IL106641A - Cyanoguanidine derivatives and pharmaceutical k-channel blocker compositions containing them - Google Patents

Cyanoguanidine derivatives and pharmaceutical k-channel blocker compositions containing them

Info

Publication number
IL106641A
IL106641A IL10664193A IL10664193A IL106641A IL 106641 A IL106641 A IL 106641A IL 10664193 A IL10664193 A IL 10664193A IL 10664193 A IL10664193 A IL 10664193A IL 106641 A IL106641 A IL 106641A
Authority
IL
Israel
Prior art keywords
alkyl
compound
cyano
pyridyl
hydrogen
Prior art date
Application number
IL10664193A
Other languages
English (en)
Other versions
IL106641A0 (en
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of IL106641A0 publication Critical patent/IL106641A0/xx
Publication of IL106641A publication Critical patent/IL106641A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL10664193A 1992-08-13 1993-08-10 Cyanoguanidine derivatives and pharmaceutical k-channel blocker compositions containing them IL106641A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92979592A 1992-08-13 1992-08-13

Publications (2)

Publication Number Publication Date
IL106641A0 IL106641A0 (en) 1993-12-08
IL106641A true IL106641A (en) 2001-01-11

Family

ID=25458467

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10664193A IL106641A (en) 1992-08-13 1993-08-10 Cyanoguanidine derivatives and pharmaceutical k-channel blocker compositions containing them

Country Status (16)

Country Link
US (1) US5567722A (fr)
EP (1) EP0655057B1 (fr)
JP (1) JPH08500111A (fr)
CN (1) CN1039997C (fr)
AT (1) ATE158279T1 (fr)
AU (2) AU4530693A (fr)
DE (1) DE69314041T2 (fr)
DK (1) DK0655057T3 (fr)
ES (1) ES2107049T3 (fr)
GR (1) GR3025640T3 (fr)
IL (1) IL106641A (fr)
MX (1) MX9304882A (fr)
MY (1) MY110826A (fr)
TW (1) TW223017B (fr)
WO (2) WO1994004499A1 (fr)
ZA (1) ZA935619B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09508382A (ja) * 1994-01-28 1997-08-26 ジ・アップジョン・カンパニー Ｋ−チャネル遮断薬用シアノグアニジン類
AUPN193095A0 (en) * 1995-03-24 1995-04-27 Polychip Pharmaceuticals Pty Ltd Potassium ion channel blockers
AR008290A1 (es) * 1996-08-15 1999-12-29 Smithkline Beecham Corp Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios.
WO1998006398A1 (fr) * 1996-08-15 1998-02-19 Smithkline Beecham Corporation Antagonistes du recepteur il-8
EP1917244A2 (fr) 2005-08-24 2008-05-07 Abbott GmbH & Co. KG Composes guanidine a substitution hetaryl et utilisation en tant que partenaires de liaison pour des recepteurs de 5-ht5
CN113683535B (zh) * 2020-05-18 2022-08-30 中国药科大学 含氰胍结构的化合物及其制备方法与用途
CN112042664B (zh) * 2020-09-18 2022-06-10 广州古神生物科技有限公司 防霉抗菌剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1489879A (en) * 1974-12-20 1977-10-26 Leo Pharm Prod Ltd N'-cyano-n'-3-pyridylguanidines
NL8000869A (nl) * 1979-02-16 1980-08-19 Eisai Co Ltd Cyanoguanidine-derivaten en werkwijze voor de bereiding daarvan.
JPH01166119A (ja) * 1987-12-23 1989-06-30 Hitachi Ltd データ入力装置の制御方式
NZ229828A (en) * 1988-08-09 1992-03-26 Squibb & Sons Inc Aryl cyanoguanidine derivatives and pharmaceutical compositions
CA2009074C (fr) * 1989-02-03 1999-07-27 David Wayne Robertson Ameliorations concernant les derives de guanidine
US5006523A (en) * 1989-10-26 1991-04-09 E. R. Squibb & Sons, Inc. Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers

Also Published As

Publication number Publication date
EP0655057A1 (fr) 1995-05-31
ES2107049T3 (es) 1997-11-16
JPH08500111A (ja) 1996-01-09
ZA935619B (en) 1995-02-03
WO1994004500A1 (fr) 1994-03-03
DE69314041T2 (de) 1998-02-05
CN1090575A (zh) 1994-08-10
GR3025640T3 (en) 1998-03-31
AU4530693A (en) 1994-03-15
TW223017B (fr) 1994-05-01
IL106641A0 (en) 1993-12-08
WO1994004499A1 (fr) 1994-03-03
US5567722A (en) 1996-10-22
MX9304882A (es) 1994-07-29
CN1039997C (zh) 1998-09-30
DE69314041D1 (de) 1997-10-23
DK0655057T3 (da) 1998-04-14
AU4683193A (en) 1994-03-15
MY110826A (en) 1999-05-31
EP0655057B1 (fr) 1997-09-17
ATE158279T1 (de) 1997-10-15

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
RH1 Patent not in force