IL109580A - Monomeric bile acid derivatives processes for their preparation and the use of these compounds as medicaments - Google Patents

Monomeric bile acid derivatives processes for their preparation and the use of these compounds as medicaments

Info

Publication number
IL109580A
IL109580A IL10958094A IL10958094A IL109580A IL 109580 A IL109580 A IL 109580A IL 10958094 A IL10958094 A IL 10958094A IL 10958094 A IL10958094 A IL 10958094A IL 109580 A IL109580 A IL 109580A
Authority
IL
Israel
Prior art keywords
bile acid
mmol
compounds
acid
mixture
Prior art date
Application number
IL10958094A
Other languages
English (en)
Other versions
IL109580A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL109580A0 publication Critical patent/IL109580A0/xx
Publication of IL109580A publication Critical patent/IL109580A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL10958094A 1993-05-08 1994-05-06 Monomeric bile acid derivatives processes for their preparation and the use of these compounds as medicaments IL109580A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4315439 1993-05-08

Publications (2)

Publication Number Publication Date
IL109580A0 IL109580A0 (en) 1994-08-26
IL109580A true IL109580A (en) 1999-03-12

Family

ID=6487634

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10958094A IL109580A (en) 1993-05-08 1994-05-06 Monomeric bile acid derivatives processes for their preparation and the use of these compounds as medicaments

Country Status (18)

Country Link
US (1) US5610151A (cg-RX-API-DMAC7.html)
EP (1) EP0624594B1 (cg-RX-API-DMAC7.html)
JP (1) JP3424978B2 (cg-RX-API-DMAC7.html)
KR (1) KR100333151B1 (cg-RX-API-DMAC7.html)
AT (1) ATE183191T1 (cg-RX-API-DMAC7.html)
AU (1) AU673419B2 (cg-RX-API-DMAC7.html)
CA (1) CA2123052C (cg-RX-API-DMAC7.html)
CZ (1) CZ289209B6 (cg-RX-API-DMAC7.html)
DE (1) DE59408602D1 (cg-RX-API-DMAC7.html)
DK (1) DK0624594T3 (cg-RX-API-DMAC7.html)
ES (1) ES2136677T3 (cg-RX-API-DMAC7.html)
FI (1) FI942077L (cg-RX-API-DMAC7.html)
GR (1) GR3031541T3 (cg-RX-API-DMAC7.html)
HU (1) HUT67574A (cg-RX-API-DMAC7.html)
IL (1) IL109580A (cg-RX-API-DMAC7.html)
NO (1) NO304794B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ260471A (cg-RX-API-DMAC7.html)
TW (1) TW289021B (cg-RX-API-DMAC7.html)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
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ES2111092T3 (es) * 1992-06-12 1998-03-01 Hoechst Ag Derivados de acidos biliares, procedimiento para su preparacion y utilizacion de estos compuestos como medicamentos.
TW289020B (cg-RX-API-DMAC7.html) * 1993-05-08 1996-10-21 Hoechst Sktiengesellschaft
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6107494A (en) * 1994-09-13 2000-08-22 G.D. Searle And Company Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
DE19845403B4 (de) * 1998-10-02 2005-02-10 Aventis Pharma Deutschland Gmbh Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19849722A1 (de) * 1998-10-28 2000-05-04 Aventis Pharma Gmbh Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
MXPA01006470A (es) * 1998-12-23 2003-06-06 Searle Llc Combinaciones de inhibidores de transporte de acido biliar ileal y agentes de secuentro de acido biliar para indicaciones cardiovasculares.
US6462091B1 (en) 1998-12-23 2002-10-08 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications
DK1140189T3 (da) 1998-12-23 2003-09-15 Searle Llc Kombinationer af ileal galdesyre-transportinhibitorer og fibrinsyrederivater til cardiovaskulære indikationer
EP1340509A1 (en) * 1998-12-23 2003-09-03 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
US6489366B1 (en) * 1998-12-23 2002-12-03 G. D. Searle, Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
EP1340510A1 (en) 1998-12-23 2003-09-03 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
CZ20012344A3 (cs) * 1998-12-23 2002-01-16 G. D. Searle Llc Kombinace pro kardiovaskulární indikace
ES2200587T3 (es) * 1998-12-23 2004-03-01 G.D. Searle Llc Combinaciones de inhibidors del transporte de acidos biliares del ileon e inhibidores de la proteina de transferencia de colesteril ester para indicaciones cardiovasculares.
DE19941764A1 (de) 1999-09-02 2001-03-15 Aventis Pharma Gmbh Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente
EE200200143A (et) * 1999-09-22 2003-04-15 Aventis Pharma Deutschland Gmbh 4-bensüülaminokinoliini konjugaadid sapphappega ja nende heteroanaloogid, nende valmistamismeetod ning neid ühendeid sisaldavad ravimid ja nende kasutamine
US20020061888A1 (en) * 2000-03-10 2002-05-23 Keller Bradley T. Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
US6586434B2 (en) 2000-03-10 2003-07-01 G.D. Searle, Llc Method for the preparation of tetrahydrobenzothiepines
US6624155B2 (en) * 2001-05-01 2003-09-23 Board Of Trustees Of The University Of Arkansas Hybrid cholinergic agents and compositions
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JP2005518347A (ja) * 2001-11-02 2005-06-23 ジー．ディー． サール エルエルシー 頂端ナトリウム共依存性胆汁酸輸送（ａｓｂｔ）およびタウロコール酸塩取り込みの阻害剤としての新規一および二フッ化ベンゾチエピン化合物
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Also Published As

Publication number Publication date
FI942077A0 (fi) 1994-05-05
IL109580A0 (en) 1994-08-26
ATE183191T1 (de) 1999-08-15
CA2123052A1 (en) 1994-11-09
HU9401408D0 (en) 1994-08-29
NO941680L (no) 1994-11-09
EP0624594A3 (de) 1996-05-01
ES2136677T3 (es) 1999-12-01
FI942077A7 (fi) 1994-11-09
AU6194994A (en) 1994-11-10
CZ289209B6 (cs) 2001-12-12
JP3424978B2 (ja) 2003-07-07
US5610151A (en) 1997-03-11
NO941680D0 (no) 1994-05-06
CA2123052C (en) 2005-04-26
KR100333151B1 (ko) 2002-09-04
DE59408602D1 (de) 1999-09-16
TW289021B (cg-RX-API-DMAC7.html) 1996-10-21
FI942077L (fi) 1994-11-09
AU673419B2 (en) 1996-11-07
NO304794B1 (no) 1999-02-15
JPH072891A (ja) 1995-01-06
NZ260471A (en) 1995-04-27
CZ113794A3 (en) 1994-11-16
HUT67574A (en) 1995-04-28
EP0624594A2 (de) 1994-11-17
DK0624594T3 (da) 1999-12-13
GR3031541T3 (en) 2000-01-31
EP0624594B1 (de) 1999-08-11

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