IL109968A - Substituted nitrogen heterocycles process for their production and pharmaceutical compositions containing them - Google Patents
Substituted nitrogen heterocycles process for their production and pharmaceutical compositions containing themInfo
- Publication number
- IL109968A IL109968A IL10996894A IL10996894A IL109968A IL 109968 A IL109968 A IL 109968A IL 10996894 A IL10996894 A IL 10996894A IL 10996894 A IL10996894 A IL 10996894A IL 109968 A IL109968 A IL 109968A
- Authority
- IL
- Israel
- Prior art keywords
- production
- pharmaceutical compositions
- compositions containing
- substituted nitrogen
- nitrogen heterocycles
- Prior art date
Links
- 229910052757 nitrogen Inorganic materials 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- DQFQCHIDRBIESA-UHFFFAOYSA-N 1-benzazepine Chemical class N1C=CC=CC2=CC=CC=C12 DQFQCHIDRBIESA-UHFFFAOYSA-N 0.000 abstract 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939311948A GB9311948D0 (en) | 1993-06-10 | 1993-06-10 | Substituted nitrogen heterocycles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL109968A0 IL109968A0 (en) | 1994-10-07 |
| IL109968A true IL109968A (en) | 1999-11-30 |
Family
ID=10736919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10996894A IL109968A (en) | 1993-06-10 | 1994-06-10 | Substituted nitrogen heterocycles process for their production and pharmaceutical compositions containing them |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5502048A (de) |
| EP (1) | EP0702673B1 (de) |
| JP (1) | JPH08511513A (de) |
| AT (1) | ATE163409T1 (de) |
| AU (1) | AU684789B2 (de) |
| CA (1) | CA2161251A1 (de) |
| DE (1) | DE69408668T2 (de) |
| DK (1) | DK0702673T3 (de) |
| ES (1) | ES2112546T3 (de) |
| GB (2) | GB9311948D0 (de) |
| HU (1) | HU9501709D0 (de) |
| IL (1) | IL109968A (de) |
| NZ (1) | NZ266855A (de) |
| TW (1) | TW282459B (de) |
| WO (1) | WO1994029275A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9212308D0 (en) * | 1992-06-10 | 1992-07-22 | Ici Plc | Therapeutic compositions |
| GB9311948D0 (en) * | 1993-06-10 | 1993-07-28 | Zeneca Ltd | Substituted nitrogen heterocycles |
| US5801168A (en) * | 1994-06-09 | 1998-09-01 | Zeneca Limited | Substituted nitrogen heterocycles |
| US5977125A (en) * | 1994-10-31 | 1999-11-02 | Eisai Co., Ltd. | Mono-or polyenic carboxylic acid derivatives |
| US5476933A (en) * | 1994-11-16 | 1995-12-19 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Azepine synthesis via a diels-alder reaction |
| CN1084747C (zh) * | 1996-03-08 | 2002-05-15 | 曾尼卡有限公司 | 作为神经活性剂的吡咯并苯并氮杂䓬衍生物 |
| US6191166B1 (en) | 1997-11-21 | 2001-02-20 | Elan Pharmaceuticals, Inc. | Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis |
| US6211235B1 (en) | 1996-11-22 | 2001-04-03 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting β-amyloid peptide release and/or its synthesis |
| US6683075B1 (en) | 1996-12-23 | 2004-01-27 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use |
| US6635632B1 (en) * | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6774125B2 (en) * | 1998-06-22 | 2004-08-10 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6509331B1 (en) | 1998-06-22 | 2003-01-21 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6552013B1 (en) | 1998-06-22 | 2003-04-22 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6569851B1 (en) * | 1998-06-22 | 2003-05-27 | Elan Pharmaceutials, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6528505B1 (en) | 1998-06-22 | 2003-03-04 | Elan Pharmaceuticals, Inc. | Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US20050192265A1 (en) * | 2003-03-20 | 2005-09-01 | Thompson Richard C. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds |
| GB0900641D0 (en) * | 2009-01-15 | 2009-02-25 | Syngenta Ltd | Novel herbicides |
| GB0901835D0 (en) * | 2009-02-04 | 2009-03-11 | Syngenta Ltd | Novel herbicides |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1340334A (en) * | 1970-07-06 | 1973-12-12 | Rees A H | Synthesis of benzazetropolones and hence of kynurenic acids |
| JPS5129522B2 (de) * | 1972-07-13 | 1976-08-26 | ||
| JPS5520970B2 (de) * | 1972-07-15 | 1980-06-06 | ||
| DE3269625D1 (en) * | 1981-08-11 | 1986-04-10 | Ciba Geigy Ag | Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and the compounds for therapeutical use |
| US4410520A (en) * | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| US4473575A (en) * | 1982-07-19 | 1984-09-25 | Ciba-Geigy Corporation | 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids |
| US4575503A (en) * | 1983-02-10 | 1986-03-11 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| US4477446A (en) * | 1983-07-01 | 1984-10-16 | Usv Pharmaceutical Corporation | 1-Benzazepines and their pharmaceutical uses |
| DE3416695A1 (de) * | 1984-05-05 | 1985-11-07 | Bayer Ag, 5090 Leverkusen | Amidinohydrazone von tetralin-, chromon-, thiochromon- und tretrahydrochinolin-derivaten, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| US5322943A (en) * | 1985-09-12 | 1994-06-21 | The Upjohn Company | Piperazine compounds which are substituted |
| US5266684A (en) * | 1988-05-02 | 1993-11-30 | The Reagents Of The University Of California | Peptide mixtures |
| US4885364A (en) * | 1988-11-23 | 1989-12-05 | E. R. Squibb & Sons, Inc. | Resolution process for benzazepine intermediates |
| US5229413A (en) * | 1989-05-05 | 1993-07-20 | G. D. Searle & Co. | Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders |
| JPH0347123A (ja) * | 1989-05-05 | 1991-02-28 | G D Searle & Co | インドール―２―カルボキシレート化合物類を含有するｃｎｓ疾患治療用組成物 |
| US5026700A (en) * | 1989-05-16 | 1991-06-25 | Merrell Dow Pharmaceuticals | Certain quinolines and thienopyridines as excitatory amino acid antagonists |
| CA2016465A1 (en) * | 1989-06-02 | 1990-12-02 | Zola Phillip Horovitz | Method for preventing or treating anxiety employing a calcium channel blocker |
| JPH0334977A (ja) * | 1989-06-29 | 1991-02-14 | Yoshitomi Pharmaceut Ind Ltd | イミダゾリルベンゾラクタム化合物 |
| ES2089033T3 (es) * | 1989-10-20 | 1996-10-01 | Otsuka Pharma Co Ltd | Compuestos benzoheterociclicos. |
| US5622832A (en) * | 1990-02-28 | 1997-04-22 | Genetics Institute, Inc. | Arachidonic acid releasing phospholipase A2 enzyme and methods of use |
| US5051442A (en) * | 1990-04-25 | 1991-09-24 | Merrell Dow Pharmaceuticals Inc. | 3-indolyl thioacetate derivatives and NMDA receptor antagonistic use thereof |
| US5182366A (en) * | 1990-05-15 | 1993-01-26 | Huebner Verena D | Controlled synthesis of peptide mixtures using mixed resins |
| EP0459561B1 (de) * | 1990-05-31 | 1995-09-20 | MERCK SHARP & DOHME LTD. | Dioxo-tetrahydrochinolinderivate |
| GB9022785D0 (en) * | 1990-10-19 | 1990-12-05 | Merck Sharp & Dohme | Therapeutic agents |
| US5189054A (en) * | 1990-11-02 | 1993-02-23 | Merrell Dow Pharmaceuticals Inc. | 3-amidoindolyl derivatives and pharmaceutical compositions thereof |
| CA2054339C (en) * | 1990-11-02 | 2002-12-24 | Francesco G. Salituro | 3-amidoindolyl derivatives |
| GB9026389D0 (en) * | 1990-12-05 | 1991-01-23 | Merck Sharp & Dohme | Therapeutic agents |
| GB9100028D0 (en) * | 1991-01-02 | 1991-02-20 | Ici Plc | Compounds |
| WO1992013535A1 (en) * | 1991-02-06 | 1992-08-20 | Research Corporation Technologies, Inc. | Anticonvulsant substituted quinazolones |
| US5330768A (en) * | 1991-07-05 | 1994-07-19 | Massachusetts Institute Of Technology | Controlled drug delivery using polymer/pluronic blends |
| EP0542689B1 (de) * | 1991-11-15 | 1998-09-23 | Phafag Aktiengesellschaft | Verwendung von 1-(aminoalkyl)-3-Quinoxalin-2-on Derivaten zur Herstellung von neuroprotektiven Mitteln |
| JP2712144B2 (ja) * | 1992-02-06 | 1998-02-10 | 田辺製薬株式会社 | 血小板凝集抑制組成物 |
| GB9206266D0 (en) * | 1992-03-23 | 1992-05-06 | Merck Sharp & Dohme | Therapeutic agents |
| GB9212308D0 (en) * | 1992-06-10 | 1992-07-22 | Ici Plc | Therapeutic compositions |
| JP3301024B2 (ja) * | 1992-06-22 | 2002-07-15 | ザ・リージェンツ・オブ・ザ・ユニバーシテイ・オブ・カリフォルニア | グリシンレセプター拮抗物質及びその用途 |
| CA2098446A1 (en) * | 1992-09-30 | 1994-03-31 | Eckard Weber | 2,5-dihydro-2,5-dioxo-1h-azepines and 2,5-dihydro-2-oxo-1h-azepines and the use thereof as excitatory amino acid and glycine receptor antagonists |
| US5514690A (en) * | 1992-11-17 | 1996-05-07 | E. R. Squibb & Sons, Inc. | Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of quinoline and indoline |
| US5428069A (en) * | 1993-01-11 | 1995-06-27 | The United States Of America As Represented By The Department Of Health & Human Services | Treating cognition with, aminocyclopropanecarboxylic derivatives |
| AU6246394A (en) * | 1993-02-22 | 1994-09-14 | Cavalier Pharmaceuticals, Inc. | Use of heparin to inhibit interleukin-8 |
| ZA941290B (en) * | 1993-02-26 | 1995-08-25 | Res Dev Foundation | Combination cisplatin/tamoxifen therapy for human cancers |
| GB9311948D0 (en) * | 1993-06-10 | 1993-07-28 | Zeneca Ltd | Substituted nitrogen heterocycles |
-
1993
- 1993-06-10 GB GB939311948A patent/GB9311948D0/en active Pending
-
1994
- 1994-06-06 GB GB9411242A patent/GB9411242D0/en active Pending
- 1994-06-09 EP EP94917115A patent/EP0702673B1/de not_active Expired - Lifetime
- 1994-06-09 WO PCT/GB1994/001243 patent/WO1994029275A1/en active IP Right Grant
- 1994-06-09 DK DK94917115T patent/DK0702673T3/da active
- 1994-06-09 CA CA002161251A patent/CA2161251A1/en not_active Abandoned
- 1994-06-09 HU HU9501709A patent/HU9501709D0/hu unknown
- 1994-06-09 AT AT94917115T patent/ATE163409T1/de not_active IP Right Cessation
- 1994-06-09 ES ES94917115T patent/ES2112546T3/es not_active Expired - Lifetime
- 1994-06-09 DE DE69408668T patent/DE69408668T2/de not_active Expired - Fee Related
- 1994-06-09 US US08/255,613 patent/US5502048A/en not_active Expired - Fee Related
- 1994-06-09 NZ NZ266855A patent/NZ266855A/en unknown
- 1994-06-09 AU AU68544/94A patent/AU684789B2/en not_active Ceased
- 1994-06-09 JP JP7501484A patent/JPH08511513A/ja active Pending
- 1994-06-10 IL IL10996894A patent/IL109968A/xx not_active IP Right Cessation
- 1994-08-24 TW TW083107776A patent/TW282459B/zh active
-
1995
- 1995-10-19 US US08/547,696 patent/US5656626A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL109968A0 (en) | 1994-10-07 |
| US5502048A (en) | 1996-03-26 |
| ES2112546T3 (es) | 1998-04-01 |
| DK0702673T3 (da) | 1998-11-23 |
| US5656626A (en) | 1997-08-12 |
| NZ266855A (en) | 1997-09-22 |
| AU684789B2 (en) | 1998-01-08 |
| TW282459B (de) | 1996-08-01 |
| AU6854494A (en) | 1995-01-03 |
| ATE163409T1 (de) | 1998-03-15 |
| EP0702673A1 (de) | 1996-03-27 |
| JPH08511513A (ja) | 1996-12-03 |
| EP0702673B1 (de) | 1998-02-25 |
| GB9411242D0 (en) | 1994-07-27 |
| DE69408668D1 (de) | 1998-04-02 |
| HU9501709D0 (en) | 1996-03-28 |
| WO1994029275A1 (en) | 1994-12-22 |
| GB9311948D0 (en) | 1993-07-28 |
| DE69408668T2 (de) | 1998-07-09 |
| CA2161251A1 (en) | 1994-12-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL109968A (en) | Substituted nitrogen heterocycles process for their production and pharmaceutical compositions containing them | |
| IL117091A (en) | Methylphenyloxazolidinone derivatives pharmaceutical compositions containing the same and processes for the preparation threreof | |
| HUP0000323A3 (en) | N-substituted 2-cyanopyrrolidine derivatives, process for producing them and pharmaceutical compositions containing them | |
| HUP9603494A3 (en) | Hydroxycarboxamide derivatives, pharmaceutical compositions containing them, process for the preparation thereof | |
| HUP9802565A3 (en) | N-benzyl-dioxothiazolidinylmethyl-benzamide derivatives, pharmaceutical compositions containing them and process for producing the same | |
| ZA965752B (en) | Triphenylethylenes, process for their production, pharmaceutical preparations that contain these triphenylethylenes as well as their use for the production of pharmaceutical agents. | |
| UA32543C2 (uk) | Арилацетаміди, що мають анальгетичну дію, спосіб їх одержання, фармацевтична композиція та спосіб її одержання | |
| PL337499A1 (en) | Novel 2-(iminomethyl)aminophenylic derivatives, their production and application as drugs and pharmaceutic agents containing such derivatives | |
| AU6611396A (en) | New oxazolidinone derivatives, processes for the production thereof and pharmaceutical agents containing these compounds | |
| HUP0201937A3 (en) | Substituted 1,5-dihydropyrrol-2-on derivatives, process for producing them and pharmaceutical compositions containing them having nmda receptor antagonist effect | |
| NZ509762A (en) | 5-Azatricyclo[3.3.1.1<3,7>]decane derivatives, pharmaceuticals thereof, and their use as cholinergic receptor agonists and antagonists | |
| DE69330754T2 (de) | 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ[b]AZEPINE ALS NMDA REZEPTOR ANTAGONISTEN | |
| HUP9900040A3 (en) | Tetrahydroquinolines as nmda antagonists, process for producing them and pharmaceutical compositions containing them | |
| HUT67963A (en) | Benzodiazepine derivatives as cck-receptor antagonits and pharmaceutical compositions containing them | |
| HUP0001165A3 (en) | Acylaminoalkenylene-amide derivatives as nk1 and nk2 antagonists, pharmaceutical compositions containing them and process for producing them | |
| MX9708394A (es) | Composicion farmaceutica que contiene clorhidrato de tiagabina y el proceso para su preparacion. | |
| HUP9602640A2 (en) | Substituted benzoyl-guanidine derivatives, process for producing them, pharmaceutical compositions containing them and the use of the compds. | |
| BG102229A (en) | Endothelium receptor antagonists | |
| AU6921196A (en) | 5-ht3 receptor antagonists for dyskinesia | |
| ZA9610335B (en) | Amidinopyrroline derivatives, processes for their production and pharmaceutical agents containing these compounds. | |
| HUT72468A (en) | 17-(substituted by n-containing heteroring)-androstene derivatives and pharmaceutical compositions containing the same and process for producing them | |
| MX9606264A (es) | Compuestos de 1-fenil-2-dimetilaminometil-ciclohexan-1-ol como sustancias farmacologicas activas. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| MM9K | Patent not in force due to non-payment of renewal fees |