IL105623A - Oxazaborolidine Catalysts for Anantyslective Reduction of Prochiral Ketones - Google Patents

Oxazaborolidine Catalysts for Anantyslective Reduction of Prochiral Ketones

Info

Publication number
IL105623A
IL105623A IL105623A IL10562393A IL105623A IL 105623 A IL105623 A IL 105623A IL 105623 A IL105623 A IL 105623A IL 10562393 A IL10562393 A IL 10562393A IL 105623 A IL105623 A IL 105623A
Authority
IL
Israel
Prior art keywords
phenyl
oxazaborolidine
borane
alkyl
chiral
Prior art date
Application number
IL105623A
Other languages
English (en)
Hebrew (he)
Other versions
IL105623A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL105623A0 publication Critical patent/IL105623A0/xx
Publication of IL105623A publication Critical patent/IL105623A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Polyurethanes Or Polyureas (AREA)
IL105623A 1992-05-14 1993-05-06 Oxazaborolidine Catalysts for Anantyslective Reduction of Prochiral Ketones IL105623A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88331792A 1992-05-14 1992-05-14

Publications (2)

Publication Number Publication Date
IL105623A0 IL105623A0 (en) 1993-09-22
IL105623A true IL105623A (en) 1998-02-22

Family

ID=25382382

Family Applications (1)

Application Number Title Priority Date Filing Date
IL105623A IL105623A (en) 1992-05-14 1993-05-06 Oxazaborolidine Catalysts for Anantyslective Reduction of Prochiral Ketones

Country Status (21)

Country Link
US (1) US5552548A (sv)
EP (1) EP0640089B1 (sv)
JP (1) JP2525127B2 (sv)
KR (2) KR0149208B1 (sv)
AT (1) ATE146790T1 (sv)
AU (1) AU659929B2 (sv)
CA (1) CA2134096C (sv)
DE (1) DE69306945T2 (sv)
DK (1) DK0640089T3 (sv)
ES (1) ES2096275T3 (sv)
FI (1) FI107259B (sv)
GR (1) GR3022171T3 (sv)
HU (1) HU215089B (sv)
IL (1) IL105623A (sv)
MX (1) MX9302785A (sv)
MY (1) MY111251A (sv)
NO (1) NO300500B1 (sv)
NZ (1) NZ249302A (sv)
TW (1) TW232696B (sv)
WO (1) WO1993023408A1 (sv)
ZA (1) ZA933340B (sv)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06329679A (ja) * 1993-01-20 1994-11-29 Nissan Chem Ind Ltd 光学活性β−アミノアルコキシボラン錯体
TW416958B (en) * 1993-05-14 2001-01-01 Pfizer Enantioselective oxazaborolidine catalysts
WO1995002585A1 (en) * 1993-07-16 1995-01-26 Pfizer Inc. Enanthioselective preparation of thiazole derivatives
DK0724552T3 (da) * 1993-11-30 1997-12-22 Pfizer Fremgangsmåde til fremstilling af chiralt tetralon
US5495054A (en) * 1994-05-31 1996-02-27 Sepracor, Inc. Tetrahydroindeno[1,2-D][1,3,2]oxazaboroles and their use as enantioselective catalysts
AU2792497A (en) * 1996-09-18 1998-04-14 Shionogi & Co., Ltd. Process for preparing optically acitve alcohol by reduction with asymmetric borane
ES2130083B1 (es) * 1997-08-04 2000-01-16 Esteve Labor Dr Procedimiento para la obtencion de los enantiomeros de cizolirtina.
US6509472B2 (en) 2000-09-11 2003-01-21 Schering Corporation 4-Cyclohexyl-1,3,2-oxazaborolidine chiral accessories
NZ573456A (en) * 2006-06-26 2010-08-27 Basf Se Borane ether complexes for organic reactions
EP2139845A1 (en) * 2007-02-26 2010-01-06 Teva Pharmaceutical Industries Ltd. Intermediates and processes for the synthesis of ramelteon
WO2008124072A1 (en) * 2007-04-05 2008-10-16 The Board Of Regents Of The University Of Texas System Palmerolides: methods of preparation and derivatives thereof
NZ581391A (en) * 2007-04-30 2012-06-29 Adolor Corp Compositions of (-)-e-10-oh-nt and methods for their synthesis and use
EP2098519A1 (en) * 2007-05-31 2009-09-09 Teva Pharmaceutical Industries Ltd. Process for the synthesis of ramelteon and its intermediates
US20090082568A1 (en) * 2007-09-21 2009-03-26 Basf Aktiengesellschaft Accelerated reduction of organic substances with boranes
WO2009056993A2 (en) * 2007-11-01 2009-05-07 Teva Pharmaceutical Industries Ltd. A process for the synthesis of ramelteon and its intermediates
WO2010045565A1 (en) * 2008-10-16 2010-04-22 Teva Pharmaceutical Industries Ltd. Process for the synthesis of ramelteon and its intermediates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943635A (en) * 1987-08-27 1990-07-24 President & Fellows Of Harvard College Enantioselective reduction of ketones
US5157129A (en) * 1990-04-18 1992-10-20 Merck & Co., Inc. Enantiospecific synthesis of s-(+)-5,6-dihydro-4-(r-amino)-4h-thieno(2,3-b)thiopyran-2-sulfonamide-7,7-dioxide
US5039802A (en) * 1990-04-18 1991-08-13 Merck & Co., Inc. Arylation process for preparation of chiral catalysts for ketone reduction
JPH06329679A (ja) * 1993-01-20 1994-11-29 Nissan Chem Ind Ltd 光学活性β−アミノアルコキシボラン錯体
TW416958B (en) * 1993-05-14 2001-01-01 Pfizer Enantioselective oxazaborolidine catalysts

Also Published As

Publication number Publication date
FI932174A (fi) 1993-11-15
ATE146790T1 (de) 1997-01-15
CA2134096A1 (en) 1993-11-25
IL105623A0 (en) 1993-09-22
FI932174A0 (fi) 1993-05-13
TW232696B (sv) 1994-10-21
HU9301395D0 (en) 1993-09-28
WO1993023408A1 (en) 1993-11-25
DK0640089T3 (da) 1997-06-16
ZA933340B (en) 1994-11-14
JP2525127B2 (ja) 1996-08-14
AU3593193A (en) 1993-12-13
AU659929B2 (en) 1995-06-01
NO300500B1 (no) 1997-06-09
HUT65136A (en) 1994-04-28
GR3022171T3 (en) 1997-03-31
US5552548A (en) 1996-09-03
KR950701637A (ko) 1995-04-28
NO944297L (no) 1994-11-11
KR0149208B1 (ko) 1998-10-15
HU215089B (hu) 1998-09-28
MY111251A (en) 1999-10-30
NO944297D0 (no) 1994-11-11
EP0640089B1 (en) 1996-12-27
EP0640089A1 (en) 1995-03-01
MX9302785A (es) 1994-02-28
CA2134096C (en) 1997-11-25
ES2096275T3 (es) 1997-03-01
NZ249302A (en) 1996-11-26
FI107259B (sv) 2001-06-29
DE69306945T2 (de) 1997-05-07
JPH07503734A (ja) 1995-04-20
DE69306945D1 (de) 1997-02-06

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