPH09504302A (ru) |
| AU (1) | AU691201B2 (ru) |
| BR (1) | BR9407933A (ru) |
| CA (1) | CA2173875A1 (ru) |
| FI (1) | FI961804A (ru) |
| IL (1) | IL111431A0 (ru) |
| NO (1) | NO961725D0 (ru) |
| RU (1) | RU2126418C1 (ru) |
| WO (1) | WO1995012611A1 (ru) |
| ZA (1) | ZA948541B (ru) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11505522A (ja) * | 1995-04-21 | 1999-05-21 | ノバルティス・アクチエンゲゼルシャフト | エンドセリン阻害剤としてのｎ−アロイルアミノ酸アミド |
| AU7130296A (en) * | 1995-09-28 | 1997-04-17 | Ciba-Geigy Japan Limited | Antagonists of endothelin receptors |
| IT1291823B1 (it) * | 1997-04-08 | 1999-01-21 | Menarini Ricerche Spa | Composti pseudo-peptidici, loro preparazione ed uso in formulazioni farmaceutiche |
| GB9708119D0 (en) * | 1997-04-22 | 1997-06-11 | Glaxo Group Ltd | Chemical compounds |
| US6291511B1 (en) | 1997-05-29 | 2001-09-18 | Merck & Co., Inc. | Biarylalkanoic acids as cell adhesion inhibitors |
| US6221888B1 (en) | 1997-05-29 | 2001-04-24 | Merck & Co., Inc. | Sulfonamides as cell adhesion inhibitors |
| DE19745146A1 (de) * | 1997-10-14 | 1999-04-15 | Basf Ag | Neue pharmazeutisch wirksame Verbindungen, ihre Herstellung und Verwendung |
| GB9723407D0 (en) | 1997-11-05 | 1998-01-07 | Ciba Geigy Ag | Organic compounds |
| US6020347A (en) * | 1997-11-18 | 2000-02-01 | Merck & Co., Inc. | 4-substituted-4-piperidine carboxamide derivatives |
| US6191171B1 (en) | 1997-11-20 | 2001-02-20 | Merck & Co., Inc. | Para-aminomethylaryl carboxamide derivatives |
| US6090841A (en) * | 1997-11-21 | 2000-07-18 | Merck & Co., Inc. | Substituted pyrrole derivatives as cell adhesion inhibitors |
| MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
| IL138246A0 (en) * | 1998-04-23 | 2001-10-31 | Novartis Ag | Certain thiol inhibitors of endothelin-converting enzyme |
| US6423727B1 (en) | 1998-04-23 | 2002-07-23 | Novartis Ag | Certain thiol inhibitors of endothelin-converting enzyme |
| US6426354B1 (en) | 1998-04-23 | 2002-07-30 | Novartis Ag | Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme |
| GB9811159D0 (en) * | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
| CA2360740A1 (en) | 1999-03-02 | 2000-09-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cathepsin s |
| EP1452522A3 (en) * | 1999-03-15 | 2005-02-09 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions as protease inhibitors |
| KR100679878B1 (ko) * | 1999-04-26 | 2007-02-07 | 아지노모토 가부시키가이샤 | 멜라노사이트-자극 호르몬 억제제 |
| US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
| GB0003111D0 (en) | 2000-02-10 | 2000-03-29 | Novartis Ag | Organic compounds |
| MY129000A (en) | 2000-08-31 | 2007-03-30 | Tanabe Seiyaku Co | INHIBITORS OF a4 MEDIATED CELL ADHESION |
| US6887877B2 (en) | 2001-06-11 | 2005-05-03 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of Flavivirus infections |
| MY140707A (en) * | 2002-02-28 | 2010-01-15 | Mitsubishi Tanabe Pharma Corp | Process for preparing a phenylalanine derivative and intermediates thereof |
| AU2003265398A1 (en) * | 2002-08-09 | 2004-02-25 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds and methods to modulate coagulation |
| EP1562897B1 (en) | 2002-11-12 | 2009-09-16 | Merck & Co., Inc. | Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer s disease |
| WO2005014534A1 (en) | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| US7208601B2 (en) * | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
| CA2531796A1 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| GB0514071D0 (en) * | 2005-07-07 | 2005-08-17 | Zealand Pharma As | N- or C- terminally modified small peptides |
| US20090012010A1 (en) * | 2007-05-18 | 2009-01-08 | Neuromed Phramaceuticals Ltd. | Amino acid derivatives as calcium channel blockers |
| EP2538981B1 (en) * | 2010-02-23 | 2017-12-20 | F. Hoffmann-La Roche AG | Compositions and methods for the diagnosis and treatment of tumor |
| EA030857B1 (ru) * | 2013-06-11 | 2018-10-31 | Селджин Интернэшнл Ii Сарл | Новые модуляторы рецептора glp-1 |
| US10758569B2 (en) | 2014-01-13 | 2020-09-01 | The General Hospital Corporation | Heteroaryl disulfide compounds as allosteric effectors for increasing the oxygen-binding affinity of hemoglobin |
| US20160331783A1 (en) * | 2014-01-13 | 2016-11-17 | The General Hospital Corporation | Bisamide compounds as allosteric effectors for reducing the oxygen-binding affinity of hemoglobin |
| US10829440B2 (en) * | 2015-06-12 | 2020-11-10 | Brown University | Antibacterial compounds and methods of making and using same |
| CN108821994A (zh) * | 2018-05-24 | 2018-11-16 | 三峡大学 | 一类双羟基酰氧基双酰胺类药物中间体及其制备方法 |
| US11555010B2 (en) | 2019-07-25 | 2023-01-17 | Brown University | Diamide antimicrobial agents |
| RU2716258C1 (ru) * | 2019-07-30 | 2020-03-11 | Автономная некоммерческая образовательная организация высшего образования Сколковский институт науки и технологий | Пептидный антагонист нмда-рецептора |
| JP2023530267A (ja) | 2020-06-10 | 2023-07-14 | アリゴス セラピューティクス インコーポレイテッド | コロナウイルス、ピコルナウイルス及びノロウイルス感染を治療するための抗ウイルス化合物 |
| FR3111544A1 (fr) * | 2020-06-18 | 2021-12-24 | Universite Paris-Saclay | Nouveaux composés dipeptidiques, leur procédé de fabrication et une nouvelle application thérapeutique de composés dipeptidiques. |
| RU2769051C1 (ru) * | 2021-06-30 | 2022-03-28 | Общество с ограниченной ответственностью "ТЕРРАНОВА КАПИТАЛ" | Пептид, улучшающий функциональные свойства эндотелия сосудов, фармацевтическая композиция на его основе и способ ее применения |
| KR20240035513A (ko) | 2021-07-09 | 2024-03-15 | 알리고스 테라퓨틱스 인코포레이티드 | 항바이러스 화합물 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5623142B2 (ru) * | 1974-07-01 | 1981-05-29 | ||
| US4025644A (en) * | 1974-12-18 | 1977-05-24 | Daiichi Seiyaku Co., Ltd. | Tyrosine derivatives and use |
| DE2901667A1 (de) * | 1979-01-17 | 1980-07-31 | Troponwerke Gmbh & Co Kg | Pharmazeutische verwendung von dipeptiden |
| EP0072058A1 (en) * | 1981-08-10 | 1983-02-16 | Duphar International Research B.V | Multiple-compartment syringe |
| US4395401A (en) * | 1981-09-09 | 1983-07-26 | Smithkline Beckman Corporation | Renally active dipeptides |
| JPS58133260A (ja) * | 1982-02-02 | 1983-08-08 | 河村 純郎 | 多段注射器 |
| DE3332633A1 (de) * | 1983-09-09 | 1985-04-04 | Luitpold-Werk Chemisch-pharmazeutische Fabrik GmbH & Co, 8000 München | Substituierte carbonsaeurederivate, verfahren zu ihrer herstellung, und arzneimittel |
| EP0212550A3 (en) * | 1985-08-14 | 1989-05-10 | G.D. Searle & Co. | Substituted dipeptide amides |
| AU598750B2 (en) * | 1985-09-27 | 1990-07-05 | Mitsubishi Chemical Corporation | Phenylalanine derivative and proteinase inhibitor |
| ES2017924B3 (es) * | 1985-10-11 | 1991-03-16 | Duphar Int Res B V | Inyector automatico. |
| DK130387A (da) * | 1986-03-14 | 1987-09-15 | Syntex Inc | Transglutaminase inhibitorer |
| US5187156A (en) * | 1988-03-16 | 1993-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same |
| CA1326108C (en) * | 1988-04-12 | 1994-01-11 | Sun Hyuk Kim | Cck antagonists |
| JPH0347163A (ja) * | 1989-06-30 | 1991-02-28 | Fujisawa Pharmaceut Co Ltd | アントラキノン誘導体およびその製造 |
| CA2032559C (en) * | 1989-12-28 | 2001-11-06 | Kiyofumi Ishikawa | Endothelin antagonistic cyclic pentapeptides |
| US5284828A (en) * | 1990-05-14 | 1994-02-08 | Fujisawa Pharmaceutical Co. Ltd. | Peptide compound and its preparation |
| CA2043741C (en) * | 1990-06-07 | 2003-04-01 | Kiyofumi Ishikawa | Endothelin antagonistic peptide derivatives |
| DK220890D0 (da) * | 1990-09-14 | 1990-09-14 | Ole Buchardt | Fremgangsmaade til fremstilling af c-terminalt amiderede peptider |
| EP0668770A1 (en) * | 1991-04-24 | 1995-08-30 | Warner-Lambert Company | $g(a)-SUBSTITUTED POLYPEPTIDES HAVING THERAPEUTIC ACTIVITY |
| TW270116B (ru) * | 1991-04-25 | 1996-02-11 | Hoffmann La Roche | |
| EP0584290B1 (en) * | 1991-05-16 | 2000-08-30 | Warner-Lambert Company | Endothelin antagonists |
| RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| WO1993008799A1 (en) * | 1991-11-05 | 1993-05-13 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
| TW224462B (ru) * | 1992-02-24 | 1994-06-01 | Squibb & Sons Inc | |
| US5550138A (en) * | 1992-03-25 | 1996-08-27 | Takeda Chemical Industries, Ltd. | Condensed thiadiazole derivative, method of its production, and use thereof |
| NZ247440A (en) * | 1992-05-06 | 1995-04-27 | Squibb & Sons Inc | Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof |
| EP0650484B1 (en) * | 1992-07-17 | 2000-01-26 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
-
1994
- 1994-10-17 AU AU78565/94A patent/AU691201B2/en not_active Ceased
- 1994-10-17 RU RU96112148A patent/RU2126418C1/ru active
- 1994-10-17 US US08/637,720 patent/US5780498A/en not_active Expired - Fee Related
- 1994-10-17 CA CA002173875A patent/CA2173875A1/en not_active Abandoned
- 1994-10-17 BR BR9407933A patent/BR9407933A/pt not_active Application Discontinuation
- 1994-10-17 EP EP94929557A patent/EP0728145A1/en not_active Ceased
- 1994-10-17 WO PCT/EP1994/003418 patent/WO1995012611A1/en not_active Application Discontinuation
- 1994-10-17 JP JP7512982A patent/JPH09504302A/ja active Pending
- 1994-10-27 IL IL11143194A patent/IL111431A0/xx unknown
- 1994-10-31 ZA ZA948541A patent/ZA948541B/xx unknown
-
1996
- 1996-04-26 FI FI961804A patent/FI961804A/fi unknown
- 1996-04-29 NO NO961725A patent/NO961725D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU7856594A (en) | 1995-05-23 |
| NO961725L (no) | 1996-04-29 |
| WO1995012611A1 (en) | 1995-05-11 |
| RU2126418C1 (ru) | 1999-02-20 |
| US5780498A (en) | 1998-07-14 |
| ZA948541B (en) | 1995-05-02 |
| FI961804A (fi) | 1996-04-30 |
| NO961725D0 (no) | 1996-04-29 |
| CA2173875A1 (en) | 1995-05-11 |
| BR9407933A (pt) | 1996-11-26 |
| EP0728145A1 (en) | 1996-08-28 |
| JPH09504302A (ja) | 1997-04-28 |
| AU691201B2 (en) | 1998-05-14 |
| FI961804A0 (fi) | 1996-04-26 |
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