IL105035A - Substituted pipecolinic acid derivatives, their preparation and pharmaceutical compositions containing them - Google Patents
Substituted pipecolinic acid derivatives, their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL105035A IL105035A IL105035A IL10503593A IL105035A IL 105035 A IL105035 A IL 105035A IL 105035 A IL105035 A IL 105035A IL 10503593 A IL10503593 A IL 10503593A IL 105035 A IL105035 A IL 105035A
- Authority
- IL
- Israel
- Prior art keywords
- lower alkyl
- phenyl
- halo
- hydroxy
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85071692A | 1992-03-13 | 1992-03-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL105035A0 IL105035A0 (en) | 1993-07-08 |
| IL105035A true IL105035A (en) | 1997-07-13 |
Family
ID=25308925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL105035A IL105035A (en) | 1992-03-13 | 1993-03-12 | Substituted pipecolinic acid derivatives, their preparation and pharmaceutical compositions containing them |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5807870A (pl) |
| EP (1) | EP0560268B1 (pl) |
| JP (1) | JP3258422B2 (pl) |
| KR (1) | KR950700253A (pl) |
| AP (1) | AP393A (pl) |
| AT (1) | ATE116640T1 (pl) |
| AU (1) | AU670582B2 (pl) |
| CA (1) | CA2131185C (pl) |
| CZ (1) | CZ285589B6 (pl) |
| DE (1) | DE69300043T2 (pl) |
| DK (1) | DK0560268T3 (pl) |
| ES (1) | ES2066623T3 (pl) |
| FI (1) | FI944217A0 (pl) |
| GR (1) | GR3015622T3 (pl) |
| HU (2) | HUT70617A (pl) |
| IL (1) | IL105035A (pl) |
| NO (1) | NO302570B1 (pl) |
| NZ (1) | NZ251267A (pl) |
| OA (1) | OA10092A (pl) |
| PH (1) | PH30734A (pl) |
| PL (1) | PL176362B1 (pl) |
| RU (1) | RU2140911C1 (pl) |
| SK (1) | SK280161B6 (pl) |
| WO (1) | WO1993018003A1 (pl) |
| ZA (1) | ZA931776B (pl) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| JPH07504654A (ja) | 1992-03-11 | 1995-05-25 | ナルヘックス リミテッド | オキソ及びヒドロキシ置換炭化水素のアミン誘導体 |
| ATE253050T1 (de) | 1992-03-11 | 2003-11-15 | Narhex Ltd | Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen |
| US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
| EP0656887B1 (en) | 1992-08-25 | 1998-10-28 | G.D. Searle & Co. | Hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| US5846993A (en) * | 1992-12-22 | 1998-12-08 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| EP0610745A3 (en) * | 1993-02-09 | 1994-09-28 | Miles Inc | Novel aminomethylene derivatives as immunosuppressants. |
| IL110898A0 (en) * | 1993-09-10 | 1994-11-28 | Narhex Australia Pty Ltd | Polar-substituted hydrocarbons |
| US5527829A (en) * | 1994-05-23 | 1996-06-18 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| CA2137406C (en) * | 1994-12-06 | 2005-09-13 | Pierre Louis Beaulieu | Process for key intermediates for hiv protease inhibitors |
| US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| US5914332A (en) | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5883252A (en) * | 1996-01-26 | 1999-03-16 | Vertex Pharmaceuticals Incorporated | Aspartyl protease inhibitors |
| US5705647A (en) * | 1996-09-05 | 1998-01-06 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
| US5962725A (en) | 1996-09-05 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir |
| US5925759A (en) | 1996-09-05 | 1999-07-20 | Agouron Pharmaceuticals, Inc. | Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors |
| US6232333B1 (en) | 1996-11-21 | 2001-05-15 | Abbott Laboratories | Pharmaceutical composition |
| US6001851A (en) * | 1997-03-13 | 1999-12-14 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| US6084107A (en) * | 1997-09-05 | 2000-07-04 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
| US6251906B1 (en) | 1998-05-15 | 2001-06-26 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| CA2395987C (en) | 2000-01-19 | 2009-12-22 | Abbott Laboratories | Improved pharmaceutical formulations |
| ES2275675T3 (es) * | 2000-03-23 | 2007-06-16 | Elan Pharmaceuticals, Inc. | Compuestos y metodos para tratar la enfermedad de alzheimer. |
| US6992081B2 (en) | 2000-03-23 | 2006-01-31 | Elan Pharmaceuticals, Inc. | Compounds to treat Alzheimer's disease |
| EP1666452A2 (en) | 2000-06-30 | 2006-06-07 | Elan Pharmaceuticals, Inc. | Compounds to treat Alzheimer's disease |
| US20030096864A1 (en) * | 2000-06-30 | 2003-05-22 | Fang Lawrence Y. | Compounds to treat alzheimer's disease |
| PE20020276A1 (es) | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| US6846813B2 (en) * | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
| CN1217920C (zh) * | 2000-06-30 | 2005-09-07 | 艾兰制药公司 | 治疗早老性痴呆的化合物 |
| EP1401452A1 (en) * | 2001-06-27 | 2004-03-31 | Elan Pharmaceuticals, Inc. | Beta-hydroxyamine derivatives useful in the treatment of alzheimer's disease |
| US20070213407A1 (en) * | 2001-06-29 | 2007-09-13 | Elan Pharmaceuticals And Pharmacia & Upjohn Company Llc | Compounds to treat Alzheimer's disease |
| WO2004103360A1 (ja) | 2003-05-22 | 2004-12-02 | Lead Chemical Co.,Ltd. | 抗ウイルス作用を有する化合物および配合剤 |
| BRPI0510746A (pt) | 2004-06-10 | 2007-11-20 | Univ Michigan State | sìntese de caprolactama a partir de lisina |
| US8106090B2 (en) * | 2005-07-20 | 2012-01-31 | Eli Lilly And Company | 1-amino linked compounds |
| US8283466B2 (en) * | 2007-02-20 | 2012-10-09 | Board Of Trustees Of Michigan State University | Catalytic deamination for caprolactam production |
| KR101518079B1 (ko) | 2007-03-12 | 2015-05-06 | 넥타르 테라퓨틱스 | 올리고머-프로테아제 억제제 컨주게이트 |
| EP2262538B1 (en) | 2008-03-12 | 2014-12-10 | Nektar Therapeutics | Oligomer-amino acid conjugate |
| KR20110046487A (ko) * | 2008-07-24 | 2011-05-04 | 드라스 코포레이션 | 사이클릭 아미드 모노머들의 형성 방법, 그 유도체 및 형성 방법 |
| US20120108501A1 (en) | 2009-06-12 | 2012-05-03 | Nektar Therapeutics | Protease Inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3789347D1 (de) * | 1986-10-14 | 1994-04-21 | Banyu Pharma Co Ltd | 5-Substituierte Amino-4-hydroxy-pentansäure-Derivate und deren Verwendung. |
| CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| JPH07106992B2 (ja) * | 1988-06-13 | 1995-11-15 | 三菱石油株式会社 | ２，６―ジメチルナフタレンの分離方法 |
| EP0361341A3 (en) * | 1988-09-28 | 1991-07-03 | Miles Inc. | Therapeutics for aids based on inhibitors of hiv protease |
| GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| GB8927915D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Novel alcohols |
| CA2060844A1 (en) * | 1991-02-08 | 1992-08-09 | Yabe Yuichiro | Beta-amino-alpha-hydroxycarboxylic acids and their use |
| MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
| ZA931777B (en) * | 1992-03-13 | 1993-09-23 | Bio Mega Boehringer Ingelheim | Substituted pyrrolidine derivatives as HIV protease inhibitors. |
| IL110255A (en) * | 1993-07-16 | 1998-12-06 | Merck & Co Inc | Formation and resolution of 2-tert-butylcarboxamido-piperazine |
| US5480887A (en) * | 1994-02-02 | 1996-01-02 | Eli Lilly And Company | Protease inhibitors |
| GB2292146A (en) * | 1994-08-11 | 1996-02-14 | Merck & Co Inc | HIV protease inhibitors useful for the treatment of AIDS |
-
1993
- 1993-03-09 DE DE69300043T patent/DE69300043T2/de not_active Expired - Lifetime
- 1993-03-09 ES ES93103712T patent/ES2066623T3/es not_active Expired - Lifetime
- 1993-03-09 AT AT93103712T patent/ATE116640T1/de active
- 1993-03-09 DK DK93103712.1T patent/DK0560268T3/da active
- 1993-03-09 EP EP93103712A patent/EP0560268B1/en not_active Expired - Lifetime
- 1993-03-10 AP APAP/P/1993/000495A patent/AP393A/en active
- 1993-03-11 PH PH45862A patent/PH30734A/en unknown
- 1993-03-12 WO PCT/CA1993/000096 patent/WO1993018003A1/en not_active Ceased
- 1993-03-12 HU HU9402613A patent/HUT70617A/hu unknown
- 1993-03-12 FI FI944217A patent/FI944217A0/fi unknown
- 1993-03-12 IL IL105035A patent/IL105035A/xx not_active IP Right Cessation
- 1993-03-12 AU AU38808/93A patent/AU670582B2/en not_active Ceased
- 1993-03-12 PL PL93305166A patent/PL176362B1/pl unknown
- 1993-03-12 CZ CZ942232A patent/CZ285589B6/cs not_active IP Right Cessation
- 1993-03-12 CA CA002131185A patent/CA2131185C/en not_active Expired - Lifetime
- 1993-03-12 SK SK1090-94A patent/SK280161B6/sk unknown
- 1993-03-12 ZA ZA931776A patent/ZA931776B/xx unknown
- 1993-03-12 RU RU94040841A patent/RU2140911C1/ru active
- 1993-03-12 NZ NZ251267A patent/NZ251267A/en unknown
- 1993-03-15 JP JP05414293A patent/JP3258422B2/ja not_active Expired - Fee Related
-
1994
- 1994-08-05 OA OA60550A patent/OA10092A/en unknown
- 1994-09-12 NO NO943383A patent/NO302570B1/no unknown
- 1994-09-13 KR KR1019940703190A patent/KR950700253A/ko not_active Abandoned
-
1995
- 1995-03-27 GR GR950400700T patent/GR3015622T3/el unknown
- 1995-06-23 HU HU95P/P00429P patent/HU211854A9/hu unknown
-
1996
- 1996-12-11 US US08/763,464 patent/US5807870A/en not_active Expired - Lifetime
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| HP | Change in proprietorship | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| RH1 | Patent not in force |