IE780364L - Heterocyclic-substituted cephalosporins. - Google Patents

Heterocyclic-substituted cephalosporins.

Info

Publication number
IE780364L
IE780364L IE780364A IE36478A IE780364L IE 780364 L IE780364 L IE 780364L IE 780364 A IE780364 A IE 780364A IE 36478 A IE36478 A IE 36478A IE 780364 L IE780364 L IE 780364L
Authority
IE
Ireland
Prior art keywords
compounds
treatment
protective groups
represents hydrogen
component
Prior art date
Application number
IE780364A
Other versions
IE46651B1 (en
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of IE780364L publication Critical patent/IE780364L/en
Publication of IE46651B1 publication Critical patent/IE46651B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The compounds correspond to the formula: <IMAGE> in which R1 represents hydrogen or certain protective groups, R2 represents certain alkyl radicals, R3 represents C1-C4 alkyl or alkoxy radicals and A represents hydrogen, an alkali metal, alkaline-earth metal, magnesium or amine cation or an ester group; the preferred compounds have the syn configuration. The preparation is carried out by creating the amide bond from the carboxyl component and the substituted 7-aminocephem component, followed by an acid hydrolysis, a hydrogenolysis or a treatment with thiourea when it is desired to remove the protective groups R1 and A. The compounds are active with respect to gram (+) and (-) bacteri; they can be used in the treatment of relevant infections. [GB1575180A]
IE364/78A 1977-02-18 1978-02-20 New oxime derivatives of 3-thiadiazolyl thiomethyl-7-aminothiazolylacetamido-cephalosporanic acid,processes for preparing them and pharmaceutical compositions containing them IE46651B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7704745A FR2381053A1 (en) 1977-02-18 1977-02-18 NEW OXIMES DERIVED FROM 3-THIADIAZOLYL THIOMETHYL 7-AMINOTHIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Publications (2)

Publication Number Publication Date
IE780364L true IE780364L (en) 1978-08-18
IE46651B1 IE46651B1 (en) 1983-08-10

Family

ID=9186946

Family Applications (1)

Application Number Title Priority Date Filing Date
IE364/78A IE46651B1 (en) 1977-02-18 1978-02-20 New oxime derivatives of 3-thiadiazolyl thiomethyl-7-aminothiazolylacetamido-cephalosporanic acid,processes for preparing them and pharmaceutical compositions containing them

Country Status (23)

Country Link
JP (1) JPS53108996A (en)
AT (1) AT355722B (en)
AU (1) AU516076B2 (en)
BE (1) BE864074A (en)
CA (1) CA1132537A (en)
CH (1) CH633016A5 (en)
DE (1) DE2806226A1 (en)
DK (1) DK68978A (en)
ES (2) ES467090A1 (en)
FI (1) FI69468C (en)
FR (1) FR2381053A1 (en)
GB (1) GB1575180A (en)
GR (1) GR71703B (en)
HU (1) HU181961B (en)
IE (1) IE46651B1 (en)
IL (1) IL54043A (en)
LU (1) LU79080A1 (en)
NL (1) NL7801834A (en)
PT (1) PT67673B (en)
SE (1) SE434268B (en)
SU (1) SU841590A3 (en)
YU (1) YU41583B (en)
ZA (1) ZA78847B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE878514A (en) * 1978-09-04 1980-02-29 Fujisawa Pharmaceutical Co PROCESS FOR THE PREPARATION OF 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS WITH DISUBSTITUTION IN POSITIONS 3 AND 7, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIBACTERIAL ACTIVITY
BE878433A (en) * 1978-08-31 1980-02-25 Fujisawa Pharmaceutical Co PROCESS FOR THE PREPARATION OF 3-CEPHEM-4-CARBOXYLIC ACID DERIVATIVES 3,7-DISUBSTITUTED, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIBACTERIAL ACTIVITY
DE2714880A1 (en) * 1977-04-02 1978-10-26 Hoechst Ag CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
US4341775A (en) * 1978-09-11 1982-07-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
DE2945248A1 (en) * 1978-11-13 1980-05-22 Fujisawa Pharmaceutical Co CEPHEM COMPOUNDS, METHOD FOR THEIR PRODUCTION AND ANTIBACTERIAL PHARMACEUTICAL AGENTS CONTAINING THE SAME
US4399132A (en) * 1980-08-11 1983-08-16 American Cyanamid Company 7-Beta-[alpha-syn-methoxyimino-alpha-(2-aminothiazol-4-yl)-acetamido]-3-[(1,2,3-thiadiazol-5-ylthio)methyl]-3-cephem-4-carboxylic acid and C1 -C6 alkyl derivatives thereof
US4761409A (en) * 1984-08-16 1988-08-02 Sumitomo Pharmaceuticals Company, Limited Cephem derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
DK154939C (en) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd METHOD OF ANALOGUE FOR THE PREPARATION OF THIAZOLYLACETAMIDO-CEPHEM COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS OR ESTERS THEREOF
DK162391C (en) * 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co ANALOGY PROCEDURE FOR PREPARING SYN-ISOMERS OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS
DE2760484C2 (en) * 1976-04-14 1992-12-03 Takeda Chemical Industries, Ltd., Osaka, Jp

Also Published As

Publication number Publication date
NL7801834A (en) 1978-08-22
GR71703B (en) 1983-06-21
IE46651B1 (en) 1983-08-10
PT67673B (en) 1980-03-03
YU33678A (en) 1983-01-21
IL54043A0 (en) 1978-04-30
FI780444A (en) 1978-08-19
GB1575180A (en) 1980-09-17
AU3337578A (en) 1979-08-23
AU516076B2 (en) 1981-05-14
CA1132537A (en) 1982-09-28
FI69468B (en) 1985-10-31
BE864074A (en) 1978-08-17
YU41583B (en) 1987-10-31
ES467090A1 (en) 1979-06-01
ZA78847B (en) 1979-03-28
DK68978A (en) 1978-08-19
ATA120978A (en) 1979-08-15
JPS53108996A (en) 1978-09-22
CH633016A5 (en) 1982-11-15
FI69468C (en) 1986-02-10
AT355722B (en) 1980-03-25
PT67673A (en) 1978-03-01
HU181961B (en) 1983-11-28
DE2806226A1 (en) 1978-08-24
IL54043A (en) 1983-02-23
FR2381053B1 (en) 1979-06-01
SE434268B (en) 1984-07-16
FR2381053A1 (en) 1978-09-15
SU841590A3 (en) 1981-06-23
SE7800790L (en) 1978-08-19
ES475956A1 (en) 1979-12-16
LU79080A1 (en) 1978-09-28

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