ES467090A1 - Oxime derivatives of 3-thiadiazolylthiomethyl-7-aminothiazolylacetamido-cephalosporanic acid processes for preparing them and pharmaceutical compositions containing them - Google Patents

Oxime derivatives of 3-thiadiazolylthiomethyl-7-aminothiazolylacetamido-cephalosporanic acid processes for preparing them and pharmaceutical compositions containing them

Info

Publication number
ES467090A1
ES467090A1 ES467090A ES467090A ES467090A1 ES 467090 A1 ES467090 A1 ES 467090A1 ES 467090 A ES467090 A ES 467090A ES 467090 A ES467090 A ES 467090A ES 467090 A1 ES467090 A1 ES 467090A1
Authority
ES
Spain
Prior art keywords
aminothiazolylacetamido
thiadiazolylthiomethyl
preparing
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES467090A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES467090A1 publication Critical patent/ES467090A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The compounds correspond to the formula: < IMAGE > in which R1 represents hydrogen or certain protective groups, R2 represents certain alkyl radicals, R3 represents C1-C4 alkyl or alkoxy radicals and A represents hydrogen, an alkali metal, alkaline-earth metal, magnesium or amine cation or an ester group the preferred compounds have the syn configuration. The preparation is carried out by creating the amide bond from the carboxyl component and the substituted 7-aminocephem component, followed by an acid hydrolysis, a hydrogenolysis or a treatment with thiourea when it is desired to remove the protective groups R1 and A. The compounds are active with respect to gram (+) and (-) bacteri they can be used in the treatment of relevant infections.
ES467090A 1977-02-18 1978-02-17 Oxime derivatives of 3-thiadiazolylthiomethyl-7-aminothiazolylacetamido-cephalosporanic acid processes for preparing them and pharmaceutical compositions containing them Expired ES467090A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7704745A FR2381053A1 (en) 1977-02-18 1977-02-18 NEW OXIMES DERIVED FROM 3-THIADIAZOLYL THIOMETHYL 7-AMINOTHIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
ES467090A1 true ES467090A1 (en) 1979-06-01

Family

ID=9186946

Family Applications (2)

Application Number Title Priority Date Filing Date
ES467090A Expired ES467090A1 (en) 1977-02-18 1978-02-17 Oxime derivatives of 3-thiadiazolylthiomethyl-7-aminothiazolylacetamido-cephalosporanic acid processes for preparing them and pharmaceutical compositions containing them
ES475956A Expired ES475956A1 (en) 1977-02-18 1978-12-13 Oxime derivatives of 3-thiadiazolylthiomethyl-7-aminothiazolylacetamido-cephalosporanic acid processes for preparing them and pharmaceutical compositions containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES475956A Expired ES475956A1 (en) 1977-02-18 1978-12-13 Oxime derivatives of 3-thiadiazolylthiomethyl-7-aminothiazolylacetamido-cephalosporanic acid processes for preparing them and pharmaceutical compositions containing them

Country Status (23)

Country Link
JP (1) JPS53108996A (en)
AT (1) AT355722B (en)
AU (1) AU516076B2 (en)
BE (1) BE864074A (en)
CA (1) CA1132537A (en)
CH (1) CH633016A5 (en)
DE (1) DE2806226A1 (en)
DK (1) DK68978A (en)
ES (2) ES467090A1 (en)
FI (1) FI69468C (en)
FR (1) FR2381053A1 (en)
GB (1) GB1575180A (en)
GR (1) GR71703B (en)
HU (1) HU181961B (en)
IE (1) IE46651B1 (en)
IL (1) IL54043A (en)
LU (1) LU79080A1 (en)
NL (1) NL7801834A (en)
PT (1) PT67673B (en)
SE (1) SE434268B (en)
SU (1) SU841590A3 (en)
YU (1) YU41583B (en)
ZA (1) ZA78847B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE878433A (en) * 1978-08-31 1980-02-25 Fujisawa Pharmaceutical Co PROCESS FOR THE PREPARATION OF 3-CEPHEM-4-CARBOXYLIC ACID DERIVATIVES 3,7-DISUBSTITUTED, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIBACTERIAL ACTIVITY
BE878514A (en) * 1978-09-04 1980-02-29 Fujisawa Pharmaceutical Co PROCESS FOR THE PREPARATION OF 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS WITH DISUBSTITUTION IN POSITIONS 3 AND 7, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIBACTERIAL ACTIVITY
DE2714880A1 (en) * 1977-04-02 1978-10-26 Hoechst Ag CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
US4341775A (en) * 1978-09-11 1982-07-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
DE2945248A1 (en) * 1978-11-13 1980-05-22 Fujisawa Pharmaceutical Co CEPHEM COMPOUNDS, METHOD FOR THEIR PRODUCTION AND ANTIBACTERIAL PHARMACEUTICAL AGENTS CONTAINING THE SAME
US4399132A (en) * 1980-08-11 1983-08-16 American Cyanamid Company 7-Beta-[alpha-syn-methoxyimino-alpha-(2-aminothiazol-4-yl)-acetamido]-3-[(1,2,3-thiadiazol-5-ylthio)methyl]-3-cephem-4-carboxylic acid and C1 -C6 alkyl derivatives thereof
US4761409A (en) * 1984-08-16 1988-08-02 Sumitomo Pharmaceuticals Company, Limited Cephem derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
DK154939C (en) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd METHOD OF ANALOGUE FOR THE PREPARATION OF THIAZOLYLACETAMIDO-CEPHEM COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS OR ESTERS THEREOF
DK162391C (en) * 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co ANALOGY PROCEDURE FOR PREPARING SYN-ISOMERS OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS
GR63088B (en) * 1976-04-14 1979-08-09 Takeda Chemical Industries Ltd Preparation process of novel cephalosporins

Also Published As

Publication number Publication date
AT355722B (en) 1980-03-25
NL7801834A (en) 1978-08-22
BE864074A (en) 1978-08-17
PT67673A (en) 1978-03-01
JPS53108996A (en) 1978-09-22
IE780364L (en) 1978-08-18
LU79080A1 (en) 1978-09-28
IL54043A (en) 1983-02-23
DE2806226A1 (en) 1978-08-24
YU41583B (en) 1987-10-31
FR2381053B1 (en) 1979-06-01
GB1575180A (en) 1980-09-17
FI69468B (en) 1985-10-31
SU841590A3 (en) 1981-06-23
SE434268B (en) 1984-07-16
CA1132537A (en) 1982-09-28
AU3337578A (en) 1979-08-23
HU181961B (en) 1983-11-28
FI780444A (en) 1978-08-19
AU516076B2 (en) 1981-05-14
DK68978A (en) 1978-08-19
SE7800790L (en) 1978-08-19
FR2381053A1 (en) 1978-09-15
IL54043A0 (en) 1978-04-30
ES475956A1 (en) 1979-12-16
ATA120978A (en) 1979-08-15
YU33678A (en) 1983-01-21
FI69468C (en) 1986-02-10
IE46651B1 (en) 1983-08-10
GR71703B (en) 1983-06-21
ZA78847B (en) 1979-03-28
PT67673B (en) 1980-03-03
CH633016A5 (en) 1982-11-15

Similar Documents

Publication Publication Date Title
ES474288A1 (en) 3-Substituted-6-substituted-7-oxo-1-azabicyclo (3.2.0)-hept-2-ene-2-carboxylic acid, its preparation and pharmaceutical compositions containing it.
JPS5569586A (en) 11* 66 and 22substitutedd11carbaa22penenn 33carboxylic acid
MY101359A (en) 7-acylamino-3-vinylcephalosporanic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, their starting compounds and their preparation
BG93979A (en) N-(4-PIPERIDINYL)(DIHYDROBENZOFURAN OR DIHYDRO-2H-BENZOPYRAN)CARBOXAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THEM, METHOD OF PREPARING THE DERIVATIVES AND THEIR APPLICATION
TW369535B (en) A pyrazolopyridine compound and the process for preparing thereof
ES8103072A1 (en) Cephem compounds, processes for their preparation and pharmaceutical compositions containing them.
KR830009107A (en) Method for preparing 2-phenem compound
ES2131207T3 (en) AMIDAS DERIVATIVES OF VALPROIC ACID AND 2-VALPROENOIC ACID AND ITS USE AS ANTICONVULSIVES.
ES474289A1 (en) 3-Substituted-6-(1&#39;hydroxethyl)-7-oxo-1-azabicyclo(3.2.0.)-hept-2-ene-2-carboxylic acid, its preparation and pharmaceutical compositions containing it.
ES455089A1 (en) Oxime derivatives of 7-aminothiazolylacetamido-cephalosporanic acid processes for preparing them and pharmaceutical compositions incorporating them
ES8306160A1 (en) New cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds.
ES8200645A1 (en) Muramyldipeptide derivatives, process for preparing said compounds and pharmaceutical compositions containing said compounds.
ES469425A1 (en) N-Alkyl-N-acyl derivatives of thienamycin
ES8307239A1 (en) (2-Oxo-3-tetrahydrothienylcarbamoyl)-alkylthio acids, their salts and esters, their preparation and pharmaceutical compositions containing them.
ES467090A1 (en) Oxime derivatives of 3-thiadiazolylthiomethyl-7-aminothiazolylacetamido-cephalosporanic acid processes for preparing them and pharmaceutical compositions containing them
MX9800704A (en) Esters and amides as pla2 inhibitors.
ES8401077A1 (en) Cephalosporin esters, process for their preparation and pharmaceutical compositions containing them.
ES8505922A1 (en) Derivatives of 4-phenyl-4-oxo-buten-2-oic acid, their preparation, medicaments and compositions containing them.
ES461764A1 (en) Oxime derivatives of 3-carbamoyloxymethyl-7-amino-thiazolyl-acetamido-ceph-3-em-4-carboxylic acid processes for preparing them and pharmaceutical compositions containing them
ES8601183A1 (en) 1,2-dithiolan derivatives, process for their production pharmaceutical compositions containing them and their use
DE69429753D1 (en) Antibiotic cephalosporins and processes for their preparation
ES8200689A1 (en) Acylated cephalosporin analogs, process for their preparation and pharmaceutical compositions comprising them.
ES472749A1 (en) N-substituted 2-hydrazono-propionic acid derivatives, process for their preparation and pharmaceutical compositions containing them.
GB1530872A (en) Derivatives of 7-(2-amino-4-thiazolylacetamido)-cephalosporanic acid processes for preparing them and pharmaceutical compositions containing them
GB1055221A (en) Pyridobenzoxazepine derivatives