IL105112A - Semi-synthetic glycosaminoglycans with heparin or heparan structure of alpha-l-iduronic-2-o-sulfate acid modified in position 2 and their preparation - Google Patents

Semi-synthetic glycosaminoglycans with heparin or heparan structure of alpha-l-iduronic-2-o-sulfate acid modified in position 2 and their preparation

Info

Publication number
IL105112A
IL105112A IL10511293A IL10511293A IL105112A IL 105112 A IL105112 A IL 105112A IL 10511293 A IL10511293 A IL 10511293A IL 10511293 A IL10511293 A IL 10511293A IL 105112 A IL105112 A IL 105112A
Authority
IL
Israel
Prior art keywords
iduronic
heparin
alpha
synthetic glycosaminoglycans
semi
Prior art date
Application number
IL10511293A
Other languages
English (en)
Other versions
IL105112A0 (en
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of IL105112A0 publication Critical patent/IL105112A0/xx
Publication of IL105112A publication Critical patent/IL105112A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
IL10511293A 1992-04-17 1993-03-19 Semi-synthetic glycosaminoglycans with heparin or heparan structure of alpha-l-iduronic-2-o-sulfate acid modified in position 2 and their preparation IL105112A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITBO920141A IT1260137B (it) 1992-04-17 1992-04-17 Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato

Publications (2)

Publication Number Publication Date
IL105112A0 IL105112A0 (en) 1993-07-08
IL105112A true IL105112A (en) 1997-01-10

Family

ID=11338176

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10511293A IL105112A (en) 1992-04-17 1993-03-19 Semi-synthetic glycosaminoglycans with heparin or heparan structure of alpha-l-iduronic-2-o-sulfate acid modified in position 2 and their preparation

Country Status (18)

Country Link
US (1) US5430133A (enExample)
EP (1) EP0565863B1 (enExample)
JP (1) JP2702376B2 (enExample)
KR (1) KR0171624B1 (enExample)
AT (1) ATE154616T1 (enExample)
AU (1) AU658498B2 (enExample)
CA (1) CA2093147C (enExample)
DE (1) DE69311619T2 (enExample)
DK (1) DK0565863T3 (enExample)
ES (1) ES2103992T3 (enExample)
FI (1) FI106556B (enExample)
GR (1) GR3024419T3 (enExample)
IL (1) IL105112A (enExample)
IT (1) IT1260137B (enExample)
NO (1) NO305992B1 (enExample)
NZ (1) NZ247196A (enExample)
TW (1) TW239148B (enExample)
ZA (1) ZA931798B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
IT1264102B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali
IT1264101B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2
US6127347A (en) * 1994-01-12 2000-10-03 Univ Michigan Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
US5583121A (en) * 1994-01-12 1996-12-10 Michigan State University Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
US6255295B1 (en) 1996-12-23 2001-07-03 Nutramax Laboratories, Inc. Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
HK1045532A1 (zh) * 1999-06-30 2002-11-29 Hamilton Civic Hospitals Research Development, Inc. 抑制与凝结有关凝结因子的肝素成份
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
EP1315539A2 (en) * 2000-09-08 2003-06-04 Leo Pharma A/S Antithrombotic compositions
US7575886B2 (en) 2002-03-11 2009-08-18 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
GB0216861D0 (en) * 2002-07-19 2002-08-28 Univ Birmingham Saccharide libraries
RU2318521C1 (ru) * 2006-08-02 2008-03-10 Роман Владиславович Бочаров Способ проведения антикоагулянтной терапии у детей с термической травмой
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
US20090035787A1 (en) * 2007-07-23 2009-02-05 The University Of North Carolina At Chapel Hill Enzymatic synthesis of sulfated polysaccharides without iduronic acid residues
CN102791742B (zh) * 2010-01-19 2014-12-24 动量制药公司 评价肝素制剂
DK3144325T3 (da) * 2010-09-14 2021-01-25 Univ Miyazaki Heparin med høj renhed og fremstillingsfremgangsmåde dertil
WO2012088416A2 (en) 2010-12-23 2012-06-28 The University Of North Carolina At Chapel Hill Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
DE102011077393A1 (de) * 2011-06-10 2012-12-13 Johannes Reinmüller Antiinfektives Mittel
JP6670235B2 (ja) 2013-06-17 2020-03-18 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｏｒｔｈ Ｃａｒｏｌｉｎａ Ａｔ Ｃｈａｐｅｌ Ｈｉｌｌ 可逆的ヘパリン分子、その製法及びその使用方法
WO2018165656A1 (en) 2017-03-10 2018-09-13 The University Of North Carolina At Chapel Hill Short-acting heparin-based anticoagulant compounds and methods
US11993627B2 (en) 2017-07-03 2024-05-28 The University Of North Carolina At Chapel Hill Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides
US11865137B2 (en) 2017-11-03 2024-01-09 The University Of North Carolina At Chapel Hill Sulfated oligosaccharides having anti-inflammatory activity
WO2019246264A1 (en) 2018-06-20 2019-12-26 The University Of North Carolina At Chapel Hill Cell protective methods and compositions
WO2021097345A1 (en) 2019-11-13 2021-05-20 The University Of North Carolina At Chapel Hill Heparan sulfate (hs) oligosaccharides effect in liver ischemia reperfusion injury

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987223A (en) * 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
DE3821271A1 (de) * 1988-06-23 1989-12-28 Solco Basel Ag Derivatisiertes heparin, verfahren zu dessen herstellung und arzneimittel, welches dieses enthaelt
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5464942A (en) * 1990-07-24 1995-11-07 Seikagaku Kogyo Kabushiki Kaisha Phospholipid- or lipid-linked glycosaminoglycan and process for producing the same
US5200523A (en) * 1990-10-10 1993-04-06 Monsanto Company Synthesis of nojirimycin derivatives
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3

Also Published As

Publication number Publication date
FI931741L (fi) 1993-10-18
EP0565863B1 (en) 1997-06-18
JPH0616703A (ja) 1994-01-25
KR0171624B1 (ko) 1999-02-01
ES2103992T3 (es) 1997-10-01
NZ247196A (en) 1995-02-24
DE69311619T2 (de) 1997-12-11
FI106556B (fi) 2001-02-28
NO305992B1 (no) 1999-08-30
AU658498B2 (en) 1995-04-13
FI931741A0 (fi) 1993-04-16
CA2093147A1 (en) 1993-10-18
NO931184D0 (no) 1993-03-30
CA2093147C (en) 1999-01-26
KR930021650A (ko) 1993-11-22
TW239148B (enExample) 1995-01-21
JP2702376B2 (ja) 1998-01-21
ITBO920141A1 (it) 1993-10-17
EP0565863A2 (en) 1993-10-20
US5430133A (en) 1995-07-04
EP0565863A3 (en) 1993-11-10
IT1260137B (it) 1996-03-28
ITBO920141A0 (it) 1992-04-17
IL105112A0 (en) 1993-07-08
NO931184L (no) 1993-10-18
GR3024419T3 (en) 1997-11-28
DK0565863T3 (da) 1997-12-15
ZA931798B (en) 1993-11-22
AU3689593A (en) 1993-10-21
DE69311619D1 (de) 1997-07-24
ATE154616T1 (de) 1997-07-15

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Legal Events

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MM9K Patent not in force due to non-payment of renewal fees