IL111274A - Derivatives of 6-O-demethyl galanthamine - and pharmaceutical compositions containing them - Google Patents

Derivatives of 6-O-demethyl galanthamine - and pharmaceutical compositions containing them

Info

Publication number
IL111274A
IL111274A IL11127494A IL11127494A IL111274A IL 111274 A IL111274 A IL 111274A IL 11127494 A IL11127494 A IL 11127494A IL 11127494 A IL11127494 A IL 11127494A IL 111274 A IL111274 A IL 111274A
Authority
IL
Israel
Prior art keywords
hydrogen
derivatives
pharmaceutical compositions
compositions containing
alkylaminocarbonyl
Prior art date
Application number
IL11127494A
Other languages
English (en)
Other versions
IL111274A0 (en
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of IL111274A0 publication Critical patent/IL111274A0/xx
Publication of IL111274A publication Critical patent/IL111274A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL11127494A 1993-10-15 1994-10-13 Derivatives of 6-O-demethyl galanthamine - and pharmaceutical compositions containing them IL111274A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/137,440 US6323195B1 (en) 1993-10-15 1993-10-15 Galanthamine derivatives as acetylcholinesterase inhibitors

Publications (2)

Publication Number Publication Date
IL111274A0 IL111274A0 (en) 1994-12-29
IL111274A true IL111274A (en) 2000-11-21

Family

ID=22477446

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11127494A IL111274A (en) 1993-10-15 1994-10-13 Derivatives of 6-O-demethyl galanthamine - and pharmaceutical compositions containing them

Country Status (23)

Country Link
US (2) US6323195B1 (sv)
EP (2) EP0653427B1 (sv)
JP (1) JP2664344B2 (sv)
KR (1) KR0169114B1 (sv)
CN (1) CN1039911C (sv)
AT (1) ATE212348T1 (sv)
AU (1) AU696249B2 (sv)
CA (1) CA2118174C (sv)
CZ (1) CZ287071B6 (sv)
DE (1) DE69429708T2 (sv)
DK (1) DK0653427T3 (sv)
EG (1) EG20472A (sv)
ES (1) ES2171428T3 (sv)
FI (1) FI108723B (sv)
IL (1) IL111274A (sv)
NO (1) NO310415B1 (sv)
NZ (1) NZ264683A (sv)
PL (1) PL177730B1 (sv)
PT (1) PT653427E (sv)
RO (1) RO114133B1 (sv)
RU (1) RU2114850C1 (sv)
TW (1) TW363969B (sv)
ZA (1) ZA948062B (sv)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9514821D0 (en) * 1995-07-19 1995-09-20 Sod Conseils Rech Applic Galanthamine derivatives
AT403803B (de) * 1996-04-19 1998-05-25 Sanochemia Ltd Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
AU1738800A (en) * 1998-11-23 2000-06-13 Bonnie Davis Dosage formulations for acetylcholinesterase inhibitors
HUP0104778A3 (en) 1998-12-24 2004-05-28 Janssen Pharmaceutica Nv Controlled release galantamine composition
US6159476A (en) * 1999-01-11 2000-12-12 Herbaceuticals Herbal supplement for increased muscle strength and endurance for athletes
US8603546B2 (en) * 1999-01-11 2013-12-10 Herbaceuticals Inc. Herbal supplement for increased muscle strength and endurance for athletes
DE69913138T2 (de) * 1999-03-31 2004-08-26 Eisai Co., Ltd. Stabilisierte zusammensetzung mit nootropen wirkstoffen
PL201694B1 (pl) * 1999-10-26 2009-04-30 Janssen Pharmaceutica Nv Roztwór doustny zawierający galantaminę, sposób jego wytwarzania i zastosowanie
MXPA02005667A (es) 1999-12-10 2004-09-10 Bonnie Davis Analogos de galantamina y licoramina como moduladores de los receptores nicotinicos.
CA2368966A1 (en) 2000-03-31 2001-10-11 Sanochemia Pharmazeutika Aktiengesellschaft New derivatives and analogues of galanthamine
US20030162770A1 (en) * 2002-02-22 2003-08-28 Davis Bonnie M. Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
US20050191349A1 (en) * 2003-12-31 2005-09-01 Garth Boehm Galantamine formulations
WO2005065662A1 (en) * 2003-12-31 2005-07-21 Actavis Group Hf Solid dosage formulations of galantamine
WO2006004201A1 (ja) * 2004-07-01 2006-01-12 Eisai R & D Management Co., Ltd. 神経再生促進剤
DK1895994T3 (da) * 2005-05-13 2010-12-20 Alza Corp Multilagsmedikamentleveringssystem med barriere mod reservoirmaterialeflow
US20080188510A1 (en) * 2005-05-23 2008-08-07 Eisai R & D Management Co., Ltd. Novel methods using zonisamide
ATE473219T1 (de) * 2005-09-22 2010-07-15 Galantos Pharma Gmbh Cholinerge enhancer mit verbesserter durchgängigkeit durch die blut-hirn-schranke zur behandlung von krankheiten, die mit kognitiven störungen einhergehen
EP1777222A1 (en) * 2005-09-22 2007-04-25 Galantos Pharma GmbH Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
US20090253654A1 (en) 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
US20070104771A1 (en) * 2005-09-23 2007-05-10 Jay Audett Transdermal galantamine delivery system
JP5504253B2 (ja) 2008-04-14 2014-05-28 ニューロダイン ライフ サイエンス インコーポレイテッド ヒトの脳疾患の治療のためのプロドラッグとしてのガランタミン誘導体
MX2012000939A (es) * 2009-07-23 2012-06-08 Shire Llc Profarmacos de peptidos y aminoacidos de galantamina y usos de los mismos.
WO2013160728A1 (en) 2012-04-26 2013-10-31 Alma Mater Studiorum - Universita' Di Bologna Dual targeting compounds for the treatment of alzheimer's disease
EP3628315A1 (en) 2018-09-28 2020-04-01 Université de Caen Normandie Combination of acetylcholinesterase inhibitor and 5-ht4 receptor agonist as neuroprotective agent in the treatment of neurodegenerative diseases
CN113292420A (zh) * 2021-05-27 2021-08-24 神隆医药（常熟）有限公司 加兰他敏中间体原料2-溴-5-羟基-4-甲氧基苯甲酸回收方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL122665B1 (en) 1978-11-21 1982-08-31 Edinen Zentar Chim Process for preparing novel dienones of narvedine type and their derivatives
US4663318A (en) 1986-01-15 1987-05-05 Bonnie Davis Method of treating Alzheimer's disease
US6150354A (en) * 1987-01-15 2000-11-21 Bonnie Davis Compounds for the treatment of Alzheimer's disease
KR100195399B1 (ko) * 1987-05-04 1999-06-15 보니데이비스 알쯔하이머 병 치료용 의약
NL8800350A (nl) 1988-02-12 1989-09-01 Stichting Biomedical Research Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.
CA2108880A1 (en) 1991-05-14 1992-11-15 Ernir Snorrason Treatment of fatigue syndrome with cholinesterase inhibitors
US5231093A (en) * 1991-10-01 1993-07-27 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
US5153193A (en) 1991-10-01 1992-10-06 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs

Also Published As

Publication number Publication date
ATE212348T1 (de) 2002-02-15
US6323195B1 (en) 2001-11-27
CZ287071B6 (en) 2000-08-16
NZ264683A (en) 1998-03-25
DK0653427T3 (da) 2002-04-15
ES2171428T3 (es) 2002-09-16
CZ254694A3 (en) 1995-09-13
CA2118174A1 (en) 1995-04-16
JPH07188240A (ja) 1995-07-25
AU696249B2 (en) 1998-09-03
PT653427E (pt) 2002-06-28
FI944821A0 (sv) 1994-10-13
RO114133B1 (ro) 1999-01-29
DE69429708D1 (de) 2002-03-14
PL177730B1 (pl) 2000-01-31
EG20472A (en) 1999-05-31
NO943893L (no) 1995-04-18
EP1020470A2 (en) 2000-07-19
KR0169114B1 (ko) 1999-01-15
NO310415B1 (no) 2001-07-02
JP2664344B2 (ja) 1997-10-15
NO943893D0 (no) 1994-10-14
FI108723B (sv) 2002-03-15
DE69429708T2 (de) 2002-08-29
CA2118174C (en) 2000-01-18
ZA948062B (en) 1995-06-06
RU2114850C1 (ru) 1998-07-10
EP0653427A1 (en) 1995-05-17
IL111274A0 (en) 1994-12-29
AU7581494A (en) 1995-05-04
KR950011443A (ko) 1995-05-15
CN1111245A (zh) 1995-11-08
US5777108A (en) 1998-07-07
RU94036448A (ru) 1996-09-10
EP1020470A3 (en) 2000-07-26
FI944821A (sv) 1995-04-16
PL305456A1 (en) 1995-04-18
EP0653427B1 (en) 2002-01-23
CN1039911C (zh) 1998-09-23
TW363969B (en) 1999-07-11

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
HCA Change of name of proprietor(s) after amalgamation
FF Patent granted
KB Patent renewed
EXP Patent expired