IL106935A - Substituted cyclohexane derivatives for inhibition of glucose-6-phosphatase system of mammalian livers - Google Patents
Substituted cyclohexane derivatives for inhibition of glucose-6-phosphatase system of mammalian liversInfo
- Publication number
- IL106935A IL106935A IL10693593A IL10693593A IL106935A IL 106935 A IL106935 A IL 106935A IL 10693593 A IL10693593 A IL 10693593A IL 10693593 A IL10693593 A IL 10693593A IL 106935 A IL106935 A IL 106935A
- Authority
- IL
- Israel
- Prior art keywords
- glucose
- inhibition
- cyclohexane derivatives
- substituted cyclohexane
- phosphatase system
- Prior art date
Links
- 102000003638 Glucose-6-Phosphatase Human genes 0.000 title abstract 2
- 108010086800 Glucose-6-Phosphatase Proteins 0.000 title abstract 2
- 125000000113 cyclohexyl group Chemical class [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 title abstract 2
- 210000004185 liver Anatomy 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/383—Cycloaliphatic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4018—Esters of cycloaliphatic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Cyclones (AREA)
- Pyridine Compounds (AREA)
- Transceivers (AREA)
- Mobile Radio Communication Systems (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4230156 | 1992-09-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL106935A0 IL106935A0 (en) | 1993-12-28 |
| IL106935A true IL106935A (en) | 1997-07-13 |
Family
ID=6467599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10693593A IL106935A (en) | 1992-09-09 | 1993-09-07 | Substituted cyclohexane derivatives for inhibition of glucose-6-phosphatase system of mammalian livers |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5451573A (pt) |
| EP (1) | EP0587087B1 (pt) |
| JP (1) | JPH06211737A (pt) |
| KR (1) | KR100299205B1 (pt) |
| CN (1) | CN1042329C (pt) |
| AT (1) | ATE181237T1 (pt) |
| AU (1) | AU662836B2 (pt) |
| CA (1) | CA2105707A1 (pt) |
| CZ (1) | CZ284995B6 (pt) |
| DE (1) | DE59309649D1 (pt) |
| DK (1) | DK0587087T3 (pt) |
| ES (1) | ES2135429T3 (pt) |
| FI (1) | FI933902A (pt) |
| GR (1) | GR3030953T3 (pt) |
| HK (1) | HK1011934A1 (pt) |
| HU (1) | HUT64843A (pt) |
| IL (1) | IL106935A (pt) |
| NO (1) | NO179671C (pt) |
| PH (1) | PH30278A (pt) |
| PL (1) | PL300328A1 (pt) |
| RU (1) | RU2131248C1 (pt) |
| TW (1) | TW255880B (pt) |
| ZA (1) | ZA936610B (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4404848A1 (de) * | 1994-02-16 | 1995-08-17 | Hoechst Ag | Substituierte Cyclohexanolester, ihre Verwendung zur Behandlung von Krankheiten und pharmazeutische Präparate |
| DE4408082A1 (de) * | 1994-03-10 | 1995-09-14 | Hoechst Ag | Substituierte Propan-Derivate, Verfahren zu ihrer Herstellung und die Anwendung der Verbindungen zur Behandlung von Krankheiten |
| DE4416433A1 (de) * | 1994-05-10 | 1995-11-16 | Hoechst Ag | Cyclohexan-Derivate, Verfahren zu ihrer Herstellung und die Verwendung der Verbindungen zur Behandlung von Krankheiten |
| AR012449A1 (es) * | 1997-04-18 | 2000-10-18 | Hoechst Marion Roussell Deutschland Gmbh | Kodaistatinas a, b, c y d, proceso para su produccion, y su uso. |
| JP4810558B2 (ja) * | 1997-08-08 | 2011-11-09 | 江崎グリコ株式会社 | リン酸化糖およびその製造方法 |
| DE19740080A1 (de) * | 1997-09-12 | 1999-03-18 | Hoechst Marion Roussel De Gmbh | Neue Phthalaldehyd-Derivate, Verfahren zu deren Herstellung und deren Verwendung |
| HUP0203129A3 (en) | 1999-10-25 | 2003-12-29 | Sanofi Aventis Deutschland | Aromatic di-keto derivatives, process for producing them and use them as pharmaceuticals |
| CA2567984C (en) | 2004-06-03 | 2014-05-20 | Eisai Co., Ltd. | Intermediates for the preparation of analogs of halichondrin b |
| ZA200700755B (en) * | 2004-07-26 | 2009-05-27 | Chugai Pharmaceutical Co Ltd | Novel cyclohexane derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes |
| CN104311571B (zh) | 2007-10-03 | 2019-07-02 | 卫材R&D管理有限公司 | 用于合成软海绵素b类似物的中间体和方法 |
| MX2010010902A (es) | 2008-04-04 | 2010-12-21 | Eisai R&D Man Co Ltd | Analogos de halicondrina b. |
| US20100112098A1 (en) * | 2008-10-31 | 2010-05-06 | Naturex, S.A. | Effects of a decaffeinated green coffee extract on body weight control by regulation of glucose metabolism |
| CN102803254B (zh) | 2010-01-26 | 2016-09-14 | 卫材R&D管理有限公司 | 用于软海绵素b类似物合成的呋喃并[3,2-b]吡喃衍生物 |
| RU2710545C2 (ru) | 2013-11-04 | 2019-12-27 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Реакции макроциклизации и промежуточные соединения и другие фрагменты, пригодные в получении аналогов халихондрина b |
| MX370611B (es) | 2013-12-06 | 2019-12-18 | Eisai R&D Man Co Ltd | Metodos utiles en la sintesis de analogos de halicondrina b. |
| US10308661B2 (en) | 2015-05-07 | 2019-06-04 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides |
| MX2018009794A (es) | 2016-02-12 | 2018-12-17 | Eisai R&D Man Co Ltd | Intermediarios en la sintesis de eribulina y metodos de sintesis relacionados. |
| MX2018016329A (es) | 2016-06-30 | 2019-09-18 | Eisai R&D Man Co Ltd | Reaccion de prins e intermediarios utiles en la sintesis de macrolidos de halicondrina y analogos de los mismos. |
| MX2020006945A (es) | 2018-01-03 | 2020-11-09 | Eisai R&D Man Co Ltd | Reaccion de prins y compuestos utiles en la sintesis de macrolidos de halicondrina y analogos de los mismos. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60192555A (ja) * | 1984-03-13 | 1985-10-01 | Osaka Chem Lab | 抗アレルギ−食品 |
| JPS60243016A (ja) * | 1984-05-17 | 1985-12-03 | Tsumura Juntendo Inc | 抗インフルエンザウイルス剤 |
| EP0466198A1 (en) * | 1984-05-23 | 1992-01-15 | Green Cross Corporation | A lipoxygenase inhibitor |
| DE3603576A1 (de) * | 1986-02-06 | 1987-08-13 | Code Kaffee Handel | Verwendung von gerbstoffen und/oder chlorogensaeure sowie nahrungs-, genuss- und/oder arzneimittel mit gerbstoff- und/oder chlorogensaeurezusatz |
-
1993
- 1993-09-03 TW TW082107191A patent/TW255880B/zh active
- 1993-09-06 AT AT93114260T patent/ATE181237T1/de not_active IP Right Cessation
- 1993-09-06 ES ES93114260T patent/ES2135429T3/es not_active Expired - Lifetime
- 1993-09-06 DK DK93114260T patent/DK0587087T3/da active
- 1993-09-06 DE DE59309649T patent/DE59309649D1/de not_active Expired - Fee Related
- 1993-09-06 EP EP93114260A patent/EP0587087B1/de not_active Expired - Lifetime
- 1993-09-07 FI FI933902A patent/FI933902A/fi unknown
- 1993-09-07 HU HU9302527A patent/HUT64843A/hu unknown
- 1993-09-07 PH PH46828A patent/PH30278A/en unknown
- 1993-09-07 US US08/116,564 patent/US5451573A/en not_active Expired - Fee Related
- 1993-09-07 IL IL10693593A patent/IL106935A/xx not_active IP Right Cessation
- 1993-09-08 CZ CZ931867A patent/CZ284995B6/cs not_active IP Right Cessation
- 1993-09-08 CA CA002105707A patent/CA2105707A1/en not_active Abandoned
- 1993-09-08 CN CN93116663A patent/CN1042329C/zh not_active Expired - Fee Related
- 1993-09-08 AU AU46170/93A patent/AU662836B2/en not_active Ceased
- 1993-09-08 JP JP5223056A patent/JPH06211737A/ja not_active Abandoned
- 1993-09-08 PL PL93300328A patent/PL300328A1/xx unknown
- 1993-09-08 RU RU93045145A patent/RU2131248C1/ru active
- 1993-09-08 ZA ZA936610A patent/ZA936610B/xx unknown
- 1993-09-08 NO NO933201A patent/NO179671C/no not_active IP Right Cessation
- 1993-09-09 KR KR1019930018066A patent/KR100299205B1/ko not_active IP Right Cessation
-
1998
- 1998-12-11 HK HK98113223A patent/HK1011934A1/xx unknown
-
1999
- 1999-08-11 GR GR990402034T patent/GR3030953T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU4617093A (en) | 1994-03-17 |
| NO179671C (no) | 1996-11-27 |
| ES2135429T3 (es) | 1999-11-01 |
| HU9302527D0 (en) | 1993-11-29 |
| GR3030953T3 (en) | 1999-11-30 |
| ZA936610B (en) | 1994-03-28 |
| EP0587087B1 (de) | 1999-06-16 |
| PL300328A1 (en) | 1994-03-21 |
| NO933201D0 (no) | 1993-09-08 |
| CN1042329C (zh) | 1999-03-03 |
| CZ186793A3 (en) | 1994-03-16 |
| HUT64843A (en) | 1994-03-28 |
| JPH06211737A (ja) | 1994-08-02 |
| TW255880B (pt) | 1995-09-01 |
| NO933201L (no) | 1994-03-10 |
| CA2105707A1 (en) | 1994-03-10 |
| ATE181237T1 (de) | 1999-07-15 |
| KR100299205B1 (ko) | 2001-11-22 |
| KR940006580A (ko) | 1994-04-25 |
| FI933902A0 (fi) | 1993-09-07 |
| FI933902A (fi) | 1994-03-10 |
| US5451573A (en) | 1995-09-19 |
| EP0587087A1 (de) | 1994-03-16 |
| HK1011934A1 (en) | 1999-07-23 |
| DK0587087T3 (da) | 1999-12-06 |
| RU2131248C1 (ru) | 1999-06-10 |
| DE59309649D1 (de) | 1999-07-22 |
| AU662836B2 (en) | 1995-09-14 |
| CZ284995B6 (cs) | 1999-04-14 |
| PH30278A (en) | 1997-02-20 |
| NO179671B (no) | 1996-08-19 |
| CN1086806A (zh) | 1994-05-18 |
| IL106935A0 (en) | 1993-12-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL106935A (en) | Substituted cyclohexane derivatives for inhibition of glucose-6-phosphatase system of mammalian livers | |
| ATE149485T1 (de) | Substituierte heterocyclische carbonsäureamidester, ihre herstellung und ihre verwendung als arzneimittel | |
| NZ236589A (en) | A-nor-steroid-3-carboxylic acid derivatives and pharmaceutical compositions | |
| ZA937081B (en) | Azaquinoxalines processes for their preparation and their use | |
| GR3022116T3 (en) | Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them | |
| HUT66660A (en) | Intermediates for producing 9-[(substituted glicyl)-amido]-6-demetyl-6-deoxy-tetracyclines and pharmaceutical compositions containing them | |
| NO955352L (no) | Metylfosforsyreester, fremgangsmåte for fremstilling samt anvendelse | |
| AU1797888A (en) | Preparation of 5-acylamino-2,4,6-triiodo-or tribromo-benzoic acid derivatives | |
| HUT67028A (en) | Indole derivatives, pharmeceutical compositions comprising them and process for their production | |
| MY101970A (en) | Zwitterionic bicyclic compounds and their salts, solvates, hydrates and esters. | |
| FI933903A0 (fi) | Substituerade cyklohexanderivat, foerfarande foer framstaellning daerav och anvaendning av foereningar foer behandling av sjukdomar | |
| GR71716B (pt) | ||
| HU9301875D0 (en) | 4-imino-quinolines, pharmaceutical preparatives containing them and methods for producing said compounds and preparatives | |
| GR3021736T3 (en) | N-substitued 3-azabicyclo 3.2.0]heptane derivatives useful as neuroleptic agents etc. | |
| IL91212A0 (en) | 6-fluoro-3,5-dihydroxy carboxylic acids and derivatives thereof,a process for the preparation thereof and pharmaceutical compositions containing them | |
| HUT49122A (en) | Process for producing pharmaceutical compositions containing pyridyl-ethanol-amine as active component and the active component | |
| DE59206181D1 (de) | (1'S)-Hydroxyalkyloxapenem-3-carbonsäuren und ihre Verwendung als Betalactamasehemmer | |
| HUT73562A (en) | Thiocarbamoyl-pyrazole derivatives, keto-carboxylic acid ester intermediates thereof, preparations thereof, using the pyrazole derivatives and microbicide compositions containing these compounds | |
| ATE23528T1 (de) | +/- 2-((3,4-methylenedioxy)phenethyl)-5-((3carboxamido-4-hydroxy)-alpha-hydroxybenzyl)pyrrolidine, pharmazeutische zusammenstellungen die sie enthalten, verfahren zur herstellung und deren zwischenprodukte. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| RH1 | Patent not in force |