TW282459B - - Google Patents

Info

Publication number
TW282459B
TW282459B TW083107776A TW83107776A TW282459B TW 282459 B TW282459 B TW 282459B TW 083107776 A TW083107776 A TW 083107776A TW 83107776 A TW83107776 A TW 83107776A TW 282459 B TW282459 B TW 282459B
Authority
TW
Taiwan
Prior art keywords
substituent
azepines
benz
antagonists
alkynyl
Prior art date
Application number
TW083107776A
Other languages
English (en)
Inventor
David Mclaren Charles
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of TW282459B publication Critical patent/TW282459B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
TW083107776A 1993-06-10 1994-08-24 TW282459B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939311948A GB9311948D0 (en) 1993-06-10 1993-06-10 Substituted nitrogen heterocycles
GB9411242A GB9411242D0 (en) 1993-06-10 1994-06-06 Substituted nitrogen heterocycles

Publications (1)

Publication Number Publication Date
TW282459B true TW282459B (zh) 1996-08-01

Family

ID=10736919

Family Applications (1)

Application Number Title Priority Date Filing Date
TW083107776A TW282459B (zh) 1993-06-10 1994-08-24

Country Status (15)

Country Link
US (2) US5502048A (zh)
EP (1) EP0702673B1 (zh)
JP (1) JPH08511513A (zh)
AT (1) ATE163409T1 (zh)
AU (1) AU684789B2 (zh)
CA (1) CA2161251A1 (zh)
DE (1) DE69408668T2 (zh)
DK (1) DK0702673T3 (zh)
ES (1) ES2112546T3 (zh)
GB (2) GB9311948D0 (zh)
HU (1) HU9501709D0 (zh)
IL (1) IL109968A (zh)
NZ (1) NZ266855A (zh)
TW (1) TW282459B (zh)
WO (1) WO1994029275A1 (zh)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles
US5801168A (en) * 1994-06-09 1998-09-01 Zeneca Limited Substituted nitrogen heterocycles
US5977125A (en) 1994-10-31 1999-11-02 Eisai Co., Ltd. Mono-or polyenic carboxylic acid derivatives
US5476933A (en) * 1994-11-16 1995-12-19 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Azepine synthesis via a diels-alder reaction
IL126095A0 (en) * 1996-03-08 1999-05-09 Zeneca Ltd Azolobenzazepine derivatives as neurogically active agents
US6211235B1 (en) 1996-11-22 2001-04-03 Elan Pharmaceuticals, Inc. Compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6191166B1 (en) * 1997-11-21 2001-02-20 Elan Pharmaceuticals, Inc. Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6569851B1 (en) * 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) * 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US20050192265A1 (en) * 2003-03-20 2005-09-01 Thompson Richard C. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
GB0900641D0 (en) * 2009-01-15 2009-02-25 Syngenta Ltd Novel herbicides
GB0901835D0 (en) * 2009-02-04 2009-03-11 Syngenta Ltd Novel herbicides

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1340334A (en) * 1970-07-06 1973-12-12 Rees A H Synthesis of benzazetropolones and hence of kynurenic acids
JPS5129522B2 (zh) * 1972-07-13 1976-08-26
JPS5520970B2 (zh) * 1972-07-15 1980-06-06
CY1403A (en) * 1981-08-11 1987-12-18 Ciba Geigy Ag Benzazepin-2-ones
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4575503A (en) * 1983-02-10 1986-03-11 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4477446A (en) * 1983-07-01 1984-10-16 Usv Pharmaceutical Corporation 1-Benzazepines and their pharmaceutical uses
DE3416695A1 (de) * 1984-05-05 1985-11-07 Bayer Ag, 5090 Leverkusen Amidinohydrazone von tetralin-, chromon-, thiochromon- und tretrahydrochinolin-derivaten, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
US5322943A (en) * 1985-09-12 1994-06-21 The Upjohn Company Piperazine compounds which are substituted
US5266684A (en) * 1988-05-02 1993-11-30 The Reagents Of The University Of California Peptide mixtures
US4885364A (en) * 1988-11-23 1989-12-05 E. R. Squibb & Sons, Inc. Resolution process for benzazepine intermediates
US5229413A (en) * 1989-05-05 1993-07-20 G. D. Searle & Co. Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders
JPH0347123A (ja) * 1989-05-05 1991-02-28 G D Searle & Co インドール―２―カルボキシレート化合物類を含有するｃｎｓ疾患治療用組成物
US5026700A (en) * 1989-05-16 1991-06-25 Merrell Dow Pharmaceuticals Certain quinolines and thienopyridines as excitatory amino acid antagonists
CA2016465A1 (en) * 1989-06-02 1990-12-02 Zola Phillip Horovitz Method for preventing or treating anxiety employing a calcium channel blocker
JPH0334977A (ja) * 1989-06-29 1991-02-14 Yoshitomi Pharmaceut Ind Ltd イミダゾリルベンゾラクタム化合物
KR0167349B1 (ko) * 1989-10-20 1999-02-18 오스카 아끼히꼬 벤조헤테로 고리 화합물
US5622832A (en) * 1990-02-28 1997-04-22 Genetics Institute, Inc. Arachidonic acid releasing phospholipase A2 enzyme and methods of use
US5051442A (en) * 1990-04-25 1991-09-24 Merrell Dow Pharmaceuticals Inc. 3-indolyl thioacetate derivatives and NMDA receptor antagonistic use thereof
US5182366A (en) * 1990-05-15 1993-01-26 Huebner Verena D Controlled synthesis of peptide mixtures using mixed resins
DE69113115T2 (de) * 1990-05-31 1996-06-13 Merck Sharp & Dohme Dioxo-tetrahydrochinolinderivate.
GB9022785D0 (en) * 1990-10-19 1990-12-05 Merck Sharp & Dohme Therapeutic agents
US5189054A (en) * 1990-11-02 1993-02-23 Merrell Dow Pharmaceuticals Inc. 3-amidoindolyl derivatives and pharmaceutical compositions thereof
CA2054339C (en) * 1990-11-02 2002-12-24 Francesco G. Salituro 3-amidoindolyl derivatives
GB9026389D0 (en) * 1990-12-05 1991-01-23 Merck Sharp & Dohme Therapeutic agents
GB9100028D0 (en) * 1991-01-02 1991-02-20 Ici Plc Compounds
WO1992013535A1 (en) * 1991-02-06 1992-08-20 Research Corporation Technologies, Inc. Anticonvulsant substituted quinazolones
US5330768A (en) * 1991-07-05 1994-07-19 Massachusetts Institute Of Technology Controlled drug delivery using polymer/pluronic blends
EP0542689B1 (en) * 1991-11-15 1998-09-23 Phafag Aktiengesellschaft Use of 1-(aminoalkyl)-3-quinoxaline-2-on derivatives for the preparation of neuroprotective compositions
CA2087743C (en) * 1992-02-06 1999-04-27 Akio Odawara Pharmaceutical composition for inhibiting platelet aggregation
GB9206266D0 (en) * 1992-03-23 1992-05-06 Merck Sharp & Dohme Therapeutic agents
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
WO1994000124A1 (en) * 1992-06-22 1994-01-06 Eckard Weber Glycine receptor antagonists and the use thereof
CA2098446A1 (en) * 1992-09-30 1994-03-31 Eckard Weber 2,5-dihydro-2,5-dioxo-1h-azepines and 2,5-dihydro-2-oxo-1h-azepines and the use thereof as excitatory amino acid and glycine receptor antagonists
US5514690A (en) * 1992-11-17 1996-05-07 E. R. Squibb & Sons, Inc. Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of quinoline and indoline
US5428069A (en) * 1993-01-11 1995-06-27 The United States Of America As Represented By The Department Of Health & Human Services Treating cognition with, aminocyclopropanecarboxylic derivatives
AU6246394A (en) * 1993-02-22 1994-09-14 Cavalier Pharmaceuticals, Inc. Use of heparin to inhibit interleukin-8
ZA941290B (en) * 1993-02-26 1995-08-25 Res Dev Foundation Combination cisplatin/tamoxifen therapy for human cancers
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles

Also Published As

Publication number Publication date
AU6854494A (en) 1995-01-03
IL109968A (en) 1999-11-30
CA2161251A1 (en) 1994-12-22
WO1994029275A1 (en) 1994-12-22
GB9311948D0 (en) 1993-07-28
GB9411242D0 (en) 1994-07-27
DK0702673T3 (da) 1998-11-23
DE69408668D1 (de) 1998-04-02
EP0702673A1 (en) 1996-03-27
IL109968A0 (en) 1994-10-07
US5656626A (en) 1997-08-12
DE69408668T2 (de) 1998-07-09
NZ266855A (en) 1997-09-22
HU9501709D0 (en) 1996-03-28
ATE163409T1 (de) 1998-03-15
EP0702673B1 (en) 1998-02-25
US5502048A (en) 1996-03-26
ES2112546T3 (es) 1998-04-01
JPH08511513A (ja) 1996-12-03
AU684789B2 (en) 1998-01-08

Similar Documents

Publication Publication Date Title
TW282459B (zh)
AU6310696A (en) Substituted dihydrodibenz/b,f/azepines useful for treating nervous system disorders
MY117251A (en) Use of central cannabinoid receptor antagonists for the preparation of drugs
AU3153097A (en) Pharmaceutical for treatment of neurological and neuropsychiatric disorders
AU3642795A (en) Endothelin receptor antagonists for the treatment of emesis
IL117091A (en) Methylphenyloxazolidinone derivatives pharmaceutical compositions containing the same and processes for the preparation threreof
ZA200201788B (en) Substituted 1,5-dihydropyrrol-2-on derivatives as NMDA receptor antagonists for the treatment of pain.
DE69330754T2 (de) 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ[b]AZEPINE ALS NMDA REZEPTOR ANTAGONISTEN
MY127686A (en) Monofluoroalkyl derivatives
EP0759441A3 (en) Methods of treating neuropeptide Y-associated conditions
AU3745795A (en) Use of CCK-B receptor antagonists for the treatment of sleepdisorders
AU7671198A (en) Methods for the inhibition of neuronal activity by local delivery of adenosi ne
ZA978792B (en) N-substituted azaheterocyclic compounds.
NZ329839A (en) Combination of a compound which inhibits acetylcholinesterase or exhibits muscarinergic action and a compound which increases the endogenous extracellular adenosine level for treating dementia
AU1160700A (en) Ppar gamma ligands
ZA961172B (en) Open cast mining apparatus.
ZA983842B (en) Processes and intermediates for preparing substituted indazole derivatives.
MX9706744A (es) Proceso novedosos para preparar derivados de 2,3-dihidro-benzofuranol.
EP0754464A3 (en) Methods of treating neuropeptide Y-associated conditions
EP1248617A4 (en) NEW NMDA / NR2B ANTAGONISTS OF 2-AZA-BICYCLO 2.2.2] OCTANE
ZA966452B (en) Process for the preparation of substituted aminocarbonyltriazolinones.
MY123517A (en) Process for preparing 10, 11-methanobenzosuberane derivatives
PL322253A1 (en) Application of antiestrogenes in controlling male fetrility
AU6921196A (en) 5-ht3 receptor antagonists for dyskinesia
ZA9711057B (en) Process for the preparation of nmda antagonists.