IL104324A0 - Variant of human kunitz-type protease inhibitor - Google Patents

Variant of human kunitz-type protease inhibitor

Info

Publication number
IL104324A0
IL104324A0 IL104324A IL10432493A IL104324A0 IL 104324 A0 IL104324 A0 IL 104324A0 IL 104324 A IL104324 A IL 104324A IL 10432493 A IL10432493 A IL 10432493A IL 104324 A0 IL104324 A0 IL 104324A0
Authority
IL
Israel
Prior art keywords
variant
protease inhibitor
type protease
human kunitz
kunitz
Prior art date
Application number
IL104324A
Other languages
English (en)
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of IL104324A0 publication Critical patent/IL104324A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
IL104324A 1992-01-07 1993-01-06 Variant of human kunitz-type protease inhibitor IL104324A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK9200002 1992-01-07
DK9200340 1992-11-16

Publications (1)

Publication Number Publication Date
IL104324A0 true IL104324A0 (en) 1993-05-13

Family

ID=26068350

Family Applications (1)

Application Number Title Priority Date Filing Date
IL104324A IL104324A0 (en) 1992-01-07 1993-01-06 Variant of human kunitz-type protease inhibitor

Country Status (13)

Country Link
EP (1) EP0621872A1 (fr)
JP (1) JPH07504891A (fr)
AU (1) AU675926B2 (fr)
CA (1) CA2127246A1 (fr)
CZ (1) CZ164494A3 (fr)
FI (1) FI943234A0 (fr)
HU (1) HUT70293A (fr)
IL (1) IL104324A0 (fr)
NO (1) NO942549L (fr)
NZ (1) NZ246570A (fr)
RU (1) RU94036773A (fr)
WO (1) WO1993014122A1 (fr)
ZA (1) ZA9396B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455338A (en) * 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
WO1995018830A2 (fr) * 1994-01-11 1995-07-13 Protein Engineering Corporation Inhibiteurs de la plasmine humaine derives des domaines de kunitz
ATE275583T1 (de) * 1994-01-11 2004-09-15 Dyax Corp KALLIKREINHEMMENDE ßKUNITZ-DOMÄNEß-PROTEINE UND DERIVATEN DAVON
US6057287A (en) * 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
US5589359A (en) * 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
ATE226249T1 (de) * 1994-08-05 2002-11-15 Chiron Corp Herstellung des inhibitors fuer die komplexbildung des gewebefaktors
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US6242414B1 (en) 1995-06-07 2001-06-05 Chiron Corporation Regulation of cytokine synthesis and release
WO1996040224A1 (fr) * 1995-06-07 1996-12-19 Chiron Corporation Regulation de la synthese et de la liberation de la cytokine
US6521410B1 (en) * 1998-08-25 2003-02-18 Knut Kleesiek Mutant of tissue factor pathway inhibitor, DNA sequence and use for detecting thrombotic disorders
CN1325889A (zh) * 2000-05-26 2001-12-12 上海博德基因开发有限公司 一种新的多肽——人Kazal型抑制因子11和编码这种多肽的多核苷酸
EP2298278B1 (fr) 2002-06-07 2015-11-11 Dyax Corp. Prévention et réduction de perte sanguine et la réponse inflammatoire
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
TR201900937T4 (tr) 2002-08-28 2019-02-21 Dyax Corp Organların ve dokuların muhafaza edilmesine yönelik yöntem.
US6989369B2 (en) 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
PT1663281E (pt) 2003-08-29 2014-03-17 Dyax Corp Inibidores de proteases poli-peguilados
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US7276480B1 (en) 2005-12-30 2007-10-02 Dyax Corp. Prevention and reduction of blood loss
KR101792032B1 (ko) 2008-12-19 2017-11-02 백스터 인터내셔널 인코포레이티드 Ｔｆｐｉ 억제제 및 사용 방법
WO2010080833A1 (fr) 2009-01-06 2010-07-15 Dyax Corp. Traitement de la mucosite par des inhibiteurs de kallikréine
EP3459564B1 (fr) 2010-01-06 2021-10-27 Takeda Pharmaceutical Company Limited Protéines de liaison de kallicréine plasmatique
AU2011227714B2 (en) 2010-03-19 2014-09-04 Takeda Pharmaceutical Company Limited TFPI inhibitors and methods of use
KR102169651B1 (ko) 2011-01-06 2020-10-23 다이액스 코포레이션 혈장 칼리크레인 결합 단백질
CN109111505A (zh) 2012-03-21 2019-01-01 百深有限责任公司 Tfpi抑制剂及其使用方法
IL311156A (en) 2015-12-11 2024-04-01 Takeda Pharmaceuticals Co Plasma kallikrein inhibitors and their uses in the treatment of hereditary angioedema attack

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
DK408089D0 (da) * 1989-08-18 1989-08-18 Novo Nordisk As Proteiner

Also Published As

Publication number Publication date
AU675926B2 (en) 1997-02-27
JPH07504891A (ja) 1995-06-01
NO942549D0 (no) 1994-07-06
FI943234A (fi) 1994-07-06
NO942549L (no) 1994-09-07
FI943234A0 (fi) 1994-07-06
HU9401990D0 (en) 1994-09-28
RU94036773A (ru) 1996-09-27
EP0621872A1 (fr) 1994-11-02
AU3346093A (en) 1993-08-03
NZ246570A (en) 1996-09-25
CA2127246A1 (fr) 1993-07-22
ZA9396B (en) 1993-08-10
HUT70293A (en) 1995-09-28
WO1993014122A1 (fr) 1993-07-22
CZ164494A3 (en) 1994-12-15

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