IL108581A0 - Process for the preparation of taxol, taxol analogues, and their intermediates - Google Patents
Process for the preparation of taxol, taxol analogues, and their intermediatesInfo
- Publication number
- IL108581A0 IL108581A0 IL10858194A IL10858194A IL108581A0 IL 108581 A0 IL108581 A0 IL 108581A0 IL 10858194 A IL10858194 A IL 10858194A IL 10858194 A IL10858194 A IL 10858194A IL 108581 A0 IL108581 A0 IL 108581A0
- Authority
- IL
- Israel
- Prior art keywords
- taxol
- intermediates
- analogs
- synthesis
- preparation
- Prior art date
Links
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 7
- 229930012538 Paclitaxel Natural products 0.000 title abstract 5
- 229960001592 paclitaxel Drugs 0.000 title abstract 5
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical compound O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 abstract 4
- BMYNFMYTOJXKLE-UHFFFAOYSA-N DL-isoserine Natural products NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 2
- 229930014667 baccatin III Natural products 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- RZARFIRJROUVLM-UHFFFAOYSA-N 3-azaniumyl-2-hydroxy-3-phenylpropanoate Chemical class OC(=O)C(O)C(N)C1=CC=CC=C1 RZARFIRJROUVLM-UHFFFAOYSA-N 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 238000005222 photoaffinity labeling Methods 0.000 abstract 1
- 125000002456 taxol group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1509593A | 1993-02-05 | 1993-02-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL108581A0 true IL108581A0 (en) | 1994-05-30 |
Family
ID=21769500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10858194A IL108581A0 (en) | 1993-02-05 | 1994-02-07 | Process for the preparation of taxol, taxol analogues, and their intermediates |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US5770745A (xx) |
| EP (2) | EP1260507A1 (xx) |
| JP (1) | JP3031715B2 (xx) |
| CN (2) | CN1102829A (xx) |
| AT (1) | ATE253563T1 (xx) |
| AU (1) | AU695530B2 (xx) |
| BR (1) | BR9405687C1 (xx) |
| CA (1) | CA2155304C (xx) |
| DE (1) | DE69433297T2 (xx) |
| IL (1) | IL108581A0 (xx) |
| NZ (1) | NZ262030A (xx) |
| WO (1) | WO1994018186A1 (xx) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5973160A (en) * | 1992-12-23 | 1999-10-26 | Poss; Michael A. | Methods for the preparation of novel sidechain-bearing taxanes |
| EP1260507A1 (en) | 1993-02-05 | 2002-11-27 | Bryn Mawr College | Synthesis of taxol, analogs and intermediates with variable A-nng side chains |
| US5684175A (en) * | 1993-02-05 | 1997-11-04 | Napro Biotherapeutics, Inc. | C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor |
| US5442065A (en) * | 1993-09-09 | 1995-08-15 | Board Of Regents, The University Of Texas System | Synthesis of tetrahydroquinoline enediyne core analogs of dynemicin |
| US5677470A (en) * | 1994-06-28 | 1997-10-14 | Tanabe Seiyaku Co., Ltd. | Baccatin derivatives and processes for preparing the same |
| CA2162759A1 (en) * | 1994-11-17 | 1996-05-18 | Kenji Tsujihara | Baccatin derivatives and processes for preparing the same |
| WO1998013359A1 (de) * | 1996-09-24 | 1998-04-02 | Marigen S.A. | Ultramikroemulsionen aus spontan dispergierbaren konzentraten mit antitumoral und antiviral wirksamen estern von baccatin-iii-verbindungen |
| US5750737A (en) * | 1996-09-25 | 1998-05-12 | Sisti; Nicholas J. | Method for paclitaxel synthesis |
| CA2188190A1 (en) * | 1996-10-18 | 1998-04-18 | Sarala Balachandran | The semi-synthesis of a protected bacatin iii compound |
| US6150537A (en) | 1997-12-12 | 2000-11-21 | Emory University | Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents |
| US6020507A (en) * | 1998-03-02 | 2000-02-01 | Bristol-Myers Squibb Company | Synthesis of paclitaxel from baccatin III by protection of the 7-hydroxyl of baccatin III using a strong base and an electrophile |
| IL139316A0 (en) | 1998-05-01 | 2001-11-25 | Napro Biotherapeutics Inc | Methods and intermediate compounds for preparing paclitaxel |
| FI981717A (fi) | 1998-08-07 | 2000-02-08 | Borealis As | Katalysaattorikomponentti, joka käsittää magnesiumia, titaania, halogeenia ja elektronidonorin, sen valmistus ja käyttö |
| US6025516A (en) * | 1998-10-14 | 2000-02-15 | Chiragene, Inc. | Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes |
| AU776216B2 (en) * | 1999-05-28 | 2004-09-02 | Bristol-Myers Squibb Company | Semi-synthesis of paclitaxel using dialkyldichlorosilanes |
| US6136999A (en) * | 1999-06-21 | 2000-10-24 | Napro Biotherapeutics, Inc. | C-2 hydroxyl protected-n-acyl (2R,3S)-3-phenylisoserine substituted phenyl activated esters and method for production thereof |
| US6143902A (en) * | 1999-06-21 | 2000-11-07 | Napro Biotherapeutics, Inc. | C-2 hydroxyl protected-N-acyl (2R,3S)-3-phenylisoserine N-imido activated esters and method for production thereof |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| JP2003522170A (ja) * | 2000-02-02 | 2003-07-22 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | 抗腫瘍剤としてのｃ７カーボネート置換タキサン |
| PT1165549E (pt) * | 2000-02-02 | 2008-06-20 | Univ Florida State Res Found | Taxanos substituídos em c7 por carbamoíloxi como agentes anti-tumorais |
| US6452024B1 (en) | 2000-02-22 | 2002-09-17 | Chaichem Pharmaceuticals International | Process for extraction and purification of paclitaxel from natural sources |
| US6362217B2 (en) * | 2000-03-17 | 2002-03-26 | Bristol-Myers Squibb Company | Taxane anticancer agents |
| US6358996B1 (en) | 2000-06-09 | 2002-03-19 | Napro Biotherapeutics, Inc. | Stable isotope labeling of paclitaxel |
| WO2001098286A1 (en) * | 2000-06-22 | 2001-12-27 | Nitromed, Inc. | Nitrosated and nitrosylated taxanes, compositions and methods of use |
| ATE352052T1 (de) * | 2000-08-18 | 2007-02-15 | Nikon Corp | Haltevorrichtung für optisches element |
| AU2001288805A1 (en) | 2000-09-22 | 2002-04-02 | Bristol-Myers Squibb Company | Method for reducing toxicity of combined chemotherapies |
| IL157993A0 (en) * | 2001-03-23 | 2004-03-28 | Napro Biotherapeutics Inc | Molecular conjugates for use in cancer treatment and methods for the preparation thereof |
| DE01924282T1 (de) * | 2001-03-23 | 2007-04-19 | Scinopharm Taiwan, Ltd. | Verfahren zur herstellung von taxanderivaten |
| US6479679B1 (en) | 2001-04-25 | 2002-11-12 | Napro Biotherapeutics, Inc. | Two-step conversion of protected taxane ester to paclitaxel |
| US6452025B1 (en) | 2001-04-25 | 2002-09-17 | Napro Biotherapeutics, Inc. | Three-step conversion of protected taxane ester to paclitaxel |
| US6653501B2 (en) | 2001-06-27 | 2003-11-25 | Napro Biotherapeutics, Inc. | Chiral resolution method for producing compounds useful in the synthesis of taxanes |
| AU2002234248A1 (en) * | 2001-11-29 | 2003-06-17 | University Of Maryland | Process for extraction and purification of lutein, zeaxanthin and rare carotenoids from marigold flowers and plants |
| ITMI20020782A1 (it) * | 2002-04-12 | 2003-10-13 | Indena Spa | Processo semisintetico per la preparazione di n-debenzoilpaclitaxel |
| US7981928B2 (en) | 2002-09-05 | 2011-07-19 | Nanodynamics, Inc. | Chemotherapy method using x-rays |
| AU2003273671A1 (en) * | 2002-10-09 | 2004-05-04 | Phytogen Life Sciences, Inc. | Novel taxanes and methods related to use and preparation thereof |
| US6759539B1 (en) | 2003-02-27 | 2004-07-06 | Chaichem Pharmaceuticals International | Process for isolation and purification of paclitaxel from natural sources |
| US7202370B2 (en) * | 2003-10-27 | 2007-04-10 | Conor Medsystems, Inc. | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III |
| EP1877742A2 (en) * | 2005-04-12 | 2008-01-16 | X-Rite, Inc. | Systems and methods for measuring a like-color region of an object |
| CA2634453A1 (en) * | 2005-12-21 | 2007-06-28 | Tapestry Pharmaceuticals, Inc. | Novel compounds and methods for forming taxanes and using the same |
| US20070225510A1 (en) * | 2006-03-27 | 2007-09-27 | Henri John T | Convergent Process for the Synthesis of Taxane Derivatives |
| GB0701523D0 (en) | 2007-01-26 | 2007-03-07 | Chatham Biotec Ltd | Semi-synthetic process for the preparation of taxane derivatives |
| KR101096282B1 (ko) | 2009-04-24 | 2011-12-20 | 주식회사 삼양제넥스 | 탁산 유도체를 제조하는 방법 |
| WO2017055522A1 (en) | 2015-09-29 | 2017-04-06 | Academisch Medisch Centrum | Stabilized env proteins of hiv |
| US11344618B2 (en) | 2017-08-26 | 2022-05-31 | Academisch Medisch Centrum | HIV envelope glycoprotein immunogens |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2601676B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Procede de preparation du taxol et du desacetyl-10 taxol |
| FR2629818B1 (fr) * | 1988-04-06 | 1990-11-16 | Centre Nat Rech Scient | Procede de preparation du taxol |
| FR2629819B1 (fr) * | 1988-04-06 | 1990-11-16 | Rhone Poulenc Sante | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii |
| US5175315A (en) * | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| US5136060A (en) * | 1989-11-14 | 1992-08-04 | Florida State University | Method for preparation of taxol using an oxazinone |
| US5015744A (en) * | 1989-11-14 | 1991-05-14 | Florida State University | Method for preparation of taxol using an oxazinone |
| FR2658513B1 (fr) * | 1990-02-21 | 1994-02-04 | Rhone Poulenc Sante | Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r). |
| FR2680506B1 (fr) * | 1991-08-19 | 1994-09-02 | Rhone Poulenc Rorer Sa | Procede de preparation de derives de la beta-phenylisoserine et leur utilisation. |
| FR2687151B1 (fr) | 1992-02-07 | 1994-03-25 | Rhone Poulenc Rorer Sa | Nouveaux derives de la baccatine iii et de la desacetyl-10 baccatine iii, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2687150B1 (fr) * | 1992-02-07 | 1995-04-28 | Rhone Poulenc Rorer Sa | Procede de preparation de derives du taxane. |
| US5319112A (en) * | 1992-08-18 | 1994-06-07 | Virgnia Tech Intellectual Properties, Inc. | Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol |
| US5470866A (en) * | 1992-08-18 | 1995-11-28 | Virginia Polytechnic Institute And State University | Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol |
| FR2696460B1 (fr) | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
| EP1260507A1 (en) | 1993-02-05 | 2002-11-27 | Bryn Mawr College | Synthesis of taxol, analogs and intermediates with variable A-nng side chains |
| US5684175A (en) * | 1993-02-05 | 1997-11-04 | Napro Biotherapeutics, Inc. | C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor |
| FR2703353B1 (fr) * | 1993-03-29 | 1995-05-05 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés de la beta-phénylisosérine. |
| US5679807A (en) | 1995-01-30 | 1997-10-21 | Hauser, Inc. | Preparation of taxol and docetaxel through primary amines |
-
1994
- 1994-02-04 EP EP02014256A patent/EP1260507A1/en not_active Withdrawn
- 1994-02-04 BR BR9405687-0A patent/BR9405687C1/pt not_active Application Discontinuation
- 1994-02-04 AU AU61336/94A patent/AU695530B2/en not_active Expired
- 1994-02-04 CA CA2155304A patent/CA2155304C/en not_active Expired - Lifetime
- 1994-02-04 EP EP94907973A patent/EP0682660B1/en not_active Expired - Lifetime
- 1994-02-04 DE DE69433297T patent/DE69433297T2/de not_active Expired - Lifetime
- 1994-02-04 NZ NZ262030A patent/NZ262030A/en unknown
- 1994-02-04 JP JP6518249A patent/JP3031715B2/ja not_active Expired - Fee Related
- 1994-02-04 AT AT94907973T patent/ATE253563T1/de not_active IP Right Cessation
- 1994-02-04 WO PCT/US1994/001293 patent/WO1994018186A1/en active IP Right Grant
- 1994-02-05 CN CN94102253A patent/CN1102829A/zh active Pending
- 1994-02-07 IL IL10858194A patent/IL108581A0/xx unknown
- 1994-12-15 US US08/357,507 patent/US5770745A/en not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/483,083 patent/US5939566A/en not_active Expired - Lifetime
-
1998
- 1998-02-09 US US09/020,742 patent/US6262281B1/en not_active Expired - Fee Related
-
1999
- 1999-02-19 US US09/253,325 patent/US6072060A/en not_active Expired - Fee Related
-
2000
- 2000-03-01 CN CN00103725A patent/CN1284501A/zh active Pending
- 2000-04-11 US US09/547,327 patent/US6307088B1/en not_active Expired - Fee Related
-
2001
- 2001-05-22 US US09/863,889 patent/US6509484B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0682660A4 (xx) | 1995-12-20 |
| DE69433297T2 (de) | 2004-10-21 |
| EP1260507A1 (en) | 2002-11-27 |
| EP0682660B1 (en) | 2003-11-05 |
| US6307088B1 (en) | 2001-10-23 |
| JP3031715B2 (ja) | 2000-04-10 |
| CA2155304A1 (en) | 1994-08-18 |
| AU695530B2 (en) | 1998-08-13 |
| DE69433297D1 (de) | 2003-12-11 |
| US6072060A (en) | 2000-06-06 |
| BR9405687A (pt) | 1995-11-21 |
| US6509484B2 (en) | 2003-01-21 |
| ATE253563T1 (de) | 2003-11-15 |
| CN1284501A (zh) | 2001-02-21 |
| JPH08506587A (ja) | 1996-07-16 |
| US6262281B1 (en) | 2001-07-17 |
| BR9405687C1 (pt) | 2001-08-07 |
| EP0682660A1 (en) | 1995-11-22 |
| CA2155304C (en) | 2010-07-20 |
| US5770745A (en) | 1998-06-23 |
| US20020052517A1 (en) | 2002-05-02 |
| WO1994018186A1 (en) | 1994-08-18 |
| NZ262030A (en) | 1997-10-24 |
| US5939566A (en) | 1999-08-17 |
| CN1102829A (zh) | 1995-05-24 |
| AU6133694A (en) | 1994-08-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL108581A0 (en) | Process for the preparation of taxol, taxol analogues, and their intermediates | |
| EA199800031A1 (ru) | Синтез паклитаксела из предшественников соединений и способы их получения | |
| EA199800024A1 (ru) | Синтез паклитаксела из соединений-предшественников и способы их получения | |
| AU4242993A (en) | Cultured (taxus) tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds | |
| HUT75195A (en) | Sidechain-bearing taxane derivatives, intermediates and processes for preparation thereof | |
| DE69031534T2 (de) | Verfahren zur Herstellung von optisch aktiven Zyklobutannukleosiden | |
| FR2741620B1 (fr) | Procede de preparation de composes a groupement beta-hydroxy -delta-lactone analogues de la (+) compactine et de la (+) mevinoline | |
| IL129100A0 (en) | Method for paclitaxel synthesis and a C7-CBZ baccatin III compound | |
| EA199800048A1 (ru) | С-2′-гидроксил-бензил защищенный, n-карбамат защищенный (2r,3s)-3-фенилизосерин и способ его получения | |
| YU102289A (en) | Process for obtaining s-enanthiomerical glutaramides | |
| SI1114815T1 (en) | Process to prepare taxol | |
| KR890014457A (ko) | 신규 아족시 화합물 및 그의 제조방법 | |
| GB1534991A (en) | Thromboxane intermediates | |
| EP0408053A3 (en) | Monocyclic terpene derivatives | |
| HUT49120A (en) | Process for producing 16-methoxy-16-methyl-prostaglandin el derivative and its intermediate | |
| ATE157187T1 (de) | Werbesäule | |
| DE69915081D1 (de) | Verfahren zur herstellung von c-4-deacetyltaxanen | |
| CA2307548A1 (en) | Process for converting 9-dihydro-13-acetylbaccatin iii into taxol and derivatives thereof | |
| AR002507A1 (es) | Proceso mejorado para sintetizar intermediarios de carbapenem | |
| GB1461904A (en) | Prostaglandin intermediates and process for the production thereof | |
| MX9800042A (es) | Metodos, composiciones, y/o articulos de limpieza/saneamiento, para superficies inanimadas no alimenticias. | |
| MX9604593A (es) | Composicion de revestimiento curable | |
| ES8604509A1 (es) | Procedimiento para la obtencion del ester metilico del acido7-((1r,2r,3r)-3-hidroxi-2-((e)-(3r)-3-hidroxi-4-fenoxi-1-bu-tenil)-5-oxociclopentil)-4,5-heptadenoico |