IL101850A - תולדות 11-)4-פיפרידיניל(-אימידאזו ]b-1 ,2[ ]3[ בנזאזפין, הכנתן ותכשירי רוקחות המכילים אותן - Google Patents
תולדות 11-)4-פיפרידיניל(-אימידאזו ]b-1 ,2[ ]3[ בנזאזפין, הכנתן ותכשירי רוקחות המכילים אותןInfo
- Publication number
- IL101850A IL101850A IL10185092A IL10185092A IL101850A IL 101850 A IL101850 A IL 101850A IL 10185092 A IL10185092 A IL 10185092A IL 10185092 A IL10185092 A IL 10185092A IL 101850 A IL101850 A IL 101850A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- 4alkyl
- compound
- represents hydrogen
- halo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Detergent Compositions (AREA)
- Paper (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71448691A | 1991-06-13 | 1991-06-13 | |
| US85363192A | 1992-03-18 | 1992-03-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL101850A0 IL101850A0 (en) | 1992-12-30 |
| IL101850A true IL101850A (he) | 1996-01-31 |
Family
ID=27109168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10185092A IL101850A (he) | 1991-06-13 | 1992-05-13 | תולדות 11-)4-פיפרידיניל(-אימידאזו ]b-1 ,2[ ]3[ בנזאזפין, הכנתן ותכשירי רוקחות המכילים אותן |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5468743A (he) |
| EP (2) | EP0588858B1 (he) |
| JP (1) | JP2845407B2 (he) |
| KR (1) | KR0184017B1 (he) |
| CN (2) | CN1033586C (he) |
| AT (1) | ATE250061T1 (he) |
| AU (1) | AU652840B2 (he) |
| CA (1) | CA2103242C (he) |
| DE (1) | DE69233205T2 (he) |
| DK (1) | DK0588858T3 (he) |
| DZ (1) | DZ1582A1 (he) |
| ES (1) | ES2207632T3 (he) |
| FI (1) | FI104175B1 (he) |
| HR (1) | HRP920155A2 (he) |
| HU (2) | HU221016B1 (he) |
| IE (1) | IE921918A1 (he) |
| IL (1) | IL101850A (he) |
| MA (1) | MA22553A1 (he) |
| MX (1) | MX9202856A (he) |
| NO (2) | NO934492D0 (he) |
| NZ (1) | NZ242774A (he) |
| PT (1) | PT588858E (he) |
| SG (1) | SG47823A1 (he) |
| SI (1) | SI9200105B (he) |
| TN (1) | TNSN92048A1 (he) |
| TW (1) | TW218381B (he) |
| WO (1) | WO1992022551A1 (he) |
| YU (1) | YU61192A (he) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL101851A (he) * | 1991-06-13 | 1996-05-14 | Janssen Pharmaceutica Nv | תולדות 01 - )4 - פיפרידיניל - ו- פיפרידינילידן( - אימידאזו ]a -1,2[ פירולו, תיאנו או פוראנו( ]3,2[ אזפין, הכנתן ותכשירי רוקחות המכיליםאותן ותרכב |
| GR1001393B (el) * | 1992-10-12 | 1993-10-29 | Janssen Pharmaceutica Nv | Παράγωγα ιμιδαζο[2,1-Β] 3] βενζαζεπίνης, συν?έσεις και μέ?οδος χρήσεως. |
| US5932569A (en) * | 1992-12-04 | 1999-08-03 | Janssen Pharmaceutica, N.V. | Triazolobenzazepine derivatives |
| PT708776E (pt) * | 1993-07-13 | 2001-06-29 | Janssen Pharmaceutica Nv | Imidazoazepinas anti-alergicas |
| TW382017B (en) * | 1995-12-27 | 2000-02-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives |
| TW527186B (en) | 1996-03-19 | 2003-04-11 | Janssen Pharmaceutica Nv | Fused imidazole derivatives as multidrug resistance modulators |
| ATE233104T1 (de) * | 1997-09-18 | 2003-03-15 | Janssen Pharmaceutica Nv | Kondensierte imidazolderivate zur erhöhung der oralen bioverfügbarkeit von pharmazeutika |
| CA2355939C (en) * | 1998-12-19 | 2010-12-14 | Janssen Pharmaceutica N.V. | Antihistaminic spiro compounds |
| CA2448735C (en) | 2001-06-12 | 2008-10-28 | Janssen Pharmaceutica N.V. | Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine |
| CN1160557C (zh) * | 2001-09-03 | 2004-08-04 | 北京埃索特核电子机械有限公司 | 钴60γ射线源-碘化铯或钨酸镉阵列探测器集装箱检测设备 |
| EP1858896B1 (en) | 2005-03-08 | 2010-08-18 | Janssen Pharmaceutica NV | Diaza-spiro-[4.4]-nonane derivatives as neurokinin (nk1) antagonists |
| US20070077302A1 (en) * | 2005-09-30 | 2007-04-05 | Azaam Alli | Methods for stabilizing ophthalmic compositions |
| US20070077303A1 (en) * | 2005-09-30 | 2007-04-05 | Azaam Alli | Methods for providing oxidatively stable ophthalmic compositions |
| EP3150209B1 (en) * | 2006-03-31 | 2019-07-24 | Vistakon Pharmaceuticals, LLC | Ocular allergy treatments |
| US20080139531A1 (en) * | 2006-12-04 | 2008-06-12 | Alcon Manufacturing Ltd. | Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair |
| US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
| EP2131834A2 (en) * | 2007-04-11 | 2009-12-16 | Alcon Research, Ltd. | Use of an inhibitor of tnfa plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis |
| CN102548536A (zh) * | 2009-10-01 | 2012-07-04 | 爱尔康研究有限公司 | 奥洛他定组合物及其用途 |
| AR079170A1 (es) * | 2009-12-10 | 2011-12-28 | Lilly Co Eli | Compuesto de ciclopropil-benzamida-imidazo-benzazepina inhibidor de diacil-glicerol aciltransferasa, sal del mismo, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de obesidad o para mejorar la sensibilidad a insulina y compuesto intermedio par |
| RU2014102493A (ru) * | 2011-06-29 | 2015-08-10 | Аллерган, Инк. | Алкафтадин для применения при лечении уртикарии |
| WO2014080259A1 (en) * | 2012-11-21 | 2014-05-30 | Enaltec Labs Pvt. Ltd. | Novel polymorphic forms of alcaftadine |
| WO2014083571A1 (en) | 2012-11-29 | 2014-06-05 | Neuland Laboratories Limited | A process for the preparation of alcaftadine |
| US9255105B2 (en) | 2012-12-06 | 2016-02-09 | Enaltec Labs Private Limited | Process of preparing alcaftadine |
| US9682984B2 (en) | 2013-03-25 | 2017-06-20 | Crystal Pharma S.A.U. | Methods for the preparation of alcaftadine |
| CN103408549B (zh) * | 2013-06-14 | 2016-01-20 | 苏州汇和药业有限公司 | 一种阿卡他定中间体的制备方法 |
| DK3186242T3 (da) | 2014-08-29 | 2021-12-20 | Tes Pharma S R L | Alfa-amino-beta-carboxymuconsyre-semialdehyd-decarboxylasehæmmere |
| CN104710427A (zh) * | 2014-12-20 | 2015-06-17 | 威海法莫斯特医药技术开发有限公司 | 一种阿卡他定新晶型 |
| CN104860920B (zh) * | 2015-04-15 | 2017-08-25 | 武汉武药科技有限公司 | 一种阿卡他定中间体的制备方法 |
| CN104987337B (zh) * | 2015-07-28 | 2018-01-12 | 武汉武药科技有限公司 | 一种制备阿卡他定的氧化方法 |
| CN105130993B (zh) * | 2015-07-28 | 2018-01-12 | 武汉武药科技有限公司 | 一种合成阿卡他定的新氧化方法 |
| AU2017310520A1 (en) | 2016-08-12 | 2019-03-21 | Silk Technologies, Ltd. | Silk-derived protein for treating inflammation |
| CN108727384A (zh) * | 2018-07-07 | 2018-11-02 | 张正光 | 一种阿卡他定中间体的制备方法 |
| AU2021291684A1 (en) | 2020-06-15 | 2022-12-08 | Alkem Laboratories Limited | Combination of alcaftadine and a corticosteroid |
| KR20230163413A (ko) | 2021-04-01 | 2023-11-30 | 알켐 라보라토리즈 리미티드 | 알카프타딘을 포함하는 비강 조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4148903A (en) * | 1977-07-28 | 1979-04-10 | Merck & Co., Inc. | Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines |
| GB8900380D0 (en) * | 1989-01-09 | 1989-03-08 | Janssen Pharmaceutica Nv | 2-aminopyrimidinone derivatives |
| AU8902591A (en) * | 1990-10-10 | 1992-05-20 | Schering Corporation | Substituted imidazobenzazepines and imidazopyridoazepines |
| IL101851A (he) * | 1991-06-13 | 1996-05-14 | Janssen Pharmaceutica Nv | תולדות 01 - )4 - פיפרידיניל - ו- פיפרידינילידן( - אימידאזו ]a -1,2[ פירולו, תיאנו או פוראנו( ]3,2[ אזפין, הכנתן ותכשירי רוקחות המכיליםאותן ותרכב |
-
1992
- 1992-05-13 IL IL10185092A patent/IL101850A/he not_active IP Right Cessation
- 1992-05-15 NZ NZ242774A patent/NZ242774A/en not_active IP Right Cessation
- 1992-05-16 CN CN92105040A patent/CN1033586C/zh not_active Expired - Lifetime
- 1992-05-18 DZ DZ920051A patent/DZ1582A1/fr active
- 1992-05-21 TW TW081103954A patent/TW218381B/zh not_active IP Right Cessation
- 1992-06-09 HU HU9303553A patent/HU221016B1/hu unknown
- 1992-06-09 SG SG1996004579A patent/SG47823A1/en unknown
- 1992-06-09 WO PCT/EP1992/001330 patent/WO1992022551A1/en active IP Right Grant
- 1992-06-09 AT AT92911635T patent/ATE250061T1/de active
- 1992-06-09 DE DE69233205T patent/DE69233205T2/de not_active Expired - Lifetime
- 1992-06-09 CA CA002103242A patent/CA2103242C/en not_active Expired - Lifetime
- 1992-06-09 DK DK92911635T patent/DK0588858T3/da active
- 1992-06-09 PT PT92911635T patent/PT588858E/pt unknown
- 1992-06-09 ES ES92911635T patent/ES2207632T3/es not_active Expired - Lifetime
- 1992-06-09 EP EP92911635A patent/EP0588858B1/en not_active Expired - Lifetime
- 1992-06-09 KR KR1019930703788A patent/KR0184017B1/ko not_active IP Right Cessation
- 1992-06-09 EP EP92201666A patent/EP0518435A1/en active Pending
- 1992-06-09 JP JP4510733A patent/JP2845407B2/ja not_active Expired - Lifetime
- 1992-06-09 AU AU19001/92A patent/AU652840B2/en not_active Expired
- 1992-06-09 US US08/142,474 patent/US5468743A/en not_active Expired - Lifetime
- 1992-06-10 HR HR920155A patent/HRP920155A2/hr not_active Application Discontinuation
- 1992-06-11 MA MA22843A patent/MA22553A1/fr unknown
- 1992-06-12 YU YU61192A patent/YU61192A/sh unknown
- 1992-06-12 MX MX9202856A patent/MX9202856A/es unknown
- 1992-06-12 SI SI9200105A patent/SI9200105B/sl unknown
- 1992-06-15 TN TNTNSN92048A patent/TNSN92048A1/fr unknown
- 1992-07-01 IE IE191892A patent/IE921918A1/en not_active Application Discontinuation
-
1993
- 1993-12-09 NO NO934492D patent/NO934492D0/no unknown
- 1993-12-09 NO NO934492A patent/NO300636B1/no not_active IP Right Cessation
- 1993-12-10 FI FI935556A patent/FI104175B1/fi not_active IP Right Cessation
-
1995
- 1995-06-06 HU HU95P/P00164P patent/HU211289A9/hu unknown
-
1996
- 1996-04-24 CN CN96106116A patent/CN1070368C/zh not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0588858B1 (en) | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | |
| AU676701B2 (en) | Antiallergic triazolobenzazepine derivatives | |
| EP0588859B1 (en) | Imidazo[1,2-a](pyrrolo, thieno or furano)[3,2-d]azepine derivatives, compositions and methods of use | |
| AU676702B2 (en) | Antiallergic imidazo{1,2-a}(pyrrolo, thieno or furano){2,3-d}azepine derivatives | |
| US5595988A (en) | Triazolo(pyrrolo, thieno or furano)azepine derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |