IL101358A - Tiagabine hydrochloride crystalline monohydrate, its preparation and pharmaceutical preparations containing the same - Google Patents

Tiagabine hydrochloride crystalline monohydrate, its preparation and pharmaceutical preparations containing the same

Info

Publication number
IL101358A
IL101358A IL10135892A IL10135892A IL101358A IL 101358 A IL101358 A IL 101358A IL 10135892 A IL10135892 A IL 10135892A IL 10135892 A IL10135892 A IL 10135892A IL 101358 A IL101358 A IL 101358A
Authority
IL
Israel
Prior art keywords
hydrochloride monohydrate
tiagabine hydrochloride
crystalline
monohydrate
pharmaceutical composition
Prior art date
Application number
IL10135892A
Other languages
English (en)
Hebrew (he)
Other versions
IL101358A0 (en
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of IL101358A0 publication Critical patent/IL101358A0/xx
Publication of IL101358A publication Critical patent/IL101358A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Transceivers (AREA)
  • Mobile Radio Communication Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL10135892A 1991-04-02 1992-03-24 Tiagabine hydrochloride crystalline monohydrate, its preparation and pharmaceutical preparations containing the same IL101358A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK91582A DK58291D0 (da) 1991-04-02 1991-04-02 Krystalinsk stof og dets fremstilling

Publications (2)

Publication Number Publication Date
IL101358A0 IL101358A0 (en) 1992-11-15
IL101358A true IL101358A (en) 1996-08-04

Family

ID=8095193

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10135892A IL101358A (en) 1991-04-02 1992-03-24 Tiagabine hydrochloride crystalline monohydrate, its preparation and pharmaceutical preparations containing the same

Country Status (15)

Country Link
US (1) US5354760A (fr)
EP (1) EP0579681B1 (fr)
AT (1) ATE180781T1 (fr)
AU (1) AU661483B2 (fr)
CA (1) CA2107223C (fr)
DE (1) DE69229339T2 (fr)
DK (2) DK58291D0 (fr)
ES (1) ES2134801T3 (fr)
FI (1) FI110096B (fr)
GR (1) GR3030919T3 (fr)
IL (1) IL101358A (fr)
NO (1) NO304113B1 (fr)
NZ (1) NZ242191A (fr)
WO (1) WO1992017473A1 (fr)
ZA (1) ZA922297B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750140A (en) * 1994-05-20 1998-05-12 Novo Nordisk A/S Transdermal delivery of tiagabine
PL183678B1 (pl) * 1995-05-05 2002-06-28 Novo Nordisk As Środek farmaceutyczny zawierający tiagabinę i sposób wytwarzania środka farmaceutycznego zawierającego tiagabinę
DE19525598C2 (de) * 1995-07-13 1997-09-25 Max Planck Gesellschaft Schlafmittel
AU736514B2 (en) * 1995-07-13 2001-07-26 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Non-allosteric gabaa agonists for treating sleep disorders
UA52661C2 (uk) * 1996-06-14 2003-01-15 Ново Нордіск А/С Безводна кристалічна форма гідрохлориду r(-)-n-(4,4-ди(3-метилтієн-2-іл)бут-3-еніл) ніпекотинової кислоти
US5914333A (en) * 1996-07-31 1999-06-22 Novo Nordisk A/S Treatment of psychotic disorders
IE970588A1 (en) 1997-08-01 2000-08-23 Elan Corp Plc Controlled release pharmaceutical compositions containing tiagabine
FR2771292B1 (fr) * 1997-11-21 2000-02-18 Ethypharm Lab Prod Ethiques Spheroides contenant de la tiagabine, procede de preparation et compositions pharmaceutiques
US6410520B2 (en) 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
US6562974B2 (en) 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
EP2316468A1 (fr) 2002-02-22 2011-05-04 Shire LLC Système de distribution et méthodes de protection et d'administration de dextroamphetamine
CN1314684C (zh) * 2003-12-24 2007-05-09 中国科学院上海有机化学研究所 噻加宾及其消旋体和s－构型的合成方法及其无定形粉末的制法
WO2005122698A2 (fr) * 2003-12-24 2005-12-29 Sun Pharmaceutical Industries Limited Nouvelles formes polymorphes stables d'un anticonvulsif
WO2005092886A1 (fr) * 2004-03-29 2005-10-06 Ranbaxy Laboratories Limited Procede de preparation d'une forme amorphe de la tiagabine
US20080269495A1 (en) * 2004-08-04 2008-10-30 Prosenjit Bose Process for Preparation of Piperidine Carboxylic Acid
US20060105038A1 (en) * 2004-11-12 2006-05-18 Eurand Pharmaceuticals Limited Taste-masked pharmaceutical compositions prepared by coacervation
US20080064727A1 (en) * 2006-08-18 2008-03-13 Cephalon, Inc. Crystalline forms of tiagabine hydrochloride
US20080051435A1 (en) * 2006-08-18 2008-02-28 Cephalon, Inc. Crystalline and amorphous forms of tiagabine
CN101857591B (zh) * 2009-04-09 2013-06-05 北京京卫燕康药物研究所有限公司 盐酸噻加宾晶型及其制备方法
CN103554093B (zh) * 2013-11-12 2015-10-21 四川科瑞德凯华制药有限公司 噻加宾乙酯盐酸盐及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK288385D0 (da) * 1985-06-26 1985-06-26 Novo Industri As Aminosyrederivater
ES2058061T3 (es) * 1985-10-25 1994-11-01 Beecham Group Plc Derivado de piperidina, su preparacion y su uso como medicamento.
US4910312A (en) * 1985-11-08 1990-03-20 Warner-Lambert Company Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof

Also Published As

Publication number Publication date
WO1992017473A1 (fr) 1992-10-15
ATE180781T1 (de) 1999-06-15
GR3030919T3 (en) 1999-11-30
CA2107223C (fr) 2005-02-15
NO304113B1 (no) 1998-10-26
NO933524L (no) 1993-10-01
NZ242191A (en) 1994-07-26
DE69229339T2 (de) 1999-12-30
AU1641592A (en) 1992-11-02
ES2134801T3 (es) 1999-10-16
US5354760A (en) 1994-10-11
JPH06506209A (ja) 1994-07-14
EP0579681B1 (fr) 1999-06-02
ZA922297B (en) 1992-12-30
EP0579681A1 (fr) 1994-01-26
AU661483B2 (en) 1995-07-27
DK58291D0 (da) 1991-04-02
FI110096B (fi) 2002-11-29
IL101358A0 (en) 1992-11-15
FI934298A (fi) 1993-09-30
DK0579681T3 (da) 1999-11-15
FI934298A0 (fi) 1993-09-30
DE69229339D1 (de) 1999-07-08
NO933524D0 (no) 1993-10-01
CA2107223A1 (fr) 1992-10-03

Similar Documents

Publication Publication Date Title
EP0579681B1 (fr) Monohydrate d'hydrochlorure de tiagabine cristalline, sa preparation et son utilisation
US5958951A (en) Modified form of the R(-)-N-(4,4-di(3-methylthien-2-yl)but-3-enyl)-nipecotic acid hydrochloride
BG61323B2 (bg) Производни на пиперидина,тяхното получаване и използването им като лекарства
EP1861389A1 (fr) Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique
EP0703915B1 (fr) Xamoneline tartrate
EP1309557B1 (fr) Amlodipine hemimaleate
EP0906309B1 (fr) Forme modifiee de l'hydrochlorure de l'acide r(-)-n-(4,4-di(3-methylthien-2-yl)but-3-enyl)-nipecotique
KR20040043171A (ko) Ｒ-티옥트산의 트로메타몰 염의 신규한 개질체 및 이의제조방법
FR2753970A1 (fr) Derives de n-(benzothiazol-2-yl) piperidine-1-ethanamine, leur preparation et leur application en therapeutique
WO2006090263A1 (fr) Chlorhydrate de donepezil de formule i stable et son procede de preparation et d'utilisation dans des compositions pharmaceutiques
JP3001975B2 (ja) 結晶性チアガビン塩酸塩−水和物、その製造方法および用途
US20030022922A1 (en) Amlodipine free base
AU2001100436A4 (en) Amlodipine hemimaleate
KR100491636B1 (ko) R(-)-n-[4,4-디(3-메틸티엔-2-일)부트-3-엔일)-니페코트산염산염의변형된형태
CA2257931C (fr) Forme modifiee de l'hydrochlorure de l'acide r(-)-n-(4,4-di(3-methylthien-2-yl)but-3-enyl)-nipecotique
SI21067A2 (sl) Amlodipin hemimaleat
JP2001527064A (ja) １−メチル−５−ｐ−トルオイルピロール−２−アセトアミド酢酸グアイアシルエステル（ＭＥＤ１５）の新規多形結晶
AT5463U1 (de) Amlodipinhemimaleat

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired