IE914163A1 - Use of xanthines for the preparation of a medicament having¹immuno supressing activity - Google Patents
Use of xanthines for the preparation of a medicament having¹immuno supressing activityInfo
- Publication number
- IE914163A1 IE914163A1 IE416391A IE416391A IE914163A1 IE 914163 A1 IE914163 A1 IE 914163A1 IE 416391 A IE416391 A IE 416391A IE 416391 A IE416391 A IE 416391A IE 914163 A1 IE914163 A1 IE 914163A1
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- compound
- group
- compounds
- xanthines
- Prior art date
Links
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 title claims abstract description 88
- 238000002360 preparation method Methods 0.000 title claims description 19
- 239000003814 drug Substances 0.000 title claims description 10
- 229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 title abstract description 61
- 230000000694 effects Effects 0.000 title description 19
- 150000001875 compounds Chemical class 0.000 claims abstract description 100
- 230000004913 activation Effects 0.000 claims abstract description 39
- 210000004698 lymphocyte Anatomy 0.000 claims abstract description 36
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 24
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 18
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 16
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims abstract description 12
- 229930195733 hydrocarbon Natural products 0.000 claims abstract description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 7
- 125000001931 aliphatic group Chemical group 0.000 claims abstract description 7
- HJPRDDKCXVCFOH-UHFFFAOYSA-N 1,3-dibutyl-7-(2-oxopropyl)purine-2,6-dione Chemical compound O=C1N(CCCC)C(=O)N(CCCC)C2=C1N(CC(C)=O)C=N2 HJPRDDKCXVCFOH-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229950004687 denbufylline Drugs 0.000 claims abstract description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 6
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims abstract description 5
- 239000004215 Carbon black (E152) Substances 0.000 claims abstract description 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims abstract description 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims abstract description 4
- 125000004043 oxo group Chemical group O=* 0.000 claims abstract description 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims abstract description 4
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 claims description 35
- 229960001476 pentoxifylline Drugs 0.000 claims description 31
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 18
- 241000124008 Mammalia Species 0.000 claims description 15
- 229940075420 xanthine Drugs 0.000 claims description 10
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 9
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 10
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- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
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- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 8
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- QSXXLDDWVCEBFP-UHFFFAOYSA-N 7-(ethoxymethyl)-1-(5-hydroxy-5-methylhexyl)-3-methylpurine-2,6-dione Chemical compound CN1C(=O)N(CCCCC(C)(C)O)C(=O)C2=C1N=CN2COCC QSXXLDDWVCEBFP-UHFFFAOYSA-N 0.000 description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 4
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 4
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
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- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
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- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
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- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 229960004559 theobromine Drugs 0.000 description 1
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- 229940104230 thymidine Drugs 0.000 description 1
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- 208000005057 thyrotoxicosis Diseases 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
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- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62048090A | 1990-11-30 | 1990-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IE914163A1 true IE914163A1 (en) | 1992-06-03 |
Family
ID=24486121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE416391A IE914163A1 (en) | 1990-11-30 | 1991-11-29 | Use of xanthines for the preparation of a medicament having¹immuno supressing activity |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0490181A1 (https=) |
| JP (1) | JPH06100450A (https=) |
| KR (1) | KR920009399A (https=) |
| CA (1) | CA2056723A1 (https=) |
| HU (1) | HUT59825A (https=) |
| IE (1) | IE914163A1 (https=) |
| IL (1) | IL100195A0 (https=) |
| PT (1) | PT99659A (https=) |
| TW (1) | TW205507B (https=) |
| ZA (1) | ZA919438B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0573617A1 (en) * | 1991-05-24 | 1993-12-15 | Fred Hutchinson Cancer Research Center | Modulation of cellular response to external stimuli |
| DE4411660A1 (de) * | 1994-04-05 | 1995-10-12 | Hoechst Ag | Verwendung von Xanthinderivaten zur Reduktion der pathologischen Hyperreagibilität eosinophiler Granulozyten, neue Xanthinverbindungen und Verfahren zu deren Herstellung |
| DE4430127A1 (de) * | 1994-08-25 | 1996-03-14 | Hoechst Ag | Kombinationspräparat, enthaltend Cyclosporin A oder FK506 und ein Xanthinderivat |
| DE4430128A1 (de) | 1994-08-25 | 1996-02-29 | Hoechst Ag | Kombinationspräparat mit immunsuppressiven, kardiovaskulären und cerebralen Wirkungen |
| US6323201B1 (en) | 1994-12-29 | 2001-11-27 | The Regents Of The University Of California | Compounds for inhibition of ceramide-mediated signal transduction |
| ATE234099T1 (de) * | 1998-04-24 | 2003-03-15 | Leuven K U Res & Dev | Immununterdrückende effekte von 8 substituierten xanthinderivaten |
| US6930101B1 (en) | 1999-05-17 | 2005-08-16 | The Regents Of The University Of California | Thiazolopyrimidines useful as TNFα inhibitors |
| US7253176B1 (en) | 2000-05-04 | 2007-08-07 | K.U. Leuven Research & Development | Immunosuppressive effects of 8-substituted xanthine derivatives |
| CN101998957B (zh) | 2008-02-29 | 2013-06-05 | 康塞特医药品有限公司 | 取代的黄嘌呤衍生物 |
| US20110053961A1 (en) | 2009-02-27 | 2011-03-03 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| IN2012DN01642A (https=) | 2009-09-02 | 2015-06-05 | Concert Pharmaceuticals Inc | |
| WO2012031138A2 (en) | 2010-09-01 | 2012-03-08 | Concert Pharmaceuticals, Inc. | Polymorphs of (s)-1-(4,4,6,6,6-pentadeutero-5-hydroxyhexyl)-3-7-dimethyl-1h-purine-2,6(3h,7h)dione |
| WO2013013052A1 (en) | 2011-07-19 | 2013-01-24 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| EA201491878A8 (ru) | 2012-04-13 | 2015-02-27 | Концерт Фармасьютикалс, Инк. | Замещенные ксантиновые производные |
| WO2013159006A1 (en) | 2012-04-20 | 2013-10-24 | Concert Pharmaceuticals, Inc. | Polymorphs of (s)-1-(4,4,6,6,6-pentadeutero-5-hydroxyhexyl)-3,7-dimethyl-1h-purine-2,6(3h,7h)-dione |
| US9549869B2 (en) | 2012-06-29 | 2017-01-24 | Hill-Rom Canado Respiratory Ltd. | Wearable thorax percussion device |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0063827B1 (fr) * | 1980-05-02 | 1985-08-14 | Societe Des Produits Nestle S.A. | 1-Isopropyl- et 1-isobutyl-3,7-diméthylxanthine comme médicaments |
| US4965271A (en) * | 1986-12-31 | 1990-10-23 | Hoechst Roussel Pharmaceuticals, Inc. | Method of inhibiting the activity of leukocyte derived cytokines |
| IL100536A (en) * | 1986-12-31 | 1994-05-30 | Hoechst Roussel Pharma | Pharmaceutical preparations containing a history of xanthine Stopping an immune response and relieving adverse conditions resulting from intracellular intervention in an immune response |
| GB8918297D0 (en) * | 1989-08-10 | 1989-09-20 | Beecham Group Plc | Novel treatment |
-
1991
- 1991-11-28 IL IL100195A patent/IL100195A0/xx unknown
- 1991-11-28 EP EP91120425A patent/EP0490181A1/en not_active Withdrawn
- 1991-11-29 HU HU913721A patent/HUT59825A/hu unknown
- 1991-11-29 JP JP3316210A patent/JPH06100450A/ja active Pending
- 1991-11-29 PT PT99659A patent/PT99659A/pt not_active Application Discontinuation
- 1991-11-29 IE IE416391A patent/IE914163A1/en not_active Application Discontinuation
- 1991-11-29 KR KR1019910021768A patent/KR920009399A/ko not_active Withdrawn
- 1991-11-29 CA CA002056723A patent/CA2056723A1/en not_active Abandoned
- 1991-11-29 ZA ZA919438A patent/ZA919438B/xx unknown
-
1992
- 1992-03-06 TW TW081101708A patent/TW205507B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| JPH06100450A (ja) | 1994-04-12 |
| EP0490181A1 (en) | 1992-06-17 |
| KR920009399A (ko) | 1992-06-25 |
| ZA919438B (en) | 1992-08-26 |
| IL100195A0 (en) | 1992-08-18 |
| HUT59825A (en) | 1992-07-28 |
| TW205507B (https=) | 1993-05-11 |
| PT99659A (pt) | 1992-10-30 |
| HU913721D0 (en) | 1992-02-28 |
| CA2056723A1 (en) | 1992-05-31 |
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