IL104574A - N-[[3,4-dichlorophenyl)amino] carbonyl]-2,3-dihydro benzofuran-5-sulfonamide its preparation and antitumor compositions containing it and uses thereof - Google Patents
N-[[3,4-dichlorophenyl)amino] carbonyl]-2,3-dihydro benzofuran-5-sulfonamide its preparation and antitumor compositions containing it and uses thereofInfo
- Publication number
- IL104574A IL104574A IL10457493A IL10457493A IL104574A IL 104574 A IL104574 A IL 104574A IL 10457493 A IL10457493 A IL 10457493A IL 10457493 A IL10457493 A IL 10457493A IL 104574 A IL104574 A IL 104574A
- Authority
- IL
- Israel
- Prior art keywords
- dichlorophenyl
- carbonyl
- amino
- sulfonamide
- preparation
- Prior art date
Links
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 title 1
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
- VAMFSFIPDOODFH-UHFFFAOYSA-N 1-(3,4-dichlorophenyl)-3-(2,3-dihydro-1-benzofuran-5-ylsulfonyl)urea Chemical compound C1=C(Cl)C(Cl)=CC=C1NC(=O)NS(=O)(=O)C1=CC=C(OCC2)C2=C1 VAMFSFIPDOODFH-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Undergarments, Swaddling Clothes, Handkerchiefs Or Underwear Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/831,604 US5254582A (en) | 1992-02-05 | 1992-02-05 | Antitumor compositions and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL104574A0 IL104574A0 (en) | 1993-06-10 |
| IL104574A true IL104574A (en) | 1997-02-18 |
Family
ID=25259448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10457493A IL104574A (en) | 1992-02-05 | 1993-02-01 | N-[[3,4-dichlorophenyl)amino] carbonyl]-2,3-dihydro benzofuran-5-sulfonamide its preparation and antitumor compositions containing it and uses thereof |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5254582A (de) |
| EP (1) | EP0555036B1 (de) |
| JP (1) | JP3210117B2 (de) |
| KR (1) | KR100246148B1 (de) |
| CN (1) | CN1044239C (de) |
| AT (1) | ATE170853T1 (de) |
| AU (1) | AU658043B2 (de) |
| BR (1) | BR9300469A (de) |
| CA (1) | CA2088719A1 (de) |
| CY (1) | CY2101B1 (de) |
| CZ (1) | CZ282753B6 (de) |
| DE (1) | DE69320844T2 (de) |
| DK (1) | DK0555036T3 (de) |
| ES (1) | ES2121940T3 (de) |
| FI (1) | FI930453L (de) |
| HU (2) | HU213231B (de) |
| IL (1) | IL104574A (de) |
| MX (1) | MX9300558A (de) |
| MY (1) | MY109640A (de) |
| NO (1) | NO302472B1 (de) |
| NZ (1) | NZ245818A (de) |
| RU (1) | RU2072996C1 (de) |
| SG (1) | SG79181A1 (de) |
| YU (1) | YU48915B (de) |
| ZA (1) | ZA93689B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5116874A (en) * | 1985-09-23 | 1992-05-26 | Eli Lilly And Company | Anti-tumor method and compounds |
| US5529999A (en) * | 1994-03-04 | 1996-06-25 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
| AU709107B2 (en) * | 1996-08-22 | 1999-08-19 | Dong Wha Pharmaceutical Industrial Co., Ltd. | Arylsulfonylimidazolone derivatives as an antitumor agent |
| EP0929540A4 (de) * | 1996-10-04 | 2001-12-12 | Lilly Co Eli | Antitumor-zusamensetzungen und behandlungsverfahren |
| US6281240B1 (en) * | 1997-04-10 | 2001-08-28 | Eli Lilly And Company | Diarylsulfonylureas for use in treating secretory diarrhea |
| US5932407A (en) * | 1997-04-30 | 1999-08-03 | Eastman Kodak Company | Color photographic element containing oxidized developer-scavenging naphtholic coupler forming wash-out dye |
| EP1663978B1 (de) | 2003-07-23 | 2007-11-28 | Bayer Pharmaceuticals Corporation | Fluorsubstituierter omega-carboxyaryldiphenylharnstoff zur behandlung und prävention von krankheiten und leiden |
| US8772269B2 (en) | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
| WO2006030947A1 (ja) * | 2004-09-13 | 2006-03-23 | Eisai R & D Management Co., Ltd. | スルホンアミド含有化合物の血管新生阻害物質との併用 |
| JP5134247B2 (ja) * | 2004-09-13 | 2013-01-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド含有化合物の血管新生阻害物質との併用 |
| US20100291592A1 (en) | 2006-04-20 | 2010-11-18 | Taro Semba | Novel marker for sensitivity against sulfonamide compound |
| CN104941647B (zh) * | 2015-06-18 | 2017-07-04 | 四川之江高新材料股份有限公司 | 合成n‑甲基吗啉的方法及所用的负载型催化剂 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3083207A (en) * | 1963-03-26 | Indolinesulfonylureas | ||
| US1208561A (en) * | 1914-09-14 | 1916-12-12 | Stephen E Huff | Sound-box attachment for phonographs. |
| US3097242A (en) * | 1960-06-29 | 1963-07-09 | Olin Mathieson | Hydrindene sulfonylureas |
| US3102121A (en) * | 1961-06-29 | 1963-08-27 | Olin Mathieson | Novel cumaransulfonylureas and 2,3-dihydrothionaphthenesulfonylureas |
| BE634577A (de) * | 1962-04-11 | |||
| US3849110A (en) * | 1963-01-07 | 1974-11-19 | Lilly Co Eli | Herbicidal method employing aryl-sulfonylureas or salts thereof |
| US3736122A (en) * | 1969-04-10 | 1973-05-29 | C Tung | Method of controlling plant growth |
| IL69621A0 (en) * | 1982-09-02 | 1983-12-30 | Duphar Int Res | Pharmaceutical compositions having antitumor activity,comprising certain phenylurea derivatives |
| CA1208561A (en) * | 1984-01-19 | 1986-07-29 | Marius S. Brouwer | Pharmaceutical compositions containing benzoylurea compounds |
| US4845128A (en) * | 1984-06-27 | 1989-07-04 | Eli Lilly And Company | N([(4-trifluoromethylphenyl)amino]carbonyl)benzene sulfonamides |
| JPS6163671A (ja) * | 1984-09-05 | 1986-04-01 | Shionogi & Co Ltd | ２，３−ジヒドロベンゾフラン−５−スルホンアミド誘導体および降圧利尿剤 |
| US5116874A (en) * | 1985-09-23 | 1992-05-26 | Eli Lilly And Company | Anti-tumor method and compounds |
| IL80032A (en) * | 1985-09-23 | 1992-07-15 | Lilly Co Eli | Anti-tumor phenyl-aminocarbonylsulfonamides,their preparation and pharmaceutical compositions containing them |
| CA1331464C (en) * | 1987-05-12 | 1994-08-16 | Eli Lilly And Company | Anti-tumor method and compounds |
| NZ238911A (en) * | 1990-07-17 | 1993-10-26 | Lilly Co Eli | Furyl, pyrrolyl and thienyl sulphonyl urea derivatives, pharmaceutical compositions and intermediates therefor |
| US5169860A (en) * | 1992-03-13 | 1992-12-08 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
-
1992
- 1992-02-05 US US07/831,604 patent/US5254582A/en not_active Expired - Fee Related
-
1993
- 1993-01-28 JP JP01241993A patent/JP3210117B2/ja not_active Expired - Fee Related
- 1993-02-01 AT AT93300710T patent/ATE170853T1/de not_active IP Right Cessation
- 1993-02-01 ZA ZA93689A patent/ZA93689B/xx unknown
- 1993-02-01 CZ CZ93120A patent/CZ282753B6/cs not_active IP Right Cessation
- 1993-02-01 DE DE69320844T patent/DE69320844T2/de not_active Expired - Fee Related
- 1993-02-01 IL IL10457493A patent/IL104574A/xx not_active IP Right Cessation
- 1993-02-01 NZ NZ245818A patent/NZ245818A/en unknown
- 1993-02-01 ES ES93300710T patent/ES2121940T3/es not_active Expired - Lifetime
- 1993-02-01 EP EP93300710A patent/EP0555036B1/de not_active Expired - Lifetime
- 1993-02-01 DK DK93300710T patent/DK0555036T3/da active
- 1993-02-01 SG SG9603380A patent/SG79181A1/en unknown
- 1993-02-02 AU AU32183/93A patent/AU658043B2/en not_active Ceased
- 1993-02-02 FI FI930453A patent/FI930453L/fi unknown
- 1993-02-02 MX MX9300558A patent/MX9300558A/es not_active IP Right Cessation
- 1993-02-02 YU YU5893A patent/YU48915B/sh unknown
- 1993-02-02 RU RU9393004535A patent/RU2072996C1/ru active
- 1993-02-02 MY MYPI93000160A patent/MY109640A/en unknown
- 1993-02-03 CA CA002088719A patent/CA2088719A1/en not_active Abandoned
- 1993-02-03 CN CN93100977A patent/CN1044239C/zh not_active Expired - Fee Related
- 1993-02-03 KR KR1019930001408A patent/KR100246148B1/ko not_active Expired - Fee Related
- 1993-02-03 NO NO930380A patent/NO302472B1/no not_active IP Right Cessation
- 1993-02-03 BR BR9300469A patent/BR9300469A/pt not_active Application Discontinuation
- 1993-02-03 HU HU9300288A patent/HU213231B/hu not_active IP Right Cessation
-
1995
- 1995-06-22 HU HU95P/P00400P patent/HU211561A9/hu unknown
-
1998
- 1998-10-19 CY CY9800043A patent/CY2101B1/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| RH1 | Patent not in force |