IL110553A - Process for the preparation of 9-amino camptothecin from the 12-nitro derivative, pharmaceutical compositions containing it and certain intermediates - Google Patents

Process for the preparation of 9-amino camptothecin from the 12-nitro derivative, pharmaceutical compositions containing it and certain intermediates

Info

Publication number
IL110553A
IL110553A IL110553A IL11055394A IL110553A IL 110553 A IL110553 A IL 110553A IL 110553 A IL110553 A IL 110553A IL 11055394 A IL11055394 A IL 11055394A IL 110553 A IL110553 A IL 110553A
Authority
IL
Israel
Prior art keywords
formula
compound
amino camptothecin
obtaining
preparation
Prior art date
Application number
IL110553A
Other languages
English (en)
Other versions
IL110553A0 (en
Inventor
Cabri Walter
Candiani Ilaria
Zarini Franco
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of IL110553A0 publication Critical patent/IL110553A0/xx
Publication of IL110553A publication Critical patent/IL110553A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
IL110553A 1993-08-06 1994-08-03 Process for the preparation of 9-amino camptothecin from the 12-nitro derivative, pharmaceutical compositions containing it and certain intermediates IL110553A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939316352A GB9316352D0 (en) 1993-08-06 1993-08-06 Process for the preparation of 9-amino camptothecin

Publications (2)

Publication Number Publication Date
IL110553A0 IL110553A0 (en) 1994-11-11
IL110553A true IL110553A (en) 1997-03-18

Family

ID=10740090

Family Applications (1)

Application Number Title Priority Date Filing Date
IL110553A IL110553A (en) 1993-08-06 1994-08-03 Process for the preparation of 9-amino camptothecin from the 12-nitro derivative, pharmaceutical compositions containing it and certain intermediates

Country Status (15)

Country Link
US (1) US6403603B1 (fi)
EP (1) EP0663914A1 (fi)
JP (2) JP3556223B2 (fi)
KR (1) KR950703565A (fi)
CN (1) CN1048296C (fi)
AU (1) AU678587B2 (fi)
CA (1) CA2145514C (fi)
FI (1) FI951581A0 (fi)
GB (1) GB9316352D0 (fi)
HU (1) HUT71240A (fi)
IL (1) IL110553A (fi)
RU (1) RU2145325C1 (fi)
TW (1) TW269691B (fi)
WO (1) WO1995004736A1 (fi)
ZA (1) ZA945878B (fi)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9319944D0 (en) * 1993-09-28 1993-11-17 Erba Carlo Spa Process for the preparation of 9-amino camptothecin
GB9410388D0 (en) * 1994-05-24 1994-07-13 Erba Carlo Spa Method for the preparation of 9-amino camptothecin
CN1324032C (zh) * 2004-01-07 2007-07-04 重庆医药工业研究院有限责任公司 一种新的9－硝基喜树碱晶型和药物组合物
CN1312155C (zh) * 2005-01-21 2007-04-25 华东理工大学 一种分离纯化9－硝基喜树碱的方法
CN102731516B (zh) * 2011-04-07 2014-07-02 宁波天衡药业股份有限公司 一类具有抗肿瘤活性的喜树碱衍生物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2150234A1 (de) * 1971-10-08 1973-04-12 Basf Ag Verfahren zur herstellung von camptothecin und camptothecin-derivaten
US4894456A (en) * 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5180722A (en) * 1987-04-14 1993-01-19 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
US5225404A (en) * 1989-11-06 1993-07-06 New York University Methods of treating colon tumors with tumor-inhibiting camptothecin compounds
DE4134885C2 (de) * 1991-10-23 1994-04-07 Praezisions Ventil Gmbh Betätigungsaufsatz für einen Sprühbehälter

Also Published As

Publication number Publication date
AU678587B2 (en) 1997-06-05
ZA945878B (en) 1995-03-10
AU7229094A (en) 1995-02-28
JPH08506597A (ja) 1996-07-16
WO1995004736A1 (en) 1995-02-16
KR950703565A (ko) 1995-09-20
JP3556223B2 (ja) 2004-08-18
CA2145514A1 (en) 1995-02-16
US6403603B1 (en) 2002-06-11
RU95112573A (ru) 1997-02-20
IL110553A0 (en) 1994-11-11
EP0663914A1 (en) 1995-07-26
TW269691B (fi) 1996-02-01
HUT71240A (en) 1995-11-28
FI951581A (fi) 1995-04-03
CA2145514C (en) 2006-06-06
CN1113384A (zh) 1995-12-13
FI951581A0 (fi) 1995-04-03
RU2145325C1 (ru) 2000-02-10
CN1048296C (zh) 2000-01-12
JP2004217665A (ja) 2004-08-05
GB9316352D0 (en) 1993-09-22

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees