IL103862A - Stabilized pharmaceutical composition of non-glycosylated recombinant human IL2 in reduced form and its preparation process - Google Patents
Stabilized pharmaceutical composition of non-glycosylated recombinant human IL2 in reduced form and its preparation processInfo
- Publication number
- IL103862A IL103862A IL10386292A IL10386292A IL103862A IL 103862 A IL103862 A IL 103862A IL 10386292 A IL10386292 A IL 10386292A IL 10386292 A IL10386292 A IL 10386292A IL 103862 A IL103862 A IL 103862A
- Authority
- IL
- Israel
- Prior art keywords
- recombinant human
- reduced form
- pharmaceutical composition
- preparation process
- glycosylated recombinant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9115418A FR2684878B1 (fr) | 1991-12-12 | 1991-12-12 | Composition pharmaceutique stabilisee d'il2 humaine recombinante non glycosylee sous forme reduite et son procede de preparation. |
Publications (2)
Publication Number | Publication Date |
---|---|
IL103862A0 IL103862A0 (en) | 1993-04-04 |
IL103862A true IL103862A (en) | 1997-02-18 |
Family
ID=9419958
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10386292A IL103862A (en) | 1991-12-12 | 1992-11-24 | Stabilized pharmaceutical composition of non-glycosylated recombinant human IL2 in reduced form and its preparation process |
Country Status (18)
Country | Link |
---|---|
US (1) | US5340574A (de) |
EP (1) | EP0554634B1 (de) |
JP (1) | JP3291340B2 (de) |
KR (1) | KR930012023A (de) |
AT (1) | ATE135917T1 (de) |
AU (1) | AU662940B2 (de) |
CA (1) | CA2085142A1 (de) |
DE (1) | DE69209486T2 (de) |
DK (1) | DK0554634T3 (de) |
ES (1) | ES2084965T3 (de) |
FR (1) | FR2684878B1 (de) |
GR (1) | GR3019440T3 (de) |
HU (1) | HU218103B (de) |
IL (1) | IL103862A (de) |
MX (1) | MX9207199A (de) |
RU (1) | RU2107511C1 (de) |
UA (1) | UA26898C2 (de) |
ZA (1) | ZA929627B (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU9280798A (en) * | 1997-10-03 | 1999-04-27 | Shionogi & Co., Ltd. | Process for freeze-drying proteins |
CN1245216C (zh) * | 1999-10-04 | 2006-03-15 | 希龙公司 | 稳定化的含多肽的液体药物组合物 |
EA008038B1 (ru) | 2003-01-08 | 2007-02-27 | Чирон Корпорейшн | Стабилизированные водные композиции, содержащие ингибитор пути метаболизма, тканевого фактора (tfpi) или вариант ингибитора пути метаболизма тканевого фактора |
JP2008501639A (ja) * | 2004-04-23 | 2008-01-24 | ノベシン リミテッド | タンパク質を安定化、保護及び可溶化させるための方法及びキット |
NZ601927A (en) * | 2010-04-27 | 2013-07-26 | Scil Technology Gmbh | Stable aqueous mia/cd-rap formulations (cartilage derived retinoic acid sensitive protein) |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE251001C (de) * | ||||
FR353150A (fr) * | 1905-04-08 | 1905-09-04 | Gerardo Caffaro | Compteurs à gaz |
FR452598A (fr) * | 1912-12-26 | 1913-05-19 | Lanston Monotype Corp Ltd | Perfectionnements apportés aux machines servant à la composition typographique |
DE3575072D1 (de) * | 1984-03-28 | 1990-02-08 | Cetus Corp | Pharmazeutische zusammensetzungen von mikrobenerzeugtem interleukin-2. |
EP0158487B1 (de) * | 1984-04-09 | 1991-08-28 | Takeda Chemical Industries, Ltd. | Stabile Interleukin-2-Zusammensetzung |
US4572798A (en) * | 1984-12-06 | 1986-02-25 | Cetus Corporation | Method for promoting disulfide bond formation in recombinant proteins |
US4748234A (en) * | 1985-06-26 | 1988-05-31 | Cetus Corporation | Process for recovering refractile bodies containing heterologous proteins from microbial hosts |
US4816440A (en) * | 1985-09-26 | 1989-03-28 | Cetus Corporation | Stable formulation of biologically active proteins for parenteral injection |
DK585886A (da) * | 1985-12-24 | 1987-06-25 | Takeda Chemical Industries Ltd | Immunstimulerende middel og anvendelse deraf |
JPH0645551B2 (ja) * | 1986-01-07 | 1994-06-15 | 塩野義製薬株式会社 | インタ−ロイキン−2組成物 |
US4933433A (en) * | 1986-01-31 | 1990-06-12 | E. I. Du Pont De Nemours And Company | Recombinant interleukin-2 composition and process for making it |
DE3621828A1 (de) * | 1986-06-28 | 1988-01-14 | Biotest Pharma Gmbh | Stabilisierung eines fuer therapeutische zwecke, insbesondere beim menschen, bestimmten interleukin-2-praeparates sowie dieses praeparat enthaltende stabilisierte waessrige loesung oder feststoff |
US4931544A (en) * | 1986-09-04 | 1990-06-05 | Cetus Corporation | Succinylated interleukin-2 for pharmaceutical compositions |
US5037644A (en) * | 1986-10-27 | 1991-08-06 | Cetus Corporation | Pharmaceutical compositions of recombinant interleukin-2 and formulation processes |
US4931543A (en) * | 1987-05-11 | 1990-06-05 | Cetus Corporation | Process for recovering microbially produced interleukin-2 |
US4863726A (en) * | 1987-05-29 | 1989-09-05 | Cetus Corporation | Combination therapy using immunotoxins with interleukin-2 |
US5004605A (en) * | 1987-12-10 | 1991-04-02 | Cetus Corporation | Low pH pharmaceutical compositions of recombinant β-interferon |
US5215743A (en) * | 1988-04-13 | 1993-06-01 | Maninder Singh | Tumor necrosis factor formulations |
US5078997A (en) * | 1988-07-13 | 1992-01-07 | Cetus Corporation | Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers |
FR2635527B1 (fr) * | 1988-07-28 | 1992-06-12 | Roussel Uclaf | Il2 humaine recombinante non glycosylee sous forme reduite, son procede d'obtention et son application comme medicament |
US4902502A (en) * | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
FR2660863B1 (fr) * | 1990-04-17 | 1994-01-21 | Roussel Uclaf | Utilisation d'un polypeptide ayant l'activite de l'interleukine 2 humaine pour preparer une composition pharmaceutique destinee au traitement de cancers primitifs de la plevre. |
US5204094A (en) * | 1991-01-17 | 1993-04-20 | Roussel Uclaf | Treatment of pneumothorax |
-
1991
- 1991-12-12 FR FR9115418A patent/FR2684878B1/fr not_active Expired - Fee Related
-
1992
- 1992-11-24 IL IL10386292A patent/IL103862A/xx not_active IP Right Cessation
- 1992-12-10 AU AU30041/92A patent/AU662940B2/en not_active Ceased
- 1992-12-11 JP JP35229692A patent/JP3291340B2/ja not_active Expired - Lifetime
- 1992-12-11 RU RU92004553A patent/RU2107511C1/ru active
- 1992-12-11 ES ES92403362T patent/ES2084965T3/es not_active Expired - Lifetime
- 1992-12-11 HU HU9203925A patent/HU218103B/hu not_active IP Right Cessation
- 1992-12-11 DK DK92403362.4T patent/DK0554634T3/da active
- 1992-12-11 US US07/989,230 patent/US5340574A/en not_active Expired - Lifetime
- 1992-12-11 EP EP92403362A patent/EP0554634B1/de not_active Expired - Lifetime
- 1992-12-11 KR KR1019920023909A patent/KR930012023A/ko not_active Application Discontinuation
- 1992-12-11 DE DE69209486T patent/DE69209486T2/de not_active Expired - Lifetime
- 1992-12-11 MX MX9207199A patent/MX9207199A/es not_active IP Right Cessation
- 1992-12-11 CA CA002085142A patent/CA2085142A1/fr not_active Abandoned
- 1992-12-11 AT AT92403362T patent/ATE135917T1/de not_active IP Right Cessation
- 1992-12-11 ZA ZA929627A patent/ZA929627B/xx unknown
-
1993
- 1993-06-08 UA UA93002691A patent/UA26898C2/uk unknown
-
1996
- 1996-03-28 GR GR950402527T patent/GR3019440T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ZA929627B (en) | 1993-12-13 |
DE69209486T2 (de) | 1996-09-12 |
FR2684878A1 (fr) | 1993-06-18 |
EP0554634B1 (de) | 1996-03-27 |
UA26898C2 (uk) | 1999-12-29 |
AU3004192A (en) | 1993-06-17 |
HU9203925D0 (en) | 1993-03-29 |
IL103862A0 (en) | 1993-04-04 |
KR930012023A (ko) | 1993-07-20 |
RU2107511C1 (ru) | 1998-03-27 |
ES2084965T3 (es) | 1996-05-16 |
US5340574A (en) | 1994-08-23 |
HUT63575A (en) | 1993-09-28 |
DK0554634T3 (da) | 1996-07-01 |
AU662940B2 (en) | 1995-09-21 |
EP0554634A1 (de) | 1993-08-11 |
CA2085142A1 (fr) | 1993-06-13 |
DE69209486D1 (de) | 1996-05-02 |
ATE135917T1 (de) | 1996-04-15 |
MX9207199A (es) | 1993-07-01 |
GR3019440T3 (en) | 1996-06-30 |
FR2684878B1 (fr) | 1994-02-11 |
JPH05345728A (ja) | 1993-12-27 |
JP3291340B2 (ja) | 2002-06-10 |
HU218103B (hu) | 2000-06-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
HCA | Change of name of proprietor(s) after amalgamation | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |