IL106079A0 - 2'-deoxy-2',2'-difluoro(4-substituted pyrimidine)nucleosides having anti-viral and anti-cancer activity and intermediates - Google Patents
2'-deoxy-2',2'-difluoro(4-substituted pyrimidine)nucleosides having anti-viral and anti-cancer activity and intermediatesInfo
- Publication number
- IL106079A0 IL106079A0 IL106079A IL10607993A IL106079A0 IL 106079 A0 IL106079 A0 IL 106079A0 IL 106079 A IL106079 A IL 106079A IL 10607993 A IL10607993 A IL 10607993A IL 106079 A0 IL106079 A0 IL 106079A0
- Authority
- IL
- Israel
- Prior art keywords
- deoxy
- difluoro
- intermediates
- nucleosides
- viral
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90231492A | 1992-06-22 | 1992-06-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL106079A0 true IL106079A0 (en) | 1993-10-20 |
Family
ID=25415673
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL106079A IL106079A0 (en) | 1992-06-22 | 1993-06-21 | 2'-deoxy-2',2'-difluoro(4-substituted pyrimidine)nucleosides having anti-viral and anti-cancer activity and intermediates |
Country Status (21)
Country | Link |
---|---|
US (1) | US5430026A (xx) |
EP (1) | EP0576230B1 (xx) |
JP (1) | JPH0656876A (xx) |
KR (1) | KR940005657A (xx) |
CN (1) | CN1084177A (xx) |
AT (1) | ATE137243T1 (xx) |
AU (1) | AU664096B2 (xx) |
BR (1) | BR9302430A (xx) |
CA (1) | CA2098875A1 (xx) |
CZ (1) | CZ123193A3 (xx) |
DE (1) | DE69302330T2 (xx) |
DK (1) | DK0576230T3 (xx) |
ES (1) | ES2087657T3 (xx) |
FI (1) | FI932870A (xx) |
GR (1) | GR3020064T3 (xx) |
HU (1) | HUT64769A (xx) |
IL (1) | IL106079A0 (xx) |
MX (1) | MX9303711A (xx) |
NO (1) | NO932289L (xx) |
PL (1) | PL299414A1 (xx) |
YU (1) | YU43193A (xx) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5559222A (en) * | 1995-02-03 | 1996-09-24 | Eli Lilly And Company | Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose |
GB2321454A (en) * | 1997-01-24 | 1998-07-29 | Norsk Hydro As | Gemcitabine esters and amides |
GB9708611D0 (en) * | 1997-04-28 | 1997-06-18 | Univ Cardiff | Chemical compounds |
US6326507B1 (en) | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
WO2001024763A2 (en) | 1999-10-01 | 2001-04-12 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
GB0009486D0 (en) * | 2000-04-17 | 2000-06-07 | Univ Cardiff | Chemical compounds |
US7435755B2 (en) | 2000-11-28 | 2008-10-14 | The Trustees Of Dartmouth College | CDDO-compounds and combination therapies thereof |
CA2472581C (en) | 2002-01-15 | 2012-06-26 | Trustees Of Dartmouth College | Tricyclic-bis-enone derivatives and methods of use thereof |
AU2003217402A1 (en) * | 2002-02-14 | 2003-09-04 | Pharmasset Inc | Modified fluorinated nucleoside analogues |
US7265096B2 (en) | 2002-11-04 | 2007-09-04 | Xenoport, Inc. | Gemcitabine prodrugs, pharmaceutical compositions and uses thereof |
WO2004050678A2 (en) * | 2002-12-03 | 2004-06-17 | Baylor University | Compounds resistant to metabolic deactivation and methods of use |
US7214791B2 (en) * | 2004-07-01 | 2007-05-08 | Shenzhen Hande Technology Co., Ltd. | Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material |
UA86119C2 (xx) * | 2004-12-17 | 2009-03-25 | Эли Лилли Энд Компани | Амідні проліки гемцитабіну, їх композиції та застосування$амидные пролекарства гемцитабина, их композиции и применение |
ATE458743T1 (de) * | 2005-03-04 | 2010-03-15 | Fresenius Kabi Oncology Ltd | Zwischenprodukt und verfahren zur herstellung von an beta-anomeren angereicherten 2'-desoxy,2',2'- difluor-d-ribufuranosylnukleosiden |
CN1693309A (zh) * | 2005-04-18 | 2005-11-09 | 成都正开生物科技发展有限公司 | N4-(取代的氧羰基)-2′,2′-二氟-2′-脱氧胞苷衍生物及其应用 |
AT502635A1 (de) * | 2005-11-09 | 2007-05-15 | Saischek Und Partner Meg | Neue 1,3-dithioverbindungen, verfahren zu deren herstellung und ihre verwendung |
GB0609178D0 (en) * | 2006-05-09 | 2006-06-21 | Univ Cardiff | Novel compounds |
WO2008064132A2 (en) | 2006-11-17 | 2008-05-29 | Trustees Of Dartmouth College | Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth |
WO2008064133A1 (en) | 2006-11-17 | 2008-05-29 | Trustees Of Dartmouth College | Synthesis and biological activities of new tricyclic-bis-enones (tbes) |
US8921340B2 (en) | 2006-11-17 | 2014-12-30 | Trustees Of Dartmouth College | Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions |
CN108434151A (zh) | 2008-01-11 | 2018-08-24 | 里亚塔医药公司 | 合成三萜类化合物及用以治病之方法 |
TW201004627A (en) | 2008-04-18 | 2010-02-01 | Reata Pharmaceuticals Inc | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
EA022588B1 (ru) | 2008-04-18 | 2016-01-29 | Ритэ Фамэсутикл, Инк. | Антиоксидантные модуляторы воспаления: производные олеанолевой кислоты с насыщением в с-кольце |
US8124799B2 (en) | 2008-04-18 | 2012-02-28 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17 |
WO2009146218A2 (en) | 2008-04-18 | 2009-12-03 | Reata Pharmaceuticals, Inc. | Compounds including an anti-inflammatory pharmacore and methods of use |
MX2010011439A (es) | 2008-04-18 | 2011-01-25 | Reata Pharmaceuticals Inc | Moduladores de inflamacion antioxidantes: derivados del acido oleanolico homologacion c-17. |
DE102011077393A1 (de) | 2011-06-10 | 2012-12-13 | Johannes Reinmüller | Antiinfektives Mittel |
AU2013243873B2 (en) | 2012-04-04 | 2016-08-25 | Halozyme, Inc. | Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane |
US8921419B2 (en) | 2012-05-08 | 2014-12-30 | Trustees Of Dartmouth College | Triterpenoids and compositions containing the same |
JP2015535261A (ja) * | 2012-10-29 | 2015-12-10 | コクリスタル ファーマ,インコーポレイテッド | ウイルス感染及び癌の治療のためのピリミジンヌクレオチド及びその一リン酸プロドラッグ |
WO2016078160A1 (zh) * | 2014-11-17 | 2016-05-26 | 常州方圆制药有限公司 | 胞苷衍生物及其应用 |
WO2019222435A1 (en) | 2018-05-16 | 2019-11-21 | Halozyme, Inc. | Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20 |
GR1009958B (el) * | 2019-04-24 | 2021-03-18 | ΕΝΟΡΑΣΙΣ ΑΝΩΝΥΜΗ ΕΜΠΟΡΙΚΗ ΕΤΑΙΡΕΙΑ ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΚΑΙ ΙΑΤΡΙΚΩΝ ΥΛΙΚΩΝ ΚΑΙ ΜΗΧΑΝΗΜΑΤΩΝ με δ.τ. "ΕΝΟΡΑΣΙΣ Α.Ε." | Παραγωγα γεμσιταβινης και μεθοδοι δημιουργιας παραγωγων γεμσιταβινης |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
ZA859008B (en) * | 1984-12-04 | 1987-07-29 | Lilly Co Eli | The treatment of tumors in mammals |
IL77133A (en) * | 1984-12-04 | 1991-01-31 | Lilly Co Eli | Antineoplastic pharmaceutical compositions containing pentofuranoside derivatives,some new such compounds and their preparation |
CA1295998C (en) * | 1985-07-29 | 1992-02-18 | Sai P. Sunkara | Nucleosides and their use as antineoplastic agents |
ES2176279T3 (es) * | 1987-08-28 | 2002-12-01 | Lilly Co Eli | Procedimiento estereoselectivo para preparar 2`-2`-difluorolactonen protegidos. |
US4965374A (en) * | 1987-08-28 | 1990-10-23 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
US4914028A (en) * | 1988-02-10 | 1990-04-03 | Eli Lilly And Company | Method of preparing beta-2',2'-difluoronucleosides |
DE68923387T2 (de) * | 1988-02-16 | 1996-01-25 | Lilly Co Eli | 2',3'-Dideoxy-2',2'-difluornucleoside. |
EP0339161A1 (en) * | 1988-04-01 | 1989-11-02 | Merrell Dow Pharmaceuticals Inc. | Novel fluorophosphonate nucleotide derivatives |
JPH0232093A (ja) * | 1988-06-08 | 1990-02-01 | Merrell Dow Pharmaceut Inc | 抗レトロウィルスジフルオロ化ヌクレオシド類 |
WO1991015498A2 (en) * | 1990-04-04 | 1991-10-17 | Nycomed Imaging As | Nucleoside derivatives |
-
1992
- 1992-06-21 YU YU43193A patent/YU43193A/sh unknown
-
1993
- 1993-06-18 AU AU41348/93A patent/AU664096B2/en not_active Expired - Fee Related
- 1993-06-21 CA CA002098875A patent/CA2098875A1/en not_active Abandoned
- 1993-06-21 ES ES93304819T patent/ES2087657T3/es not_active Expired - Lifetime
- 1993-06-21 IL IL106079A patent/IL106079A0/xx unknown
- 1993-06-21 NO NO932289A patent/NO932289L/no unknown
- 1993-06-21 HU HU9301824A patent/HUT64769A/hu unknown
- 1993-06-21 AT AT93304819T patent/ATE137243T1/de not_active IP Right Cessation
- 1993-06-21 JP JP5149170A patent/JPH0656876A/ja active Pending
- 1993-06-21 BR BR9302430A patent/BR9302430A/pt not_active Application Discontinuation
- 1993-06-21 CN CN93107739A patent/CN1084177A/zh active Pending
- 1993-06-21 DK DK93304819.1T patent/DK0576230T3/da active
- 1993-06-21 KR KR1019930011311A patent/KR940005657A/ko not_active Application Discontinuation
- 1993-06-21 MX MX9303711A patent/MX9303711A/es unknown
- 1993-06-21 FI FI932870A patent/FI932870A/fi not_active Application Discontinuation
- 1993-06-21 EP EP93304819A patent/EP0576230B1/en not_active Expired - Lifetime
- 1993-06-21 DE DE69302330T patent/DE69302330T2/de not_active Expired - Fee Related
- 1993-06-21 PL PL29941493A patent/PL299414A1/xx unknown
- 1993-06-21 CZ CZ931231A patent/CZ123193A3/cs unknown
- 1993-10-29 US US08/146,368 patent/US5430026A/en not_active Expired - Fee Related
-
1996
- 1996-05-27 GR GR960401428T patent/GR3020064T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
YU43193A (sh) | 1997-01-08 |
CZ123193A3 (en) | 1994-04-13 |
AU4134893A (en) | 1993-12-23 |
KR940005657A (ko) | 1994-03-22 |
US5430026A (en) | 1995-07-04 |
GR3020064T3 (en) | 1996-08-31 |
MX9303711A (es) | 1994-05-31 |
JPH0656876A (ja) | 1994-03-01 |
HU9301824D0 (en) | 1993-09-28 |
PL299414A1 (en) | 1993-12-27 |
NO932289D0 (no) | 1993-06-21 |
FI932870A0 (fi) | 1993-06-21 |
EP0576230B1 (en) | 1996-04-24 |
DK0576230T3 (da) | 1996-05-20 |
AU664096B2 (en) | 1995-11-02 |
CN1084177A (zh) | 1994-03-23 |
DE69302330T2 (de) | 1996-10-10 |
BR9302430A (pt) | 1994-01-11 |
ES2087657T3 (es) | 1996-07-16 |
CA2098875A1 (en) | 1993-12-23 |
ATE137243T1 (de) | 1996-05-15 |
HUT64769A (en) | 1994-02-28 |
FI932870A (fi) | 1993-12-23 |
NO932289L (no) | 1993-12-23 |
EP0576230A1 (en) | 1993-12-29 |
DE69302330D1 (de) | 1996-05-30 |
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