IL102171A - Pyrimidinyl bisphosphonic esters as anti-inflammatories and pharmaceutical compositions containing them - Google Patents

Pyrimidinyl bisphosphonic esters as anti-inflammatories and pharmaceutical compositions containing them

Info

Publication number
IL102171A
IL102171A IL10217192A IL10217192A IL102171A IL 102171 A IL102171 A IL 102171A IL 10217192 A IL10217192 A IL 10217192A IL 10217192 A IL10217192 A IL 10217192A IL 102171 A IL102171 A IL 102171A
Authority
IL
Israel
Prior art keywords
phenyl
alkyl
compound
pyrimidinyl
oxo
Prior art date
Application number
IL10217192A
Other languages
English (en)
Other versions
IL102171A0 (en
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of IL102171A0 publication Critical patent/IL102171A0/xx
Publication of IL102171A publication Critical patent/IL102171A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL10217192A 1991-07-03 1992-06-11 Pyrimidinyl bisphosphonic esters as anti-inflammatories and pharmaceutical compositions containing them IL102171A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72504691A 1991-07-03 1991-07-03
US72504791A 1991-07-03 1991-07-03

Publications (2)

Publication Number Publication Date
IL102171A0 IL102171A0 (en) 1993-01-14
IL102171A true IL102171A (en) 1996-11-14

Family

ID=27111084

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10217192A IL102171A (en) 1991-07-03 1992-06-11 Pyrimidinyl bisphosphonic esters as anti-inflammatories and pharmaceutical compositions containing them

Country Status (19)

Country Link
US (1) US5397774A (enExample)
EP (2) EP0521622B1 (enExample)
JP (1) JPH06509100A (enExample)
CN (1) CN1031826C (enExample)
AT (1) ATE152728T1 (enExample)
AU (1) AU653428B2 (enExample)
CA (1) CA2110167A1 (enExample)
CZ (1) CZ19595A3 (enExample)
DE (1) DE69219602D1 (enExample)
FI (1) FI935944A0 (enExample)
HU (2) HUT70758A (enExample)
IE (1) IE922162A1 (enExample)
IL (1) IL102171A (enExample)
MX (1) MX9203945A (enExample)
NO (1) NO940009L (enExample)
RU (1) RU2079506C1 (enExample)
SK (1) SK277986B6 (enExample)
TW (1) TW222638B (enExample)
WO (1) WO1993001198A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07509712A (ja) * 1992-08-07 1995-10-26 ジ・アップジョン・カンパニー 抗炎症剤としてのホスホノ酢酸エステルおよびホスホノ酢酸
JPH08502287A (ja) * 1992-10-09 1996-03-12 ジ・アップジョン・カンパニー 抗炎症剤としてのピリミジンビスホスホン酸エステルおよび（アルコキシメチルホスフィニル）アルキルホスホン酸
JPH09504010A (ja) * 1993-10-20 1997-04-22 ジ・アップジョン・カンパニー 抗関節炎剤および抗炎症剤としてのピリミジノン
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
IT1303672B1 (it) * 1998-07-28 2001-02-23 Nicox Sa Sali nitrati di farmaci attivi nei disordini ossei
US6579860B1 (en) * 1998-12-25 2003-06-17 Toray Industries, Inc. Interleukin-6 production inhibitors
AU4203500A (en) 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
AU4331500A (en) 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
RU2183610C1 (ru) * 2000-11-15 2002-06-20 Институт молекулярной генетики РАН Высокомеченный тритием n-[3-(3-цианопиразоло[1,5-а]пиримидин-7-ил)фенил]-n-этилацетамид
AU783516B2 (en) 2001-04-30 2005-11-03 Warner-Lambert Company Methods, kits and compositions for using pyrrole derivatives
EP1926734A1 (en) 2005-08-22 2008-06-04 Amgen Inc. Pyrazolopyridine and pyrazolopyrimidine compounds useful as kinase enzymes modulators
EP2270021A1 (en) 2009-06-18 2011-01-05 Centre National de la Recherche Scientifique Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability
ES2650464T3 (es) * 2011-10-14 2018-01-18 Aktsionernoe Obshcestvo "Proizvodstvenno-Kommercheskaya Assotsiatsiya AZT" Sales de ésteres del ácido carbamoil-fosfónico que actúan como inhibidores selectivos de la producción del virus de la inmunodeficiencia humana VIH-1
US10183949B2 (en) 2014-08-29 2019-01-22 The University Of Tokyo Pyrimidinone derivative having autotaxin-inhibitory activity
JP6632532B2 (ja) * 2014-08-29 2020-01-22 国立大学法人 東京大学 オートタキシン阻害活性を有するピリミジノン誘導体

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
DE2703712A1 (de) * 1977-01-29 1978-08-03 Bayer Ag Substituierte pyrimidinon eckige klammer auf (di)-thio eckige klammer zu -phosphor-(phosphon)-saeureester bzw. -esteramide, verfahren zu ihrer herstellung und ihre verwendung als insektizide, akarizide und nematizide
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
PH27078A (en) * 1984-12-21 1993-02-01 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonates
DE3626058A1 (de) * 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
IL84493A (en) * 1986-11-21 1993-01-14 Ciba Geigy Ag Aromatically substituted azacycloalkylalk - anediphosphonic acids, their preparation and pharmaceutical compositions containing them
US5071840A (en) * 1986-12-19 1991-12-10 Norwich Eaton Pharmaceuticals, Inc. Certain heterocyclic substituted diphosphonate compounds pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
DE3719513A1 (de) * 1987-06-11 1988-12-22 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4990503A (en) * 1988-08-12 1991-02-05 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic bisphosphonic acid derivatives
JPH07509241A (ja) * 1992-07-16 1995-10-12 ジ・アップジョン・カンパニー 抗炎症および抗関節炎薬としてのホスホノ誘導体
JPH08502287A (ja) * 1992-10-09 1996-03-12 ジ・アップジョン・カンパニー 抗炎症剤としてのピリミジンビスホスホン酸エステルおよび（アルコキシメチルホスフィニル）アルキルホスホン酸

Also Published As

Publication number Publication date
SK277986B6 (en) 1995-09-13
US5397774A (en) 1995-03-14
IE922162A1 (en) 1993-01-13
EP0521622B1 (en) 1997-08-13
HU211488A9 (en) 1995-11-28
FI935944A7 (fi) 1993-12-30
AU653428B2 (en) 1994-09-29
ATE152728T1 (de) 1997-05-15
RU2079506C1 (ru) 1997-05-20
CN1068332A (zh) 1993-01-27
EP0593575A1 (en) 1994-04-27
EP0521622A1 (en) 1993-01-07
NO940009D0 (no) 1994-01-03
HUT70758A (en) 1995-10-30
MX9203945A (es) 1993-04-01
JPH06509100A (ja) 1994-10-13
TW222638B (enExample) 1994-04-21
IL102171A0 (en) 1993-01-14
SK150493A3 (en) 1994-11-09
DE69219602D1 (de) 1997-06-12
AU2240892A (en) 1993-02-11
NO940009L (no) 1994-01-09
CA2110167A1 (en) 1993-01-21
CN1031826C (zh) 1996-05-22
HU9400003D0 (en) 1994-05-30
CZ19595A3 (en) 1995-10-18
EP0593575B1 (en) 1997-05-07
FI935944L (fi) 1993-12-30
WO1993001198A1 (en) 1993-01-21
FI935944A0 (fi) 1993-12-30

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