IL108754A0 - 2-benzyl-polycyclic guanine derivatives and process for preparing them - Google Patents

2-benzyl-polycyclic guanine derivatives and process for preparing them

Info

Publication number
IL108754A0
IL108754A0 IL10875494A IL10875494A IL108754A0 IL 108754 A0 IL108754 A0 IL 108754A0 IL 10875494 A IL10875494 A IL 10875494A IL 10875494 A IL10875494 A IL 10875494A IL 108754 A0 IL108754 A0 IL 108754A0
Authority
IL
Israel
Prior art keywords
benzyl
preparing
guanine derivatives
polycyclic guanine
polycyclic
Prior art date
Application number
IL10875494A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of IL108754A0 publication Critical patent/IL108754A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL10875494A 1993-02-26 1994-02-24 2-benzyl-polycyclic guanine derivatives and process for preparing them IL108754A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2354993A 1993-02-26 1993-02-26
US2459993A 1993-02-26 1993-02-26

Publications (1)

Publication Number Publication Date
IL108754A0 true IL108754A0 (en) 1994-06-24

Family

ID=26697306

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10875494A IL108754A0 (en) 1993-02-26 1994-02-24 2-benzyl-polycyclic guanine derivatives and process for preparing them

Country Status (14)

Country Link
US (1) US5939419A (member.php)
EP (1) EP0686157A1 (member.php)
JP (1) JPH08507068A (member.php)
KR (1) KR960701058A (member.php)
CN (1) CN1118600A (member.php)
AU (1) AU681875B2 (member.php)
CA (1) CA2156918A1 (member.php)
FI (1) FI953981A0 (member.php)
HU (1) HUT72640A (member.php)
IL (1) IL108754A0 (member.php)
NZ (1) NZ262797A (member.php)
SG (1) SG43809A1 (member.php)
TW (1) TW270118B (member.php)
WO (1) WO1994019351A1 (member.php)

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US6403799B1 (en) * 1999-10-21 2002-06-11 Agouron Pharmaceuticals, Inc. Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
ATE395349T1 (de) * 2001-08-28 2008-05-15 Schering Corp Polycyclische guanin phosphodiesterase inhibitoren
EP1790652A1 (en) * 2001-08-28 2007-05-30 Schering Corporation Polycyclic guanine phosphodiesterase V inhibitors
AU2002324846B2 (en) 2001-08-31 2007-05-10 Childrens Hospital Medical Center Phosphodiesterase activity and regulation of phosphodiesterase 1-B-mediated signaling in brain
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US8859564B2 (en) 2008-12-06 2014-10-14 Intra-Cellular Therapies, Inc. Pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione derivatives useful as inhibitors of phosphodiesterase 1
US11464781B2 (en) 2009-02-25 2022-10-11 Intra-Cellular Therapies, Inc. PDE1 inhibitors for ophthalmic disorders
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ES2745819T3 (es) 2014-08-07 2020-03-03 Intra Cellular Therapies Inc Derivados de imidazo[1,2-a]-pirazolo[4,3-e]-pirimidin-4-ona con actividad inhibidora de la PDE1
HK1243342A1 (zh) 2014-09-17 2018-07-13 Intra-Cellular Therapies, Inc. 化合物和方法
CA2969597C (en) 2014-12-06 2023-10-24 Intra-Cellular Therapies, Inc. 1h-pyrazolo[4,3-c][1,5]naphthyridin-4(5h)-one compounds and their use as pde2 inhibitors
CN107205999B (zh) 2014-12-06 2021-08-03 细胞内治疗公司 有机化合物
JP6770775B2 (ja) 2015-10-16 2020-10-21 アッヴィ・インコーポレイテッド （３Ｓ，４Ｒ）−３−エチル−４−（３Ｈ−イミダゾ［１，２−ａ］ピロロ［２，３−ｅ］−ピラジン−８−イル）−Ｎ−（２，２，２−トリフルオロエチル）ピロリジン−１−カルボキサミドおよびそれの固体型の製造方法
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Also Published As

Publication number Publication date
WO1994019351A1 (en) 1994-09-01
EP0686157A1 (en) 1995-12-13
AU681875B2 (en) 1997-09-11
CN1118600A (zh) 1996-03-13
AU6268794A (en) 1994-09-14
KR960701058A (ko) 1996-02-24
FI953981A7 (fi) 1995-08-24
HU9502464D0 (en) 1995-10-30
HUT72640A (en) 1996-05-28
TW270118B (member.php) 1996-02-11
FI953981A0 (fi) 1995-08-24
JPH08507068A (ja) 1996-07-30
SG43809A1 (en) 1997-11-14
CA2156918A1 (en) 1994-09-01
US5939419A (en) 1999-08-17
NZ262797A (en) 1997-08-22

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