IL109177A - Inhibitor of stem cell proliferation antibody thereto pharmaceutical compositions containing the inhibitor its use in the manufacture of medicaments and in an in vitro method for treating bone marrow and gene comprising a recombinant DNA encoding such protein inhibitor - Google Patents
Inhibitor of stem cell proliferation antibody thereto pharmaceutical compositions containing the inhibitor its use in the manufacture of medicaments and in an in vitro method for treating bone marrow and gene comprising a recombinant DNA encoding such protein inhibitorInfo
- Publication number
- IL109177A IL109177A IL10917794A IL10917794A IL109177A IL 109177 A IL109177 A IL 109177A IL 10917794 A IL10917794 A IL 10917794A IL 10917794 A IL10917794 A IL 10917794A IL 109177 A IL109177 A IL 109177A
- Authority
- IL
- Israel
- Prior art keywords
- inhibitor
- stem cell
- medicaments
- cell proliferation
- gene
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11547395A IL115473A (en) | 1994-03-30 | 1995-09-29 | Pharmaceutical compositions and compounds for inhibition of stem cell proliferation, use of such compounds in the manufacture of medicaments for this purpose, and in vitro methods for treating bone marrow and for preparing hematopoietic cells for therapy |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4094293A | 1993-03-31 | 1993-03-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL109177A0 IL109177A0 (en) | 1994-06-24 |
IL109177A true IL109177A (en) | 2000-12-06 |
Family
ID=21913839
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10917794A IL109177A (en) | 1993-03-31 | 1994-03-30 | Inhibitor of stem cell proliferation antibody thereto pharmaceutical compositions containing the inhibitor its use in the manufacture of medicaments and in an in vitro method for treating bone marrow and gene comprising a recombinant DNA encoding such protein inhibitor |
Country Status (17)
Country | Link |
---|---|
US (3) | US6022848A (ru) |
EP (1) | EP0691988B1 (ru) |
JP (1) | JPH08510997A (ru) |
CN (1) | CN1089344C (ru) |
AT (1) | ATE225370T1 (ru) |
AU (1) | AU694111B2 (ru) |
CA (1) | CA2159506A1 (ru) |
DE (1) | DE69431473T2 (ru) |
DK (1) | DK0691988T3 (ru) |
ES (1) | ES2185649T3 (ru) |
IL (1) | IL109177A (ru) |
NZ (1) | NZ263736A (ru) |
PT (1) | PT691988E (ru) |
RU (1) | RU2155066C2 (ru) |
TW (1) | TW403761B (ru) |
UA (1) | UA40613C2 (ru) |
WO (1) | WO1994022915A1 (ru) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69431473T2 (de) * | 1993-03-31 | 2003-08-07 | Pro-Neuron, Inc. | Inhibitor der stammzellproliferation und seine verwendung |
AU712204C (en) * | 1993-03-31 | 2004-02-26 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
US6610654B2 (en) * | 1993-03-31 | 2003-08-26 | Wellstat Therapeutics Corporation | Inhibitor of stem cell proliferation and uses thereof |
US5861483A (en) | 1996-04-03 | 1999-01-19 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
AU762472B2 (en) | 1998-03-13 | 2003-06-26 | University Of British Columbia, The | Therapeutic chemokine receptor antagonists |
CA2305787A1 (en) * | 2000-05-09 | 2001-11-09 | The University Of British Columbia | Cxcr4 antagonist treatment of hematopoietic cells |
CA2245224A1 (en) * | 1998-08-14 | 2000-02-14 | Jiang-Hong Giong | Chemokine receptor antagonists and chemotherapeutics |
US7378098B2 (en) * | 2000-04-12 | 2008-05-27 | The University Of British Columbia | CXC chemokine receptor 4 agonist peptides |
CA2335109A1 (en) * | 2000-04-12 | 2001-10-12 | Chemokine Therapeutics Corporation | Cxcr4 agonist treatment of hematopoietic cells |
US20050059584A1 (en) * | 2002-08-16 | 2005-03-17 | Ahmed Merzouk | Novel chemokine mimetics synthesis and their use |
US7368425B2 (en) * | 2006-03-24 | 2008-05-06 | Chemokine Therapeutics Corp. | Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis |
WO2002046373A1 (en) * | 2000-12-06 | 2002-06-13 | Hariri Robert J | Method of collecting placental stem cells |
US7311905B2 (en) * | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
US20080152629A1 (en) * | 2000-12-06 | 2008-06-26 | James Edinger | Placental stem cell populations |
EP2316919B1 (en) * | 2001-02-14 | 2015-10-07 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
US6515001B2 (en) | 2001-03-05 | 2003-02-04 | Chemokine Therapeutic Corporation | IL-8 receptor ligands-drugs for inflammatory and autoimmune diseases |
US7498171B2 (en) * | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
CN1668733A (zh) * | 2002-05-30 | 2005-09-14 | 细胞基因公司 | 利用jnk或mkk抑制剂调节细胞分化并治疗骨髓增生异常和脊髓发育不良综合症的方法 |
WO2004012765A1 (fr) * | 2002-08-02 | 2004-02-12 | Oleg Iliich Epshtein | Preparation medicinale et procede de traitement d'un syndrome pathologique determine par une perturbation de l'hematopoiese |
WO2004047770A2 (en) * | 2002-11-26 | 2004-06-10 | Anthrogenesis Corporation | Cytotherapeutics, cytotherapeutic units and methods for treatments using them |
NZ542127A (en) * | 2003-02-13 | 2008-04-30 | Anthrogenesis Corp | Use of umbilical cord blood to treat individuals having a disease, disorder or condition |
GB0321337D0 (en) * | 2003-09-11 | 2003-10-15 | Massone Mobile Advertising Sys | Method and system for distributing advertisements |
EP1694328A4 (en) * | 2003-12-02 | 2010-02-17 | Celgene Corp | METHOD AND COMPOSITIONS FOR THE TREATMENT AND SUPPLY OF HEMOGLOBINOPATHY AND ANEMIA |
CA2558289C (en) * | 2004-08-18 | 2018-05-15 | Ipf Pharmaceuticals Gmbh | Peptides for the treatment of herpes virus infections |
RU2283654C1 (ru) * | 2005-03-30 | 2006-09-20 | Борис Владимирович Афанасьев | Способ получения ростовых факторов белковой природы, ростовой фактор белковой природы и ингибитор пролиферации фибробластов |
NZ612132A (en) | 2005-10-13 | 2015-01-30 | Anthrogenesis Corp | Immunomodulation using placental stem cells |
EP1976978A2 (en) | 2005-12-29 | 2008-10-08 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
CN108559725A (zh) | 2005-12-29 | 2018-09-21 | 人类起源公司 | 胎盘干细胞群 |
KR101496745B1 (ko) * | 2006-06-09 | 2015-03-04 | 가부시키가이샤 야쿠르트 혼샤 | 인간 암세포의 불사화에 관련되는 유전자 및 그 용도 |
EP3103462A1 (en) | 2007-02-12 | 2016-12-14 | Anthrogenesis Corporation | Treatment of inflammatory diseases using placental stem cells |
US20100172830A1 (en) * | 2007-03-29 | 2010-07-08 | Cellx Inc. | Extraembryonic Tissue cells and method of use thereof |
TWM322542U (en) * | 2007-05-23 | 2007-11-21 | Universal Scient Ind Co Ltd | Testing machine |
US9200253B1 (en) | 2007-08-06 | 2015-12-01 | Anthrogenesis Corporation | Method of producing erythrocytes |
RU2010116271A (ru) * | 2007-09-26 | 2011-11-10 | Селджин Селльюлар Терапьютикс (Us) | Ангиогенные клетки из плацентарного перфузата человека |
KR20190132556A (ko) * | 2007-09-28 | 2019-11-27 | 안트로제네시스 코포레이션 | 인간 태반 관류액 및 인간 태반-유래 중간체 천연 킬러 세포를 사용한 종양 억제 방법 |
DK2217329T3 (en) * | 2007-11-07 | 2018-04-23 | Anthrogenesis Corp | APPLICATION OF NAVLINE BLOOD IN THE TREATMENT OF COMPLIANCES IN CONNECTION WITH PREGNANCY BIRTH |
PL2942392T3 (pl) * | 2008-06-30 | 2019-02-28 | Janssen Biotech, Inc | Różnicowanie pluripotencjalnych komórek macierzystych |
NZ591294A (en) * | 2008-08-20 | 2012-10-26 | Anthrogenesis Corp | Treatment of stroke using isolated placental cells |
MX339624B (es) * | 2008-08-20 | 2016-06-02 | Anthrogenesis Corp | Composiciones mejoradas de celulas y metodos para preparar las mismas. |
AU2009283161A1 (en) * | 2008-08-22 | 2010-02-25 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
JP5869342B2 (ja) * | 2008-11-19 | 2016-02-24 | アンスロジェネシス コーポレーション | 羊膜由来接着細胞 |
DK2375907T3 (da) * | 2008-11-21 | 2019-06-11 | Celularity Inc | Behandling af sygdomme, lidelser eller tilstande i lungerne under anvendelse af placentaceller |
NZ619359A (en) | 2009-07-02 | 2015-07-31 | Anthrogenesis Corp | Method of producing erythrocytes without feeder cells |
CA2787992A1 (en) * | 2010-01-26 | 2011-08-04 | Anthrogenesis Corporation | Treatment of bone-related cancers using placental stem cells |
TW201703777A (zh) | 2010-04-07 | 2017-02-01 | 安瑟吉納西斯公司 | 利用胎盤幹細胞之血管新生 |
US8562973B2 (en) | 2010-04-08 | 2013-10-22 | Anthrogenesis Corporation | Treatment of sarcoidosis using placental stem cells |
MX342995B (es) | 2010-07-13 | 2016-10-21 | Anthrogenesis Corp | Métodos de generar células asesinas naturales. |
AU2011352036A1 (en) | 2010-12-31 | 2013-07-18 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory RNA molecules |
CN113559126A (zh) | 2011-06-01 | 2021-10-29 | 人类起源公司 | 利用胎盘干细胞治疗疼痛 |
US9925221B2 (en) | 2011-09-09 | 2018-03-27 | Celularity, Inc. | Treatment of amyotrophic lateral sclerosis using placental stem cells |
US9763983B2 (en) | 2013-02-05 | 2017-09-19 | Anthrogenesis Corporation | Natural killer cells from placenta |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1142466A (en) * | 1979-01-09 | 1983-03-08 | Cesar Milstein | Cell lines |
US4683194A (en) * | 1984-05-29 | 1987-07-28 | Cetus Corporation | Method for detection of polymorphic restriction sites and nucleic acid sequences |
GB8711614D0 (en) * | 1987-05-16 | 1987-06-24 | Medical Res Council | Proteins |
US5449759A (en) * | 1987-05-16 | 1995-09-12 | Somatogen, Inc. | Hemoglobins with intersubunit desulfide bonds |
US5545727A (en) * | 1989-05-10 | 1996-08-13 | Somatogen, Inc. | DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin |
SG47987A1 (en) * | 1989-05-10 | 1998-04-17 | Somatogen Inc | Production in bacteria and yeast of haemoglobin and analogues thereof |
DK0494268T4 (da) * | 1989-09-25 | 1999-11-08 | Genetics Inst | Fremgangsmåde til inhibering af stamcellers vækst |
US5239061A (en) * | 1990-06-20 | 1993-08-24 | Research Corporation Technologies, Inc. | Modified human hemoglobin, blood substitutes containing the same, and vectors for expressing the modified hemoglobin |
CA2098818A1 (en) * | 1990-12-20 | 1992-06-21 | Tim Townes | Transgenic, cross-linked hemoglobin |
WO1992020369A1 (en) | 1991-05-14 | 1992-11-26 | Dana Farber Cancer Institute | Use of hemoglobin in a method for the treatment of tumors with chemotherapeutic agents |
US5334706A (en) | 1992-01-30 | 1994-08-02 | Baxter International | Administration of low dose hemoglobin to increase perfusion |
US5786334A (en) | 1992-08-14 | 1998-07-28 | Technology Resources International, Inc. | Hexapeptide having immunostimulatory activity |
DE69431473T2 (de) * | 1993-03-31 | 2003-08-07 | Pro-Neuron, Inc. | Inhibitor der stammzellproliferation und seine verwendung |
US5939391A (en) | 1993-03-31 | 1999-08-17 | Pro-Neuron, Inc. | Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation |
US5631219A (en) | 1994-03-08 | 1997-05-20 | Somatogen, Inc. | Method of stimulating hematopoiesis with hemoglobin |
US5861483A (en) | 1996-04-03 | 1999-01-19 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
-
1994
- 1994-03-29 DE DE69431473T patent/DE69431473T2/de not_active Expired - Fee Related
- 1994-03-29 WO PCT/US1994/003349 patent/WO1994022915A1/en active IP Right Grant
- 1994-03-29 AU AU64937/94A patent/AU694111B2/en not_active Ceased
- 1994-03-29 RU RU95119854/14A patent/RU2155066C2/ru active
- 1994-03-29 CA CA002159506A patent/CA2159506A1/en not_active Abandoned
- 1994-03-29 DK DK94912327T patent/DK0691988T3/da active
- 1994-03-29 EP EP94912327A patent/EP0691988B1/en not_active Expired - Lifetime
- 1994-03-29 CN CN94192220A patent/CN1089344C/zh not_active Expired - Fee Related
- 1994-03-29 NZ NZ263736A patent/NZ263736A/xx not_active IP Right Cessation
- 1994-03-29 AT AT94912327T patent/ATE225370T1/de not_active IP Right Cessation
- 1994-03-29 UA UA95094339A patent/UA40613C2/ru unknown
- 1994-03-29 JP JP6522261A patent/JPH08510997A/ja active Pending
- 1994-03-29 PT PT94912327T patent/PT691988E/pt unknown
- 1994-03-29 ES ES94912327T patent/ES2185649T3/es not_active Expired - Lifetime
- 1994-03-30 IL IL10917794A patent/IL109177A/xx not_active IP Right Cessation
- 1994-04-08 TW TW083103091A patent/TW403761B/zh not_active IP Right Cessation
- 1994-09-30 US US08/316,424 patent/US6022848A/en not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/477,669 patent/US6432917B1/en not_active Expired - Fee Related
-
2001
- 2001-04-23 US US09/839,164 patent/US20020098583A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IL109177A0 (en) | 1994-06-24 |
RU2155066C2 (ru) | 2000-08-27 |
PT691988E (pt) | 2003-02-28 |
EP0691988A4 (en) | 1997-07-30 |
US6022848A (en) | 2000-02-08 |
UA40613C2 (ru) | 2001-08-15 |
TW403761B (en) | 2000-09-01 |
AU6493794A (en) | 1994-10-24 |
US20020098583A1 (en) | 2002-07-25 |
CN1089344C (zh) | 2002-08-21 |
EP0691988A1 (en) | 1996-01-17 |
CN1124491A (zh) | 1996-06-12 |
WO1994022915A1 (en) | 1994-10-13 |
NZ263736A (en) | 2000-12-22 |
CA2159506A1 (en) | 1994-10-13 |
JPH08510997A (ja) | 1996-11-19 |
ES2185649T3 (es) | 2003-05-01 |
US6432917B1 (en) | 2002-08-13 |
AU694111B2 (en) | 1998-07-16 |
DE69431473D1 (de) | 2002-11-07 |
ATE225370T1 (de) | 2002-10-15 |
DE69431473T2 (de) | 2003-08-07 |
EP0691988B1 (en) | 2002-10-02 |
DK0691988T3 (da) | 2003-04-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |