IL103096A - תהליך לטיהור 2-])דימתילאמינו(מתיל -1-)3-מתוקספיניל( ציקלוהקסאנול והמלחים שלו. - Google Patents

תהליך לטיהור 2-])דימתילאמינו(מתיל -1-)3-מתוקספיניל( ציקלוהקסאנול והמלחים שלו.

Info

Publication number
IL103096A
IL103096A IL10309692A IL10309692A IL103096A IL 103096 A IL103096 A IL 103096A IL 10309692 A IL10309692 A IL 10309692A IL 10309692 A IL10309692 A IL 10309692A IL 103096 A IL103096 A IL 103096A
Authority
IL
Israel
Prior art keywords
trans
process according
isomer
methyl
cyclohexanol
Prior art date
Application number
IL10309692A
Other languages
English (en)
Other versions
IL103096A0 (en
Inventor
Stephen Cherekez
Ori Lerman
Michael Tennenbaum
Hasalia Avner
Tamar Kunyevski
Original Assignee
Chemagis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemagis Ltd filed Critical Chemagis Ltd
Priority to IL10309692A priority Critical patent/IL103096A/he
Publication of IL103096A0 publication Critical patent/IL103096A0/xx
Priority to KR1019930017930A priority patent/KR100266927B1/ko
Priority to AT0180593A priority patent/ATA180593A/de
Priority to DE4330240A priority patent/DE4330240A1/de
Priority to US08/117,803 priority patent/US5414129A/en
Publication of IL103096A publication Critical patent/IL103096A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
    • C07C211/04—Mono-, di- or tri-methylamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/09—Diamines
    • C07C211/12—1,6-Diaminohexanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL10309692A 1992-09-08 1992-09-08 תהליך לטיהור 2-])דימתילאמינו(מתיל -1-)3-מתוקספיניל( ציקלוהקסאנול והמלחים שלו. IL103096A (he)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IL10309692A IL103096A (he) 1992-09-08 1992-09-08 תהליך לטיהור 2-])דימתילאמינו(מתיל -1-)3-מתוקספיניל( ציקלוהקסאנול והמלחים שלו.
KR1019930017930A KR100266927B1 (ko) 1992-09-08 1993-09-07 2-((디메틸아미노)메틸)-1-(3-메톡시페닐)사이클로헥산올 및 그의 염의 정제 방법
AT0180593A ATA180593A (de) 1992-09-08 1993-09-07 Verfahren zur isolation von reinem trans-2-((dimethylamino)methyl)-1-(3-methoxy-phenyl)cyclohexanol-hydrochlorid
DE4330240A DE4330240A1 (de) 1992-09-08 1993-09-07 Verfahren zur Reinigung und Isolation von trans-2-[(Dimethylamino)methyl]-1- (3-methoxyphenyl)cyclohexanol-Hydrochlorid
US08/117,803 US5414129A (en) 1992-09-08 1993-09-08 Process for the purification of 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol and its salts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL10309692A IL103096A (he) 1992-09-08 1992-09-08 תהליך לטיהור 2-])דימתילאמינו(מתיל -1-)3-מתוקספיניל( ציקלוהקסאנול והמלחים שלו.

Publications (2)

Publication Number Publication Date
IL103096A0 IL103096A0 (en) 1993-02-21
IL103096A true IL103096A (he) 1996-12-05

Family

ID=11064009

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10309692A IL103096A (he) 1992-09-08 1992-09-08 תהליך לטיהור 2-])דימתילאמינו(מתיל -1-)3-מתוקספיניל( ציקלוהקסאנול והמלחים שלו.

Country Status (5)

Country Link
US (1) US5414129A (he)
KR (1) KR100266927B1 (he)
AT (1) ATA180593A (he)
DE (1) DE4330240A1 (he)
IL (1) IL103096A (he)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0778262A2 (en) 1995-12-07 1997-06-11 Chemagis Ltd. Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1-(3-methoxyphenyl)cyclohexanol and its salts
WO1999003820A1 (en) * 1997-07-15 1999-01-28 Russinsky Limited Tramadol, salts thereof and process for their preparation

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0149311B1 (ko) * 1995-07-28 1998-10-15 김광호 화소 간 기생 용량 차이가 없는 액정 표시 장치용 기판
IL119121A (en) * 1996-08-22 2000-11-21 Chemagis Ltd Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride
US5877351A (en) * 1997-12-24 1999-03-02 Wyckoff Chemical Company, Inc. Preparation and purification process for 2- (dimethylamino) methyl!-1-(3-methoxphenyl)-cyclohexanol and its salts
GB9800656D0 (en) * 1998-01-14 1998-03-11 Macfarlan Smith Ltd Improved purification process
GB9800657D0 (en) * 1998-01-14 1998-03-11 Macfarlan Smith Ltd Improved purification process
IT1298597B1 (it) * 1998-03-06 2000-01-12 Secifarma Spa Processo per la purificazione dell'(rr,ss)-2-(dimetilammino)metil- 1-(3-metossifenil)-cicloesanolo dall'(rs,sr)-2-(dimetilammino)
EP1077923B1 (en) * 1998-05-22 2004-01-02 Mallinckrodt Inc. An improved synthesis and purification of (r*,r*)-2- (dimethylamino) methyl]-1-( 3-methoxyphenyl) cyclohexanol hydrochloride
SK19002001A3 (sk) * 1999-06-22 2002-05-09 Grnenthal Gmbh Spôsob delenia diastereomérnych báz 2-[(dimetylamino)metyl]-1- (3-metoxyfenyl)-cyklohexanolu)
DE10049481A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte C-Cyclohexylmethylamin-Derivate
US6649783B2 (en) 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
WO2003048113A1 (en) 2001-11-30 2003-06-12 Sepracor Inc. Tramadol analogs and uses thereof
US8487002B2 (en) * 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
TWI319713B (en) * 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
JP5269595B2 (ja) * 2005-09-09 2013-08-21 アンジェリーニ ラボファーム リミテッド ライアビリティ カンパニー １日１回投与用トラゾドン組成物
EP1785412A1 (en) * 2005-11-14 2007-05-16 IPCA Laboratories Limited Tramadol recovery process

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452011A (en) * 1967-01-06 1969-06-24 Upjohn Co 4-phenyl-perhydrocycloalkoxazines
US3830934A (en) * 1967-07-27 1974-08-20 Gruenenthal Chemie Analgesic and antitussive compositions and methods
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0778262A2 (en) 1995-12-07 1997-06-11 Chemagis Ltd. Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1-(3-methoxyphenyl)cyclohexanol and its salts
EP0778262A3 (en) * 1995-12-07 1998-04-29 Chemagis Ltd. Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1-(3-methoxyphenyl)cyclohexanol and its salts
WO1999003820A1 (en) * 1997-07-15 1999-01-28 Russinsky Limited Tramadol, salts thereof and process for their preparation

Also Published As

Publication number Publication date
US5414129A (en) 1995-05-09
KR100266927B1 (ko) 2000-09-15
DE4330240A1 (de) 1994-03-10
IL103096A0 (en) 1993-02-21
ATA180593A (de) 1997-08-15
KR940006989A (ko) 1994-04-26

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