IL105891A - חלקיקים זעירים, תהליכים להכנתם ומדיית ניגוד אולטראסונית המכילה אותם - Google Patents
חלקיקים זעירים, תהליכים להכנתם ומדיית ניגוד אולטראסונית המכילה אותםInfo
- Publication number
- IL105891A IL105891A IL10589193A IL10589193A IL105891A IL 105891 A IL105891 A IL 105891A IL 10589193 A IL10589193 A IL 10589193A IL 10589193 A IL10589193 A IL 10589193A IL 105891 A IL105891 A IL 105891A
- Authority
- IL
- Israel
- Prior art keywords
- microparticles
- contrast media
- production
- ultrasonic contrast
- water
- Prior art date
Links
- 239000011859 microparticle Substances 0.000 title claims abstract description 51
- 238000000034 method Methods 0.000 title claims abstract description 37
- 230000008569 process Effects 0.000 title claims description 22
- 239000002872 contrast media Substances 0.000 title claims description 19
- 229940039231 contrast media Drugs 0.000 title claims description 17
- 238000002360 preparation method Methods 0.000 title description 4
- 239000002253 acid Substances 0.000 claims abstract description 12
- 229920000728 polyester Polymers 0.000 claims abstract description 10
- 239000002245 particle Substances 0.000 claims description 47
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
- 239000000243 solution Substances 0.000 claims description 21
- 239000000725 suspension Substances 0.000 claims description 20
- 239000007789 gas Substances 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 238000004519 manufacturing process Methods 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 14
- 229930195725 Mannitol Natural products 0.000 claims description 14
- 239000000594 mannitol Substances 0.000 claims description 14
- 235000010355 mannitol Nutrition 0.000 claims description 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 11
- 235000019441 ethanol Nutrition 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 9
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 7
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 7
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
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- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 4
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- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical class CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 claims description 4
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
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- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
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- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
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- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 1
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
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- 229940068977 polysorbate 20 Drugs 0.000 description 1
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- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
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- 239000013587 production medium Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- ACXGJHCPFCFILV-UHFFFAOYSA-M sodium;2-(4-chloro-2-methylphenoxy)acetate;3,6-dichloro-2-methoxybenzoic acid Chemical compound [Na+].COC1=C(Cl)C=CC(Cl)=C1C(O)=O.CC1=CC(Cl)=CC=C1OCC([O-])=O ACXGJHCPFCFILV-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4219723A DE4219723A1 (de) | 1992-06-13 | 1992-06-13 | Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL105891A0 IL105891A0 (en) | 1993-10-20 |
| IL105891A true IL105891A (he) | 1998-10-30 |
Family
ID=6461144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10589193A IL105891A (he) | 1992-06-13 | 1993-06-02 | חלקיקים זעירים, תהליכים להכנתם ומדיית ניגוד אולטראסונית המכילה אותם |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0644777B2 (he) |
| JP (1) | JPH07507780A (he) |
| KR (1) | KR100254746B1 (he) |
| CN (1) | CN1064851C (he) |
| AT (1) | ATE163134T1 (he) |
| AU (1) | AU686103B2 (he) |
| CA (1) | CA2138010A1 (he) |
| DE (2) | DE4219723A1 (he) |
| DK (1) | DK0644777T4 (he) |
| ES (1) | ES2115060T5 (he) |
| FI (1) | FI945837A0 (he) |
| GR (1) | GR3026498T3 (he) |
| HU (1) | HU217121B (he) |
| IL (1) | IL105891A (he) |
| NO (1) | NO307646B1 (he) |
| NZ (1) | NZ253115A (he) |
| TW (1) | TW239079B (he) |
| WO (1) | WO1993025242A1 (he) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5578292A (en) | 1991-11-20 | 1996-11-26 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
| USRE39146E1 (en) | 1990-04-02 | 2006-06-27 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
| US6989141B2 (en) | 1990-05-18 | 2006-01-24 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| US7083778B2 (en) | 1991-05-03 | 2006-08-01 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| US6613306B1 (en) | 1990-04-02 | 2003-09-02 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| NZ244147A (en) † | 1991-09-03 | 1994-09-27 | Hoechst Ag | Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents |
| IL104084A (he) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | תרחיפים מימיים בני קיימא של שלפוחיות עמידות בפני לחץ וממולאות בגז, הכנתם, וגורמי ניגוד המכילים אותם |
| PT711179E (pt) * | 1993-07-30 | 2005-03-31 | Imcor Pharmaceutical Company | Composicoes de microbolhas estabilizadas para ultra-som |
| US5798091A (en) * | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
| GB9318288D0 (en) * | 1993-09-03 | 1993-10-20 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| GB9417941D0 (en) * | 1994-09-06 | 1994-10-26 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| US5540909A (en) * | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
| DE19508049C2 (de) * | 1995-02-23 | 1997-02-06 | Schering Ag | Verwendung von Methylenmalondiesterderivaten zur Herstellung von gasenthaltenden Mikropartikeln |
| DE19510690A1 (de) * | 1995-03-14 | 1996-09-19 | Schering Ag | Polymere Nano- und/oder Mikropartikel, Verfahren zu deren Herstellung, sowie Verwendung in medizinischen Diagnostik und Therapie |
| US5804162A (en) * | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
| US5611344A (en) * | 1996-03-05 | 1997-03-18 | Acusphere, Inc. | Microencapsulated fluorinated gases for use as imaging agents |
| CZ281298A3 (cs) * | 1996-03-05 | 1999-01-13 | Acusphere, Inc. | Fluorované plyny v mikrokapslích jako zobrazující činidla pro ultrazvukové vyšetření |
| US6017310A (en) * | 1996-09-07 | 2000-01-25 | Andaris Limited | Use of hollow microcapsules |
| US6068600A (en) * | 1996-12-06 | 2000-05-30 | Quadrant Healthcare (Uk) Limited | Use of hollow microcapsules |
| US6045777A (en) * | 1997-06-30 | 2000-04-04 | Acusphere, Inc. | Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases |
| GB9800813D0 (en) | 1998-01-16 | 1998-03-11 | Andaris Ltd | Improved ultrasound contrast imaging method and apparatus |
| DE19925311B4 (de) | 1999-05-27 | 2004-06-09 | Schering Ag | Mehrstufen-Verfahren zur Herstellung von gasgefüllten Mikrokapseln |
| DE10013850A1 (de) * | 2000-03-15 | 2001-09-20 | Schering Ag | Gasgefüllte Mikrokapseln enthaltend funktionalisiertes Polyalkylcyanacrylat, sowie Verfahren zu deren Herstellung |
| US8012457B2 (en) | 2004-06-04 | 2011-09-06 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4265251A (en) * | 1979-06-28 | 1981-05-05 | Rasor Associates, Inc. | Method of determining pressure within liquid containing vessel |
| EP0586875A1 (de) * | 1988-02-05 | 1994-03-16 | Schering Aktiengesellschaft | Ultraschallkontrastmittel, Verfahren zu deren Herstellung und deren Verwendung als Diagnostika und Therapeutika |
| AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
| NZ244147A (en) * | 1991-09-03 | 1994-09-27 | Hoechst Ag | Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents |
-
1992
- 1992-06-13 DE DE4219723A patent/DE4219723A1/de not_active Withdrawn
-
1993
- 1993-06-02 IL IL10589193A patent/IL105891A/he not_active IP Right Cessation
- 1993-06-05 DE DE59308146T patent/DE59308146D1/de not_active Expired - Fee Related
- 1993-06-05 EP EP93912897A patent/EP0644777B2/de not_active Expired - Lifetime
- 1993-06-05 CA CA002138010A patent/CA2138010A1/en not_active Abandoned
- 1993-06-05 NZ NZ253115A patent/NZ253115A/en unknown
- 1993-06-05 KR KR1019940704526A patent/KR100254746B1/ko not_active IP Right Cessation
- 1993-06-05 AT AT93912897T patent/ATE163134T1/de not_active IP Right Cessation
- 1993-06-05 AU AU43232/93A patent/AU686103B2/en not_active Ceased
- 1993-06-05 WO PCT/EP1993/001425 patent/WO1993025242A1/de active IP Right Grant
- 1993-06-05 HU HU9403566A patent/HU217121B/hu not_active IP Right Cessation
- 1993-06-05 DK DK93912897T patent/DK0644777T4/da active
- 1993-06-05 JP JP6501098A patent/JPH07507780A/ja not_active Ceased
- 1993-06-05 ES ES93912897T patent/ES2115060T5/es not_active Expired - Lifetime
- 1993-06-12 CN CN931070155A patent/CN1064851C/zh not_active Expired - Fee Related
- 1993-06-15 TW TW082104757A patent/TW239079B/zh active
-
1994
- 1994-12-12 FI FI945837A patent/FI945837A0/fi not_active Application Discontinuation
- 1994-12-12 NO NO944805A patent/NO307646B1/no unknown
-
1998
- 1998-04-03 GR GR980400681T patent/GR3026498T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR100254746B1 (ko) | 2000-08-01 |
| ES2115060T3 (es) | 1998-06-16 |
| WO1993025242A1 (de) | 1993-12-23 |
| CN1064851C (zh) | 2001-04-25 |
| FI945837A (fi) | 1994-12-12 |
| HUT69380A (en) | 1995-09-28 |
| DK0644777T4 (da) | 2004-02-23 |
| NO307646B1 (no) | 2000-05-08 |
| DE59308146D1 (de) | 1998-03-19 |
| EP0644777A1 (de) | 1995-03-29 |
| EP0644777B2 (de) | 2003-10-15 |
| EP0644777B1 (de) | 1998-02-11 |
| AU686103B2 (en) | 1998-02-05 |
| HU9403566D0 (en) | 1995-02-28 |
| NO944805D0 (no) | 1994-12-12 |
| ES2115060T5 (es) | 2004-06-16 |
| DK0644777T3 (da) | 1998-09-23 |
| HU217121B (hu) | 1999-11-29 |
| NO944805L (no) | 1994-12-12 |
| CN1082924A (zh) | 1994-03-02 |
| GR3026498T3 (en) | 1998-07-31 |
| TW239079B (he) | 1995-01-21 |
| JPH07507780A (ja) | 1995-08-31 |
| ATE163134T1 (de) | 1998-02-15 |
| CA2138010A1 (en) | 1993-12-23 |
| FI945837A0 (fi) | 1994-12-12 |
| IL105891A0 (en) | 1993-10-20 |
| NZ253115A (en) | 1996-01-26 |
| KR950701823A (ko) | 1995-05-17 |
| AU4323293A (en) | 1994-01-04 |
| DE4219723A1 (de) | 1993-12-16 |
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