IL103862A - Stabilized pharmaceutical composition of non-glycosylated recombinant human IL2 in reduced form and its preparation process - Google Patents

Stabilized pharmaceutical composition of non-glycosylated recombinant human IL2 in reduced form and its preparation process

Info

Publication number
IL103862A
IL103862A IL10386292A IL10386292A IL103862A IL 103862 A IL103862 A IL 103862A IL 10386292 A IL10386292 A IL 10386292A IL 10386292 A IL10386292 A IL 10386292A IL 103862 A IL103862 A IL 103862A
Authority
IL
Israel
Prior art keywords
recombinant human
reduced form
pharmaceutical composition
preparation process
glycosylated recombinant
Prior art date
Application number
IL10386292A
Other languages
English (en)
Other versions
IL103862A0 (en
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of IL103862A0 publication Critical patent/IL103862A0/xx
Publication of IL103862A publication Critical patent/IL103862A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL10386292A 1991-12-12 1992-11-24 Stabilized pharmaceutical composition of non-glycosylated recombinant human IL2 in reduced form and its preparation process IL103862A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9115418A FR2684878B1 (fr) 1991-12-12 1991-12-12 Composition pharmaceutique stabilisee d'il2 humaine recombinante non glycosylee sous forme reduite et son procede de preparation.

Publications (2)

Publication Number Publication Date
IL103862A0 IL103862A0 (en) 1993-04-04
IL103862A true IL103862A (en) 1997-02-18

Family

ID=9419958

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10386292A IL103862A (en) 1991-12-12 1992-11-24 Stabilized pharmaceutical composition of non-glycosylated recombinant human IL2 in reduced form and its preparation process

Country Status (18)

Country Link
US (1) US5340574A (xx)
EP (1) EP0554634B1 (xx)
JP (1) JP3291340B2 (xx)
KR (1) KR930012023A (xx)
AT (1) ATE135917T1 (xx)
AU (1) AU662940B2 (xx)
CA (1) CA2085142A1 (xx)
DE (1) DE69209486T2 (xx)
DK (1) DK0554634T3 (xx)
ES (1) ES2084965T3 (xx)
FR (1) FR2684878B1 (xx)
GR (1) GR3019440T3 (xx)
HU (1) HU218103B (xx)
IL (1) IL103862A (xx)
MX (1) MX9207199A (xx)
RU (1) RU2107511C1 (xx)
UA (1) UA26898C2 (xx)
ZA (1) ZA929627B (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999018119A1 (fr) * 1997-10-03 1999-04-15 Shionogi & Co., Ltd. Procede de lyophilisation de proteines
HUP0203133A3 (en) * 1999-10-04 2005-07-28 Chiron Corp Emeryville Stabilized liquid polypeptide-containing pharmaceutical compositions
WO2004062689A1 (en) 2003-01-08 2004-07-29 Chiron Corporation Stabilized aqueous compositions comprising tissue factor pathway inhibitor (tfpi) or tissue factor pathway inhibitor variant
JP2008501639A (ja) * 2004-04-23 2008-01-24 ノベシン リミテッド タンパク質を安定化、保護及び可溶化させるための方法及びキット
RU2739078C2 (ru) * 2010-04-27 2020-12-21 ЭсСиАйЭл Текнолоджи ГмбХ Стабильные водные композиции белка MIA/CD-RAP

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE251001C (xx) *
FR353150A (fr) * 1905-04-08 1905-09-04 Gerardo Caffaro Compteurs à gaz
FR452598A (fr) * 1912-12-26 1913-05-19 Lanston Monotype Corp Ltd Perfectionnements apportés aux machines servant à la composition typographique
EP0211835B1 (en) * 1984-03-28 1990-01-03 Cetus Corporation Pharmaceutical compositions of microbially produced interleukin-2
DE3583880D1 (de) * 1984-04-09 1991-10-02 Takeda Chemical Industries Ltd Stabile interleukin-2-zusammensetzung.
US4572798A (en) * 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
US4748234A (en) * 1985-06-26 1988-05-31 Cetus Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
US4816440A (en) * 1985-09-26 1989-03-28 Cetus Corporation Stable formulation of biologically active proteins for parenteral injection
DK585886A (da) * 1985-12-24 1987-06-25 Takeda Chemical Industries Ltd Immunstimulerende middel og anvendelse deraf
JPH0645551B2 (ja) * 1986-01-07 1994-06-15 塩野義製薬株式会社 インタ−ロイキン−２組成物
US4933433A (en) * 1986-01-31 1990-06-12 E. I. Du Pont De Nemours And Company Recombinant interleukin-2 composition and process for making it
DE3621828A1 (de) * 1986-06-28 1988-01-14 Biotest Pharma Gmbh Stabilisierung eines fuer therapeutische zwecke, insbesondere beim menschen, bestimmten interleukin-2-praeparates sowie dieses praeparat enthaltende stabilisierte waessrige loesung oder feststoff
US4931544A (en) * 1986-09-04 1990-06-05 Cetus Corporation Succinylated interleukin-2 for pharmaceutical compositions
US5037644A (en) * 1986-10-27 1991-08-06 Cetus Corporation Pharmaceutical compositions of recombinant interleukin-2 and formulation processes
US4931543A (en) * 1987-05-11 1990-06-05 Cetus Corporation Process for recovering microbially produced interleukin-2
US4863726A (en) * 1987-05-29 1989-09-05 Cetus Corporation Combination therapy using immunotoxins with interleukin-2
US5004605A (en) * 1987-12-10 1991-04-02 Cetus Corporation Low pH pharmaceutical compositions of recombinant β-interferon
US5215743A (en) * 1988-04-13 1993-06-01 Maninder Singh Tumor necrosis factor formulations
US5078997A (en) * 1988-07-13 1992-01-07 Cetus Corporation Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers
FR2635527B1 (fr) * 1988-07-28 1992-06-12 Roussel Uclaf Il2 humaine recombinante non glycosylee sous forme reduite, son procede d'obtention et son application comme medicament
US4902502A (en) * 1989-01-23 1990-02-20 Cetus Corporation Preparation of a polymer/interleukin-2 conjugate
FR2660863B1 (fr) * 1990-04-17 1994-01-21 Roussel Uclaf Utilisation d'un polypeptide ayant l'activite de l'interleukine 2 humaine pour preparer une composition pharmaceutique destinee au traitement de cancers primitifs de la plevre.
US5204094A (en) * 1991-01-17 1993-04-20 Roussel Uclaf Treatment of pneumothorax

Also Published As

Publication number Publication date
EP0554634A1 (fr) 1993-08-11
FR2684878A1 (fr) 1993-06-18
GR3019440T3 (en) 1996-06-30
EP0554634B1 (fr) 1996-03-27
DK0554634T3 (da) 1996-07-01
ZA929627B (en) 1993-12-13
JPH05345728A (ja) 1993-12-27
MX9207199A (es) 1993-07-01
US5340574A (en) 1994-08-23
RU2107511C1 (ru) 1998-03-27
AU662940B2 (en) 1995-09-21
JP3291340B2 (ja) 2002-06-10
CA2085142A1 (fr) 1993-06-13
DE69209486T2 (de) 1996-09-12
KR930012023A (ko) 1993-07-20
AU3004192A (en) 1993-06-17
FR2684878B1 (fr) 1994-02-11
ATE135917T1 (de) 1996-04-15
IL103862A0 (en) 1993-04-04
UA26898C2 (uk) 1999-12-29
HU9203925D0 (en) 1993-03-29
HU218103B (hu) 2000-06-28
HUT63575A (en) 1993-09-28
ES2084965T3 (es) 1996-05-16
DE69209486D1 (de) 1996-05-02

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Legal Events

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KB Patent renewed
HCA Change of name of proprietor(s) after amalgamation
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KB Patent renewed
EXP Patent expired