IL104258A - a-SUBSTITUTED BENZENEMETHANAMINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
a-SUBSTITUTED BENZENEMETHANAMINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- IL104258A IL104258A IL104258A IL10425892A IL104258A IL 104258 A IL104258 A IL 104258A IL 104258 A IL104258 A IL 104258A IL 10425892 A IL10425892 A IL 10425892A IL 104258 A IL104258 A IL 104258A
- Authority
- IL
- Israel
- Prior art keywords
- hydrogen
- alkyl
- radical
- halo
- trifluoromethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
- C07D215/60—N-oxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP91203430 | 1991-12-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL104258A0 IL104258A0 (en) | 1993-05-13 |
| IL104258A true IL104258A (en) | 1997-04-15 |
Family
ID=8208118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL104258A IL104258A (en) | 1991-12-30 | 1992-12-29 | a-SUBSTITUTED BENZENEMETHANAMINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US5407961A (zh) |
| EP (1) | EP0620809B1 (zh) |
| JP (1) | JPH07502524A (zh) |
| CN (1) | CN1033451C (zh) |
| AP (1) | AP406A (zh) |
| AT (1) | ATE149484T1 (zh) |
| AU (1) | AU664874B2 (zh) |
| CA (1) | CA2125676A1 (zh) |
| DE (1) | DE69217992T2 (zh) |
| FI (1) | FI943120A0 (zh) |
| HU (1) | HUT67030A (zh) |
| IL (1) | IL104258A (zh) |
| MX (1) | MX9207620A (zh) |
| NO (1) | NO942481D0 (zh) |
| TW (1) | TW249227B (zh) |
| WO (1) | WO1993013052A1 (zh) |
| ZA (1) | ZA9210079B (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE75693B1 (en) * | 1990-07-10 | 1997-09-10 | Janssen Pharmaceutica Nv | HIV-inhibiting benzeneacetamide derivatives |
| US6031003A (en) * | 1991-08-23 | 2000-02-29 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US6001884A (en) * | 1991-08-23 | 1999-12-14 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US6313146B1 (en) | 1991-08-23 | 2001-11-06 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US5767310A (en) * | 1993-03-19 | 1998-06-16 | Merck & Co., Inc. | Phenoxyphenylacetic acid derivatives |
| US5686478A (en) * | 1993-07-20 | 1997-11-11 | Merck & Co. Inc. | Endothelin antagonists |
| US5559135A (en) * | 1994-09-14 | 1996-09-24 | Merck & Co., Inc. | Endothelin antagonists bearing pyridyl amides |
| US5538991A (en) * | 1994-09-14 | 1996-07-23 | Merck & Co., Inc. | Endothelin antagonists bearing 5-membered heterocyclic amides |
| PL183499B1 (pl) | 1994-10-21 | 2002-06-28 | Nps Pharma Inc | Związki do modulowania receptorów wapniowych i kompozycje farmaceutyczne |
| US5981599A (en) | 1996-05-01 | 1999-11-09 | Nps Pharmaceuticals, Inc. | Inorganic ion receptor active compounds |
| BR9911385A (pt) * | 1998-06-19 | 2001-03-13 | Us Health | Composição, processos para dissociar um ìon de metal de uma proteìna contendo dedo de zinco, para inativar um vìrus e para selecionar um composto capaz de dissociar um ìon de metal quelado com um dedo de zinco de uma proteìna viral, vìrus isolado e inativado, kit para selecionar um composto capaz de dissociar um ìon de metal de um dedo de zinco de uma proteìna viral, composição viricida, e, formulação farmacêutica. |
| EP1104239B1 (de) | 1998-08-13 | 2004-02-18 | Bayer CropScience GmbH | Herbizide mittel mit acylierten aminophenylsulfonylharnstoffen |
| CA2716347C (en) | 2008-02-21 | 2017-06-20 | Sequoia Pharmaceuticals, Inc. | Amino acid inhibitors of cytochrome p450 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4246429A (en) * | 1978-06-23 | 1981-01-20 | Janssen Pharmaceutica, N.V. | Novel α-amino-phenylacetic acid derivatives |
| IT1226300B (it) * | 1988-07-26 | 1990-12-27 | Zambon Spa | Processo per la preparazione di intermedi per la sintesi del diltiazem. |
| IE75693B1 (en) * | 1990-07-10 | 1997-09-10 | Janssen Pharmaceutica Nv | HIV-inhibiting benzeneacetamide derivatives |
-
1992
- 1992-12-22 US US08/240,735 patent/US5407961A/en not_active Expired - Lifetime
- 1992-12-22 DE DE69217992T patent/DE69217992T2/de not_active Expired - Fee Related
- 1992-12-22 WO PCT/EP1992/002995 patent/WO1993013052A1/en active IP Right Grant
- 1992-12-22 HU HU9401381A patent/HUT67030A/hu unknown
- 1992-12-22 AU AU32581/93A patent/AU664874B2/en not_active Ceased
- 1992-12-22 CA CA002125676A patent/CA2125676A1/en not_active Abandoned
- 1992-12-22 JP JP51143793A patent/JPH07502524A/ja active Pending
- 1992-12-22 EP EP93901721A patent/EP0620809B1/en not_active Expired - Lifetime
- 1992-12-22 AT AT93901721T patent/ATE149484T1/de active
- 1992-12-28 TW TW081110389A patent/TW249227B/zh active
- 1992-12-29 MX MX9207620A patent/MX9207620A/es unknown
- 1992-12-29 ZA ZA9210079A patent/ZA9210079B/xx unknown
- 1992-12-29 AP APAP/P/1992/000469A patent/AP406A/en active
- 1992-12-29 CN CN92115152A patent/CN1033451C/zh not_active Expired - Fee Related
- 1992-12-29 IL IL104258A patent/IL104258A/xx not_active IP Right Cessation
-
1994
- 1994-06-29 FI FI943120A patent/FI943120A0/fi not_active Application Discontinuation
- 1994-06-30 NO NO942481A patent/NO942481D0/no unknown
-
1995
- 1995-03-07 US US08/400,218 patent/US5480912A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL104258A0 (en) | 1993-05-13 |
| JPH07502524A (ja) | 1995-03-16 |
| AU3258193A (en) | 1993-07-28 |
| AU664874B2 (en) | 1995-12-07 |
| DE69217992D1 (de) | 1997-04-10 |
| CA2125676A1 (en) | 1993-07-08 |
| CN1033451C (zh) | 1996-12-04 |
| FI943120A (fi) | 1994-06-29 |
| FI943120A0 (fi) | 1994-06-29 |
| US5480912A (en) | 1996-01-02 |
| ATE149484T1 (de) | 1997-03-15 |
| NO942481L (zh) | 1994-06-30 |
| HUT67030A (en) | 1995-01-30 |
| US5407961A (en) | 1995-04-18 |
| DE69217992T2 (de) | 1997-06-12 |
| EP0620809A1 (en) | 1994-10-26 |
| WO1993013052A1 (en) | 1993-07-08 |
| CN1073936A (zh) | 1993-07-07 |
| MX9207620A (es) | 1993-06-01 |
| HU9401381D0 (en) | 1994-08-29 |
| NO942481D0 (zh) | 1994-06-30 |
| TW249227B (zh) | 1995-06-11 |
| ZA9210079B (en) | 1994-06-29 |
| EP0620809B1 (en) | 1997-03-05 |
| AP406A (en) | 1995-09-22 |
| AP9200469A0 (en) | 1993-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| RH | Patent void |