IL109991A - Dna sequence comprising a gene cluster encoding branched chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis - Google Patents

Dna sequence comprising a gene cluster encoding branched chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis

Info

Publication number
IL109991A
IL109991A IL10999194A IL10999194A IL109991A IL 109991 A IL109991 A IL 109991A IL 10999194 A IL10999194 A IL 10999194A IL 10999194 A IL10999194 A IL 10999194A IL 109991 A IL109991 A IL 109991A
Authority
IL
Israel
Prior art keywords
dna sequence
branched chain
gene cluster
streptomyces avermitilis
dehydrogenase complex
Prior art date
Application number
IL10999194A
Other languages
English (en)
Other versions
IL109991A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL109991A0 publication Critical patent/IL109991A0/xx
Priority to IL15416103A priority Critical patent/IL154161A0/xx
Priority to IL15416203A priority patent/IL154162A0/xx
Publication of IL109991A publication Critical patent/IL109991A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/04—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with a disulfide as acceptor (1.2.4)
    • C12Y102/04004—3-Methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (1.2.4.4), i.e. branched-chain-alpha-ketoacid dehydrogenase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
IL10999194A 1993-12-16 1994-06-13 Dna sequence comprising a gene cluster encoding branched chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis IL109991A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL15416103A IL154161A0 (en) 1993-12-16 2003-01-27 Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis
IL15416203A IL154162A0 (en) 1993-12-16 2003-01-27 Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16860293A 1993-12-16 1993-12-16

Publications (2)

Publication Number Publication Date
IL109991A0 IL109991A0 (en) 1994-10-07
IL109991A true IL109991A (en) 2005-08-31

Family

ID=22612168

Family Applications (3)

Application Number Title Priority Date Filing Date
IL10999194A IL109991A (en) 1993-12-16 1994-06-13 Dna sequence comprising a gene cluster encoding branched chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis
IL15416103A IL154161A0 (en) 1993-12-16 2003-01-27 Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis
IL15416203A IL154162A0 (en) 1993-12-16 2003-01-27 Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL15416103A IL154161A0 (en) 1993-12-16 2003-01-27 Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis
IL15416203A IL154162A0 (en) 1993-12-16 2003-01-27 Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis

Country Status (21)

Country Link
US (1) US5707839A (pl)
EP (1) EP0734443A1 (pl)
JP (1) JP2800921B2 (pl)
KR (1) KR100209842B1 (pl)
CN (2) CN1056189C (pl)
AU (2) AU6805894A (pl)
BR (1) BR9408337A (pl)
CA (1) CA2177269A1 (pl)
CO (1) CO4340655A1 (pl)
CZ (1) CZ174496A3 (pl)
EC (1) ECSP941123A (pl)
EG (1) EG22869A (pl)
FI (1) FI942725L (pl)
HU (1) HUT76092A (pl)
IL (3) IL109991A (pl)
NO (2) NO962544D0 (pl)
NZ (3) NZ329675A (pl)
PE (1) PE11096A1 (pl)
PL (1) PL178993B1 (pl)
WO (1) WO1995016781A1 (pl)
ZA (1) ZA944092B (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466102A (en) * 1993-12-16 1995-11-14 Kennametal Inc. System for coupling machine tools
US6248579B1 (en) 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
YU50900A (sh) * 1998-02-13 2004-03-12 Pfizer Produsts Inc. Streptomyces avermitilis gen koji usmerava odnos b2:b1 avermektina
US6197591B1 (en) 1998-09-14 2001-03-06 Pfizer Inc. Streptomyces avermitilis regulatory genes for increased avermectin production
ES2272299T3 (es) 1999-08-12 2007-05-01 Pfizer Products Inc. Gen de streptomyces avermitilis que dirige la relacion de avermectinas b2:b1.
DE10356092B4 (de) * 2003-12-01 2008-04-03 Siemens Audiologische Technik Gmbh Hörgerät mit drahtlosem Übertragungssystem

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987003907A1 (en) * 1985-12-17 1987-07-02 Lubrizol Genetics, Inc. Isolation of genes for biosynthesis of polyketide antibiotics
US5077278A (en) * 1987-01-23 1991-12-31 Pfizer Inc. Non-natural demethylavermectins compositions and method of use
IN167980B (pl) * 1987-01-23 1991-01-19 Pfizer
ATE89604T1 (de) * 1987-10-23 1993-06-15 Pfizer Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen.
DE69023036T2 (de) * 1989-03-31 1996-06-13 Merck & Co Inc Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung.
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use

Also Published As

Publication number Publication date
AU9421998A (en) 1999-03-04
CO4340655A1 (es) 1996-07-30
NO962544L (no) 1996-06-14
NO20070802L (no) 1996-06-14
IL154161A0 (en) 2003-07-31
PE11096A1 (es) 1996-04-12
CN1137806A (zh) 1996-12-11
FI942725A7 (fi) 1995-06-17
HUT76092A (en) 1997-06-30
EP0734443A1 (en) 1996-10-02
NZ329675A (en) 1998-10-28
FI942725L (fi) 1995-06-17
JPH09500283A (ja) 1997-01-14
WO1995016781A1 (en) 1995-06-22
CN1056189C (zh) 2000-09-06
KR100209842B1 (ko) 1999-07-15
PL314977A1 (en) 1996-09-30
NO962544D0 (no) 1996-06-14
NZ266526A (en) 1997-12-19
ZA944092B (en) 1995-12-11
FI942725A0 (fi) 1994-06-09
EG22869A (en) 2003-09-30
PL178993B1 (pl) 2000-07-31
ECSP941123A (es) 1994-12-15
CZ174496A3 (cs) 1999-05-12
IL154162A0 (en) 2003-07-31
NZ329117A (en) 1998-04-27
HU9601644D0 (en) 1996-08-28
BR9408337A (pt) 1997-08-19
CA2177269A1 (en) 1995-06-22
AU6805894A (en) 1995-07-03
JP2800921B2 (ja) 1998-09-21
CN1210150A (zh) 1999-03-10
US5707839A (en) 1998-01-13
IL109991A0 (en) 1994-10-07

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees